Abstract:
:Tumor-associated antigens (TAA) excreted into the urine of sarcoma patients can be detected by the complement-fixation assay. The authors prospectively measured TAA levels in the urine of 50 sarcoma patients postoperatively to determine whether reappearance of antigen in the urine would be predictive of disease recurrence. Twenty-five patients developed recurrence of their disease in the postoperative period, and 24 (96%) had reappearance of antigen in the urine 10.1 +/- 9.2 months prior to clinical evidence of recurrence. Of the 25 patients who remained disease free (mean follow-up, 48 months), 23 of 25 (92%) were urinary-antigen negative at last follow-up, although 8 patients had transient elevations of urinary TAA early in the postoperative period. Results indicate that postoperative measurement of urinary TAA in sarcoma patients permits selection of a subset of individuals at high risk for the development of recurrence. This knowledge can be of assistance in the postoperative management of these patients.
journal_name
Cancerjournal_title
Cancerauthors
Huth JF,Gupta RK,Eilber FR,Morton DLdoi
10.1002/1097-0142(19840315)53:6<1306::aid-cncr2820subject
Has Abstractpub_date
1984-03-15 00:00:00pages
1306-10issue
6eissn
0008-543Xissn
1097-0142journal_volume
53pub_type
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