Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma.

abstract：BACKGROUND:The axon guidance cue molecule Slit2 has been shown to suppress cancer cell invasion. However, the role of Slit2 in growth inhibition is still controversial. The authors identified a novel exon 15 (AKEQYFIP)-deleted slit2, located at the end of the second leucine-rich repeat (LRR2). Because LRR2 interacts wi...

journal_title：Cancer

authors： Lin YY,Yang CH,Sheu GT,Huang CY,Wu YC,Chuang SM,Fann MJ,Chang H,Lee H,Chang JT

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Endometrial cancer (EC) is the most common extraintestinal malignancy in Lynch syndrome (LS) and often is the sentinel malignancy, yet there is no consensus regarding LS-EC detection algorithms. In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting L...

journal_title：Cancer

authors： Ryan P,Mulligan AM,Aronson M,Ferguson SE,Bapat B,Semotiuk K,Holter S,Kwon J,Kalloger SE,Gilks CB,Gallinger S,Pollett A,Clarke BA

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the time to treatment failure and survival rate of the three-drug combination of doxorubicin, cisplatin, and ifosfamide as primary and postoperative, adjunctive treatment for teenagers and adults with osteosarcoma (OS). METHODS:Sixty-three eligible patients with n...

journal_title：Cancer

authors： Zalupski MM,Rankin C,Ryan JR,Lucas DR,Muler J,Lanier KS,Budd GT,Biermann JS,Meyers FJ,Antman K

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cause of cancer deaths; however, rates of regular screening for this cancer are low. A quality improvement (QI) program to increase CRC screening was developed for use in a managed care health plan. METHODS:Thirty-six provider organizations (POs) contracting ...

journal_title：Cancer

authors： Ganz PA,Farmer MM,Belman MJ,Garcia CA,Streja L,Dietrich AJ,Winchell C,Bastani R,Kahn KL

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprot...

journal_title：Cancer

authors： Ogbureke KU,Abdelsayed RA,Kushner H,Li L,Fisher LW

更新日期：2010-04-01 00:00:00

abstract：:Multiple independent tumors were identified in specimens from 117 of 234 prostatectomies for clinical adenocarcinoma; there were 266 incidental cancers in these 117 prostates. The clinically detected carcinoma was the largest (or only) tumor in all 202 Stage B cases. However, among 32 Stage A cases (detection by trans...

journal_title：Cancer

authors： Villers A,McNeal JE,Freiha FS,Stamey TA

更新日期：1992-11-01 00:00:00

abstract：:The possible influence of histologic grade, necrosis and size of invasive breast cancers on the five year survival rate of women treated in NSABP clinical trials with regimens of L-PAM (P) and L-PAM + 5-FU (PF) and for four years in those receiving L-PAM + 5-FU + methotrexate (PMF) was investigated. Generally, all reg...

journal_title：Cancer

authors： Fisher ER,Redmond C,Fisher B

更新日期：1983-01-15 00:00:00

abstract：BACKGROUND:Neuropilins (NRPs) are characterized as coreceptors of vascular endothelial growth factor (VEGF). In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF-induced cell proliferation, in pancreatic carcinoma cell lines ...

journal_title：Cancer

authors： Li M,Yang H,Chai H,Fisher WE,Wang X,Brunicardi FC,Yao Q,Chen C

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:Infection is a significant cause of death in patients with aplastic anemia (AA). However, few recent studies have examined infectious complications in patients with AA. METHODS:The authors retrospectively evaluated the type of infections, associated pathogens, and outcome of infectious episodes (IEs) in pat...

journal_title：Cancer

authors： Torres HA,Bodey GP,Rolston KV,Kantarjian HM,Raad II,Kontoyiannis DP

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...

journal_title：Cancer

authors： Thomas RM,Baybick JH,Elsayed AM,Sobin LH

更新日期：1994-04-15 00:00:00

abstract：:The Southwest Oncology Group in a prospective randomized study compared one year of adjuvant combination chemotherapy with continuous CMFVP to two years of intermittent L-PAM in women with operable breast cancer with histologically positive axillary lymph nodes. In fully evaluable patients with a 42-month median and 3...

journal_title：Cancer

authors： Glucksberg H,Rivkin SE,Rasmussen S,Tranum B,Gad-el-Mawla N,Costanzi J,Hoogstraten B,Athens J,Maloney T,McCracken J,Vaughn C

更新日期：1982-08-01 00:00:00

abstract：:Seventy-eight patients with disseminated testicular cancer were entered on a random prospective study evaluating three separate remission induction arms. Therapy with cis-diamminedichloroplatinum (20 mg/M2 for five consecutive days every three weeks for 3-4 courses) and bleomycin (30 units intravenous push weekly for ...

journal_title：Cancer

authors： Einhorn LH,Williams SD

更新日期：1980-09-15 00:00:00

abstract：:Pituitary adenomas rarely are metastatic. Extracranial visceral metastases of prolactinomas were not previously reported. The authors report a case of a 34-year-old man with a prolactin-producing pituitary carcinoma and histologically proven lung metastases. Pathologic examination of the pulmonary spread included elec...

journal_title：Cancer

authors： Atienza DM,Vigersky RJ,Lack EE,Carriaga M,Rusnock EJ,Tsou E,Cerrone F,Kattah JG,Sausville EA

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Uveal melanomas of the choroid and ciliary body are aggressive tumors causing the death of approximately 50% of patients. In contrast, iris melanomas only infrequently metastasize; why these differences exist is not known. The local environment can regulate cancer growth and development, and it is probable t...

journal_title：Cancer

authors： Canovas D,Rennie IG,Nichols CE,Sisley K

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Pegylated liposomal doxorubicin (PEG-LD) and docetaxel have single-agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with advanced malignancies. METHODS:Twenty-...

journal_title：Cancer

authors： Fracasso PM,Rodriguez LC,Herzog TJ,Fears CL,Goodner SA,Govindan R,Picus J,Rader JS,Tan BR,Arquette MA

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Overall, cervical cancer survival in the United States has been reported to be among the highest in the world, despite slight decreases over the last decade. Objective of the current study was to describe cervical cancer survival trends among US women and examine differences by race and stage. METHODS:This ...

journal_title：Cancer

authors： Benard VB,Watson M,Saraiya M,Harewood R,Townsend JS,Stroup AM,Weir HK,Allemani C

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Image-guided radiation therapy (IGRT) is a novel array of in-room imaging modalities that are used for tumor localization and patient setup in radiation oncology. The prevalence of IGRT use among US radiation oncologists is unknown. METHODS:A random sample of 1600 radiation oncologists was surveyed by Inter...

journal_title：Cancer

authors： Simpson DR,Lawson JD,Nath SK,Rose BS,Mundt AJ,Mell LK

更新日期：2010-08-15 00:00:00

abstract：BACKGROUND:Primary malignant splenic neoplasms are rare tumors. Apart from involvement of the spleen by malignant lymphoma, hemangiosarcoma is the most common form of primary malignant neoplasm in the spleen. The diagnosis often is made at autopsy or after spontaneous splenic rupture. The prognosis is usually poor, and...

journal_title：Cancer

authors： Søndenaa K,Heikkilä R,Nysted A,Søreide JA,Odegaard H,Pollard ML,Holter J

更新日期：1993-01-01 00:00:00

abstract：:The fine structure of a pineal germinoma was studied in tissue blocks and in tissue culture. The original tumor contained large primary tumor cells, lymphocytes, macrophages, plasma cells, and astrocytes. The large primary tumor cells were characterized by large nuclei, relatively scanty organelles, abundant glycogen,...

journal_title：Cancer

authors： Markesbery WR,Brooks WH,Milsow L,Mortara RH

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Reports utilizing data from the Commission on Cancer's National Cancer Data Base (NCDB) have previously contained evaluations of time trends for stage of disease at diagnosis, treatment, and survival for multiple tumor sites. Data collected from 1989, 1990, 1994, and 1995 for carcinoma of the gallbladder are...

journal_title：Cancer

authors： Donohue JH,Stewart AK,Menck HR

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Previous reports suggesting a correlation between lymphoproliferative disease and serum levels of beta-2-microglobulin (beta-2M) and in vitro data indicating a role of cytokines in the production of beta-2M prompted a study of serum and urine beta-2M concentration in patients with hemophagocytic syndrome (HP...

journal_title：Cancer

authors： Hibi S,Ikushima S,Fujiwara F,Hashida T,Tsunamoto K,Todo S,Imashuku S

更新日期：1995-04-01 00:00:00

abstract：:Modes of cancer growth and DNA ploidy were studied in 66 patients with mucosal carcinoma of the stomach. The modes of growth were classified into five histologic patterns; elongated tubular (three patients), expansive (18 patients), tubular and solid (14 patients), carcinoma in situ (10 patients) and infiltrative (21 ...

journal_title：Cancer

authors： Okamura T,Korenaga D,Haraguchi M,Tsujitani S,Sugimachi K,Mori M,Enjoji M

更新日期：1987-03-15 00:00:00

abstract：:From 1975 until 1984 37 children with newly diagnosed Hodgkin's disease were treated with six mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) courses with or without involved field radiotherapy (25 Gy) independent of the stage of their disease. Patients with small lymph node tumors (less than 4 cm) r...

journal_title：Cancer

authors： Behrendt H,Van Bunningen BN,Van Leeuwen EF

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-po...

journal_title：Cancer

authors： Malm IJ,Fan CJ,Yin LX,Li DX,Koch WM,Gourin CG,Pitman KT,Richmon JD,Westra WH,Kang H,Quon H,Eisele DW,Fakhry C

更新日期：2017-05-15 00:00:00

abstract：:Treatment choices for localized prostate cancer appear to vary widely, although it is unclear whether this variation is a result of patient values or other factors. The authors conducted a systematic review of the literature, identifying 70 articles that focused on prostate cancer decision making. Studies suggest that...

journal_title：Cancer

authors： Zeliadt SB,Ramsey SD,Penson DF,Hall IJ,Ekwueme DU,Stroud L,Lee JW

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Trimetrexate is an antifol that differs from methotrexate in ways that may be clinically important. Because methotrexate has activity in advanced bladder cancer, this trial was initiated. METHODS:Ambulatory patients with advanced urothelial carcinoma were treated with the nonclassic antifol trimetrexate at ...

journal_title：Cancer

authors： Witte RS,Elson P,Khandakar J,Trump DL

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Childhood cancer survivors are at risk for cardiovascular disease (CVD) because of intensive cancer therapies often accompanied by an unhealthy lifestyle. This study was aimed at 1) describing modifiable CVD risk factors in survivors and 2) investigating the association between different aspects of physical ...

journal_title：Cancer

authors： Schindera C,Zürcher SJ,Jung R,Boehringer S,Balder JW,Rueegg CS,Kriemler S,von der Weid NX

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Patients with testicular cancer can be cured by cisplatin-based chemotherapy in many cases. Thus, concern about possible late toxicities of treatment is warranted. METHODS:In this investigation, the absolute number of natural killer (NK) cells according to their CD56+ phenotype, NK cell activity, and antibo...

journal_title：Cancer

authors： Krainer M,Wolf H,Michl I,Wiltschke C,Budinsky A,Kaider A,Kratzik C,Eibl MM,Zielinski CC

更新日期：1995-01-15 00:00:00

abstract：:A controlled trial of surgical adjuvant chemotherapy for breast cancer was carried out using 551 Japanese patients. Single or combined treatment with mitomycin C (0.2 mg/kg i.v. three times within five days postoperatively) and cyclophosphamide (100 mg postoperatively daily for four months or longer) was used after ra...

journal_title：Cancer

authors： Koyama H,Wada T,Takahashi Y,Nishizawa Y,Iwanaga T,Aoki Y,Terasawa T,Kosaki G,Kajita A,Wada A

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) signaling is a target for antiangiogenic cancer therapy. The authors have previously observed that up to 40% of vessels in colorectal carcinoma (CRC) tumors are negative for VEGF receptor 2 (VEGFR2) expression. Differential activity of transforming growth factor beta...

journal_title：Cancer

authors： Kuczynski EA,Viloria-Petit AM,Coomber BL

更新日期：2011-12-15 00:00:00