Significance of urinary neopterin in patients with malignant tumors of the genitourinary tract.

Abstract:

:The urinary neopterin excretion was measured by high-performance liquid chromatography in 417 healthy subjects and in 76 patients with clinically and pathohistologically verified neoplasias of the urinary tract (bladder tumor, carcinoma of the prostate, and renal cell carcinoma). The patients with early tumor stages both with bladder tumor and carcinoma of the prostate had normal urinary neopterin levels, except one patient with bladder tumor who had a value at the upper confidence limit. Of 40 patients with higher stages of bladder tumor and carcinoma of the prostate, 35 had elevated urinary neopterin levels. Two of 10 patients with bladder tumor in stage T3, 1 of 4 patients with carcinoma of the prostate Stage C, and 2 of 15 patients with prostatic cancer Stage D showed normal neopterin levels. The patients with renal cell carcinoma did not demonstrate any definite correlation between tumor stage and urinary neopterin excretion. The current study suggests that the neopterin assay may supplement laboratory measurements in tumors of the urinary tract, providing helpful information regarding case selection for the most convenient therapeutic management and postoperative follow-up.

journal_name

Cancer

journal_title

Cancer

authors

Aulitzky W,Frick J,Fuchs D,Hausen A,Reibnegger G,Wachter H

doi

10.1002/1097-0142(19850301)55:5<1052::aid-cncr2820

subject

Has Abstract

pub_date

1985-03-01 00:00:00

pages

1052-5

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

55

pub_type

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