Immunologic and molecular evaluation of residual disease in B-cell chronic lymphocytic leukemia patients in clinical remission phase.

Abstract:

:This study evaluates residual disease in 28 B-cell chronic lymphocytic leukemia (B-CLL) patients who obtained a clinicohematologic remission after intensive chemotherapy. Sixteen of 28 patients (57%) showed a normal number of circulating B-lymphocytes, as demonstrated by the low percentage of mouse rosette-forming cells (M-RFC), surface immunoglobulins (SIg), and CD24-positive cells. Clinically, a lower number of relapses occurred in this group of patients compared to those with a persistent expansion of peripheral B-cells (P less than 0.05). In order to assess monoclonality of the residual peripheral B-cell population, the distribution of SIg light chains was investigated on the B-cell-enriched fraction of 15 of these 16 cases. Only six of them had a kappa/lambda ratio which ranged between 1.7:1 and 3:1, whereas the remaining patients still displayed a clearly imbalanced kappa/lambda Ig light chain distribution. On the other hand, the analysis of the configuration of the Ig heavy chain gene region, performed in nine cases (including five of the above six cases), showed the persistence of a rearranged pattern in all cases tested but one. Therefore, residual monoclonal B-cells were found also in the majority of cases which displayed the lowest kappa/lambda ratio, a normal bone marrow lymphocytosis and a long-lasting clinical remission. Studies at the DNA level confirm that a remission is rarely achieved in this disease in spite of intensive and prolonged chemotherapy. Nonetheless, the follow-up of B-CLL patients by conventional immunologic markers may be helpful to better define response to therapy and to predict the occurrence of clinical relapse.

journal_name

Cancer

journal_title

Cancer

authors

Brugiatelli M,Callea V,Morabito F,Oliva B,Francia Di Celle P,Fierro MT,Neri A,Foa R

doi

10.1002/1097-0142(19890515)63:10<1979::aid-cncr282

subject

Has Abstract

pub_date

1989-05-15 00:00:00

pages

1979-84

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

63

pub_type

杂志文章

相关文献

CANCER文献大全
  • Feasibility of fine-needle aspiration for assessing responses to chemotherapy in metastatic nodes marked with clips in breast cancer: A prospective registry study.

    abstract:BACKGROUND:Clips are often placed to mark axillary nodes with biopsy-confirmed metastases in patients with breast cancer. The evaluation of clipped nodes after chemotherapy can identify patients who have eradication of nodal disease. The goal of this study was to determine whether preoperative fine-needle aspiration (F...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31825

    authors: Caudle AS,Kuerer HM,Krishnamurthy S,Shin K,Hobbs BP,Ma J,Mittendorf EA,Washington AC,DeSnyder SM,Black DM,Hunt KK,Yang WT

    更新日期:2019-02-01 00:00:00

  • Basal cell carcinoma. An epidemiologic study in a defined population.

    abstract:BACKGROUND:The incidence of basal cell carcinoma (BCC) in a defined population is unknown. METHODS:The incidence of histologically diagnosed cases of BCC in a defined population of a city in southern Sweden was studied. Four 2-year periods were examined from 1970 to 1986. Cases from 1970 and 1980 were reexamined micro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920701)70:1<104::aid-cncr28207

    authors: Dahl E,Aberg M,Rausing A,Rausing EL

    更新日期:1992-07-01 00:00:00

  • Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial.

    abstract::To assess the efficacy and safety of Adriamycin (Adria Laboratories, Columbus, OH) in inoperable hepatocellular carcinoma (HCC), 60 patients were randomized to receive Adriamycin 60 to 75 mg/m2 at 3-week intervals and 46 patients to receive no antitumor therapy. The median survival rate of the Adriamycin group was 10....

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19880801)62:3<479::aid-cncr28206

    authors: Lai CL,Wu PC,Chan GC,Lok AS,Lin HJ

    更新日期:1988-08-01 00:00:00

  • Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma.

    abstract:BACKGROUND:Inactivation of the tumor suppressor gene PTEN/MMAC1/TEP1, located on chromosome 10q23, is a common event in advanced stages of diverse human malignancies. However, the prognostic role of PTEN expression in patients with hepatocellular carcinoma (HCC) has not been characterized. METHODS:One hundred five res...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11266

    authors: Hu TH,Huang CC,Lin PR,Chang HW,Ger LP,Lin YW,Changchien CS,Lee CM,Tai MH

    更新日期:2003-04-15 00:00:00

  • Wilms' tumor in adolescence.

    abstract::Two cases of Wilms' tumor in adolescent males are presented. The clinical and radiographic findings were unusual and both presented atypical gross and microscopic features that could be correlated with the radiographic findings. Histologic examination of both tumors showed evidence of tubular and glomerular maturation...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197603)37:3<1532::aid-cncr282037

    authors: Merten DF,Yang SS,Bernstein J

    更新日期:1976-03-01 00:00:00

  • Detection of human papillomavirus in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas. However, the incidence of HPV varies significantly in different geographic locations. In the current study, neoplasms from two separate geographic regions were analyzed for the presence of HPV DNA: METHODS:One hundred and ten esoph...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960815)78:4<704::AID-CNC

    authors: Suzuk L,Noffsinger AE,Hui YZ,Fenoglio-Preiser CM

    更新日期:1996-08-15 00:00:00

  • Cancer prevention through health promotion. Defining the role of physicians in public health.

    abstract::In recent years a major focus in the delivery of cancer prevention services has been on the actions of physicians in ambulatory care practice. Whereas delivery of these services has increased markedly, it is likely that physician actions overall are not producing expected measurable benefits to whole populations. The ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19940815)74:4+<1418::aid-cncr282

    authors: Love RR

    更新日期:1994-08-15 00:00:00

  • HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia.

    abstract:BACKGROUND:Chronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single-agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months. METHODS:The outcome was analyzed for 42 patients with lymphoid BP-CML who were treated with hyp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28433

    authors: Strati P,Kantarjian H,Thomas D,O'Brien S,Konoplev S,Jorgensen JL,Luthra R,Abruzzo L,Jabbour E,Quintas-Cardama A,Borthakur G,Faderl S,Ravandi F,Cortes J

    更新日期:2014-02-01 00:00:00

  • Metastatic carcinoma. The lung as the site for the clinically undiagnosed primary.

    abstract::Of 387 patients who died with lung cancer, 28 cases were reviewed (7.2%) which were clinically undiagnosed. The male:female ratio was 3.6 and mean age was 64 years in the males, 47 years in the females. The most frequent presenting symptoms were neurologic. Prior to death, 21 patients had known or suspected metastatic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830115)51:2<362::aid-cncr28205

    authors: Clary CF,Michel RP,Wang NS,Hanson RE

    更新日期:1983-01-15 00:00:00

  • Lobular neoplasia. Long term risk of breast cancer and relation to other factors.

    abstract:BACKGROUND:Lobular neoplasia (LN), also known as lobular carcinoma in situ, is an incidental histologic finding in tissue removed at breast surgery. Patients with LN are known to be predisposed to develop invasive or intraductal carcinoma (CA). This study investigates factors that influence the cancer risk in LN patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960901)78:5<1024::AID-CN

    authors: Bodian CA,Perzin KH,Lattes R

    更新日期:1996-09-01 00:00:00

  • Systematic pelvic and aortic lymphadenectomy in elderly gynecologic oncologic patients.

    abstract:BACKGROUND:Retroperitoneal lymph node dissection is a fundamental step in the surgical management of patients with pelvic gynecologic malignancies, but its applicability to geriatric patients is controversial. The objective of this study was to evaluate whether pelvic and aortic lymphadenectomy in elderly patients with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011115)92:10<2562::aid-cncr160

    authors: Giannice R,Susini T,Ferrandina G,Poerio A,Margariti PA,Carminati R,Marana E,Mancuso S,Scambia G

    更新日期:2001-11-15 00:00:00

  • Association of Langerhans cell histiocytosis with malignant neoplasms.

    abstract:BACKGROUND:The association of Langerhans cell histiocytosis (LCH) with a malignant neoplasm is rare and generally has been the subject of isolated case reports. METHODS:A recent case of LCH seen at the University of Minnesota in combination with acute lymphoblastic leukemia led the authors to review their own charts f...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930201)71:3<865::aid-cncr28207

    authors: Egeler RM,Neglia JP,Puccetti DM,Brennan CA,Nesbit ME

    更新日期:1993-02-01 00:00:00

  • Nutrition education of the cancer patient and family. Myths and realities.

    abstract::Common myths about nutrition education and care of cancer patients are debunked and realities are discussed. First, frequently held misconceptions of nonspecialized health professionals are considered. These include the myths that diet change in the population will be rapid now that dietary guidelines to prevent cance...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861015)58:8+<1887::aid-cncr282

    authors: Dwyer J

    更新日期:1986-10-15 00:00:00

  • Screening for cervical disease in mature women: strategies for improvement.

    abstract:BACKGROUND:Cervical carcinoma remains a significant health risk for the older woman. In the current study the yield of screening of mature women in an established, opportunistic screening program was examined. Strategies for improving screening in this age group were identified through examination of recent Pap test hi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10723

    authors: Colgan TJ,Clarke A,Hakh N,Seidenfeld A

    更新日期:2002-08-25 00:00:00

  • Angioimmunoblastic lymphadenopathy: a T-cell deficiency.

    abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197808)42:2<447::aid-cncr2820420

    authors: Kosmidis PA,Axelrod AR,Palacas C,Stahl M

    更新日期:1978-08-01 00:00:00

  • Effects of health insurance and race on breast carcinoma treatments and outcomes.

    abstract:BACKGROUND:The authors hypothesized that insurance payer and race would influence the care and outcomes for patients with breast carcinoma. METHODS:The authors examined treatments and adjusted risk of death (through 1997) for all incident cases of breast carcinoma occurring in Florida in 1994 (n = 11,113) by using sta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20001201)89:11<2202::aid-cncr8>3

    authors: Roetzheim RG,Gonzalez EC,Ferrante JM,Pal N,Van Durme DJ,Krischer JP

    更新日期:2000-12-01 00:00:00

  • Tibial adamantinoma: its histogenesis from ultrastructural studies.

    abstract::Only three previous reports on the ultrastructural appearance of tibial adamantinoma have been found among some 120 cases of this tumor reported in the literature. The tumor in our case is less differentiated than the cases previously reported. We believe it is of epithelial character and the possibilities of its hist...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197709)40:3<1138::aid-cncr282040

    authors: Yoneyama T,Winter WG,Milsow L

    更新日期:1977-09-01 00:00:00

  • Immunohistologic detection of lymphocyte subpopulations infiltrating in human oral cancer with special reference to its clinical significance.

    abstract::Cancer tissues from 30 patients with squamous cell carcinoma of the oral cavity were examined immunohistopathologically as to the responsiveness of the host against its own cancer cells in both biopsy and surgically resected specimens from the same patients. Subpopulations of the infiltrating lymphocytes in cancer tis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840601)53:11<2456::aid-cncr282

    authors: Hiratsuka H,Imamura M,Ishii Y,Kohama G,Kikuchi K

    更新日期:1984-06-01 00:00:00

  • Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma.

    abstract:BACKGROUND:Vascular endothelial growth factor C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor 3 (VEGFR-3). By contrast, lymphatic spread is an important prognostic factor in patients with nonsmall cell lung carcinoma (NSCLC). The objective of the current study was to determine whethe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11073

    authors: Arinaga M,Noguchi T,Takeno S,Chujo M,Miura T,Uchida Y

    更新日期:2003-01-15 00:00:00

  • Racial differences in colorectal cancer survival in the Detroit Metropolitan Area.

    abstract:BACKGROUND:Colorectal carcinoma is the second most common cause of cancer death with African Americans having lower survival compared with White Americans. The purpose of this study was to investigate the effect of demographics, clinical factors, and socioeconomic status (SES) on racial disparities in colorectal cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24408

    authors: Yan B,Noone AM,Yee C,Banerjee M,Schwartz K,Simon MS

    更新日期:2009-08-15 00:00:00

  • Type 73 human papillomavirus in esophageal squamous cell carcinoma: a novel association.

    abstract:BACKGROUND:Human papillomaviruses (HPVs) commonly cause proliferative lesions of squamous epithelia, and infection with certain HPV types carries a high risk of malignant transformation, especially in the uterine cervix but also at other sites, including the esophagus. We used molecular techniques to detect and type HP...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960615)77:12<2440::AID-C

    authors: West AB,Soloway GN,Lizarraga G,Tyrrell L,Longley JB

    更新日期:1996-06-15 00:00:00

  • Histopathologic grading and DNA ploidy in relation to survival among 206 adult astrocytic tumor patients.

    abstract:BACKGROUND:The authors studied the benefit of performing histopathologic grading and DNA ploidy characterization with respect to patient survival in a series of 206 astrocytomas (AST) for which they obtained 134 complete clinical follow-ups. METHODS:The material analyzed came from archival material, i.e., formalin-fix...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920715)70:2<538::aid-cncr28207

    authors: Salmon I,Kiss R,Dewitte O,Gras T,Pasteels JL,Brotchi J,Flament-Durand J

    更新日期:1992-07-15 00:00:00

  • Participants in prospective, randomized clinical trials for resected non-small cell lung cancer have improved survival compared with nonparticipants in such trials.

    abstract::The survival of 78 patients with resected non-small cell lung cancer entered in prospective, randomized investigational trials is compared to that of a population-based group of control patients not included in such trials. The survival of trial patients is significantly better than that of controls (P less than 0.001...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19851001)56:7<1710::aid-cncr2820

    authors: Davis S,Wright PW,Schulman SF,Hill LD,Pinkham RD,Johnson LP,Jones TW,Kellogg HB Jr,Radke HM,Sikkema WW

    更新日期:1985-10-01 00:00:00

  • High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma.

    abstract::A 29-year-old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880815)62:4<686::aid-cncr28206

    authors: Siddiqui MZ,Von Eyben FE,Spanos G

    更新日期:1988-08-15 00:00:00

  • Interleukin-2-induced lung permeability is mediated by leukotriene B4.

    abstract::Interleukin (IL)-2 therapy leads to respiratory dysfunction due to increased vascular permeability. This study examines the role of the chemoattractant, immunomodulator, and permeability-promoting agent leukotriene (LT) B4 in this setting. Sheep with chronic lung lymph fistulae were given IL-2, 10(5) U/kg as an IV bol...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19901201)66:11<2357::aid-cncr282

    authors: Klausner JM,Goldman G,Skornick Y,Valeri R,Inbar M,Shepro D,Hechtman HB

    更新日期:1990-12-01 00:00:00

  • Pleuroperitoneal shunting for malignant pleural effusions.

    abstract::Traditional therapy for malignant pleural effusions includes thoracentesis or tube drainage with instillation of irritants to achieve pleurodesis. This can require a lengthy hospitalization, causes pain and discomfort, and has an appreciable failure rate. Because of these drawbacks, the authors used a shunting device ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861215)58:12<2740::aid-cncr282

    authors: Little AG,Ferguson MK,Golomb HM,Hoffman PC,Vogelzang NJ,Skinner DB

    更新日期:1986-12-15 00:00:00

  • Early hypofractionated salvage radiotherapy for postprostatectomy biochemical recurrence.

    abstract:BACKGROUND:Postprostatectomy adjuvant or salvage radiotherapy, when using standard fractionation, requires 6.5 to 8 weeks of treatment. The authors report on the safety and efficacy of an expedited radiotherapy course for salvage prostate radiotherapy. METHODS:A total of 108 consecutive patients were treated with salv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25824

    authors: Kruser TJ,Jarrard DF,Graf AK,Hedican SP,Paolone DR,Wegenke JD,Liu G,Geye HM,Ritter MA

    更新日期:2011-06-15 00:00:00

  • Clinical outcomes and survival surrogacy studies of prostate-specific antigen declines following enzalutamide in men with metastatic castration-resistant prostate cancer previously treated with docetaxel.

    abstract:BACKGROUND:In the AFFIRM trial, enzalutamide significantly increased overall survival (OS) for men with metastatic castration-resistant prostate cancer (mCRPC) after chemotherapy versus placebo and significantly decreased prostate-specific antigen (PSA) levels. The goal of this post hoc analysis was to associate levels...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.30587

    authors: Armstrong AJ,Saad F,Phung,Dmuchowski C,Shore ND,Fizazi K,Hirmand M,Forer D,Scher HI,Bono J

    更新日期:2017-06-15 00:00:00

  • MIB-1 labeling index in nonpilocytic astrocytoma of childhood: a study of 101 cases.

    abstract:BACKGROUND:The prognosis of pediatric patients with nonpilocytic astrocytoma, and in particular those with anaplastic astrocytoma, is somewhat unpredictable. This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric as...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980615)82:12<2459::aid-c

    authors: Ho DM,Wong TT,Hsu CY,Ting LT,Chiang H

    更新日期:1998-06-15 00:00:00

  • Clinical characteristics of 45 patients with invasive pulmonary aspergillosis: retrospective analysis of 1711 lung cancer cases.

    abstract:BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24559

    authors: Yan X,Li M,Jiang M,Zou LQ,Luo F,Jiang Y

    更新日期:2009-11-01 00:00:00