Abstract:
:Between February 1980 and December 1985, splenectomies were performed in 13 patients with advanced (Stage III and IV) chronic lymphocytic leukemia (CLL). Patients had advanced disease for a median of 32 months at the time of splenectomy and all were refractory to chemotherapy. All patients were anemic with a median hematocrit of 27.5%; nine patients were thrombocytopenic with a median platelet count of 46,000/microliter. There was no surgical mortality and minimal morbidity. Median hematocrit was 35% at 1 month and 6 months postsplenectomy. Median platelet count in previously thrombocytopenic patients was 261,000/microliter at 1 month and 177,000/microliter at 6 months postsplenectomy. Median survival postsplenectomy in this advanced patient group was 24 months with four patients surviving more than 30 months. Splenectomy is a valuable adjunct to the management of end-stage CLL.
journal_name
Cancerjournal_title
Cancerauthors
Stein RS,Weikert D,Reynolds V,Greer JP,Flexner JMdoi
10.1002/1097-0142(19870515)59:10<1815::aid-cncr282subject
Has Abstractpub_date
1987-05-15 00:00:00pages
1815-8issue
10eissn
0008-543Xissn
1097-0142journal_volume
59pub_type
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