Abstract:
BACKGROUND:Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic. METHODS:The authors used conditional logistic regression to examine relative telomere length in peripheral blood leukocytes, genetic variants at telomere maintenance gene loci (TERT, TNKS2, POT1, TERF1, TERF2), and endometrial cancer risk in case-control studies nested within the Nurses' Health Study and the Women's Health Study. RESULTS:Relative telomere length was significantly inversely correlated with body mass index and weight gain since age 18 years. The authors did not observe a relationship between relative telomere length and endometrial cancer risk. Women in the shortest quartile had a multivariate-adjusted odds ratio (OR) of 1.20 (95% confidence interval [95% CI], 0.73-1.96; P for trend = .37) compared with women in the longest quartile. The authors found an elevation in endometrial cancer risk among women carrying at least 1 minor allele of RS2736122 (TERT; OR, 1.18; 95% CI, 1.01-1.38) or RS12412538 (TNKS2; OR, 1.16; 95% CI, 1.00-1.34). CONCLUSIONS:Relative telomere length was not associated with endometrial cancer risk. Other aspects of telomere maintenance remain to be explored.
journal_name
Cancerjournal_title
Cancerauthors
Prescott J,McGrath M,Lee IM,Buring JE,De Vivo Idoi
10.1002/cncr.25328subject
Has Abstractpub_date
2010-09-15 00:00:00pages
4275-82issue
18eissn
0008-543Xissn
1097-0142journal_volume
116pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Monitoring therapy in patients with brain tumors is very difficult and unreliable. It has been shown that there is no good correlation between tumor sensitivity measured in vitro and in situ tumor response to therapies. METHODS:Sequential changes in tumor size, number of DNA synthesizing cells (labelling in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19960315)77:6<1167::aid-cn
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the rate and possible reasons for false-negative (FN) reflex human papillomavirus (HPV)-DNA tests. METHODS:The authors reviewed all ThinPrep cervical specimens that were submitted for reflex HPV-DNA testing using the Digene Hybrid Capture II (HC2) method from Januar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22688
更新日期:2007-06-25 00:00:00
abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3<826::aid-cncr28207
更新日期:1994-08-01 00:00:00
abstract::Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890101)63:1<51::aid-cncr282063
更新日期:1989-01-01 00:00:00
abstract::The authors performed immunohistochemical and cytogenetic studies in a 73-year old man with malignant angioendotheliomatosis. The patient was referred for evaluation of fever of unknown origin, hepatic failure, and neurologic deterioration. Examination of a muscle biopsy revealed numerous, noncohesive atypical mononuc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900801)66:3<474::aid-cncr28206
更新日期:1990-08-01 00:00:00
abstract::Nine human hybridoma cell lines were established from a fusion of axillary lymph node lymphocytes of a patient with breast ductal carcinoma with a human lymphoblastoid cell line. The human hybridoma nature of the fusion products was confirmed by chromosomal analysis and HLA typing. The hybridomas are stable over a yea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870101)59:1<43::aid-cncr282059
更新日期:1987-01-01 00:00:00
abstract::Tissue specimens from five patients with rheumatic disease who developed lymphadenopathy were studied by an immunoperoxidase method; available biopsy material was examined for cytoplasmic immunoglobulin determinants. Three patients had follicular hyperplasia of lymph nodes with polyclonal patterns. Two patients with S...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820515)49:10<2049::aid-cncr282
更新日期:1982-05-15 00:00:00
abstract:BACKGROUND:Obesity is considered a risk factor for breast cancer. Modifying life styles that reduce obesity offers the potential for prevention and improved outcomes from cancer. The effects of obesity and breast cancer among African-American women and Hispanic women have been explored in a limited number of studies. T...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25956
更新日期:2011-08-15 00:00:00
abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27401
更新日期:2012-09-01 00:00:00
abstract::Six patients with lymphomatoid granulomatosis were studied. Two patients had eye involvement, a rare manifestation of this disease. Both had complete disappearance of disease in this area after radiation therapy. One patient presented with an autoimmune hemolytic anemia, which remitted completely with chemotherapy. Th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820515)49:10<2070::aid-cncr282
更新日期:1982-05-15 00:00:00
abstract::One hundred seventeen postmenopausal advanced breast cancer patients previously untreated with chemotherapy were randomized to receive: cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), CMF and tamoxifen (TMX), and CMF and medroxyprogesterone (MAP). Treatments B and C induced a greater proportion of responses ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19851215)56:12<2745::aid-cncr282
更新日期:1985-12-15 00:00:00
abstract:BACKGROUND:Although aging is one of the most important risk factors for cancer, elderly patients tend to be excluded from cancer clinical trials, only on the basis of chronologic age. Performance Status (PS) has been used widely to select adult patients for entry into clinical trials, but it does not include a comprehe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960115)77:2<395::AID-CNC
更新日期:1996-01-15 00:00:00
abstract::This is a report of a gastric perforation secondary to a metastasis from a primary squamous cell carcinoma of the lung in a 70-year-old white man who was being treated with cimetidine for a presumed benign gastric ulcer. The literature concerning bronchogenic carcinoma metastasizing to the stomach and small bowel is r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801015)46:8<1879::aid-cncr2820
更新日期:1980-10-15 00:00:00
abstract::The clinical and histologic data from 12 patients with "reticulum cell sarcoma" (large cell lymphoma) presenting in the skin were reviewed. Moreover, when appropriate material was available additional immunological, cytochemical and ultrastructural techniques were used to define the nature of the neoplastic cells. Eig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821001)50:7<1367::aid-cncr2820
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:In the United States, neoadjuvant chemoradiotherapy (NACRT) is widely accepted as the standard of care in the treatment of patients with locally advanced rectal cancer. In the current study, the authors attempted to examine patterns of treatment in the United States over the past decade. METHODS:Using the N...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29993
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Abnormalities in chromosome 11q13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCND1), which encodes cyclin D1, is a putative oncogene that is an important component of this region. METHODS:DNA was extracted from 32 snap-frozen specime...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940701)74:1<152::aid-cncr28207
更新日期:1994-07-01 00:00:00
abstract::Advances in clinical medicine require effective translational research. Ideally, this research will be performed by multidisciplinary teams that include both physicians and basic scientists. However, the current system does not appropriately train either physicians or basic scientists for these careers. In addition, t...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.29033
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Because studies have suggested that anemia has an adverse effect on outcome for patients with cervical carcinoma who are treated with radiation, recombinant human erythropoietin (rHuEpo) has been used increasingly to maintain hemoglobin levels in these patients. Erythropoietin may increase the risk of thromb...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11700
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:DNA flow cytometry of hepatocellular carcinoma (HCC) cells has been investigated in many studies, but, to the best of our knowledge, there are no data on DNA analysis of cirrhotic parenchyma around the HCC. In this study, cell kinetics and ploidy of parenchymal cells around HCC were performed to ascertain if...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960915)78:6<1195::AID-CN
更新日期:1996-09-15 00:00:00
abstract::The greatest decrease in breast cancer mortality is likely to derive from applying globally existing therapies at an earlier stage. A high priority of the World Health Organization (WHO) cancer control program is the outreach approach that promotes worldwide access to cancer therapies of proven values. Therefore, the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900615)65:12<2803::aid-cncr282
更新日期:1990-06-15 00:00:00
abstract:BACKGROUND:To identify potential genetic markers for severe oxaliplatin-induced chronic peripheral neuropathy (OXCPN), the authors performed a genome-wide association analysis of patients with colon cancer who received oxaliplatin-based chemotherapy. METHODS:This was a prospective study in which DNA was purified in pe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26614
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Topotecan (9-dimethylaminomethyl-10-hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of topotecan, although there has been con...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10836
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:The differential diagnosis of severe acute respiratory syndrome (SARS) in patients with cancer can be challenging. Although diagnostic criteria for SARS have been issued by the World Health Organization (WHO), simple adoption of the established criteria may lead to overdiagnosis in patients with cancer or to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20141
更新日期:2004-04-01 00:00:00
abstract::There is currently no adequate staging system for cerebral astrocytomas. A scheme for acquiring data that can be used to stage cerebral hemisphere tumors is suggested. This data base, in conjunction with treatment and survival information, may be useful in the management of childhood hemispheric tumors. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7+<1784::aid-cncr282
更新日期:1985-10-01 00:00:00
abstract::Knowledge of tumor antigenic expression is crucial to the design of therapeutic strategy. A murine monoclonal antibody (BE4) against a human melanoma membrane antigen, was used to study the in vitro expression of this antigen. By membrane immunofluorescence, BE4 reacted against 5 of 8 melanoma lines as compared to zer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850315)55:6<1276::aid-cncr2820
更新日期:1985-03-15 00:00:00
abstract:BACKGROUND:The goal of the current study was to investigate the prognostic impact of proliferative activity, together with the other classic clinicopathologic prognostic factors (tumor size, tumor grade, receptor status, ploidy, and lymph node status), in breast carcinoma by counting mitoses and evaluating S phase frac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11916
更新日期:2004-02-01 00:00:00
abstract::During the past decade, one of the major changes in the field of oncology has been in the surgical approach to primary and secondary cancer of the liver. As a result of data and experience gained in liver transplantation programs and with the application of vascular surgical principles, resectability rates have been i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810501)47:9<2162::aid-cncr2820
更新日期:1981-05-01 00:00:00
abstract::The nitroblue tetrazolium test (NBT) was evaluated in 111 patients with cancer. Patients were placed into control and "presumed infected" groups. The mean NBT score for the control group, 6.3, was significantly greater than the mean for a group of normal volunteers, 3.1, but the mean score for the "presumed infected" ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197505)35:5<1421::aid-cncr282035
更新日期:1975-05-01 00:00:00
abstract::The natural history of the development of neoplasia in experimental systems may be separated into at least three different stages, those of initiation, promotion and progression. Evidence for such distinct stages has been demonstrated in at least half a dozen different experimental systems. The stage of promotion is t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820315)49:6<1206::aid-cncr2820
更新日期:1982-03-15 00:00:00
abstract::A 78-year-old Japanese man with chronic liver disease developed hypervascular liver tumors accompanied by marked elevation of alphafetoprotein value (the highest level; 26200 ng/ml) and pathologic fracture of the femur. After an operation for the fracture followed by gastrointestinal bleeding and repeated transfusions...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<667::aid-cncr28205
更新日期:1985-08-01 00:00:00