Abstract:
:Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraductal carcinoma within the tumor mass; and intraductal carcinoma in breast tissue outside the perimeter of the primary lesion. The current study was undertaken to assess the impact of these same factors on the prognosis of 573 consecutively treated women, with invasive duct carcinomas 5 cm or less in diameter, and who underwent mastectomy. Histologic sections of all primary tumors were reviewed, and the lesions were classified according to the distribution of intraductal carcinoma present: only within the tumor (IN, 247 cases, 43%), only outside the tumor (OUT, 25 cases, 4%), within the outside (IN-OUT, 158 cases, 28%), or not seen (IFDC, 143 cases, 25%). The median follow-up period for the entire series was 56 months. Ninety-five (17%) patients were dead of disease (median time to death, 36 months). Variables that proved to be statistically significant for overall survival were nodal status (P less than 0.001), nuclear grade (P less than 0.03), and histologic grade (P less than 0.007). Nodal status (P less than 0.001), histologic grade (P less than 0.001), and tumor size (P = 0.01) were significant predictors of disease-free survival. The pattern of intraductal carcinoma, when present, was not predictive of the risk for recurrence or survival in women treated by mastectomy. These findings provide a rationale for additional surgical treatment for women whose tumors have features more likely to be associated with local failure following primary radiotherapy. To permit more detailed pathologic examination of the primary lesion, the initial excision should be carried out separately from the treatment when limited resection and radiation are to be considered as a treatment option.
journal_name
Cancerjournal_title
Cancerauthors
Rosen PP,Kinne DW,Lesser M,Hellman Sdoi
10.1002/1097-0142(19860401)57:7<1415::aid-cncr2820subject
Has Abstractpub_date
1986-04-01 00:00:00pages
1415-20issue
7eissn
0008-543Xissn
1097-0142journal_volume
57pub_type
杂志文章相关文献
CANCER文献大全abstract::Racial differences in the risk of cancer of the urinary bladder associated with cigarette smoking and alcohol consumption were examined in a study of 1663 cases (1534 whites and 129 blacks) and 4930 controls matched 3:1 by sex, race, and age to the cases. Significant increases in cancer risk associated with cigarette ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901215)66:12<2673::aid-cncr282
更新日期:1990-12-15 00:00:00
abstract::Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32069
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The uptake of thallium-201 (T1-201) in malignant tumors is associated with malignant potential (metastatic potential and proliferative activity). The grade of accumulation of T1-201 in malignant tumors may provide information regarding prognosis. METHODS:A T1-201 single photon emission computed tomography w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970715)80:2<198::aid-cnc
更新日期:1997-07-15 00:00:00
abstract::Both cytogenetic analysis and flow cytometry (FCM) have prognostic efficacy in the analysis of transitional cell carcinoma (TCC) of urinary bladder. To correlate results of the two methods, we studied a unique group of patients whose tumors had undergone prospective conventional cytogenetic analysis. Paraffin blocks o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860415)57:8<1594::aid-cncr2820
更新日期:1986-04-15 00:00:00
abstract::Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901215)66:12<2498::aid-cncr282
更新日期:1990-12-15 00:00:00
abstract::Twenty-three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<853::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Sunitinib malate is an orally bioavailable tyrosine kinase inhibitor that is active against many tyrosine kinase receptors involving crucial pathways in both healthy tissues and malignant tissues. Because its use in clinical practice is quite recent, many of its possible side effects remain unknown. In this ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26435
更新日期:2012-06-15 00:00:00
abstract:BACKGROUND:The months immediately after the completion of treatment for childhood acute lymphoblastic leukemia (ALL) are often regarded as a stressful time for children and families. In this prospective, longitudinal study, the prevalence and predictors of anxiety and depressive symptoms after the completion of treatme...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29946
更新日期:2016-05-15 00:00:00
abstract::A previously unreported high incidence of endoscopically identifiable, diffuse, largely nonulcerative esophagitis, is described in a selected population of Southern African blacks at risk of cancer of the esophagus. This is comparable with findings in similar groups in Iran and China. The incidence of dysplasia and "e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860601)57:11<2222::aid-cncr282
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excessive corticoid and androgen...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:The authors are interested in identifying molecular markers that can aid in the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their po...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25724
更新日期:2011-04-15 00:00:00
abstract::A series of 27 typical Krukenberg tumors of the ovary were analyzed. By definition, all examples were characterized by the presence of mucinous signet-ring carcinoma cells within a cellular, nonneoplastic ovarian stroma. The patients' ages ranged from 20-70 years; almost one-half were 40 years of age or younger. A pri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2438::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract::Cases of systemic lupus erythematosus, systemic sclerosis, periarteritis nodosa, and dermato- and polymyositis autopsied in Japan during a recent, 7-year period (1972-1978) were studied to assess the incidence of cancer as a complication. In comparison with the other three groups, cases of dermato- and polymyositis (D...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1841::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract::The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a sm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<490::aid-cncr28205
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20010201)91:3<484::aid-cncr1026>
更新日期:2001-02-01 00:00:00
abstract::The cases of three patients with primary carcinoid tumor of the testis were reported. The patients were 41, 44, and 83 years of age. At initial examination, all three had testicular masses with or without associated pain, and none had the carcinoid syndrome. The tumors measured 4.3 cm, 3.0 cm, and 6.5 cm in dimension....
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930901)72:5<1726::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate a regimen of sequential chemotherapy and radiotherapy for patients with Hodgkin disease. METHODS:The Cancer and Leukemia Group B conducted a Phase II study of three cycles of etoposide, vinblastine, and doxorubicin (EVA) chemotherapy followed by subtotal lymph node radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19991015)86:8<1590::aid-cn
更新日期:1999-10-15 00:00:00
abstract:BACKGROUND:Carcinoid tumors are unusual and most reports are anecdotal or limited in number. A series of 2837 cases was published in 1975. No recent large series is available. METHODS:The authors evaluated 5468 cases identified by the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer In...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970215)79:4<813::aid-cnc
更新日期:1997-02-15 00:00:00
abstract:BACKGROUND:Whether patient navigation improves outcomes for patients with comorbidities is unknown. The aims of this study were to determine the effect of comorbidities on the time to diagnostic resolution after an abnormal cancer screening test and to examine whether patient navigation improves the timeliness and like...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30316
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Leptomeningeal carcinomatosis (LC) represents a devastating complication of systemic cancer, and patients with LC have a dismal prognosis and increased mortality. The few studies that have focused on the evaluation of prognostic factors in patients with LC have resulted in contradictory results. Thus, the tr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24041
更新日期:2009-01-15 00:00:00
abstract:BACKGROUND:Methotrexate is readily absorbed from the intestinal tract. When given to patients with urinary diversion to the intestinal tract, methotrexate may be reabsorbed into the circulation, thus increasing its serum concentration and potentially increasing its toxicity. METHODS:Forty-eight patients with transitio...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-15 00:00:00
abstract:BACKGROUND:Positron emission tomography (PET) with labeled fluorodeoxyglucose (FDG) demonstrates increased tracer uptake in many neoplasms. This study was undertaken to define the patterns of FDG uptake in head and neck neoplasms before and after high dose irradiation. METHODS:Twenty-five patients were evaluated prosp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940815)74:4<1355::aid-cncr2820
更新日期:1994-08-15 00:00:00
abstract:BACKGROUND:Rapid tumor growth is caused by angiogenesis factors, growth factors, etc. We previously reported a possible connection between nitric oxide (NO) and enhanced vascular permeability in solid tumor. In the present experiment, the role of NO in solid tumor pathology was further investigated in animal tumor. ME...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1598::AID-CN
更新日期:1996-04-15 00:00:00
abstract::Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871115)60:10<2465::aid-cncr282
更新日期:1987-11-15 00:00:00
abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo-HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined. METHODS:We analyzed 88 MDS pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30632
更新日期:2017-07-15 00:00:00
abstract::Streptococcal agent OK-432 was administered at maintenance levels with conventional inductive chemotherapeutic agents to stage III and IV lung cancer patients. Survival rates were longer in patients treated with OK-432 than in patients treated without OK-432. An enhancement of lymphocyte blastogenic activity and a del...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197605)37:5<2201::aid-cncr282037
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Postprostatectomy adjuvant or salvage radiotherapy, when using standard fractionation, requires 6.5 to 8 weeks of treatment. The authors report on the safety and efficacy of an expedited radiotherapy course for salvage prostate radiotherapy. METHODS:A total of 108 consecutive patients were treated with salv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25824
更新日期:2011-06-15 00:00:00
abstract::Six patients with lymphomatoid granulomatosis were studied. Two patients had eye involvement, a rare manifestation of this disease. Both had complete disappearance of disease in this area after radiation therapy. One patient presented with an autoimmune hemolytic anemia, which remitted completely with chemotherapy. Th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820515)49:10<2070::aid-cncr282
更新日期:1982-05-15 00:00:00
abstract::Studies of chemotherapy in advanced or recurrent gynecologic cancer have focussed on ovarian, cervical, and endometrial carcinoma. For celomic epithelial carcinomas of the ovary, a large number of cytotoxic agents have been shown to be active. Dramatic improvement in frequency of response with lesser improvement in su...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19901015)60:8+<2104::aid-cncr282
更新日期:1987-10-15 00:00:00
abstract::In a county hospital, 217 patients were operated on for suspected cancer of the pancreas (186 patients) and periampullary structures (31 patients). The surgeons' philosophy was to avoid biopsy of the pancreas whenever possible, they often performed radical resection based on clinical judgment alone (8% of the resectio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820301)49:5<1035::aid-cncr2820
更新日期:1982-03-01 00:00:00