PRAD-1 (CCND1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma.


BACKGROUND:Abnormalities in chromosome 11q13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCND1), which encodes cyclin D1, is a putative oncogene that is an important component of this region. METHODS:DNA was extracted from 32 snap-frozen specimens from primary head and neck squamous carcinomas. DNA from peripheral blood lymphocytes, normal mucosa, and salivary gland tissue were used as controls. A genomic DNA probe containing the first exon of PRAD-1 was used for hybridization with specimen DNAs by the Southern technique. A 5.6-kb genomic DNA probe of immunoglobulin heavy chain was used as an internal standard for assessing PRAD-1 amplification. RESULTS:Eleven (34.4%) squamous carcinoma specimens showed PRAD-1 amplification (2- to 10-fold). Although no significant statistical correlation among amplification status, grade stage, and DNA ploidy was observed in this small cohort, amplification was more noted in high grade, high stage, and aneuploid tumors. A highly statistical correlation between PRAD-1 amplification and proliferative activity was noted (P > 0.001). CONCLUSION:The results of this study indicate that PRAD-1 amplification appears to be a late event in the tumorigenesis of head and neck carcinoma and is associated often with a subset of aggressive tumors and high proliferation neoplasms.






Callender T,el-Naggar AK,Lee MS,Frankenthaler R,Luna MA,Batsakis JG




Has Abstract


1994-07-01 00:00:00














  • Survival impact of surgical resection of primary tumor in patients with stage IV colorectal cancer: results from a large population-based cohort study.

    abstract:BACKGROUND:Currently, there is very low-quality evidence available regarding benefit of surgical resection of the primary tumor (SRPT), in patients with stage IV colorectal cancer (CRC). In the absence of randomization, the reported benefit may reflect selection of younger and healthier patients with good performance s...


    pub_type: 杂志文章


    authors: Ahmed S,Leis A,Fields A,Chandra-Kanthan S,Haider K,Alvi R,Reeder B,Pahwa P

    更新日期:2014-03-01 00:00:00

  • Combination of paclitaxel and carboplatin as second-line therapy for patients with metastatic melanoma.

    abstract:BACKGROUND:Patients with metastatic melanoma (MM) have very few therapy options. Based on reports of responses to paclitaxel and carboplatin (PC), 31 patients with MM were treated with PC. METHODS:Data regarding patients treated with PC were abstracted from medical records. Clinical outcomes as determined by the treat...


    pub_type: 杂志文章


    authors: Rao RD,Holtan SG,Ingle JN,Croghan GA,Kottschade LA,Creagan ET,Kaur JS,Pitot HC,Markovic SN

    更新日期:2006-01-15 00:00:00

  • Evaluation of chromosome aneuploidy in tissue sections of preinvasive breast carcinomas using interphase cytogenetics.

    abstract:BACKGROUND:Little is known about cellular level genetic alterations in preinvasive breast lesions, particularly lobular carcinoma in situ. METHODS:We employed fluorescence in situ hybridization (FISH) using pericentromeric (alpha satellite) probes to assess numerical alterations of chromosomes 1, 7, 8, 16, 17, and X i...


    pub_type: 杂志文章


    authors: Visscher DW,Wallis TL,Crissman JD

    更新日期:1996-01-15 00:00:00

  • VAB-3 combination chemotherapy of metastatic testicular cancer.

    abstract::The initial response and long-term follow-up of 74 evaluable patients who received combination chemotherapy for metastatic nonseminomatous testicular cancer are reported. Patients were treated with a protocol (VAB-3) including vinblastine, actinomycin-D, bleomycin, and cis-dichlorodiammine platinum (DDP). VAB-3 alone ...


    pub_type: 临床试验,杂志文章


    authors: Reynolds TF,Vugrin D,Cvitkovic E,Cheng E,Braun DW Jr,O'Hehir MA,Dukeman ME,Whitmore WF Jr,Golbey RB

    更新日期:1981-08-15 00:00:00

  • Tumor acquisition, propagation, and preservation. The culture of human colorectal cancer.

    abstract::Fourteen new colorectal cancer cell lines were developed as part of a tumor acquisition, propagation, and preservation program for biotherapy. Fifty-six specimens were received. Nine cell lines were generated from biopsies; seven of these cell lines were from metastatic lesions. Five additional cell lines were develop...


    pub_type: 杂志文章


    authors: Lewko WM,Ladd P,Hubbard D,He YJ,Vaghmar R,Husseini S,Chang L,Moore M,Thurman GB,Oldham RK

    更新日期:1989-10-15 00:00:00

  • Carcinoma of the pancreas: review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy.

    abstract::A retrospective study was done of all patients who were seen for definitive treatment of adenocarcinoma of the pancreas at the Massachusetts General Hospital from 1963 to 1973. There were a total of 145 patients. Thirty-one patients were treated with radical surgery, with a 16% operative mortality, a 5-year crude surv...


    pub_type: 杂志文章


    authors: Tepper J,Nardi G,Sutt H

    更新日期:1976-03-01 00:00:00

  • Urinary cholesterol. VII. The significance of the excretion of nonesterified cholesterol in patients with uterine carcinomas.

    abstract::The urinary excretion of nonesterified cholesterol (NEC) in 170 women with cervical and endometrial carcinomas has been investigated. Control patients (236) included: 1) women with other types of (benign and/or malignant diseases of the pelvic organs; 2) patients with non-steroid-related neoplasms; 3) patients with be...


    pub_type: 杂志文章


    authors: Acevedo HF,Campbell EA,Frich JC Jr,Merkow LP,Hayeslip D,Gilmore J

    更新日期:1975-10-01 00:00:00

  • Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics.

    abstract:BACKGROUND:Sacituzumab govitecan (IMMU-132), an antitrophoblastic cell-surface antigen (anti-Trop-2) humanized antibody-SN-38 conjugate, had encouraging efficacy in the phase 1 clinical trial. This report further examines the pharmacokinetics and safety of multiple cycles of IMMU-132 at doses of 8 or 10 mg/kg in patien...


    pub_type: 杂志文章,多中心研究


    authors: Ocean AJ,Starodub AN,Bardia A,Vahdat LT,Isakoff SJ,Guarino M,Messersmith WA,Picozzi VJ,Mayer IA,Wegener WA,Maliakal P,Govindan SV,Sharkey RM,Goldenberg DM

    更新日期:2017-10-01 00:00:00

  • Identification of a distinctive P-glycoprotein-mediated resistance phenotype in human ovarian carcinoma cells after their in vitro exposure to fractionated X-irradiation.

    abstract:BACKGROUND:Clinical drug resistance is recognized in patients previously treated with radiotherapy and after chemotherapy. In vitro exposure of mammalian tumor cells to fractionated X-irradiation also resulted in the expression of drug resistance. Analysis of the resistance phenotype of irradiated Chinese hamster ovary...


    pub_type: 杂志文章


    authors: Hill BT,Whelan RD,Hurst HC,McClean S

    更新日期:1994-06-15 00:00:00

  • Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management.

    abstract::Adenoid cystic carcinoma (ACC) of the breast is a rare histologic type of breast cancer associated with a good prognosis. A woman who earlier had a pulmonary metastasis surgically resected 6 years postmastectomy developed clinically symptomatic bleeding from a renal metastasis 12 years postmastectomy. An atypical angi...


    pub_type: 杂志文章


    authors: Herzberg AJ,Bossen EH,Walther PJ

    更新日期:1991-09-01 00:00:00

  • Randomized study of 5-FU and CCNU in pancreatic cancer: report of the Veterans Administration Surgical Adjuvant Cancer Chemotherapy Study Group.

    abstract::Between the years 1973-1977, 152 male patients from 28 participating Veterans Hospitals with histologically proven nonresectable cancer of the pancreas were randomized in a two-arm study. The treated group was to receive combination chemotherapy with 5-FU and CCNU, and the controls were to receive no chemotherapy. Bot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frey C,Twomey P,Keehn R,Elliott D,Higgins G

    更新日期:1981-01-01 00:00:00

  • Cancer mortality in Chinese immigrants to New York City. Comparison with Chinese in Tianjin and with United States-born whites.

    abstract:BACKGROUND:Cancer rates in immigrant populations are frequently found to be intermediate between the country of origin and the adopted country. Such observations play an important role in establishing the environmental origin of cancer. Chinese now constitute the third largest group immigrating to New York City. METHO...


    pub_type: 杂志文章


    authors: Stellman SD,Wang QS

    更新日期:1994-02-15 00:00:00

  • The prevalence of polyps of the large intestine in Oslo: an autopsy study.

    abstract::The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no hist...


    pub_type: 杂志文章


    authors: Vatn MH,Stalsberg H

    更新日期:1982-02-15 00:00:00

  • A population-based study of lung carcinoma in Pennsylvania: comparison of Veterans Administration and civilian populations.

    abstract:BACKGROUND:Lung carcinoma remains the major cause of cancer death in North America and is even more common among military veterans. The objective of this study was to determine whether there were differences in the characteristics and survival of Pennsylvania patients with lung carcinoma in the Veterans Administration ...


    pub_type: 杂志文章


    authors: Campling BG,Hwang WT,Zhang J,Thompson S,Litzky LA,Vachani A,Rosen IM,Algazy KM

    更新日期:2005-08-15 00:00:00

  • The prognostic significance of vascular invasion by endometrial carcinoma.

    abstract:BACKGROUND:Recently, invasion of vascular spaces by endometrial carcinoma has received particular attention as a prognostic factor. The goal of the current investigation was to re-examine the effect of vascular invasion on tumor recurrence and survival in patients with endometrial carcinoma. METHODS:Surgical specimens...


    pub_type: 杂志文章


    authors: Inoue Y,Obata K,Abe K,Ohmura G,Doh K,Yoshioka T,Hoshiai H,Noda K

    更新日期:1996-10-01 00:00:00

  • Quality of life of nasopharyngeal carcinoma patients.

    abstract:BACKGROUND:Quality of life (QOL) issues in patients with head and neck carcinoma are of importance beyond the incidence of these tumors because of the impact of the disease and its treatment on external appearance and function of the upper aerodigestive tract. Nasopharyngeal carcinoma (NPC) patients comprise a unique s...


    pub_type: 杂志文章


    authors: Talmi YP,Horowitz Z,Bedrin L,Wolf M,Chaushu G,Kronenberg J,Pfeffer MR

    更新日期:2002-02-15 00:00:00

  • Detection of human papillomavirus in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas. However, the incidence of HPV varies significantly in different geographic locations. In the current study, neoplasms from two separate geographic regions were analyzed for the presence of HPV DNA: METHODS:One hundred and ten esoph...


    pub_type: 杂志文章


    authors: Suzuk L,Noffsinger AE,Hui YZ,Fenoglio-Preiser CM

    更新日期:1996-08-15 00:00:00

  • Government support of cancer research and cancer care health benefits.

    abstract::As the federal government struggles to meet ever-growing budgetary constraints, the need for research into the causes of and potential therapies for treating cancer demands the urgent attention of Congressional leaders. This will require innovative, cost-effective approaches to address the unique needs of cancer resea...


    pub_type: 杂志文章


    authors: Mack C

    更新日期:1993-11-01 00:00:00

  • Comparison of primary osteosarcoma of flat bones with secondary osteosarcoma of any site.

    abstract:BACKGROUND:The authors hypothesized that the outcomes for young patients who present with primary osteosarcoma of flat bones or secondary osteosarcoma after other primary malignancies are similar because the sites of these tumors rarely makes them amenable to complete surgical resection. METHODS:The authors reviewed t...


    pub_type: 杂志文章


    authors: Pratt CB,Meyer WH,Rao BN,Pappo AS,Fleming ID,Luo X,Cain A,Kaste SC,Shearer PD,Jenkins JJ 3rd

    更新日期:1997-09-15 00:00:00

  • Non-Hodgkin's lymphoma in children. A comparative study of two modalities of therapy.

    abstract::Eighty-six children with non-Hodgkin's lymphoma were studied from 1964 to January 31, 1975. Seventy-six percent of the 43 patients in the nonprotocol group had far advanced disease, and 76% had Rappaport's diffuse histology. Only 11% of these patients survived free of disease. The second group of 43 patients received ...


    pub_type: 杂志文章


    authors: Wollner N,Burchenal JH,Lieberman PH,Exelby P,D'Angio G,Murphy ML

    更新日期:1976-01-01 00:00:00

  • Cis-diamminedichloride platinum II (DDP) in the treatment of penile carcinoma.

    abstract::Cis-diamminedichloride platinum II (DDP) was administered to eight patients with epidermoid carcinoma of the penis. Three of six adequately treated patients had an objective response: one patient achieved complete remission of 7 months duration and 2 patients had partial remissions of 8 and 2 months, respectively. DDP...


    pub_type: 杂志文章


    authors: Sklaroff RB,Yagoda A

    更新日期:1979-11-01 00:00:00

  • The glucose distribution in 9L rat brain multicell tumor spheroids and its effect on cell necrosis.

    abstract::The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 de...


    pub_type: 杂志文章


    authors: Li CK

    更新日期:1982-11-15 00:00:00

  • Concurrent vinblastine and radiation therapy in bladder cancer.

    abstract:BACKGROUND:Since mid-1987, 29 patients with invasive transitional cell carcinoma of the urinary bladder (T1-3 N0-X M0) were treated with concurrent radiation therapy (RT) (target dose [TD], 62-66 Gy) 1.8-2.0 Gy/day for 5 days a week with a break in the middle of treatment of 2-3 weeks and vinblastine weekly 2 mg/5-12 h...


    pub_type: 临床试验,杂志文章


    authors: Kragelj B,Jereb B,Kragelj L,Stanonik M

    更新日期:1992-12-15 00:00:00

  • The value of ultrasonic imaging and CT scanning in planning the radiotherapy for prostatic carcinoma.

    abstract::Forty-four consecutive patients with potentially curable carcinoma of the prostate were localized with an Old Delft Simulator with the methods described by Bagshaw. The isocenter and the treatment portal were marked on the skin of the patient. Subsequently, the adequacy of the portal was checked by ultrasonography and...


    pub_type: 杂志文章


    authors: Lee DJ,Leibel S,Shiels R,Sanders R,Siegelman S,Order S

    更新日期:1980-02-15 00:00:00

  • Phase I clinical trial and pharmacokinetics of carboplatin (NSC 241240) by single monthly 30-minute infusion.

    abstract::Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 e...


    pub_type: 杂志文章


    authors: Koeller JM,Trump DL,Tutsch KD,Earhart RH,Davis TE,Tormey DC

    更新日期:1986-01-15 00:00:00

  • Randomized controlled study of chemoimmunotherapy of acute myelogenous leukemia (AML) in adults with Nocardia rubra cell-wall skeleton and irradiated allogeneic AML cells.

    abstract::The effect of immunotherapy with Nocardia rubra cell-wall skeleton (N-CWS) on remission duration and survival of adults with acute myelogenous leukemia (AML) was studied in a prospective randomized controlled study. After having been induced into complete remission and having been consolidated, 73 patients were random...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ohno R,Nakamura H,Kodera Y,Ezaki K,Yokomaku S,Oguma S,Kubota Y,Shibata H,Ogawa N,Masaoka T

    更新日期:1986-04-15 00:00:00

  • Intestinal tumor and agmatine (decarboxylated arginine): low content in colon carcinoma tissue specimens and inhibitory effect on tumor cell proliferation in vitro.

    abstract:BACKGROUND:The polyamine system is a promising target for anticancer therapy. Ideally, an antineoplastic compound affecting this system should inhibit both ornithine decarboxylase and the polyamine transporter, and toxicity should be mild. Agmatine, decarboxylated L-arginine, appears to be such a compound. METHODS:Ade...


    pub_type: 杂志文章


    authors: Molderings GJ,Kribben B,Heinen A,Schröder D,Brüss M,Göthert M

    更新日期:2004-08-15 00:00:00

  • Aspiration cytology of malignant neoplasms associated with granulomas and granuloma-like features: diagnostic dilemmas.

    abstract:BACKGROUND:Malignant lymphomas and solid tumors that mimic or are associated with epithelioid granulomas are widely recognized in surgical pathology, but have received little attention in the cytopathology literature. In this study the authors present their experience with six such cases in which the presence of granul...


    pub_type: 杂志文章


    authors: Khurana KK,Stanley MW,Powers CN,Pitman MB

    更新日期:1998-04-25 00:00:00

  • Sacral plexus injury after radiotherapy for carcinoma of cervix.

    abstract::A 42-year-old woman developed lower extremity weakness and sensory loss 1 year after external and intracavitary radiotherapy for Stage IB carcinoma of cervix. She has been followed for 5 years posttreatment, and the neurologic abnormalities have persisted, but no evidence of recurrent carcinoma has been found. We beli...


    pub_type: 杂志文章


    authors: Stryker JA,Sommerville K,Perez R,Velkley DE

    更新日期:1990-10-01 00:00:00

  • Two primary carcinomas of the lung: adenocarcinoma and a metachronous squamous cell carcinoma. A case report and review of the literature.

    abstract::The case of a patient who underwent a left lower lobe lobectomy for adenocarcinoma of the lung and developed a metachronous squamous cell carcinoma of the right lung eight years later, is presented. The unusual nature of the case is emphasized utilizing a review of the literature. The criteria for diagnosing metachron...


    pub_type: 杂志文章,评审


    authors: Coffman B,Crum E,Forman WB

    更新日期:1983-01-01 00:00:00