Abstract:
BACKGROUND:There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS:Medicare beneficiaries who were 65 years old or older and were diagnosed with breast cancer at 1 of 12 cancer centers affiliated with an academic center in the southeastern United States were analyzed. Stage 0 or I patients treated with lumpectomy from 2012 to 2014 were identified. Patient, treatment, and center characteristics were analyzed for the utilization of RT. RESULTS:Among 800 women treated with lumpectomy, 64% received adjuvant radiation. The median age was 74 years. The omission of RT was more likely in older patients, stage 0 patients, and patients with more comorbidities (P < .01). Hormonal blockade was used in 41% of the patients who did not receive RT. The utilization of hormonal blockade with the omission of RT was more likely in patients with fewer comorbidities (P < .01). CONCLUSIONS:In an older cohort of patients who otherwise would have qualified for the omission of radiation, two-thirds were treated with radiation. Future guideline recommendations should address omission in the context of hormonal blockade compliance because only 41% of the patients used hormonal blockade when radiation was not delivered. Cancer 2018;124:475-81. © 2017 American Cancer Society.
journal_name
Cancerjournal_title
Cancerauthors
Wallace AS,Keene KS,Williams CP,Jackson BE,Pisu M,Partridge EE,Rocque GBdoi
10.1002/cncr.30989subject
Has Abstractpub_date
2018-02-01 00:00:00pages
475-481issue
3eissn
0008-543Xissn
1097-0142journal_volume
124pub_type
杂志文章相关文献
CANCER文献大全abstract::A case of granulocytic sarcoma involving the uterine cervix as primary manifestation without evidence of leukemia is presented. It was followed by neurological symptoms 19 months later and a right breast mass 26 months after the initial cervical lesion, but still with no evidence of leukemia. Two years and four months...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<3030::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Clear cell tumors of the thyroid gland in general are uncommon. Metastatic renal cell carcinoma (RCC) to the thyroid gland is a rare occurrence but must be considered in the differential diagnosis of a thyroid gland clear cell neoplasm to prevent misclassification, potentially resulting in inappropriate clin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10901
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS:Adult MM patients diagnosed between 1973 and 2011 were identified...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29771
更新日期:2016-02-15 00:00:00
abstract:BACKGROUND:The purpose of the study was to determine the utility of quantitation of the extracellular domain (ECD) of the HER-2/neu receptor in the serum for predicting response to treatment in patients with primary breast cancer receiving neoadjuvant therapy. METHODS:HER-2/neu ECD was measured in sera obtained from 3...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.22418
更新日期:2007-02-01 00:00:00
abstract::Despite the fact that expression of Fas ligand (FasL) in cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells plays an important role in Fas-mediated tumor killing, During tumor progression FasL-expressing tumor cells are involved in counterattacking to kill tumor-infiltrating lymphocytes (TILs). Soluble Fa...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.20270
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent the development of cancer by inhibiting cyclooxygenase (COX) enzymes, which are involved in carcinogenesis. Therefore, the authors of this report examined the association between NSAID use and the risk of squamous cell carcinoma (SCC), basal cell carc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27406
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The frequency of RET rearrangements (RET/PTC) in papillary thyroid carcinomas varies significantly according to geographic area, with the greatest incidence reported in the Belarus region, which is iodine-deficient and was contaminated severely after the Chernobyl reactor accident, and with the lowest incide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21270
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of differen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32557
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Nodal status is one of the most important prognostic factors for distal bile duct cancer. The pattern of lymphatic spread of distal bile duct cancer was analyzed by determining the frequency of involvement of various lymph nodes. MATERIALS AND METHODS:From 1973 to 1991, 29 patients with distal bile duct can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931001)72:7<2112::aid-cncr2820
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, wh...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000615)88:12+<2961::aid-cncr12
更新日期:2000-06-15 00:00:00
abstract:METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<1943::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract::Seventy-eight patients with metastatic cancer to the lungs underwent flexible fiberoptic bronchoscopy for diagnosis. The patients were divided into two groups by presenting radiographic pattern as: (I) diffuse linear interstitial infiltrations (55 patients); and (II) localized or multiple nodular opacities (23 patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831115)52:10<1949::aid-cncr282
更新日期:1983-11-15 00:00:00
abstract::Thirty-one patients were treated with cisplatin combination chemotherapy for advanced seminoma (26 Stage III or bulky Stage II testicular, and five disseminated extragonadal). Seventeen (89%) of 19 patients not previously pretreated and four (80%) of five who had received only abdominal irradiation entered continuous ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1625::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract::This study examined public attitudes toward pain associated with cancer and its treatment. A variety of issues were assessed, including the extent to which pain is associated with cancer, fear of pain as a factor in the decision to delay seeking treatment, and concerns about the use of narcotic analgesics for pain con...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2337::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Ethnic disparities in colorectal cancer (CRC) mortality are observed in the United States. The authors studied this among minority New Yorkers with CRC. METHODS:In a study of CRC patients in a New York City teaching hospital, 5-year data on demographics and clinical features were reviewed. Adjusted cancer-r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24614
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:The majority of patients with breast carcinoma with > or = 10 metastatic axillary lymph nodes (ALNs) develop recurrent disease within 5 years from diagnosis. The purpose of the current study, performed retrospectively, was to characterize the natural history of this subset of patients, both before and after ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.21182
更新日期:2005-07-15 00:00:00
abstract:BACKGROUND:Older adults are an important audience for smoking cessation programs. Over 4.5 million older adults (older than 65) continue to smoke, and the majority are long term, heavy smokers. There is evidence that smoking cessation programs tailored to older smokers can be effective. American Cancer Society (ACS) ma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941001)74:7+<2051::aid-cncr282
更新日期:1994-10-01 00:00:00
abstract::BALB/c mice were hyperimmunized with ACHN (ATCC CRL 1611, American Type Culture Collection, Rockville, Maryland), a stable in vitro cell line derived from a malignant pleural effusion in a 22-year-old man with renal cell carcinoma. The hyperimmune spleen cells were fused with NS-1 murine myeloma cells using polyethyle...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870615)59:12<2031::aid-cncr282
更新日期:1987-06-15 00:00:00
abstract:BACKGROUND:Two evidence-based therapies exist for the treatment of high-risk prostate cancer (PCA): external-beam radiotherapy (RT) with hormone therapy (H) (RT + H) and radical prostatectomy (S) with adjuvant radiotherapy (S + RT). Each of these strategies is associated with different rates of local control, distant m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26272
更新日期:2012-01-01 00:00:00
abstract::The interferon (IFN) assay of the sera from the 40 patients with head and neck cancer was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. The patients mainly had Stage III or IV lesion without distant metastasis, and previously had not received ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841001)54:7<1239::aid-cncr2820
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The usefulness of fine-needle aspiration biopsy (FNAB) for the histologic subtyping of specific sarcomas still is somewhat controversial but is becoming increasingly popular in the U.S. METHODS:To determine the accuracy and usefulness of FNAB in the differential diagnosis of myxoid sarcoma, the authors retr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20000625)90:3<167::aid-cncr5>3.0
更新日期:2000-06-25 00:00:00
abstract:BACKGROUND:We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt. METHODS:We used SEER-Medicare data from 2004-2006 to identify 4247 men who underwent RP, of whom 600 subsequently received adjuvant therapies. We used Cox regression to ident...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26012
更新日期:2011-11-01 00:00:00
abstract::Mesenchymal chondrosarcoma, an uncommon lesion of bone and extraskeletal tissue, is rare in the orbit. A case of extraskeletal mesenchymal chondrosarcoma of the orbit in a 28-year-old woman presenting with proptosis and diminution of vision in the left eye is reported. Histologically, the tumor showed areas of undiffe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931001)72:7<2224::aid-cncr2820
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:The current study was conducted to evaluate the Patient-Reported Outcomes Measurement Information System Depression Short Form (PROMIS-D-SF) as a screening measure for young adult cancer survivors (YACS) compared with a structured diagnostic interview. METHODS:A total of 249 YACS (aged 18-40 years) complete...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32689
更新日期:2020-04-01 00:00:00
abstract::Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non-small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.33159
更新日期:2020-11-15 00:00:00
abstract::This communication reports four patients treated with the anthracycline adriamycin and irradiation either concurrently or sequentially, who demonstrated apparent augumentation of radiation reactions. Two of these patients demonstrated the so-called "recall" phenomenon. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197509)36:3<946::aid-cncr2820360
更新日期:1975-09-01 00:00:00
abstract::The ability to noninvasively discriminate the most common types of renal cell carcinoma (RCC) based on their magnetic resonance imaging (MRI) appearances or their magnetic resonance phenotypes is achievable. Intracellular lipids, a histologic characteristic of the clear cell RCC, can be identified on chemical shift MR...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24237
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20782
更新日期:2005-01-01 00:00:00
abstract::Postmenopausal patients with metastatic breast cancer were treated with medroxyprogesterone acetate (MPA) (Clinovir) in dosages between 500 and 1500 mg orally per day. The relation of MPA plasma concentrations and endocrine effects were studied in a longitudinal fashion. MPA exerted suppressive effects on the basal an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840915)54:1+<1208::aid-cncr282
更新日期:1984-09-15 00:00:00