Intra-arterial iodine-131-lipiodol for unresectable hepatocellular carcinoma.

Abstract:

BACKGROUND:Hepatic artery administration of iodine-131-Lipiodol serves as a modality that delivers targeted radiation therapy to hepatocellular carcinoma. Its efficacy has been promising according to trials conducted in the adjuvant setting after hepatic resection. Further investigation of its role in the palliative setting is warranted. METHODS:A retrospective review of 72 patients with unresectable hepatocellular carcinoma treated with iodine-131-Lipiodol and followed up by the St. George Hospital Sydney's hepatobiliary service was conducted. Efficacy of treatment was determined based on progression-free and overall survival as the endpoints using the Kaplan-Meier method. RESULTS:Sixty men and 12 women with a mean age of 65 years (standard deviation = 11) underwent iodine-131-Lipiodol treatment. Chronic viral hepatitis was present in 29 (41%) patients. Fifty (69%) patients were Child-Pugh class A. Median progression-free survival was 6 months, and overall survival was 14 months; the 1-, 2-, and 3-year survival rates were 52%, 33% and 20%, respectively. Factors associated with survival include the American Joint Committee on Cancer stage (P = .03), Barcelona Clinic Liver Cancer stage (P = .05), Cancer of the Liver Italian Program score (P = .008), tumor size (P = .01), extrahepatic disease (P < .001), previous surgery (P = .02), and response to treatment (P < .001). The response to treatment was identified through a multivariate analysis as the single independent predictor for survival (hazard ratio, 3.5; 95% confidence interval, 2.2-5.4; P < .001). CONCLUSIONS:Encouraging survival outcomes may be derived through administration of iodine-131-Lipiodol in patients with unresectable hepatocellular carcinoma. The overall success of treatment may be determined by the response to treatment.

journal_name

Cancer

journal_title

Cancer

authors

Chua TC,Chu F,Butler SP,Quinn RJ,Glenn D,Liauw W,Morris DL

doi

10.1002/cncr.25283

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

4069-77

issue

17

eissn

0008-543X

issn

1097-0142

journal_volume

116

pub_type

杂志文章

相关文献

CANCER文献大全
  • Caregiver symptom burden: the risk of caring for an underserved patient with advanced cancer.

    abstract:BACKGROUND:The growing diversity of the population of the United States and the high burden of cancer-related symptoms reflect the need for caregiver research within underserved groups. In this longitudinal study, the authors assessed changes in symptom severity in caregivers and underserved minority patients diagnosed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25695

    authors: Palos GR,Mendoza TR,Liao KP,Anderson KO,Garcia-Gonzalez A,Hahn K,Nazario A,Ramondetta LM,Valero V,Lynch GR,Jibaja-Weiss ML,Cleeland CS

    更新日期:2011-03-01 00:00:00

  • Disparities in access to care at high-volume institutions for uro-oncologic procedures.

    abstract:BACKGROUND:Socioeconomic status represents an established barrier to health care access. Age, sex, and race may also play a role. The authors examined whether these affect the access to high-volume hospitals for uro-oncologic procedures in the United States. METHODS:Within the Nationwide Inpatient Sample (NIS), the au...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27440

    authors: Trinh QD,Sun M,Sammon J,Bianchi M,Sukumar S,Ghani KR,Jeong W,Dabaja A,Shariat SF,Perrotte P,Agarwal PK,Rogers CG,Peabody JO,Menon M,Karakiewicz PI

    更新日期:2012-09-15 00:00:00

  • Granulomas in melanoma patients treated with BCG immunotherapy.

    abstract::Autopsy slides from 22 melanoma patients who received bacille Calmette-Guérin BCG immunotherapy and who had a postmortem examination at the UCLA Center for the Health Sciences were examined for the presence of granulomas. Granulomas were found in six patients (29%) who received BCG but not in a group of 25 melanoma pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820101)49:1<55::aid-cncr282049

    authors: Hatzitheofilou C,Obenchain DF,Porter DD,Morton DL

    更新日期:1982-01-01 00:00:00

  • The future of research that promotes cancer screening.

    abstract::The authors draw on the lessons highlighted in preceding articles in the current supplement to provide recommendations for cancer screening intervention research and to highlight some of the many questions that will require further investigation. ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.20510

    authors: Meissner HI,Vernon SW,Rimer BK,Wilson KM,Rakowski W,Briss PA,Smith RA

    更新日期:2004-09-01 00:00:00

  • Occult papillary thyroid carcinoma at autopsy in La Plata, Argentina.

    abstract::Although clinically evident thyroid carcinoma is not a frequent neoplasm (incidence 2.7 per 100,000 persons in La Plata, Argentina), occult carcinomas are present in a high proportion of the population, but there are marked differences along geographical lines. The purpose of the present study is to establish the prev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890715)64:2<547::aid-cncr28206

    authors: Ottino A,Pianzola HM,Castelletto RH

    更新日期:1989-07-15 00:00:00

  • Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group.

    abstract::Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that patients have received over the last 4 decades. Extensive efforts to identify more effective or less toxic regimens have proved disappointing. As we enter a postgenomic era in which we now recognize OS not as a cancer of mutations bu...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.32351

    authors: Roberts RD,Lizardo MM,Reed DR,Hingorani P,Glover J,Allen-Rhoades W,Fan T,Khanna C,Sweet-Cordero EA,Cash T,Bishop MW,Hegde M,Sertil AR,Koelsche C,Mirabello L,Malkin D,Sorensen PH,Meltzer PS,Janeway KA,Gorlick R,Cro

    更新日期:2019-10-15 00:00:00

  • Prostate-specific antigen response after short-term hormone therapy plus external-beam radiotherapy and outcome in patients treated on Radiation Therapy Oncology Group study 9413.

    abstract:BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.28019

    authors: Cury FL,Hunt D,Roach M 3rd,Shipley W,Gore E,Hsu IC,Krisch RE,Seider MJ,Sandler H,Lawton C

    更新日期:2013-06-01 00:00:00

  • Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.

    abstract:BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29259

    authors: Stremitzer S,Zhang W,Yang D,Ning Y,Stintzing S,Sebio A,Sunakawa Y,Yamauchi S,Matsusaka S,El-Khoueiry R,Stift J,Wrba F,Gruenberger T,Lenz HJ

    更新日期:2015-06-01 00:00:00

  • Mucinous tumors of the ovary. Ultrastructural studies of mucinous cystadenomas with histogenetic considerations.

    abstract::On the basis of light microscopic and scanning and transmission ultrastructural observations, we have classified benign mucinous ovarian neoplasms into two types: a pure endocervical type and a mixed intestinal endocervical type. We have also reviewed the literature pertinent to the histogenetic origin of the ovarian ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197511)36:5<1709::aid-cncr282036

    authors: Fenoglio CM,Ferenczy A,Richart RM

    更新日期:1975-11-01 00:00:00

  • Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma.

    abstract:BACKGROUND:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20550

    authors: Mizutani Y,Matsubara H,Yamamoto K,Nan Li Y,Mikami K,Okihara K,Kawauchi A,Bonavida B,Miki T

    更新日期:2004-10-15 00:00:00

  • Racial disparities in cervical cancer survival over time.

    abstract:BACKGROUND:The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC). METHODS:Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were eval...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28261

    authors: Rauh-Hain JA,Clemmer JT,Bradford LS,Clark RM,Growdon WB,Goodman A,Boruta DM 2nd,Schorge JO,del Carmen MG

    更新日期:2013-10-15 00:00:00

  • Bowenoid dysplasia of the vulva.

    abstract::The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821215)50:12<2910::aid-cncr282

    authors: Ulbright TM,Stehman FB,Roth LM,Ehrlich CE,Ransburg RC

    更新日期:1982-12-15 00:00:00

  • Clear cell sarcoma. A clinicopathologic study of 27 cases.

    abstract::Clear cell sarcoma is an indolent tumor of uncertain histogenesis. Twenty-seven patients ranging in age from 9 to 57 years (average, 28.5 years) were followed an average of 7.0 years. Females outnumbered males by 2 to 1. Distal extremity locations predominated. At presentation, the tumor was localized in 21 patients, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831015)52:8<1482::aid-cncr2820

    authors: Eckardt JJ,Pritchard DJ,Soule EH

    更新日期:1983-10-15 00:00:00

  • Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh.

    abstract:BACKGROUND:The authors sought to determine whether differences existed in patterns of outcome and morbidity between the 3 thigh compartments after limb-sparing surgery and postoperative radiation therapy (RT). METHODS:A total of 255 patients with primary soft tissue sarcoma (STS) of the thigh were identified in our sa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23975

    authors: Rimner A,Brennan MF,Zhang Z,Singer S,Alektiar KM

    更新日期:2009-01-01 00:00:00

  • Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls.

    abstract:BACKGROUND:This study examined the influence of prior treatment on the course of cognitive functioning in breast cancer survivors. Changes in cognitive functioning over time were compared in breast cancer survivors treated with chemotherapy plus radiotherapy, breast cancer survivors treated with radiotherapy only, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26432

    authors: Phillips KM,Jim HS,Small BJ,Laronga C,Andrykowski MA,Jacobsen PB

    更新日期:2012-04-01 00:00:00

  • The Chicago Consensus on peritoneal surface malignancies: Management of colorectal metastases.

    abstract::The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of colorectal cancer specifically as it relates to the management of peritoneal surface malignancy. These guidelines are developed with input from leading experts, including surgical oncologists, medical oncologists, path...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32874

    authors: Chicago Consensus Working Group.

    更新日期:2020-06-01 00:00:00

  • Noninvasive and real-time monitoring of the therapeutic response of tumors in vivo with an optimized hTERT promoter.

    abstract:BACKGROUND:Telomerase is commonly recognized as an effective anticancer target. The human telomerase reverse transcriptase (hTERT), the rate-limiting component of telomerase, is expressed in most malignant tumors, but it is not found in most normal somatic cells. Here, we report a real-time and noninvasive method to mo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26476

    authors: Yu ST,Li C,Lü MH,Liang GP,Li N,Tang XD,Wu YY,Shi CM,Chen L,Li CZ,Cao YL,Fang DC,Yang SM

    更新日期:2012-04-01 00:00:00

  • Restaging surgery for women with borderline ovarian tumors: results of a French multicenter study.

    abstract:BACKGROUND:The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk fa...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.20098

    authors: Fauvet R,Boccara J,Dufournet C,David-Montefiore E,Poncelet C,Daraï E

    更新日期:2004-03-15 00:00:00

  • Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) occurs more frequently in patients with hepatitis C virus (HCV)-related chronic liver disease than those with hepatitis B virus-related disease. It is important to assess the factors affecting the development of HCC. METHODS:A long term follow-up study involving patients with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Aizawa Y,Shibamoto Y,Takagi I,Zeniya M,Toda G

    更新日期:2000-07-01 00:00:00

  • Prognostic factors in telecobalt therapy for early supraglottic carcinoma.

    abstract:BACKGROUND:The local control rates of T1 and T2 supraglottic carcinoma treated with radiation alone were reported as 71% to 92% and 59% to 83%, respectively. The factors that affect the local control rate for early supraglottic carcinoma were investigated. METHODS:From 1967 through 1985, 100 cases with early supraglot...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930701)72:1<57::aid-cncr282072

    authors: Inoue T,Matayoshi Y,Inoue T,Ikeda H,Teshima T,Murayama S

    更新日期:1993-07-01 00:00:00

  • Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome.

    abstract:BACKGROUND:The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20431

    authors: Chang G,Orav EJ,McNamara T,Tong MY,Antin JH

    更新日期:2004-08-15 00:00:00

  • Polymerase chain reaction-based restriction fragment length polymorphism analysis of the short arm of chromosome 3 in primary head and neck squamous carcinoma.

    abstract:BACKGROUND:Deletion or loss of heterozygosity (LOH) at the polymorphic loci on the short arm of chromosome 3 has been reported in a large number of renal cell, small cell lung, non-small cell lung, and cervical carcinomas, suggesting the presence of one or more putative tumor suppressor genes at chromosome 3p. Similar ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930801)72:3<881::aid-cncr28207

    authors: el-Naggar AK,Lee MS,Wang G,Luna MA,Goepfert H,Batsakis JG

    更新日期:1993-08-01 00:00:00

  • Hormone replacement therapy and lung cancer risk in Chinese.

    abstract:BACKGROUND:The association between hormone replacement therapy (HRT) and a reduced lung cancer risk has been reported in previous studies. There is a high female to male ratio in Chinese lung cancer patients, and female patients have different clinicopathological characteristics compared with Western patient population...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22987

    authors: Chen KY,Hsiao CF,Chang GC,Tsai YH,Su WC,Perng RP,Huang MS,Hsiung CA,Chen CJ,Yang PC,GEFLAC Study Group.

    更新日期:2007-10-15 00:00:00

  • Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma.

    abstract::Based on laboratory studies showing enhanced cytotoxicity of floxuridine (FUDR) when used with high doses of leucovorin (LV), a pilot study of FUDR and LV through an implantable pump was initiated for the treatment of hepatic metastases from colorectal cancer. The highest dose of LV that could be administered, taking ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900601)65:11<2446::aid-cncr282

    authors: Kemeny N,Cohen A,Bertino JR,Sigurdson ER,Botet J,Oderman P

    更新日期:1990-06-01 00:00:00

  • Estrogen receptors in patients with malignant melanoma.

    abstract::We detected cytoplasmic estrogen receptors (ER) in only 4 of 34 (12%) patients with malignant melanoma. The titers as assayed by the dextran-coated charcoal method were 3, 3, 4, and 5 fmol/mg, respectively. Our data indicate that the incidence of melanoma with detectable ER is low, which suggests that any potential cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801015)46:8<1785::aid-cncr2820

    authors: Creagan ET,Ingle JN,Woods JE,Pritchard DJ,Jiang NS

    更新日期:1980-10-15 00:00:00

  • Transition of Ki-67 index of uterine cervical tumors during radiation therapy. Immunohistochemical study.

    abstract::Histopathologic and Ki-67-staining features of cancer cells were investigated in biopsy specimens before and during radiation therapy in 29 patients with cervical squamous cell carcinoma. No morphologic changes were observed up to doses of 540 cGy. A few intact cancer cells remained up to doses of 2700 cGy. Moderate c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910801)68:3<517::aid-cncr28206

    authors: Nakano T,Oka K

    更新日期:1991-08-01 00:00:00

  • Expression of c-myc oncogene product and ras family oncogene products in various human malignant lymphomas defined by immunohistochemical techniques.

    abstract::The authors studied the expression of c-myc and ras family oncogene products in 43 cases of malignant lymphoma (ML) using the immunoperoxidase method. Unfixed frozen sections of lymph nodes from four patients with Hodgkin's disease and 39 with non-Hodgkin's lymphoma, together with normal lymph nodes, were studied by t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881115)62:10<2085::aid-cncr282

    authors: Mitani S,Sugawara I,Shiku H,Mori S

    更新日期:1988-11-15 00:00:00

  • Olive oil, other seasoning fats, and the risk of colorectal carcinoma.

    abstract:BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/(sici)1097-0142(19980201)82:3<448::aid-cnc

    authors: Braga C,La Vecchia C,Franceschi S,Negri E,Parpinel M,Decarli A,Giacosa A,Trichopoulos D

    更新日期:1998-02-01 00:00:00

  • Adult de novo acute myeloid leukemia with t(6;11)(q27;q23): results from Cancer and Leukemia Group B Study 8461 and review of the literature.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) with t(6;11)(q27;q23) is a well established but rare entity, and few studies have reported the full clinical, hematologic, and outcome data of patients with this disease. METHODS:To characterize the features of t(6;11) AML, the authors searched the Cancer and Leukemia Group B (C...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.20489

    authors: Blum W,Mrózek K,Ruppert AS,Carroll AJ,Rao KW,Pettenati MJ,Anastasi J,Larson RA,Bloomfield CD

    更新日期:2004-09-15 00:00:00

  • Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases.

    abstract:BACKGROUND:Papanicolaou smear sensitivity for cervical adenocarcinoma (CVCA) is not well established. Also uncertain are the relative contributions to falsely negative diagnoses of sampling, screening, and interpretive errors. METHODS:Papanicolaou smears were identified from all patients at our institutions with biops...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Krane JF,Granter SR,Trask CE,Hogan CL,Lee KR

    更新日期:2001-02-25 00:00:00