Abstract:
BACKGROUND:Microsatellite instability occurs frequently in hereditary nonpolyposis colorectal carcinoma, in sporadic gastrointestinal carcinoma, and in other tumors. In these tumors, slippage-related frameshift mutations have been detected at coding mononucleotide repeats in genes such as those for transforming growth factor-beta receptor type II (TGFbetaRII), mannose 6-phosphate/insulinlike growth factor II receptor (M6P/IGFIIR), hMSH3, hMSH6, and Bcl-2-associated X protein (BAX). Because these genes regulate cell growth or repair DNA mismatches, loss of their function is thought to promote tumor development. The authors screened for these frameshift mutations and investigated the incidence of microsatellite instability (MI) in hepatocellular carcinoma (HCC) in Japan. METHODS:Fifty HCC samples were analyzed in this study. The authors used polymerase chain reactions to screen for frameshift mutation at the TGFbetaRII (A)(10) tract, the M6P/IGFIIR (G)(8) tract, the hMSH3 (A)(8) tract, the hMSH6 (C)(8) tract, and the BAX (G)(8) tract. For MI analysis, matched tumor and nontumor liver DNA were investigated with respect to 10 microsatellite loci. RESULTS:No frameshift mutation was detected in any case, and only 4% of these cancers exhibited MI in comparisons between tumor and nontumor liver specimens. CONCLUSIONS:This study suggests that frameshift mutation at coding mononucleotide repeats within TGFbetaRII, M6P/IGFIIR, hMSH3, hMSH6, and BAX genes did not seem to be involved in hepatocarcinogenesis in the Japanese population studied.
journal_name
Cancerjournal_title
Cancerauthors
Saeki A,Tamura S,Ito N,Kiso S,Matsuda Y,Yabuuchi I,Kawata S,Matsuzawa Ysubject
Has Abstractpub_date
2000-03-01 00:00:00pages
1025-9issue
5eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(20000301)88:5<1025::AID-CNjournal_volume
88pub_type
杂志文章相关文献
CANCER文献大全abstract::The immunologic phenotypes of 59 cases of diffuse, aggressive, non-Hodgkin's lymphomas were determined using a battery of immunologic and cytochemical techniques. Included were cases of diffuse, large cell "histiocytic," mixed cell, undifferentiated non-Burkitt's. Burkitt's lymphoma, lymphoblastic lymphoma, and mycosi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841001)54:7<1310::aid-cncr2820
更新日期:1984-10-01 00:00:00
abstract::From April 1985 through March 1988, 24 lung cancer patients with carcinomatous pleuritis were treated with a new combined treatment modality consisting of pulmonary resection and postoperative intrathoracic chemo-thermotherapy (PICT). They consisted of 15 male patients and nine female patients. A majority of the patie...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891001)64:7<1422::aid-cncr2820
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20431
更新日期:2004-08-15 00:00:00
abstract::Nine children with acute promyelocytic leukemia (APL) are presented. This series of children represents 7% of all acute leukemias and 21% of acute myelogenous leukemias seen during the same period at the Red Cross War Memorial Children's Hospital. These figures are much higher than the incidence quoted in other series...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<933::aid-cncr28205
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Chemotherapy is known to cure a small minority of patients with acute myeloid leukemia (AML). Less is known about the risk of such patients developing subsequent cancers or about their ability to return to work. METHODS:The authors analyzed outcomes among 1892 patients who received treatment for newly diagn...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971201)80:11+<2176::aid-
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:African-American (AA) and white patients with early-stage disease who were treated with breast conservation therapy (BCT) were examined to detect differences in clinicopathologic features and outcomes as a function of race. METHODS:Clinical data from the charts of 2164 white and 207 AA patients treated with...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23881
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0142(19980201)82:3<448::aid-cnc
更新日期:1998-02-01 00:00:00
abstract::A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, outcomes and prognostic tools have yet to be clearly defined in patients with metastatic renal cell carcinoma (mRCC) who are treated with immuno-oncology (IO) checkpoint inhibitors (programmed death-ligand 1 [PD-L1] inhibitors). In the current study, the authors aimed to establish ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31595
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:The prognostic value of flow cytometric analysis of DNA content is contradictory in renal cell carcinoma (RCC). METHODS:Flow cytometric analysis was performed on 72 patients with RCC, and the relationship between the DNA content and pathologic or clinical features was investigated. RESULTS:Aneuploidy was o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930815)72:4<1319::aid-cncr2820
更新日期:1993-08-15 00:00:00
abstract::Because chronic lymphocytic leukemia is a heterogeneous disease, there are considerable efforts underway to develop increasingly accurate and precise analytics with which to estimate the probability of future events such as the need for and probability of response to therapy, progression-free survival, and survival. T...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32353
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The effect of aspirin use on 490 patients with cancer of the colon, 340 with cancer of the rectum as the first primary site, and 212 patients with polyps having no coexisting malignancies was compared with that of two groups of control subjects that consisted of 524 hospital patients having no cancers and no...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930815)72:4<1171::aid-cncr2820
更新日期:1993-08-15 00:00:00
abstract:BACKGROUND:Osteosarcoma is the most common malignant bone tumor in children and young people. Efficacy of multiagent MAP (methotrexate, doxorubicin [Adriamycin], cisplatin) chemotherapy may be influenced by multiple cellular pathways. This pilot study aimed to investigate the association of 36 candidate genetic polymor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26472
更新日期:2012-04-01 00:00:00
abstract::The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2066::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract:BACKGROUND:Podoplanin is a mucin-like glycoprotein that is important in lymphangiogenesis but not blood vessel formation. Recent studies suggested a potential role of podoplanin in certain tumor cells. The purpose of the current study was to determine the role of podoplanin in head and neck squamous cell carcinoma (HNS...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22061
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:After the introduction of a mammography screening program, the incidence of late-stage breast cancer is expected to decrease. The objective of the current study was to evaluate variations in the total incidence of breast cancer and in the incidence of breast cancers with a pathologic tumor (pT) classificatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28014
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:As androgen deprivation therapy (ADT) becomes a standard of treatment for men with recurrent or metastatic prostate cancer, evaluation of adverse effects associated with this treatment is needed. In this study, the authors evaluated the effect of ADT administered as monotherapy and in combination with local ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26064
更新日期:2011-10-01 00:00:00
abstract::A clinicopathologic study was done of 21 cutaneous, sarcoma-like lesions previously diagnosed as atypical fibroxanthoma, spindle cell carcinoma, or dermal sarcoma. These lesions were most commonly presented as a solitary, often ulcerated nodule, occurring on exposed skin of the face in the elderly or, occasionally, on...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850101)55:1<172::aid-cncr28205
更新日期:1985-01-01 00:00:00
abstract::Nine human hybridoma cell lines were established from a fusion of axillary lymph node lymphocytes of a patient with breast ductal carcinoma with a human lymphoblastoid cell line. The human hybridoma nature of the fusion products was confirmed by chromosomal analysis and HLA typing. The hybridomas are stable over a yea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870101)59:1<43::aid-cncr282059
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Cyclin-dependent kinases (CDK) and cyclins constitute the subunits of the maturation-promoting factor that controls the process of cell division. High levels of these proteins have been reported in human malignancies of the stomach, colon, breast, and lung, and have been implicated in aberrant cell division ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970815)80:4<753::aid-cnc
更新日期:1997-08-15 00:00:00
abstract:BACKGROUND:The current study determined the efficacy and toxicity of weekly paclitaxel in combination with estramustine phosphate (EMP) in patients with androgen-independent prostate carcinoma (AIPC). METHODS:Patients with progressive AIPC received 90 mg/m2 paclitaxel by 1-hour intravenous infusion weekly for 3 weeks,...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11956
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:Some vasoactive drugs have been studied in the hope of altering the vascular permeability and/or blood of tumors to enhance monoclonal antibody (MoAb) uptake. The pretreatment of interleukin-2 (IL-2), one of the vasoactive reagents, produced a generalized vascular permeability, but its function was not tumor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971215)80:12+<2650::aid-
更新日期:1997-12-15 00:00:00
abstract::We have reviewed the records of 76 patients with Stage I or II extranodal non-Hodgkin's lymphoma who were referred to the Division of Radiation Oncology, Mallinckrodt Institute of Radiology, during the years 1964 through 1974. The histologic slides were reviewed in the 67 cases in which they were available. Forty-thre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800215)45:4<653::aid-cncr28204
更新日期:1980-02-15 00:00:00
abstract::Reflected ultrasound scanning (echography) is rapidly developing into a prime tool for tumor diagnosis, outlining, and detection. The principles of echographic diagnosis of neoplasms, the accepted uses in detection and diagnosis, as well as some of the principles of internal and contour patterns are discussed. Echogra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197601)37:1+<496::aid-cncr282037
更新日期:1976-01-01 00:00:00
abstract::Actuarial progression-free survival rate at 5 years of a series of 34 patients with medulloblastoma treated by combined surgery, radiotherapy, and chemotherapy was 71%. No relapses were observed in 14 patients followed for more than 5 years. Treatment consisted of a short postoperative course of vincristine (VCR) and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1956::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract::Knowledge of tumor antigenic expression is crucial to the design of therapeutic strategy. A murine monoclonal antibody (BE4) against a human melanoma membrane antigen, was used to study the in vitro expression of this antigen. By membrane immunofluorescence, BE4 reacted against 5 of 8 melanoma lines as compared to zer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850315)55:6<1276::aid-cncr2820
更新日期:1985-03-15 00:00:00
abstract:BACKGROUND:The AJCC staging system and post-operative nomograms use patient and tumor characteristics to provide prognostic estimates after resection of retroperitoneal sarcoma (RPS). While these variables help to predict survival at the time of diagnosis and resection, the applicability of these prognostic factors to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26665
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Modern cancer treatments can cure or prolong patients' lives. However, the associated physical and psychosocial problems can detrimentally affect patients' compliance with treatment and, ultimately, their outcomes. Therefore, oncologists need to recognize the problems experienced by their patients and, when ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-10-15 00:00:00
abstract:BACKGROUND:Selective neck dissection (SND) is a mainstay of head and neck cancer treatment. A common sequela is shoulder syndrome from spinal accessory nerve (SAN) trauma. Extensive dissection in neck levels 2 and 5 leads to SAN dysfunction. However, it is not known whether limited level 2 dissection reduces SAN injury...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.32681
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The authors' goal was to characterize hospice enrollment and aggressiveness of care for pancreatic cancer patients at the end of life. METHODS:Surveillance, Epidemiology, and End Results and linked Medicare claims data (1992-2006) were used to identify patients with pancreatic cancer who had died (n = 22,81...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26115
更新日期:2011-11-01 00:00:00