Abstract:
:A collaborative study of the humoral and cellular immune status of patients with carcinoma of the Head and Neck (H&N) was conducted at the West Virginia University (WVU) hospital. In addition, blind-coded serum panels were supplied on H&N cancer patients being treated at the National Cancer Institute (NCI). Serum protein analysis of the WVU study groups revealed that at the pretreatment sampling, the alpha-1 acid glycoprotein (AGP), total complement, and IgA levels were significantly elevated. The AGP levels and total complement levels declined to normal levels in the post-treatment period, whereas the IgA levels remained elevated throughout the entire observation period. Levels of serum immune complexes (SIC) were measured in both the WVU and NCI H&N cancer populations using the polyethylene glycol (PEG) precipitation method. In both survey populations all cancer groups had significantly elevated levels of SIC when compared to any of the control populations. The SIC levels never returned to comparative normal values even in cases after successful treatment. A subpopulation of the WVU-H&N cancer study group underwent a short course of intravenous hyperalimentation prior to their treatment regimen. These patients demonstrated a transient decrease in their SIC levels as well as a concomitant increase in their in vitro cell-mediated immune (CMI) correlates. The analysis of in vitro CMI correlates of the WVU study group using both polyclonal mitogens and specific antigens demonstrated a significant depression in these parameters pretreatment and post-treatment. In addition, it was observed that the time course for elevation of selected serum proteins (i.e., IgA and SIC) correlated with concomitant drops in CMI activity. Investigations were also conducted into the effects of immune complex-rich serum fractions upon selected in vitro CMI correlates. Significant blockage of a normal donor leukocyte migration-inhibition assay was demonstrated. Also, a similar inhibition of the ability of normal human lymphocytes to form high affinity rosettes was accomplished with serum from H&N cancer patients.
journal_name
Cancerjournal_title
Cancerauthors
Veltri RW,Rodman SM,Maxim PE,Baseler MW,Sprinkle PMdoi
10.1002/1097-0142(19860615)57:12<2295::aid-cncr282subject
Has Abstractpub_date
1986-06-15 00:00:00pages
2295-308issue
12eissn
0008-543Xissn
1097-0142journal_volume
57pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Workload is extensively regulated and often used as a measure of quality in gynecologic cytology. Whether workload correlates with the sensitivity of screening in gynecologic cytology is not known. METHODS:The sensitivity of gynecologic cytology screening was measured over an 8-month period using the result...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23497
更新日期:2008-06-25 00:00:00
abstract:BACKGROUND:Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The Univ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31112
更新日期:2018-03-01 00:00:00
abstract::Estradiol and testosterone levels in the peripheral and ovarian circulation of patients with endometrial cancer and of postmenopausal women were studied. These levels proved to be the same in the two groups. The ovaries of neither group secreted estradiol. The testosterone level in the ovarian circulation of all exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1809::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::Cases of childhood cancer (less than 15 years of age at diagnosis), diagnosed between 1960 and 1984, were obtained from the Hawaii Tumor Registry, a population-based Surveillance, Epidemiology, and End Results (SEER) participant covering the entire State of Hawaii. During the 25 years of data collection, cancer was di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1758::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::Sixty-three gastrectomy specimens (21 with early intestinal type carcinoma, 21 with early diffuse carcinoma, and 21 with benign nonneoplastic lesions) were examined histochemically to determine the distribution of intestinal metaplasia (IM), particularly the sulphomucin-secreting type (Type IIB IM). The frequency and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900815)66:4<689::aid-cncr28206
更新日期:1990-08-15 00:00:00
abstract::The growth rates of recurrent hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLTX) were estimated by calculating the tumor doubling time (TDT) in 20 patients. The mean TDT, calculated by multiple measurement of tumor size, was 44.3 +/- 11.3 days (mean +/- standard error) in 12 patients with pul...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911115)68:10<2095::aid-cncr282
更新日期:1991-11-15 00:00:00
abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc
更新日期:1997-04-25 00:00:00
abstract:BACKGROUND:The purpose of the current study was to examine patient selection for an aromatase inhibitor in breast cancer patients who were free from adverse events 5 years after treatment with tamoxifen. METHODS:In all, 471 women were treated with breast-conserving surgery, axillary lymph node dissection, and radiatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22291
更新日期:2006-12-01 00:00:00
abstract::Two cases of primary non-Hodgkin's lymphomas of the breast were studied with light and electron microscopy. By light microscopy, according to Rappaport's classification, one was a poorly differentiated lymphocytic lymphoma, the other a diffuse histiocytic lymphoma. However, the ultrastructural features of the latter w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2025::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract::One hundred eighty-three patients with malignant skeletal (83) or soft tissue sarcoma (100) were entered into the multimodality preoperative limb salvage protocol. Local recurrences were observed in 5 of 183 (2.7%). Six patients required amputation because of complications, and 13 patients died within 1 year from meta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840615)53:12<2579::aid-cncr282
更新日期:1984-06-15 00:00:00
abstract:BACKGROUND:For patients with stage III through IVB head and neck squamous cell carcinoma (HNSCC), concurrent high-dose cisplatin plus radiation therapy is a widely accepted standard of care. HNSCC tumors that express high levels of vascular endothelial growth factor have been associated with a worse prognosis, and beva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27498
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1465::AID-CN
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:Epithelioid hemangioendothelioma (EHE) is a rare neoplasm of vascular origin that occurs in the liver and other organs; its etiology is unknown. METHODS:The authors analyzed the clinicopathologic and immunohistochemical features of 137 patients with EHE of the liver in an attempt to identify features that m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990201)85:3<562::aid-cnc
更新日期:1999-02-01 00:00:00
abstract::Associations were sought between specific histocompatibility antigens (HLA) of the human major histocompatibility complex and the incidence of head and neck squamous cell carcinoma (SqCC). Seventy sequential patients with SqCC and 217 control subjects from the same geographic region were typed for HLA-A, HLA-B, and HL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2327::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:It is unclear whether palliative endourologic or percutaneous urinary diversion in the treatment of advanced cancer provides significant improvement in quality or duration of life. The purpose of this study was to evaluate survival and performance status after endourologic palliative urinary diversion in pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990215)85:4<998::aid-cnc
更新日期:1999-02-15 00:00:00
abstract:BACKGROUND:Ovarian cancer patients frequently receive chemotherapy near the end of life. The purpose of the current study was to develop indicators that characterize those ovarian cancer patients who have a short life span. METHODS:The medical charts of deceased epithelial ovarian cancer patients were retrospectively ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23391
更新日期:2008-05-15 00:00:00
abstract::The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. Thes...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197604)37:4<1869::aid-cncr282037
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND:The combination of a platinating agent and etoposide has induced responses in various pediatric tumors. The study estimated the maximum tolerated dose (MTD) of an oxaliplatin and etoposide regimen in children with recurrent solid tumors. METHODS:Oxaliplatin was administered on Day 1 and etoposide on Days 1 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24054
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous system and are commonly associated with chronic seizures. To date, only case reports and small series of patients with short-term follow-up have been available for the assessment of the potential of GGs to recur and progress. METHODS...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20332
更新日期:2004-07-01 00:00:00
abstract::A prospective randomized trial was performed to evaluate the role of adjuvant local immunostimulation with bacillus Calmette-Guérin (BCG) in resected Stage I and Stage II non-small cell bronchogenic carcinoma. The patients were stratified according to extent of resection and surgical stage, and randomized to treatment...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19861201)58:11<2411::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic. METHODS:The authors used ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25328
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:Pleomorphic liposarcoma (PLS) is a rare high-grade sarcoma that has lipoblastic differentiation. In this study, the authors evaluated PLS natural history, patient outcomes, and commonly deregulated protein biomarkers. METHODS:Medical records from patients (n = 155) who had PLS from 1993 to 2010 were reviewe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26195
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Topotecan (9-dimethylaminomethyl-10-hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of topotecan, although there has been con...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10836
更新日期:2002-10-01 00:00:00
abstract::Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820315)49:6<1221::aid-cncr2820
更新日期:1982-03-15 00:00:00
abstract::Primary lymphomas of the small intestine (PIL) show definite racial and geographic distribution. Clinical and laboratory data on 132 patients with PIL treated and followed up over a 14-year period in Baghdad, Iraq, are presented. Based on the pattern of involvement of the bowel and the histopathologic appearance of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831101)52:9<1666::aid-cncr2820
更新日期:1983-11-01 00:00:00
abstract::The authors describe two cases of epithelioid sarcoma of the vulva and summarize the clinical and pathologic experience with this vulvar neoplasm. Findings indicate that epithelioid sarcoma of the vulva usually occurs in the labia majora of young women, but may occur in later life. Clinically it may mimic a Bartholin'...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19831015)52:8<1462::aid-cncr2820
更新日期:1983-10-15 00:00:00
abstract:BACKGROUND:Endometrial cancer (EC) is the most common extraintestinal malignancy in Lynch syndrome (LS) and often is the sentinel malignancy, yet there is no consensus regarding LS-EC detection algorithms. In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting L...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26323
更新日期:2012-02-01 00:00:00
abstract::A case report is presented, believed to be the first documented example of pleomorphic rhabdomyosarcoma developing in the larynx of a child. A review of the literature then follows, with evaluation of the epidemiology, treatment options, and survival of patients with this disease. Cure of this malignancy is more likel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<1012::aid-cncr2820
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine if extrapulmonary small cell carcinomas (EPSCC) should be managed using protocols similar to those for small cell lung cancer (SCLC). METHODS:Treatment strategies, survival, patterns of failure, and prognostic factors for patients with EPSCC were analyzed retrospective...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24858
更新日期:2010-02-15 00:00:00
abstract::Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197809)42:3+<1412::aid-cncr28204
更新日期:1978-09-01 00:00:00