Granulomas in melanoma patients treated with BCG immunotherapy.

Abstract:

:Autopsy slides from 22 melanoma patients who received bacille Calmette-Guérin BCG immunotherapy and who had a postmortem examination at the UCLA Center for the Health Sciences were examined for the presence of granulomas. Granulomas were found in six patients (29%) who received BCG but not in a group of 25 melanoma patients who did not have BCG immunotherapy. A number of factors were tested for correlation with the presence of granulomas in the autopsy material. Fifty-five percent of the patients who received BCG by both intralesional and time technique developed granulomas. No patients given BCG by the tine technique alone developed granulomas. No correlation was found between granulomas and the presence of symptoms after the administration of BCG, the duration of BCG immunotherapy, the patient's age, the number of BCG administrations, treatment with immunosuppressive agents, the length of survival after the last BCG administration, the presence of a positive PPD reaction, a positive history for granuloma-forming diseases and tests for immunocompetence. However, these results provide evidence that the route of BCG administration strongly influences the frequency of granulomas in melanoma patients who received BCG immunotherapy.

journal_name

Cancer

journal_title

Cancer

authors

Hatzitheofilou C,Obenchain DF,Porter DD,Morton DL

doi

10.1002/1097-0142(19820101)49:1<55::aid-cncr282049

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

55-60

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

49

pub_type

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