Abstract:
:Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER-positive lesions (greater than 5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (35%) and fibrosing adenosis (50%) to lobular and ductal hyperplasia (85%). Similarly, ER content increased from 14.5 +/- 13 fmol/mg cytosol protein in fibrocystic disease and fibrosing adenosis to 31.5 +/- 23 fmol/mg protein in epithelial hyperplastic lesions. Furthermore, the ER-PR couple was only encountered in lobular and ductal hyperplasia. The authors' data indicate that the incidence of steroid receptor parallels the intensity of hyperplasia in benign breast disease.
journal_name
Cancerjournal_title
Cancerauthors
Jacquemier JD,Rolland PH,Vague D,Lieutaud R,Spitalier JM,Martin PMdoi
10.1002/1097-0142(19820615)49:12<2534::aid-cncr282subject
Has Abstractpub_date
1982-06-15 00:00:00pages
2534-6issue
12eissn
0008-543Xissn
1097-0142journal_volume
49pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Ovarian cancer patients frequently receive chemotherapy near the end of life. The purpose of the current study was to develop indicators that characterize those ovarian cancer patients who have a short life span. METHODS:The medical charts of deceased epithelial ovarian cancer patients were retrospectively ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23391
更新日期:2008-05-15 00:00:00
abstract::Six patients with Hodgkin's disease who developed idiopathic thrombocytopenic purpura (ITP) are presented. In contrast to prior cases reported in the literature, none of these patients developed recurrent Hodgkin's disease at the time of or subsequent to their thrombocytopenia, with follow-up data available up to 10 y...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<743::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:Preclinical and clinical studies suggest synergistic activity between somatostatin analogues and mammalian target of rapamycin inhibitors. The activity and safety of everolimus was assessed in combination with octreotide long-acting repeatable (LAR) in patients with neuroendocrine tumors (NETs) of gastroente...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28726
更新日期:2014-08-15 00:00:00
abstract::Tumor weight, carcass weight, nitrogen balance, energy balance, resting energy expenditure (REE), and activity energy expenditure (AEE) were measured in normal Fischer 344 rats, free-feeding Fischer 344 rats with methylcholanthrene-induced sarcoma (TB-FF), and similar tumor-bearing rats supported with total parenteral...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820315)49:6<1212::aid-cncr2820
更新日期:1982-03-15 00:00:00
abstract:BACKGROUND:Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence. ME...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22282
更新日期:2006-12-15 00:00:00
abstract::Between February 1980 and December 1985, splenectomies were performed in 13 patients with advanced (Stage III and IV) chronic lymphocytic leukemia (CLL). Patients had advanced disease for a median of 32 months at the time of splenectomy and all were refractory to chemotherapy. All patients were anemic with a median he...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870515)59:10<1815::aid-cncr282
更新日期:1987-05-15 00:00:00
abstract::Urinary polyamine concentrations in 91 samples were assayed in 79 patients with malignant melanoma who were classified as to clinical stage, as well as to activity of disease. Patients with active disease had higher mean polyamine values, increased frequency of polyamine elevations, and increased frequency of two or m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197611)38:5<2088::aid-cncr282038
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23866
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Active surveillance (AS) with deferred treatment is an established management option for patients with prostate cancer and favorable clinical parameters. The impact of repeat biopsy after diagnosis was examined in a cohort of men with prostate cancer on AS. METHODS:In all, 186 men with prostate cancer with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23575
更新日期:2008-07-15 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract:BACKGROUND:Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare, CD20-positive, good prognostic lymphoma in children. Patients with early-stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were aske...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22762
更新日期:2007-07-01 00:00:00
abstract::A 12-year-old boy with primary reticulum cell sarcoma of the testis who is alive and free of tumor 32 months after orchiectomy, radiation therapy to inguinal, iliac and retroperitoneal lymph nodes and chemotherapy is reported. Seven previously documented cases of childhood primary testicular lymphoma are reviewed. The...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<935::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::Leukemic cells from 13 patients with therapy-related acute nonlymphocytic leukemia (ANLL) were studied by electron microscopy. All of the patients had radiotherapy, and/or alkylating agent chemotherapy for other neoplastic disease 25 to 182 months prior to the diagnosis of ANLL. All cases manifested ultrastructural ev...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810801)48:3<725::aid-cncr28204
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Stenotrophomonas maltophilia is responsible for an increasing number of infections, especially in hospitalized patients. Therapy options are limited and trimethoprim/sulfamethoxazole (TMP/SMX) is often the main treatment option for this infection. In the current study, the risk factors were determined for th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22705
更新日期:2007-06-15 00:00:00
abstract::The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911215)68:12<2612::aid-cncr282
更新日期:1991-12-15 00:00:00
abstract:BACKGROUND:Image-guided radiation therapy (IGRT) is a novel array of in-room imaging modalities that are used for tumor localization and patient setup in radiation oncology. The prevalence of IGRT use among US radiation oncologists is unknown. METHODS:A random sample of 1600 radiation oncologists was surveyed by Inter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25129
更新日期:2010-08-15 00:00:00
abstract:BACKGROUND:Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pancreatic adenocarcinoma tissues by immunohistochemical anal...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-15 00:00:00
abstract::In a series of 25 patients with head and neck cancer who had severe pain, the type and cause of the pain were analyzed. There were two types of pain: nociceptive and non-nociceptive. Nineteen (76%) patients had nociceptive pain that could be subdivided into actual nociceptive pain (9 patients), nociceptive nerve pain ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920701)70:1<178::aid-cncr28207
更新日期:1992-07-01 00:00:00
abstract::Five patients with angiosarcoma of the breast were treated with surgery, radiotherapy and an adjuvant Adriamycin containing regimen. Two patients remain disease-free at 38+ and 20+ months. The median survival of previously reported cases is 22 months with only five patients disease-free at five years. Possible hormona...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2000::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract::Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract::One hundred and sixty-two cases of Stage IA microinvasive carcinoma of the cervix are presented. These patients represent the combined experience at the University of Miami School of Medicine, Miami, Florida, and Downstate Medical Center, Brooklyn, New York. The criteria used in both institutions are 1) penetration of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<414::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract::This trial determines the feasibility for patients with resectable Stages III/IV head and neck cancer who achieved a complete response to induction chemotherapy of eliminating surgery from their treatment program. Thirty patients were treated with three cycles of cisplatin and 5-fluorouracil (5-FU), followed by reendo...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870915)60:6<1178::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830815)52:4<619::aid-cncr28205
更新日期:1983-08-15 00:00:00
abstract::Arylsulfatase B activity has been determined in 24-hour urine samples from 243 patients with colorectal cancer. Elevated activity of the enzyme was obsereved in 172 out of 243 (71%) patients. Employing Dukes' modified classification of colorectal cancer, urine arylsulfatase B activity was elevated in Dukes' A lesions-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197512)36:6<2337::aid-cncr282036
更新日期:1975-12-01 00:00:00
abstract::Two-hundred-four patients with previously untreated adenocarcinoma of rectum, rectosigmoid, and sigmoid colon were retrospectively evaluated to determine patterns of recurrence following curative resection. Seventy-eight (38%) subsequently developed recurrent disease. Of these, 40% (31/78) presented with local recurre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810915)48:6<1492::aid-cncr2820
更新日期:1981-09-15 00:00:00
abstract:BACKGROUND:: Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar. Moreover, secondary inflammation may be identified in PanCa, further complicating diagnosis. To impr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24893
更新日期:2010-04-01 00:00:00
abstract::Six patients with metastatic mixed germ-cell tumors who had been treated successfully with chemotherapy had recurring solitary enlarging masses. Four had enlarging pulmonary masses and two patients had enlarging abdominal masses. Each had the presumed chemotherapy refractory mass surgically resected and was found to h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821015)50:8<1629::aid-cncr2820
更新日期:1982-10-15 00:00:00
abstract::Eight cases of primary non-Hodgkin's lymphoma of the breast found in the pathology files of the Institute of Oncology, Ljubljana, Yugoslavia, for a period of 25 years (from 1961 to 1985) were analyzed. During the same period 5711 cases of breast carcinoma were seen. Seven cases were diffuse lymphomas, and one case was...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19871215)60:12<3033::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract::Spleen from nine patients with hairy-cell leukemia (HCL) were studied for ultrastructural alterations. In all cases, hairy cells with typical ultrastructural characteristics were observed within splenic cords and sinuses. Hairy cells had numerous cytoplasmic processes that interdigitated with cytoplasmic processes of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820415)49:8<1617::aid-cncr2820
更新日期:1982-04-15 00:00:00
abstract::Risk factors associated with local recurrences were analyzed from a series of 3445 clinical Stage I melanoma patients. In single-factor analysis, tumor thickness, ulceration, and increasing age were highly significantly predictive of recurrence (p less than 0.00001). After 5 years of follow-up, local recurrence rates ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850315)55:6<1398::aid-cncr2820
更新日期:1985-03-15 00:00:00