Abstract:
BACKGROUND:The current study was performed to describe patient characteristics, treatment patterns, survival, health care resource use (HRU), and costs among older women in the United States with advanced (American Joint Committee on Cancer stage III/IV) triple-negative breast cancer (TNBC) in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. METHODS:Women who were aged ≥66 years at the time of diagnosis and diagnosed with advanced TNBC between January 1, 2007, and January 1, 2011, in the SEER-Medicare database and who were followed for survival through December 31, 2013, were eligible. Patient demographic and clinical characteristics at the time of diagnosis, subsequent treatment patterns, and survival outcomes were analyzed. HRU and costs for the first 3 months after diagnosis, the last 3 months of life, and the time in between are summarized. All analyses were stratified by American Joint Committee on Cancer stage of disease. RESULTS:There were 1244 patients newly diagnosed with advanced TNBC; the majority were aged ≥75 years (61% with stage III disease and 57.4% with stage IV disease) and white (>70% of patients in both disease stage groups). The most common treatment approaches were surgery combined with chemotherapy for patients for stage III disease (50.6%) and chemotherapy alone or with radiotherapy for patients with stage IV disease (31.3%). Diverse chemotherapy regimens were administered for each line of therapy; nevertheless, the medications used were consistent with national guidelines. Patients with stage III and stage IV disease were found to have a similar mean number of hospitalizations and outpatient visits, but mean monthly costs were greater for patients with stage IV disease at all 3 time points. The mean cost per patient-month (in 2013 US dollars) was $4810 for patients with stage III disease and $9159 for patients with stage IV disease. CONCLUSIONS:Among older women with advanced TNBC, significant treatment variations and considerable HRU and costs exist. Further research is needed to find effective treatments with which to reduce the clinical and economic burden of this disease. Cancer 2018;124:2104-14. © 2018 American Cancer Society.
journal_name
Cancerjournal_title
Cancerauthors
Schwartz KL,Simon MS,Bylsma LC,Ruterbusch JJ,Beebe-Dimmer JL,Schultz NM,Flanders SC,Barlev A,Fryzek JP,Quek RGWdoi
10.1002/cncr.31299subject
Has Abstractpub_date
2018-05-15 00:00:00pages
2104-2114issue
10eissn
0008-543Xissn
1097-0142journal_volume
124pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Despite recent improvements in the treatment of acute lymphoblastic leukemia (ALL), adult patients still have an overall poor outcome. The future of ALL management relies on the introduction of novel targeted therapies. The authors sought to assess if protein kinases (PKs), frequently deregulated in cancer, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25113
更新日期:2010-07-15 00:00:00
abstract::Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880201)61:3<508::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Recently, a 23-gene signature was developed to produce a melanoma diagnostic score capable of differentiating malignant and benign melanocytic lesions. The primary objective of this study was to independently assess the ability of the gene signature to differentiate melanoma from benign nevi in clinically re...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30385
更新日期:2017-02-15 00:00:00
abstract::Retrospective immunocytochemical study of prolactin, growth hormone, ACTH, TSH and gonadotropins was performed on 150 pituitary adenomas from 142 patients and the results were correlated with clinical manifestations. There were 60 prolactin-positive tumors, 13 growth hormone-positive tumors, nine ACTH-positive tumors ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830815)52:4<648::aid-cncr28205
更新日期:1983-08-15 00:00:00
abstract:BACKGROUND:Epithelioid sarcoma is a highly malignant soft tissue tumor that is largely resistant to conventional chemotherapy and radiotherapy. Because paclitaxel has been proven to be effective in other human malignancies refractory to conventional chemotherapy, the authors analyzed the in vitro growth inhibitory effe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000401)88:7<1614::aid-cn
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes. METHODS:A comprehensive search identified 109 studies that collectively described the outcomes of patients with p...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26300
更新日期:2012-01-01 00:00:00
abstract::The ability to noninvasively discriminate the most common types of renal cell carcinoma (RCC) based on their magnetic resonance imaging (MRI) appearances or their magnetic resonance phenotypes is achievable. Intracellular lipids, a histologic characteristic of the clear cell RCC, can be identified on chemical shift MR...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24237
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Discrimination and trust are known barriers to accessing health care. Despite well-documented racial disparities in the ovarian cancer care continuum, the role of these barriers has not been examined. This study evaluated the association of everyday discrimination and trust in physicians with a prolonged int...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32451
更新日期:2019-12-15 00:00:00
abstract:BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24423
更新日期:2009-08-15 00:00:00
abstract::A Chinese patient with documented hepatocellular carcinoma (HCC) satisfied the criteria of Everson and Cole for spontaneous regression of malignant tumors. Subsequently he survived a tumor-free period of at least 13 years. During the period of regression, shrinkage of liver coincided with a rise of SGOT to a level com...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<332::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract:BACKGROUND:An association between laryngopharyngeal reflux (LPR) and laryngeal carcinoma has been suggested, but remains unproven. The current pilot study was performed to determine the incidence of LPR among patients with early laryngeal carcinomas or dysplasia and to examine the associations between levels of LPR and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11158
更新日期:2003-02-15 00:00:00
abstract::Granular cell tumor of the stomach is rare and may occur in association with similar tumors in the skin. Two such tumors were found in association with cutaneous granular cell tumors in two black females. Infiltrating carcinoma of the stomach was suspected at surgery in one case. All of the lesions were typical granul...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840515)53:10<2104::aid-cncr282
更新日期:1984-05-15 00:00:00
abstract:BACKGROUND:Nonperioperative strokes are rare yet potentially devastating events for children with central nervous system (CNS) tumors. The incidence of and risk factors for nonperioperative strokes in children with CNS tumors is unknown. METHODS:The authors performed a retrospective review of children from their insti...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract::In nine patients who had undergone trans-sphenoidal hypophysectomy, prolactin dynamics were studied with intravenous thyrotropin releasing hormone (TRH). Residual prolactin secretory reserve was demonstrated in seven. Five patients were TRH tested both before and after trans-sphenoidal hypophysectomy. Hypophysectomy d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2254::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Approximately 5-10% of patients with rhabdomyosarcomas (RMS) are diagnosed during the first year of life, and their clinical characteristics have been well documented. However, because RMS rarely occurs during the neonatal period, little is known about neonatal RMS. METHODS:Four patients with neonatal RMS w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1613::aid-cncr1487
更新日期:2001-09-15 00:00:00
abstract::CEA-like material was found in 51 of 62 primary human breast carcinomas and in only 2 of 12 fibroadenomas. Levels of carcinoma CEA-like material correlated weakly with cytoplasmic estradiol receptor levels, total cytosol estrogens, and cytosol progesterone. Levels of CEA-like material showed no significant correlation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<121::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract::The only prophylaxis for ovarian cancer is oophorectomy, except in the very rare case when an ovarian cancer appears to arise from the mesothelial tissue of the abdominal cavity. It has been shown that women who have taken the oral contraceptive pill for 4 or 5 years decreases the incidence of ovarian cancer by approx...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820710419
更新日期:1993-02-15 00:00:00
abstract:BACKGROUND:A sedentary life style has been consistently associated with an increased risk of colon cancer, but the evidence for its association with breast and other gynecologic cancers is limited. METHODS:Occupational information for 3783 incident patients with cancer (breast, 2736; corpus uteri, 452; and ovary, 595)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3620::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Although breast-conserving surgery was used with increasing frequency during the 1980s for management of breast cancer, most women still undergo mastectomy, and a substantial variation has been documented in the proportion of women receiving breast-conserving surgery across regions of the country. Using data...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940501)73:9<2344::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract::Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven mo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800801)46:3<452::aid-cncr28204
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:There is limited understanding of the association between barriers to care and clinical outcomes within patient navigation programs. METHODS:Secondary analyses of data from the intervention arms of the Patient Navigation Research Program were performed, which included navigated participants with abnormal br...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29607
更新日期:2015-11-15 00:00:00
abstract::The cellular DNA content of 15 benign and 34 malignant primary bone tumors was analyzed by means of flow cytophotometry. All benign tumors except one of questionable histologic type exhibited a normal DNA content (diploid), whereas 23 of 34 malignant tumors showed an abnormal DNA content (aneuploid). Closer analysis r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840101)53:1<129::aid-cncr28205
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Hypermethylation of CpG islands has been associated with silencing of various tumor suppressor genes, and the retinoid acid receptor beta (RARbeta), cellular retinol-binding protein 1 (CRBP1), and tazarotene-induced gene 1 (TIG1) genes have been associated with retinoic acid signaling. To the authors' knowle...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21392
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Traditional single-marker and multimarker molecular profiling approaches in bladder cancer do not account for major risk factors and their influence on clinical outcome. This study examined the prognostic value of molecular alterations across all disease stages after accounting for clinicopathological factor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27763
更新日期:2013-02-15 00:00:00
abstract:BACKGROUND:It is hypothesized that oligometastatic disease represents a state of potentially curable, limited metastases. Stereotactic body radiation therapy (SBRT) is an option for patients who are not amenable to or do not want resection. METHODS:From 2001 to 2006, 121 patients with < or =5 detectable metastases wer...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.23209
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Data suggest that vitamin D plays a role in the treatment and prevention of prostate cancer. The combination of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) plus dexamethasone was studied based on evidence that dexamethasone potentiates the antitumor effects of calcitriol and ameliorates hyp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21890
更新日期:2006-05-15 00:00:00
abstract::Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<472::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract::Seventy-eight patients with metastatic cancer to the lungs underwent flexible fiberoptic bronchoscopy for diagnosis. The patients were divided into two groups by presenting radiographic pattern as: (I) diffuse linear interstitial infiltrations (55 patients); and (II) localized or multiple nodular opacities (23 patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831115)52:10<1949::aid-cncr282
更新日期:1983-11-15 00:00:00
abstract::The authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. Southern blot hybridization was also performed in 23 cases to study their association with Epstein-Barr virus (EBV) and human T-cell leukemia virus type 1 (H...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<1954::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract::Unexpected nephrotoxicity has been described in high-dose, bolus ifosfamide (IFF) therapy. Renal injury is not thought to occur in patients receiving fractionated schedules, although microscopic hematuria from bladder irritation is not uncommon. IFF is undergoing trials in patients with malignant lymphomas, gynecologi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890215)63:4<649::aid-cncr28206
更新日期:1989-02-15 00:00:00