Abstract:
:Knowledge of tumor antigenic expression is crucial to the design of therapeutic strategy. A murine monoclonal antibody (BE4) against a human melanoma membrane antigen, was used to study the in vitro expression of this antigen. By membrane immunofluorescence, BE4 reacted against 5 of 8 melanoma lines as compared to zero of 13 other cell populations. Using flow cytometry, the antigenic M14 CEM melanoma cells consisted of 40% to 60% of the total cell population. Dual-parameter measurements of DNA content and membrane antigen demonstrated that the nonantigenic cells were predominantly in G0/G1 phase, whereas the antigenic cells were distributed throughout the cell cycle. Within one passage, the sorted and recultured nonantigenic population demonstrated a similar proportion of antigenic cells as the unsorted original population. It was concluded that the expression of human melanoma antigen was cell-cycle-dependent. Understanding factors that turn off the expression of antigen in G0/G1 phase may lead to better immunotherapeutic strategies.
journal_name
Cancerjournal_title
Cancerauthors
Leong SP,Bolen JL,Chee DO,Smith VR,Taylor JC,Benfield JR,Klevecz RRdoi
10.1002/1097-0142(19850315)55:6<1276::aid-cncr2820subject
Has Abstractpub_date
1985-03-15 00:00:00pages
1276-83issue
6eissn
0008-543Xissn
1097-0142journal_volume
55pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Papanicolaou smear sensitivity for cervical adenocarcinoma (CVCA) is not well established. Also uncertain are the relative contributions to falsely negative diagnoses of sampling, screening, and interpretive errors. METHODS:Papanicolaou smears were identified from all patients at our institutions with biops...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-02-25 00:00:00
abstract::Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiother...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<499::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract::International comparisons have provided striking correlations between fat consumption and risk of breast cancer, but these comparisons do not often consider variations in life style. Case-control studies carried out in several countries showed no real association between fat intake and breast cancer. There is some evi...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900915)66:14+<1321::aid-cncr28
更新日期:1990-09-15 00:00:00
abstract:BACKGROUND:Ewing's sarcomas, osteosarcomas, and rhabdomyosarcomas are significantly more responsive to chemotherapy than other sarcomas. Adjuvant chemotherapy is used routinely based on data from randomized trials. Although a percentage of children with locally advanced or metastatic tumors remain curable, few data exi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:There is little information on the function of dendritic cells in women with human papillomavirus (HPV)-related cervical squamous intraepithelial lesions (SILs). In the current study the functions of dendritic cells in the development of T-cell immunity in women with cervical SILs were assessed. METHODS:The...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.22092
更新日期:2006-09-01 00:00:00
abstract::To surgery, radiation, and chemotherapy for cancer has been added a fourth modality: multidisciplinary therapy, which is improving the survival and cure rate among children. Specialists working together in a coordinated effort suspect, confirm, then treat cancer; follow and rehabilitate the patient; analyze and report...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<876::aid-cncr282035
更新日期:1975-03-01 00:00:00
abstract::Aziridinylbenzoquinone (AZQ) was studied in a Phase II protocol for persons with glioma of the central nervous system (CNS) recurrent or progressive after surgery and radiotherapy. Patients received AZQ, 30 mg/m2 intravenously every 3 weeks if previously untreated or 27.5 mg/m2 if previously exposed to cytotoxic drugs...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850915)56:6<1311::aid-cncr2820
更新日期:1985-09-15 00:00:00
abstract:BACKGROUND:There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS:Medicare beneficiaries who were 65 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30989
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Assessment of tissue specimens obtained with common immersion-fixation followed by dehydration (IMDH) is affected by artifacts, which hinder precise evaluation of the histology and microenvironment of tumor tissues. The technical characteristics of cryobiopsy and in vivo cryotechnique (IVCT) where target org...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23701
更新日期:2008-09-01 00:00:00
abstract::The assumption that asymptomatic colorectal cancers bleed provides the rationale for widespread stool screening. The authors studied 12 patients with unoperated colorectal cancer but without colorectal symptoms and six healthy volunteers as laboratory controls. All stools were collected for 2 weeks and analyzed by the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900501)63:9<1826::aid-cncr2820
更新日期:1989-05-01 00:00:00
abstract::Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2252::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract::Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901215)66:12<2498::aid-cncr282
更新日期:1990-12-15 00:00:00
abstract:BACKGROUND:Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31162
更新日期:2018-03-01 00:00:00
abstract::In order to determine whether the use of a sequence of chemotherapeutic regimens plus BCG could produce longer durations of remission in adult acute nonlymphocytic leukemia than maintenance therapy with cytosine arabinoside, 6-thioguanine, plus BCG, a randomized study was performed at Washington University. Upon achie...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19800701)46:1<22::aid-cncr282046
更新日期:1980-07-01 00:00:00
abstract::Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated wit...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910401)67:7<1830::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract::Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880201)61:3<508::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract::The authors report a case of Stage IV, unfavorable histologic type adult nephroblastoma. The patient was treated with multimodal therapy: combination chemotherapy consisting of cyclophosphamide, doxorubicin, cisplatin, and etoposide succeeded by nephrectomy and radiation therapy. After a disease-free period of 27 mont...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920615)69:12<2990::aid-cncr282
更新日期:1992-06-15 00:00:00
abstract::Therapeutic intervention in a course of illness, while producing the desired result, also may have some adverse long-term effects on the patient. Second malignancies are one of the known complications of therapy. The treatments of gynecologic cancers by surgery, irradiation and chemotherapy have been associated with s...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19810715)48:1+<442::aid-cncr2820
更新日期:1981-07-15 00:00:00
abstract::Preoperative evaluation should focus on techniques that either preclude surgery entirely, alter the planned operation either preoperatively or intraoperatively, or suggest the need for preoperative adjuvant therapy. The presence of a synchronous colonic neoplasia should be excluded by colonoscopy or air-contrast bariu...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920901)70:3+<1328::aid-cncr282
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:The purpose of this project was to develop the M. D. Anderson Symptom Inventory (MDASI), a brief measure of the severity and impact of cancer-related symptoms. METHODS:A list of symptoms was generated from symptom inventories and by panels of clinicians. Twenty-six symptoms and 6 interference items were rat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001001)89:7<1634::aid-cncr29>3
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Reports utilizing data from the Commission on Cancer's National Cancer Data Base (NCDB) have previously contained evaluations of time trends for stage of disease at diagnosis, treatment, and survival for multiple tumor sites. Data collected from 1989, 1990, 1994, and 1995 for carcinoma of the gallbladder are...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19981215)83:12<2618::aid-c
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Because patients with germ cell tumors expect an additional life span of around 50 years after successful treatment, attention is now focused on potential long term toxicity. Limited data are available on Leydig cell function in long term survivors. METHODS:The authors measured testosterone, sex hormone bin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010401)91:7<1297::aid-cncr1132
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:There is concern that antioxidant supplement use during chemotherapy and radiation therapy may decrease treatment effects, yet the effects of such supplements on recurrence and survival are largely unknown. METHODS:The authors prospectively examined the associations between antioxidant use after breast canc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26526
更新日期:2012-04-15 00:00:00
abstract::The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901015)66:8<1748::aid-cncr2820
更新日期:1990-10-15 00:00:00
abstract:BACKGROUND:Although almost half of all incidents of breast carcinoma occur in women age > or = 65 years, not enough is known about appropriate care for patients in this age group. The objective of the current study was to evaluate the role of breast conservation therapy in the management of breast carcinoma in women ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1092::aid-cncr1425
更新日期:2001-09-01 00:00:00
abstract::Between 1964 and 1982, 862 patients with acute leukemia who were collected from medical institutions throughout the country had a survival of 5 years or longer. Their remission has been achieved mainly with a combination therapy of vincristine and prednisone in childhood acute leukemia and daunomycin, cytosine arabino...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850701)56:1<88::aid-cncr282056
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. The objective of this study was to investigate whether changes in the tumor/parenchyma interface are associated with response. METHODS:Computed tomography (CT) scans before and after therapy were reviewed in 4...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31251
更新日期:2018-04-15 00:00:00
abstract:BACKGROUND:The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS:A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cance...
journal_title:Cancer
pub_type: 共识发展会议,杂志文章,评审
doi:10.1002/cncr.30380
更新日期:2017-04-01 00:00:00
abstract::The authors describe their experience with total body irradiation (TBI) with 8 MeV-x rays in the treatment of disseminated tumors. With a dose of 125 rad, given three times with 2-week intervals, some objective remissions (6/26) were obtained, especially in patients with lymphomas. For solid tumors only subjective imp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1435::aid-cncr282039
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced parathyroid hormone-relate...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000615)88:12+<2892::aid-cncr2>
更新日期:2000-06-15 00:00:00