Relationships between steroid receptor and epithelial cell proliferation in benign fibrocystic disease of the breast.

Abstract:

:Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER-positive lesions (greater than 5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (35%) and fibrosing adenosis (50%) to lobular and ductal hyperplasia (85%). Similarly, ER content increased from 14.5 +/- 13 fmol/mg cytosol protein in fibrocystic disease and fibrosing adenosis to 31.5 +/- 23 fmol/mg protein in epithelial hyperplastic lesions. Furthermore, the ER-PR couple was only encountered in lobular and ductal hyperplasia. The authors' data indicate that the incidence of steroid receptor parallels the intensity of hyperplasia in benign breast disease.

journal_name

Cancer

journal_title

Cancer

authors

Jacquemier JD,Rolland PH,Vague D,Lieutaud R,Spitalier JM,Martin PM

doi

10.1002/1097-0142(19820615)49:12<2534::aid-cncr282

subject

Has Abstract

pub_date

1982-06-15 00:00:00

pages

2534-6

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

49

pub_type

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