Pharmacokinetic and pharmacodynamic basis for the treatment of metastatic breast cancer with high-dose medroxyprogesterone acetate.

abstract：BACKGROUND:Little is known about cellular level genetic alterations in preinvasive breast lesions, particularly lobular carcinoma in situ. METHODS:We employed fluorescence in situ hybridization (FISH) using pericentromeric (alpha satellite) probes to assess numerical alterations of chromosomes 1, 7, 8, 16, 17, and X i...

journal_title：Cancer

authors： Visscher DW,Wallis TL,Crissman JD

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...

journal_title：Cancer

authors： Koelmeyer LA,Borotkanics RJ,Alcorso J,Prah P,Winch CJ,Nakhel K,Dean CM,Boyages J

更新日期：2019-03-15 00:00:00

abstract：:The records of all 27 adult patients (age, greater than or equal to 16 years) diagnosed with cerebellar medulloblastoma between 1968 and 1986 were reviewed. Twenty-four patients (89%) were treated with postoperative megavoltage irradiation. Twenty of these patients underwent craniospinal irradiation. Sixteen patients ...

journal_title：Cancer

authors： Hazuka MB,DeBiose DA,Henderson RH,Kinzie JJ

更新日期：1992-04-15 00:00:00

abstract：:Among the patients showing evidence of cerebral metastases without previously known cancer history, lung cancer has been found 37 times as the primary tumor in our institution. There were 34 men and three women and all but two were heavy smokers. Only one presented at diagnosis with thoracic symptoms but the chest rad...

journal_title：Cancer

authors： Trillet V,Catajar JF,Croisile B,Turjman F,Aimard G,Bourrat C,Bret P,Carrie C,Chassard JL,Chauvin F

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Plasma acidic glutathione S-transferase (GST-pi) concentrations in 135 patients with gastrointestinal cancer were measured by an improved radioimmunoassay (RIA). METHODS:Blood was collected into a silicified glass tube containing a specific anticoagulant. The plasma, which was separated rapidly by centrifug...

journal_title：Cancer

authors： Fan KC,Huang YC,Li CH

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Despite growing evidence and support for shared decision making, little is known about the experiences of parents who hold more active roles than they wish. METHODS:This was a prospective cohort study of 372 parents of children with cancer and their oncologists at 2 academic pediatric hospitals. Parents wer...

journal_title：Cancer

authors： Sisk BA,Kang TI,Goldstein R,DuBois JM,Mack JW

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:A Phase II prospective trial was performed to study the efficacy of combination therapy with dexamethasone, calcitriol (1,25-dihydroxyvitamin D3), and carboplatin in patients with hormone-refractory prostate cancer (HRPC). Preclinical data from prostate cancer cell lines suggested a synergistic effect of the...

journal_title：Cancer

authors： Flaig TW,Barqawi A,Miller G,Kane M,Zeng C,Crawford ED,Glodé LM

更新日期：2006-07-15 00:00:00

abstract：:The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...

journal_title：Cancer

authors： Kellie SJ,Pratt CB,Parham DM,Fleming ID,Meyer WH,Rao BN

更新日期：1990-02-15 00:00:00

abstract：BACKGROUND:Medical records of 50 patients with malignant mesothelioma were reviewed to determine the clinical features and factors influencing survival. METHODS:Charts of all patients whose conditions were diagnosed as malignant mesothelioma were abstracted and analyzed by statistical software. RESULTS:The male-to-fe...

journal_title：Cancer

authors： Sridhar KS,Doria R,Raub WA Jr,Thurer RJ,Saldana M

更新日期：1992-12-15 00:00:00

abstract：BACKGROUND:Lysosomal proteases are implicated in cancer progression and metastasis. In the current study, using subtraction cloning for genes that are differentially expressed in metastasis, the authors isolated a clone encoding ceroid lipofuscinosis, neuronal 2 (CLN2), which is a lysosomal serine protease defective in...

journal_title：Cancer

authors： Tsukamoto T,Iida J,Dobashi Y,Furukawa T,Konishi F

更新日期：2006-04-01 00:00:00

abstract：:Twelve cases of thymic carcinoid were studied by electron microscopy and immunohistochemistry. Clinically, all of them presented either as asymptomatic, radiographically detected mediastinal masses or as neoplasms producing symptoms of thoracic structural displacement or Cushing's syndrome. By light microscopic examin...

journal_title：Cancer

authors： Wick MR,Scheithauer BW

更新日期：1984-02-01 00:00:00

abstract：:Artificial neural networks now are used in many fields. They have become well established as viable, multipurpose, robust computational methodologies with solid theoretic support and with strong potential to be effective in any discipline, especially medicine. For example, neural networks can extract new medical infor...

journal_title：Cancer

authors： Dayhoff JE,DeLeo JM

更新日期：2001-04-15 00:00:00

abstract：:A case of bronchial mucoepidermoid carcinoma is reported, the presentation of which was as cutaneous metastases. Histologic, histochemical, and ultrastructural features of the neoplasm are described, and the literature pertaining to bronchial mucoepidermoid carcinoma is reviewed. This case illustrates the potential fo...

journal_title：Cancer

authors： Metcalf JS,Maize JC,Shaw EB

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes. METHODS:A comprehensive search identified 109 studies that collectively described the outcomes of patients with p...

journal_title：Cancer

authors： Tate M,Sughrue ME,Rutkowski MJ,Kane AJ,Aranda D,McClinton L,McClinton L,Barani IJ,Parsa AT

更新日期：2012-01-01 00:00:00

abstract：:Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the best way to treat every disease or each patient and that all treatmen...

journal_title：Cancer

authors： Hrushesky WJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...

journal_title：Cancer

authors： Granter SR,Renshaw AA

更新日期：1997-04-25 00:00:00

abstract：:Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant p...

journal_title：Cancer

authors： Lippman SM,Grogan TM,Spier CM,Koopmann CF Jr,Gall EP,Shimm DS,Durie BG

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...

journal_title：Cancer

authors： Santana VM,Furman WL,McGregor LM,Billups CA

更新日期：2008-06-15 00:00:00

abstract：BACKGROUND:Thyroid tumorigenesis is characterized by a progressive loss of differentiation exhibited by a range of disease variants. The Notch receptor family (1-4) regulates developmental progression in both normal and cancerous tissues. This study sought to characterize the third Notch isoform (Notch3) across the var...

journal_title：Cancer

authors： Somnay YR,Yu XM,Lloyd RV,Leverson G,Aburjania Z,Jang S,Jaskula-Sztul R,Chen H

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The current study was performed to describe patient characteristics, treatment patterns, survival, health care resource use (HRU), and costs among older women in the United States with advanced (American Joint Committee on Cancer stage III/IV) triple-negative breast cancer (TNBC) in the Surveillance, Epidemi...

journal_title：Cancer

authors： Schwartz KL,Simon MS,Bylsma LC,Ruterbusch JJ,Beebe-Dimmer JL,Schultz NM,Flanders SC,Barlev A,Fryzek JP,Quek RGW

更新日期：2018-05-15 00:00:00

abstract：:An extrarenal malignant rhabdoid tumor (MRT) of the pelvis in a 14-year-old girl is described. The location of the tumor and age of the patient appear to be unique. The neoplasm is histologically and ultrastructurally identical to malignant rhabdoid tumor of the kidney seen in infants and very young children. The tumo...

journal_title：Cancer

authors： Frierson HF Jr,Mills SE,Innes DJ Jr

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Epithelioid sarcoma is a highly malignant soft tissue tumor that is largely resistant to conventional chemotherapy and radiotherapy. Because paclitaxel has been proven to be effective in other human malignancies refractory to conventional chemotherapy, the authors analyzed the in vitro growth inhibitory effe...

journal_title：Cancer

authors： Reinecke P,Knopf C,Schmitz M,Schneider EM,Gabbert HE,Gerharz CD

更新日期：2000-04-01 00:00:00

abstract：:A case of congenital acute lymphoblastic leukemia (ALL) displayed an X;6 translocation. This is the third reported case of ALL with an X;6 translocation. In addition, two of the three ALL cases occurred during infancy, at ages 2 months and newborn, and both translocations involved the band q15-16 region of chromosome ...

journal_title：Cancer

authors： Carney LA,Kinney JS,Higgins RR,Freeman AI,Hecht BK,Woods GM

更新日期：1992-02-01 00:00:00

abstract：:Twenty-four patients who developed extramedullary disease during the course of Philadelphia chromosome-positive chronic myelogenous leukemia are described. The most frequent sites of extramedullary disease were lymph nodes (54%), bone (37%), and skin and soft tissue (29%). The appearance of extramedullary disease was ...

journal_title：Cancer

authors： Terjanian T,Kantarjian H,Keating M,Talpaz M,McCredie K,Freireich EJ

更新日期：1987-01-15 00:00:00

abstract：BACKGROUND:In the United States, incidence rates for malignant tumors of the uterine corpus are lower among blacks than among whites, whereas mortality rates are higher among blacks. Reasons for the higher level of mortality among blacks have been debated. METHODS:Using data from the Surveillance, Epidemiology, and En...

journal_title：Cancer

authors： Sherman ME,Devesa SS

更新日期：2003-07-01 00:00:00

abstract：:This report describes a case of null cell congenital acute lymphoblastic leukemia associated with a (4;11) translocation. This chromosome abnormality is associated with acute lymphoblastic leukemia and probably more specifically with congenital acute lymphoblastic leukemia. A review of the literature is presented. ...

journal_title：Cancer

authors： Esseltine DW,Vekemans M,Seemayer T,Reece E,Gordon J,Whitehead VM

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Patients with basal cell carcinoma (BCC) demonstrate marked variation in clinical phenotype, suggesting the presence of distinct subgroups. Patients with truncal lesions comprise an interesting subgroup, because, although the pathogenesis of these tumors is unclear, there is evidence to suggest that their de...

journal_title：Cancer

authors： Ramachandran S,Fryer AA,Smith A,Lear J,Bowers B,Jones PW,Strange RC

更新日期：2001-07-15 00:00:00

abstract：BACKGROUND:Clinical practice guidelines for the management of breast carcinoma were introduced in Australia in October, 1995. This article describes the management of early-stage breast carcinoma both before and after the introduction of these guidelines. METHODS:All cases of early breast carcinoma that were diagnosed...

journal_title：Cancer

authors： White V,Pruden M,Giles G,Collins J,Jamrozik K,Inglis G,Boyages J,Hill D

更新日期：2004-08-01 00:00:00

abstract：:One hundred fifty-six evaluable patients with metastatic breast cancer were treated with vincristine, Adriamycin and cyclophosphamide alternating at fixed intervals with 5-FU and methotrexate. Immunotherapy with BCG or MER-BCG was administered to all patients in two consecutive treatment programs. Overall objective re...

journal_title：Cancer

authors： Blumenschein GR,Hortobagyi GN,Richman SP,Gutterman JU,Tashima CK,Buzdar AU,Burgess MA,Livingston RB,Hersh EM

更新日期：1980-02-15 00:00:00

abstract：:The clinical presentation of the disease and the results of treatment in 42 patients with malignant peripheral neuroectodermal tumors (MPNT) entered into the Cooperative Ewing's, soft tissue, and neuroblastoma trials of the German Society of Pediatric Oncology were retrospectively analyzed. Within the Ewing's sarcoma ...

journal_title：Cancer

authors： Jürgens H,Bier V,Harms D,Beck J,Brandeis W,Etspüler G,Gadner H,Schmidt D,Treuner J,Winkler K

更新日期：1988-01-15 00:00:00