The prognostic significance of age and pattern of metastases in stage IV-S neuroblastoma.

Abstract:

:Stage IV-S neuroblastoma is a unique disseminated neoplasia characterized by remote disease to the liver, skin, or bone marrow. Stage IV-S patients have frequent spontaneous remissions and a 60% to 90% survival rate. Many investigators have recommended minimal or no therapeutic intervention; however, some patients do experience progressive disease and ultimately die of neuroblastoma. Many authors have commented on single prognostic factors such as age and site of metastatic involvement. Five newborns were recently seen at Walter Reed Army Medical Center with Stage IV-S neuroblastoma. Four of these children died of mechanical complications associated with massive hepatomegaly, prompting this review of Stage IV-S neuroblastoma to determine prognostic factors.

journal_name

Cancer

journal_title

Cancer

authors

Stephenson SR,Cook BA,Mease AD,Ruymann FB

doi

10.1002/1097-0142(19860715)58:2<372::aid-cncr28205

subject

Has Abstract

pub_date

1986-07-15 00:00:00

pages

372-5

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

58

pub_type

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