A novel exon 15-deleted, splicing variant of Slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer.

abstract：BACKGROUND:Monitoring therapy in patients with brain tumors is very difficult and unreliable. It has been shown that there is no good correlation between tumor sensitivity measured in vitro and in situ tumor response to therapies. METHODS:Sequential changes in tumor size, number of DNA synthesizing cells (labelling in...

journal_title：Cancer

authors： Takeda N,Diksic M,Yamamoto YL

更新日期：1996-03-15 00:00:00

abstract：:The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-ric...

journal_title：Cancer

authors： Kiang DT,Frenning DH,Gay J,Goldman AI,Kennedy BJ

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Neovascularization reportedly is correlated with metastasis, recurrence, and prognosis in some types of tumors. Microvessel quantification in so-called "hot spots" has been studied extensively as the only factor reflecting angiogenesis in various malignant tumors. The objective of this report was to evaluate...

journal_title：Cancer

authors： Pavlopoulos PM,Konstantinidou AE,Agapitos E,Kavantzas N,Nikolopoulou P,Davaris P

更新日期：1998-11-15 00:00:00

abstract：:The interferon (IFN) assay of the sera from the 40 patients with head and neck cancer was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. The patients mainly had Stage III or IV lesion without distant metastasis, and previously had not received ...

journal_title：Cancer

authors： Sato M,Yoshida H,Yanagawa T,Yura Y,Urata M,Atsumi M,Furumoto N,Hayashi Y,Takegawa Y

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Telomerase is a ribonucleoprotein enzyme that extends telomere specific repeats on the ends of chromosomes. Telomerase activity has been detected frequently in various types of human tumors and has been associated with cell immortality and oncogenesis. Human telomerase reverse transcriptase (hTERT), a telome...

journal_title：Cancer

authors： Tomoda R,Seto M,Tsumuki H,Iida K,Yamazaki T,Sonoda J,Matsumine A,Uchida A

更新日期：2002-09-01 00:00:00

abstract：:A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. Thirteen similar reactions, in patients treated with single-agent DTIC, are reported in the literature. Several clinical and pa...

journal_title：Cancer

authors： Ceci G,Bella M,Melissari M,Gabrielli M,Bocchi P,Cocconi G

更新日期：1988-05-15 00:00:00

abstract：:Thirty-one patients were treated with cisplatin combination chemotherapy for advanced seminoma (26 Stage III or bulky Stage II testicular, and five disseminated extragonadal). Seventeen (89%) of 19 patients not previously pretreated and four (80%) of five who had received only abdominal irradiation entered continuous ...

journal_title：Cancer

authors： Pizzocaro G,Salvioni R,Piva L,Zanoni F,Milani A,Faustini M

更新日期：1986-10-15 00:00:00

abstract：:Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...

journal_title：Cancer

authors： Varughese RS,Lam WS,Marican AABH,Viganeshwari SH,Bhave AS,Syn NL,Wang J,Wong AL,Kumar AP,Lobie PE,Lee SC,Sethi G,Goh BC,Wang L

更新日期：2019-06-01 00:00:00

abstract：:Although the conference could not provide a definitive etiologic explanation for the observed increase in incidence of human brain tumors, particularly among the elderly, nevertheless, this interdisciplinary gathering of prominent scientists and clinicians proved invaluable in identifying new avenues of research. Clea...

journal_title：Cancer

authors： Brem S,Rozental JM,Moskal JR

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physi...

journal_title：Cancer

authors： de Glas NA,Fontein DB,Bastiaannet E,Pijpe A,De Craen AJ,Liefers GJ,Nortier HJ,de Haes HJ,van de Velde CJ,van Leeuwen FE

更新日期：2014-09-15 00:00:00

abstract：:This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvem...

journal_title：Cancer

authors： Vandenbrouck C,Sancho-Garnier H,Chassagne D,Saravane D,Cachin Y,Micheau C

更新日期：1980-07-15 00:00:00

abstract：:A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...

journal_title：Cancer

authors： Trump DL,Fahnestock R,Cloutier CT,Dickman MD

更新日期：1978-02-01 00:00:00

abstract：:Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL-N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panm...

journal_title：Cancer

authors： Collins AJ,Bloomfield CD,Peterson BA,McKenna RW

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Patients with superficial (mucosal or submucosal) esophageal carcinoma (SEC) have significantly better survival rates than patients with advanced carcinoma. Some patients with advanced esophageal carcinoma have been reported to test positive for serum p53 antibodies (Abs). Because very few patients with supe...

journal_title：Cancer

authors： Shimada H,Takeda A,Arima M,Okazumi S,Matsubara H,Nabeya Y,Funami Y,Hayashi H,Gunji Y,Suzuki T,Kobayashi S,Ochiai T

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:A clinicopathologic evaluation of clinical Stage I and II uterine sarcoma was done by the Gynecologic Oncology Group from 1979-1988. METHODS:After all eligibility criteria were met, 453 cases were evaluable and analyzed for prognostic factors. RESULTS:Of the 301 mixed mesodermal tumors (MMT), 167 were homo...

journal_title：Cancer

authors： Major FJ,Blessing JA,Silverberg SG,Morrow CP,Creasman WT,Currie JL,Yordan E,Brady MF

更新日期：1993-02-15 00:00:00

abstract：:This report is to make the general scientific community aware of availability of human tissues through this network. During the short period of its existence, this network has developed useful procedures for distributing human tumor tissue in a rapid, scientifically useful, cost-effective manner to investigators to wh...

journal_title：Cancer

authors： Clausen KP,Grizzle WE,Livolsi V,Newton WA Jr,Aamodt R

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:The purpose of the current study was to examine patient selection for an aromatase inhibitor in breast cancer patients who were free from adverse events 5 years after treatment with tamoxifen. METHODS:In all, 471 women were treated with breast-conserving surgery, axillary lymph node dissection, and radiatio...

journal_title：Cancer

authors： Freedman GM,Anderson P,Li T,Ross E,Swaby R,Goldstein L

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast tumors. METHODS:The breast tumors were analyzed by histologic, immunohistochemical, and ultrastructural techniques. RESULTS:Histologically, the tumors were com...

journal_title：Cancer

authors： Padmore RF,Lara JF,Ackerman DJ,Gales T,Sigurdson ER,Ehya H,Cooper HS,Patchefsky AS

更新日期：1996-12-15 00:00:00

abstract：:Mesenchymal chondrosarcoma of bone and soft tissues treated at the Istituto Ortopedico Rizzoli are reviewed. The skeletal locations were prominent in five cases. Only two cases were in the soft tissues. Radiographic picture in the bone shows an aggressive osteolysis, with soft tissues invasion. Histologic picture is t...

journal_title：Cancer

authors： Bertoni F,Picci P,Bacchini P,Capanna R,Innao V,Bacci G,Campanacci M

更新日期：1983-08-01 00:00:00

abstract：:A solitary hepatic tumor in a 50-year-old woman, which was observed as a hemangioma, ultimately was resected because it increased in size. The tumor volume doubling time was 28.8 months over the observed period of 30 months. The histologic diagnosis was carcinoid tumor. Immunohistochemical staining showed strong focal...

journal_title：Cancer

authors： Moriura S,Ikeda S,Hirai M,Naiki K,Fujioka T,Yokochi K,Gotou S

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:BRCA2 gene, located at chromosome 13q12.3, frequently is altered in familial types of cancer in which a "double-hit" inactivation model seems to occur. In contrast, in sporadic forms of cancer there is frequent absence of a second event (point mutations) suggesting that allelic imbalance at the BRCA2 locus m...

journal_title：Cancer

authors： Gorgoulis VG,Kotsinas A,Zacharatos P,Mariatos G,Liloglou T,Tsoli E,Kokotas S,Fassoulas C,Field JK,Kittas C

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome....

journal_title：Cancer

authors： Savarese DM,Zavarin M,Smyczynski MS,Rohrer MJ,Hutzler MJ

更新日期：2000-12-15 00:00:00

abstract：:Effective management of hepatic metastases from ocular and cutaneous melanoma remains a major therapeutic challenge. Treatment options include hepatic resection, hepatic intra-arterial (HIA) chemotherapy, chemoembolization, and hepatic perfusions. Evaluating the efficacy of these interventions is limited by the retros...

journal_title：Cancer

authors： Agarwala SS,Eggermont AM,O'Day S,Zager JS

更新日期：2014-03-15 00:00:00

abstract：:An Epstein-Barr virus (EBV)-negative lymphoma line (JBL) was established in vitro from pleural effusion of an EBV-seropositive 29-year-old Japanese female with Burkitt's lymphoma. JBL cells as well as her original lymphoma cells bore monoclonal surface IgM with lambda light chains. The JBL line grew in single cell sus...

journal_title：Cancer

authors： Miyoshi I,Hiraki S,Kubonishi I,Matsuda Y,Kishimoto H,Nakayama T,Tanaka T,Masuji H,Kimura I

更新日期：1977-12-01 00:00:00

abstract：:Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER-positive lesions (greater than 5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (35%) and fibrosing adenosis (50%) to lobula...

journal_title：Cancer

authors： Jacquemier JD,Rolland PH,Vague D,Lieutaud R,Spitalier JM,Martin PM

更新日期：1982-06-15 00:00:00

abstract：:Detailed cytogenetic studies were performed in 41 patients with cutaneous T-cell lymphoma (CTCL): four patients had limited plaques, 13 patients had generalized plaques, eight patients had cutaneous tumors, 16 patients had generalized erythroderma, and four additional patients, who had relatively benign chronic dermat...

journal_title：Cancer

authors： Whang-Peng J,Bunn PA Jr,Knutsen T,Matthews MJ,Schechter G,Minna JD

更新日期：1982-10-15 00:00:00

abstract：BACKGROUND:An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). METHODS:Patients were stratified as follows: stra...

journal_title：Cancer

authors： Fouladi M,Blaney SM,Poussaint TY,Freeman BB 3rd,McLendon R,Fuller C,Adesina AM,Hancock ML,Danks MK,Stewart C,Boyett JM,Gajjar A

更新日期：2006-11-01 00:00:00

abstract：:The identification of important prognostic factors at diagnosis of childhood leukemia has been very useful in explaining the marked differences in disease outcome. After a complete remission is achieved, it is interesting to determine whether the ability to maintain a complete remission and the patient's survival cont...

journal_title：Cancer

authors： Sather H,Coccia P,Nesbit M,Level C,Hammond D

更新日期：1981-07-15 00:00:00

abstract：BACKGROUND:This review was done to assess the outcomes and patterns of recurrence in a group of patients with Stage III endometrial carcinoma that might help guide adjuvant therapy. METHODS:A retrospective review was performed of 105 patients treated from 1970-1990 at three institutions. All patients underwent abdomin...

journal_title：Cancer

authors： Greven KM,Lanciano RM,Corn B,Case D,Randall ME

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Multimodality treatment has dramatically improved the outcome of patients with Ewing sarcoma. However, there appears to be little information concerning treatment-related complications in patients who are long-term survivors. METHODS:Forty-one patients with Ewing sarcoma who were treated between 1960-1980 a...

journal_title：Cancer

authors： Fuchs B,Valenzuela RG,Inwards C,Sim FH,Rock MG

更新日期：2003-12-15 00:00:00