Abstract:
BACKGROUND:Plasma acidic glutathione S-transferase (GST-pi) concentrations in 135 patients with gastrointestinal cancer were measured by an improved radioimmunoassay (RIA). METHODS:Blood was collected into a silicified glass tube containing a specific anticoagulant. The plasma, which was separated rapidly by centrifugation with adequate force, underwent RIA procedures (double antibody and polyethylene glycol separation method). RESULTS:The improved RIA for plasma GST-pi was specific and sensitive. Plasma GST-pi in 75% of patients with esophageal cancer, 64.44% of those with gastric cancer, 74.41% of those with colon cancer, 85.19% of those with hepatocellular carcinoma, and 60.00% of those with pancreatic cancer was elevated higher than 13.99 micrograms/l (mean + 1.96 standard deviation of normal controls). Plasma GST-pi levels in patients with gastric cancer with Stages I-II, III and IV disease increased in proper order. Plasma GST-pi concentrations in 57% of patients with colon cancer decreased to the normal range 14 days after surgery. Plasma GST-pi levels of patients with recurrent colon cancer were higher than of those with primary colon cancer. CONCLUSION:The procedure for specimen collection must be critical. Plasma GST-pi may be useful in diagnosing gastrointestinal cancer and in monitoring its clinical course.
journal_name
Cancerjournal_title
Cancerauthors
Fan KC,Huang YC,Li CHdoi
10.1002/1097-0142(19951015)76:8<1363::aid-cncr2820subject
Has Abstractpub_date
1995-10-15 00:00:00pages
1363-7issue
8eissn
0008-543Xissn
1097-0142journal_volume
76pub_type
杂志文章相关文献
CANCER文献大全abstract::Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197609)38:3<1306::aid-cncr282038
更新日期:1976-09-01 00:00:00
abstract::Six patients with lymphomatoid granulomatosis were studied. Two patients had eye involvement, a rare manifestation of this disease. Both had complete disappearance of disease in this area after radiation therapy. One patient presented with an autoimmune hemolytic anemia, which remitted completely with chemotherapy. Th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820515)49:10<2070::aid-cncr282
更新日期:1982-05-15 00:00:00
abstract:BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951201)76:11<2338::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract::Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Colorectal cancer patients undergoing chemotherapy (CT) are likely to experience multiple concurrent toxicities that, rather than appearing singularly, may be associated with one another. Graphic and tabular representations of distance matrices were used to identify associations between toxicities and to def...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23182
更新日期:2008-01-15 00:00:00
abstract:BACKGROUND:Recent advances in the treatment of nasopharyngeal carcinoma (NPC) have transpired into better treatment outcomes for patients with locoregionally advanced NPC, and have broadened the chemotherapeutic options for patients with metastatic disease. METHODS:Data for this review were identified through searches...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.20768
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Melanoma vaccine treatment appears to slow the progression of melanoma in some patients, particularly in patients in whom it stimulates cellular antimelanoma immune responses. The relationship of vaccine-induced antibody responses to clinical outcome is less clear. The purpose of this study was to investigat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950115)75:2<495::aid-cncr28207
更新日期:1995-01-15 00:00:00
abstract::A 21-year-old male with Ph1 positive acute myeloid leukemia (AML) became constipated, experienced pain in the sacral area and retained urine. These were the principle presenting complaints of his disease. With local radiotherapy and systemic chemotherapy, all neurologic symptoms and signs disappeared within three days...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810115)47:2<346::aid-cncr28204
更新日期:1981-01-15 00:00:00
abstract::Trichosporon cutaneum is a fungus known to cause superficial nodules over the distal third of hair shafts, mainly scalp hair, and to produce a clinical entity known as piedra. This superficial mycosis occurs mostly in temperate and tropical regions and is rarely seen in North America. Trichosporon cutaneum spesis is d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197509)36:3<1106::aid-cncr282036
更新日期:1975-09-01 00:00:00
abstract::This study evaluates residual disease in 28 B-cell chronic lymphocytic leukemia (B-CLL) patients who obtained a clinicohematologic remission after intensive chemotherapy. Sixteen of 28 patients (57%) showed a normal number of circulating B-lymphocytes, as demonstrated by the low percentage of mouse rosette-forming cel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890515)63:10<1979::aid-cncr282
更新日期:1989-05-15 00:00:00
abstract:BACKGROUND:Interleukin-18 (IL-18) is a novel immunoregulatory cytokine that was known previously as interferon-gamma-inducing factor. IL-18 levels can be used as a serum indicator for monitoring the clinical course of patients with hematologic malignancies and gastric carcinoma. Nitric oxide (NO) is a pleiotropic molec...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10705
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:The differential diagnosis of severe acute respiratory syndrome (SARS) in patients with cancer can be challenging. Although diagnostic criteria for SARS have been issued by the World Health Organization (WHO), simple adoption of the established criteria may lead to overdiagnosis in patients with cancer or to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20141
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:A somatic gain-of-function mutation of the Janus kinase 2 (JAK2) gene has been identified in chronic myeloproliferative disorders, which appear to have a sporadic occurrence in most individuals. The authors studied the biologic significance of the JAK2 (V617F) mutation in familial myeloproliferative disorder...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22240
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Among patients with core-needle biopsy (CNB)-diagnosed ductal carcinoma in situ (DCIS), the guidelines for the selection of patients to undergo sentinel lymph node (SLN) biopsy are not well defined, and many patients with no invasion undergo an unnecessary SLN biopsy. The objective of this study was to ident...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22216
更新日期:2006-10-15 00:00:00
abstract::Many clinicians use group support to reduce the psychosocial difficulties of persons with cancer. This study compared the long-term benefits of a thematic counseling model used both as a structure for group support and for counseling patients individually. The thematic model included eight counseling sessions focused ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860101)57:1<183::aid-cncr28205
更新日期:1986-01-01 00:00:00
abstract::The cases of three patients with primary carcinoid tumor of the testis were reported. The patients were 41, 44, and 83 years of age. At initial examination, all three had testicular masses with or without associated pain, and none had the carcinoid syndrome. The tumors measured 4.3 cm, 3.0 cm, and 6.5 cm in dimension....
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930901)72:5<1726::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract::Retinoblastoma should not be considered as the exceptional childhood cancer that shows dominant inheritance, but rather as the typical childhood cancer that embraces a prezygotic and postzygotic subgroup. Postzygotic cases are conceived as involving mutation as a first step too, but with the mutation in somatic rather...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<1022::aid-cncr28203
更新日期:1975-03-01 00:00:00
abstract::A case of squamous cell carcinoma of the tongue in a 26-year-old man developing nine years after renal transplantation is presented. This is the first such case to be reported. Within seven months, widespread tumor metastases resulted in death. Pathologic examination of the transplanted kidney demonstrated neither re-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197801)41:1<1::aid-cncr282041010
更新日期:1978-01-01 00:00:00
abstract::Diagnostic advances currently have exceeded therapeutic gain. The present, however, is a transition phase. Chemotherapy, for example, has become curative for some tumors in recent years, rather than merely palliative, due to the precision permitted by advances in molecular biology. At this time, acceleration in the ba...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901015)60:8+<1931::aid-cncr282
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) develops through the alteration of several critical pathways. This study was aimed at evaluating the influence of critical pathways on survival outcomes for patients with CRC. METHODS:Targeted next-generation sequencing of 40 genes included in the 5 critical pathways of CRC (WNT, P53...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30760
更新日期:2017-09-15 00:00:00
abstract:BACKGROUND:Pericolorectal tumor deposits (TDs) are associated with adverse outcomes in patients with colorectal cancer, and the seventh edition of the American Joint Committee on Cancer (AJCC) staging system recently classified TDs without regional lymph node metastasis as category N1c. However, the definition of TDs h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25968
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Occult hepatitis B virus (HBV) infection frequently occurs in patients with HBV surface antigen (HBsAg)-negative chronic liver disease, and much evidence suggests that it is a risk factor for hepatocellular carcinoma (HCC) development. However, to the authors' knowledge, no follow-up study has been performed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21702
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:The primary purpose of this study was to establish the maximum tolerated dose (MTD) of intravenous melphalan in combination with paclitaxel and cisplatin plus granulocyte-colony stimulating factor (G-CSF) in patients with suboptimal advanced epithelial ovarian carcinoma or primary peritoneal carcinoma. METH...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Although increasing rates of breast carcinoma incidence have been observed in Asian countries, appropriate strategies for detecting early stage breast carcinoma in such communities have been difficult to formulate, particularly because no large population screening trial specifically involving Asian women ha...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-04-15 00:00:00
abstract::Plasma levels of cyclic AMP and cyclic GMP were determined in 35 guinea pigs for up to 9 days following subcutaneous passage of L2C leukemia cells. Twenty guinea pigs into which normal syngeneic guinea pig thymocytes were passaged served as controls. Cyclic AMP levels in plasma showed little change and were only eleva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840101)53:1<79::aid-cncr282053
更新日期:1984-01-01 00:00:00
abstract::C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197803)41:3<827::aid-cncr2820410
更新日期:1978-03-01 00:00:00
abstract::Neuroendocrine small cell carcinoma is a lethal, but rare, tumor that arises most frequently in the lung. Small cell cancer also rarely may occur in the female genital tract, usually in the cervix. This article concerns the fourth reported case of neuroendocrine small cell carcinoma of the vulva. Previously, small cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910501)67:9<2415::aid-cncr2820
更新日期:1991-05-01 00:00:00
abstract::The authors administered high-dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP-16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long-term, disease-free survival...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900815)66:4<619::aid-cncr28206
更新日期:1990-08-15 00:00:00
abstract:BACKGROUND:Although aging is one of the most important risk factors for cancer, elderly patients tend to be excluded from cancer clinical trials, only on the basis of chronologic age. Performance Status (PS) has been used widely to select adult patients for entry into clinical trials, but it does not include a comprehe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960115)77:2<395::AID-CNC
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Although state Medicaid programs cover cancer screening, Medicaid beneficiaries are less likely to be screened for cancer and are more likely to present with tumors of an advanced stage than are those with other insurance. The current study was performed to determine whether state Medicaid eligibility and re...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28704
更新日期:2014-10-01 00:00:00