Abstract:
BACKGROUND:As increasing numbers of young patients with cancer survive, interest in the late effects of therapy is rising. METHODS:The sequelae of treatment were reviewed after a minimum of 5 years of observation in 109 surviving patients with sarcoma of the bladder or prostate who were enrolled in the Intergroup Rhabdomyosarcoma Studies I and II (1972-1984). The 82 male and 27 female patients were 3 weeks to 19 years of age when the diagnosis was made (median, 2 years) and were 5-29 years of age at last contact (median, 11 years). Treatment consisted of chemotherapy with vincristine, dactinomycin, and cyclophosphamide and bladder irradiation in nearly all patients. RESULTS:Fifty-four patients underwent total cystectomy, and 10 had a partial cystectomy. Of the 55 patients with bladder preservation, 1 had a urinary conduit with a nonfunctioning bladder. Thus, 54 bladders (50% of the total) remained in place as part of the urinary tract. There was no information regarding bladder function in two patients. Satisfactory bladder function was found in 38 patients (73%), 9 were incontinent, and 5 had urinary frequency with or without nocturia. Posttherapy hematuria was detected in 29% of patients. Nine of the 31 patients (29%) with follow-up renal imaging studies had a structural abnormality, chiefly hydronephrosis, which was more frequent in those with urinary diversion. Positive urine cultures were found mainly among those with enteric urinary conduits, but only two cases of pyelonephritis were documented. Abnormalities of irradiated bone and bowel were observed infrequently. Only one patient had a significantly elevated blood urea nitrogen or serum creatinine value, and only one patient was hypertensive. Most patients were still prepubertal at last follow-up. Of 24 patients who were intrapubertal or postpubertal, 7 (29%) were receiving sex hormone replacement because of delayed pubertal development. Height was decreased by 25% or more in 11 patients, as confirmed by growth chart analysis. Secondary surgical procedures other than repeat biopsy or cystectomy consisted primarily of urinary conduit revisions and repair of bowel adhesions or fistulous tracts. Information about psychosocial status was limited. CONCLUSIONS:Overall, 50% of the patients retained their bladders, and 73% of them had satisfactory bladder function. Renal function was preserved in nearly every patient.
journal_name
Cancerjournal_title
Cancerauthors
Raney B Jr,Heyn R,Hays DM,Tefft M,Newton WA Jr,Wharam M,Vassilopoulou-Sellin R,Maurer HMdoi
10.1002/1097-0142(19930401)71:7<2387::aid-cncr2820subject
Has Abstractpub_date
1993-04-01 00:00:00pages
2387-94issue
7eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns of fatigue and predictors of clinically significant fatigue 1 year after treatment completion. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32927
更新日期:2020-08-01 00:00:00
abstract::The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated. There were 17 patients with acute myelogenous leukemia (AML), six with acute lymphocytic leukemia (ALL), and one with biphenotypic leukemia. In this series of 24 patients whose disease had relapsed and who ha...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910915)68:6<1198::aid-cncr2820
更新日期:1991-09-15 00:00:00
abstract::We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was greater than 100 U/g of tissue, a valu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800515)45:10<2568::aid-cncr282
更新日期:1980-05-15 00:00:00
abstract:BACKGROUND:None of the commonly used staging criteria accurately determine the prognosis of a patient with adenocarcinoma of Barrett's esophagus. The authors therefore assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms CD44v4, v5,v6,v7, and v10 in adenocarcinoma of Barrett's esopha...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1074::aid-cn
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) and computed tomography (CT) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas (NPC) from benign lesions after radiotherapy was compared with...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.10400
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Multimodality treatment has dramatically improved the outcome of patients with Ewing sarcoma. However, there appears to be little information concerning treatment-related complications in patients who are long-term survivors. METHODS:Forty-one patients with Ewing sarcoma who were treated between 1960-1980 a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11891
更新日期:2003-12-15 00:00:00
abstract:BACKGROUND:There is limited understanding of the association between barriers to care and clinical outcomes within patient navigation programs. METHODS:Secondary analyses of data from the intervention arms of the Patient Navigation Research Program were performed, which included navigated participants with abnormal br...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29607
更新日期:2015-11-15 00:00:00
abstract:BACKGROUND:The purpose of the current study was to test the hypothesis that a lower clinical TNM stage is associated with a higher rate of pathologic complete response (pathCR) in patients with esophageal carcinoma receiving preoperative chemoradiotherapy and to determine whether outcome after pathCR is related to clin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21439
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine risk factors that affect locoregional control of nasopharyngeal carcinoma (NPC) after radiotherapy. Computed tomography (CT) is utilized for radiotherapy planning and for identifying high risk anatomic areas. METHODS:Between April 1990 and December 1993, 40 consecu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980115)82:2<261::aid-cnc
更新日期:1998-01-15 00:00:00
abstract:BACKGROUND:It has been suggested that tissue factor (TF) plays an important role in tumor metastasis. Its expression in sarcoma cells was reported to up-regulate the vascular endothelial growth factor (VEGF) gene and thereby enhance tumor angiogenesis, which is essential to tumor metastasis. Although many malignant tum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000115)88:2<295::aid-cnc
更新日期:2000-01-15 00:00:00
abstract:BACKGROUND:Pegylated liposomal doxorubicin (PEG-LD) and docetaxel have single-agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with advanced malignancies. METHODS:Twenty-...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11547
更新日期:2003-08-01 00:00:00
abstract::Oral rhabdomyosarcoma (RMS) was studied by analysis of eight such cases which presented over a 25-year period. Rhabdomyosarcoma was the fourth most common oral sarcoma (7.5%) from this period after osteosarcoma (32%), fibrosarcoma (19%), and chondrosarcoma (9%). In patients younger than 20 years, RMS was the second mo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890301)63:5<963::aid-cncr28206
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Cancer costs should be discussed by patients and providers, but information is not readily available. Results from recently published studies (in the last 5 years) on direct and indirect cancer costs may help guide these discussions. METHODS:The authors reviewed studies published between 2013 and 2017 that ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.31643
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Insular thyroid carcinoma was described originally as a tumor with aggressive behavior. However, whether a predominant insular component is an independent factor for poor prognosis is unclear. METHODS:The authors compared the clinical behavior of tumors in three groups of patients with thyroid carcinoma--13...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10947
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:Although state Medicaid programs cover cancer screening, Medicaid beneficiaries are less likely to be screened for cancer and are more likely to present with tumors of an advanced stage than are those with other insurance. The current study was performed to determine whether state Medicaid eligibility and re...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28704
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The influence of various clinicopathologic features on survival of patients with papillary thyroid carcinoma has been examined. In particular, histologic grade, which was obtained by a combined assessment of nuclear atypia, tumor necrosis, and vascular invasion (VAN score) was studied. According to this, his...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931101)72:9<2680::aid-cncr2820
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role of MET in patients with recurrent=metastatic gastric cancer who received chemotherapy. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28454
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The effect of aspirin use on 490 patients with cancer of the colon, 340 with cancer of the rectum as the first primary site, and 212 patients with polyps having no coexisting malignancies was compared with that of two groups of control subjects that consisted of 524 hospital patients having no cancers and no...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930815)72:4<1171::aid-cncr2820
更新日期:1993-08-15 00:00:00
abstract:BACKGROUND:Because medulloblastoma (MB) is rare in adults, the few studies on this condition have been retrospective, and the follow-up has tended to be short. Furthermore, the different therapeutic strategies used in these patients has made it difficult to assess survival rates and prognostic factors. METHODS:In 1989...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23003
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Patient navigation programs are emerging that aim to address disparities in clinical trial participation among medically underserved populations, including racial/ethnic minorities. However, there is a lack of consensus on the role of patient navigators within the clinical trial process as well as outcome me...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28570
更新日期:2014-04-01 00:00:00
abstract::The development of monoclonal antibodies has led to renewed interest in the use of antibodies to treat malignant disease. Unfortunately, treatment with unmodified antibodies has been disappointing. Therapy with unmodified antibodies has been limited by the failure of host effector mechanisms to eliminate antibody-coat...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19860715)58:2+<584::aid-cncr2820
更新日期:1986-07-15 00:00:00
abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197808)42:2<447::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract::Nutrients as therapy for patients with cancer are important as adjunctive therapy, i.e., adequate nutrition may be important for the success of whatever form of therapy is administered. Diets deficient in certain amino acids have some selectivity when tested against experimental tumors propagated in vivo. Such diets h...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197905)43:5+<2137::aid-cncr28204
更新日期:1979-05-01 00:00:00
abstract::Over the last several decades, significant "new eyes" have been developed that improve the diagnosis, treatment, planning, and monitoring of human cancer: computer tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomogra...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910215)67:4+<1121::aid-cncr282
更新日期:1991-02-15 00:00:00
abstract:BACKGROUND:Filanesib (ARRY-520) is a highly selective inhibitor of kinesin spindle protein, which has demonstrated preclinical antimyeloma activity. METHODS:This open-label Phase 1/2 study determined the maximum tolerated dose of Filanesib administered on Days 1 and 2 of 14-Day Cycles in patients with multiple myeloma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30892
更新日期:2017-12-01 00:00:00
abstract::A pathology review of breast cancers in Japanese and Caucasian women indicates more numerous in situ carcinomas in the Japanese. Carcinomas with uniform nuclei were also more numerous among Japanese. Japanese women showed more extensive lymphocytic infiltrates adjacent to their tumors than did Caucasian women, and als...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850701)56:1<206::aid-cncr28205
更新日期:1985-07-01 00:00:00
abstract::Pituitary adenomas rarely are metastatic. Extracranial visceral metastases of prolactinomas were not previously reported. The authors report a case of a 34-year-old man with a prolactin-producing pituitary carcinoma and histologically proven lung metastases. Pathologic examination of the pulmonary spread included elec...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911001)68:7<1605::aid-cncr2820
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Hepatic artery administration of iodine-131-Lipiodol serves as a modality that delivers targeted radiation therapy to hepatocellular carcinoma. Its efficacy has been promising according to trials conducted in the adjuvant setting after hepatic resection. Further investigation of its role in the palliative se...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25283
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Prostate-specific antigen (PSA) screening for prostate cancer has high risks of overdiagnosis, particularly among older men, and reports from screening trials indicate that it saves few lives after 11 to 13 years of follow-up. New clinical guidelines recommend against PSA screening for all men or for men age...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28932
更新日期:2014-11-15 00:00:00
abstract::One hundred thirty patients with histologically verified primary fibrosarcoma of bone, unassociated with any pre-existent benign bone condition, were treated at Memorial Sloan-Kettering Cancer Center between 1918 and 1973. This series of cases represents approximately 5% of primary malignant bone tumors treated in our...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3<837::aid-cncr2820350
更新日期:1975-03-01 00:00:00