Abstract:
BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study, the risk factors and clinical characteristics of pulmonary infection and death mediated by invasive pulmonary aspergillosis (IPA) as complications in patients with lung cancer were determined. METHODS:: The authors conducted a retrospective analysis of the clinical notes from 45 patients who had IPA. RESULTS:: Among 1711 patients with lung cancer, 45 patients contracted pulmonary aspergillosis (2.63%). There were 10 cases of proven disease and 35 cases of probable disease. In univariate analysis, the main predisposing factors were clinical stage IV disease (P = .018), chemotherapy during the month preceding infection (P = .033), and corticosteroid use (> or =3 days; P = .038). In multivariate analysis, only clinical stage IV disease (P = .018) was associated with IPA. Furthermore, the mortality rate among lung cancer patients who had pulmonary aspergillosis was 51.1% (23 of 45 patients). Of the patients who died, corticosteroid therapy (P = .001) and grade 3/4 neutropenia (P = .013) were correlated statistically with pulmonary aspergillosis in patients with lung cancer. CONCLUSIONS:: In univariate analysis, the risk factors for IPA in lung cancer included chemotherapy and corticosteroid use in the month preceding infection and clinical stage IV disease. However, in multivariate analysis, only clinical stage IV disease was identified as a risk factor for IPA. Cancer 2009. (c) 2009 American Cancer Society.
journal_name
Cancerjournal_title
Cancerauthors
Yan X,Li M,Jiang M,Zou LQ,Luo F,Jiang Ydoi
10.1002/cncr.24559subject
Has Abstractpub_date
2009-11-01 00:00:00pages
5018-25issue
21eissn
0008-543Xissn
1097-0142journal_volume
115pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921115)70:10<2410::aid-cncr282
更新日期:1992-11-15 00:00:00
abstract:BACKGROUND:Ovarian serous tumors of low malignant potential (STLMP) occasionally progress; a small percentage of patients die of the tumor. There is no known way to predict which tumors will progress. METHODS:Forty STLMP were analyzed by DNA flow cytometry and compared with 26 serous carcinomas. RESULTS:Forty percent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<3947::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:Since mid-1987, 29 patients with invasive transitional cell carcinoma of the urinary bladder (T1-3 N0-X M0) were treated with concurrent radiation therapy (RT) (target dose [TD], 62-66 Gy) 1.8-2.0 Gy/day for 5 days a week with a break in the middle of treatment of 2-3 weeks and vinblastine weekly 2 mg/5-12 h...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921215)70:12<2885::aid-cncr282
更新日期:1992-12-15 00:00:00
abstract::Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<222::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract::Treatment of 91 consecutive patients having metastatic, Stage IV melanoma who had not received any previous chemotherapy was begun between January 1977 and April 1978. The therapy included bleomycin (B) at 7.5 units subcutaneously in the first course and 15 units in subsequent courses on days 1 and 4; vincristine or O...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801201)46:11<2346::aid-cncr282
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Since endoscopic treatment was first evaluated and established as a treatment for patients with early stage gastric carcinoma, metachronous disease recurrence at other sites in the stomach after endoscopic treatment has become a major problem. METHODS:A retrospective case-control study was conducted on 10 p...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-01-15 00:00:00
abstract::Four courses of ifosfamide with mesna given by intravenous infusions were combined with bolus doxorubicin in a phase II trial to treat patients with breast cancer. Ifosfamide can deplete intracellular glutathione levels and because doxorubicin resistance may be associated with elevated levels of intracellular glutathi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900601)65:11<2421::aid-cncr282
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Central nervous system (CNS) recurrence is almost invariably fatal in patients with aggressive non-Hodgkin lymphoma (NHL). Although some protocols are intended to prevent CNS disease, the value of CNS prophylaxis in patients with aggressive NHL remains to be determined. METHODS:We retrospectively analyzed a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10699
更新日期:2002-08-01 00:00:00
abstract::Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197609)38:3<1306::aid-cncr282038
更新日期:1976-09-01 00:00:00
abstract:BACKGROUND:Two similarly effective treatment options exist for managing clinical low volume Stage II nonseminomatous germ cell testis tumors (NSGCT). Primary retroperitoneal lymph node dissection (RPLND) (with immediate adjuvant chemotherapy or chemotherapy at relapse) and primary chemotherapy have resulted in similar ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950615)75:12<2897::aid-cncr282
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:The current study evaluated the efficacy of a 10-week, group-based, cognitive-behavioral stress management (CBSM) intervention relative to a half-day seminar in improving quality of life (QoL) among men who were treated for localized prostate carcinoma (PC) with either radical prostatectomy (RP) or radiation...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.11894
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11231
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Response rates to second-line chemotherapy in recurrent high-grade glial tumors are low and new effective treatments are needed. The objective of this study was to evaluate response rates and tolerability of chemotherapy with bevacizumab and irinotecan in recurrent high-grade gliomas. METHODS:Twenty patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23401
更新日期:2008-05-15 00:00:00
abstract:BACKGROUND:Although the anticancer effects of progesterone therapy for patients with endometrial carcinoma are widely acknowledged, a detailed assessment of the resultant morphologic alterations in tumor tissue kinetics has hitherto been lacking. METHODS:Biopsy and hysterectomy specimens of 14 endometrial carcinomas (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980701)83:1<111::aid-cnc
更新日期:1998-07-01 00:00:00
abstract::Three hundred fifteen radioisotopic bone scans ranging from initial scan only to nine scans per patient, performed on 114 patients with adenocarcinoma of the prostate between 1979 and 1984, were reviewed. Seventeen patients had positive scans, ten on initial scan and seven at follow-up. Nine patients had bone pain at ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880615)61:12<2453::aid-cncr282
更新日期:1988-06-15 00:00:00
abstract:BACKGROUND:Although randomized controlled trials (RCTs) require a great deal of time, money, and effort, the majority of them have resulted in failure to verify a priori hypotheses. Therefore, the intention in the current study was to clarify the differential elements of studies with 'positive' and 'negative' outcomes....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22776
更新日期:2007-07-15 00:00:00
abstract:BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23507
更新日期:2008-06-15 00:00:00
abstract::The cases of 189 patients treated at the Surgery Service for gastric carcinoma from January 1960 to December 1978 and followed until April 1984 were reviewed in terms of evolutive behavior. Correlations between sex, age, duration of symptoms, site of tumors, lymph node metastases, stage of tumors, operability, resecta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870215)59:4<811::aid-cncr28205
更新日期:1987-02-15 00:00:00
abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<289::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract:BACKGROUND:Recent scientific advances provide the opportunity to identify women in the general population at increased breast cancer risk and to offer effective early detection and disease prevention interventions. METHODS:A pedigree assessment tool (PAT) was designed to identify women in primary care settings who are...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22202
更新日期:2006-10-15 00:00:00
abstract::From the standpoint of chemotherapy, the first progress in the treatment of Hodgkin's disease was the identification of the activity of nitrogen mustard in the 1940's. The initial antitumor effect of the drug created a great excitement. However, when all patients later relapsed, there was subsequent dejection and skep...
journal_title:Cancer
pub_type: 临床试验,历史文章,杂志文章,评审
doi:10.1002/1097-0142(197808)42:2+<979::aid-cncr282042
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Male urethral cancer is a rare neoplasm, with the published literature consisting of small single-institution retrospective series. As such, there is no objective analysis of prognostic factors and treatment outcome. The author sought to use the population-based Surveillance, Epidemiology, and End Results (S...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25787
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:To define the clinicopathologic and prognostic features of patients with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) in North America, standard criteria were used to identify patients with ATLL. METHODS:Statistical analyses used included descriptive stati...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25147
更新日期:2010-07-15 00:00:00
abstract:BACKGROUND:Interferon is approved for adjuvant treatment of patients with stage IIB/III melanoma. The identification of predictive markers that would permit selection of patients would be beneficial. Specific human leukocyte antigen (HLA) class I and II antigens have previously shown an association with response to the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25211
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:In many areas of health care, whether patients receive specific medical interventions often is influenced heavily by the local availability of resources for delivering those services. However, relations between resource availability and utilization are relatively unexplored in cancer care, including perioper...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22458
更新日期:2007-02-15 00:00:00
abstract:BACKGROUND:Image-guided radiation therapy (IGRT) is a novel array of in-room imaging modalities that are used for tumor localization and patient setup in radiation oncology. The prevalence of IGRT use among US radiation oncologists is unknown. METHODS:A random sample of 1600 radiation oncologists was surveyed by Inter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25129
更新日期:2010-08-15 00:00:00
abstract:BACKGROUND:Monitoring therapy in patients with brain tumors is very difficult and unreliable. It has been shown that there is no good correlation between tumor sensitivity measured in vitro and in situ tumor response to therapies. METHODS:Sequential changes in tumor size, number of DNA synthesizing cells (labelling in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19960315)77:6<1167::aid-cn
更新日期:1996-03-15 00:00:00
abstract::In 1982, more than 125,000 cancer cases in the United States should be preventable. Every physician should advise all patients to eliminate all tobacco use, moderate alcohol use, avoid the use of drugs which are carcinogenic, minimize sun and x-ray exposure, maintain an ideal weight, and follow a "prudent" diet. Secon...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2430::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:There are large geographic gradients in mortality rates for a number of cancers in the U.S. (e.g., rates are approximately twice as high in the northeast compared with the southwest). Risk factors such as diet fail to explain this variation. Previous studies have demonstrated that the geographic distribution...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10427
更新日期:2002-03-15 00:00:00
abstract::Tumor-associated antigens (TAA) excreted into the urine of sarcoma patients can be detected by the complement-fixation assay. The authors prospectively measured TAA levels in the urine of 50 sarcoma patients postoperatively to determine whether reappearance of antigen in the urine would be predictive of disease recurr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840315)53:6<1306::aid-cncr2820
更新日期:1984-03-15 00:00:00