Abstract:
:In nine patients who had undergone trans-sphenoidal hypophysectomy, prolactin dynamics were studied with intravenous thyrotropin releasing hormone (TRH). Residual prolactin secretory reserve was demonstrated in seven. Five patients were TRH tested both before and after trans-sphenoidal hypophysectomy. Hypophysectomy did not alter base line prolactin concentration but did decrease prolactin response to TRH from 55 ng/ml to 21 ng/ml (p less than 0.001). Post-hypophysectomy L-Dopa suppressed baseline prolactin concentrations to undetectable levels. There was no correlation between alterations in prolactin dynamics and tumor response to hypophysectomy. Trans-sphenoidal hypophysectomy is not effective in ablating prolactin secretion and serious doubts are raised about the role of altered prolactin dynamics in inducing breast cancer remission.
journal_name
Cancerjournal_title
Cancerauthors
McMillin JM,Seal US,Theologides Adoi
10.1002/1097-0142(197705)39:5<2254::aid-cncr282039subject
Has Abstractpub_date
1977-05-01 00:00:00pages
2254-7issue
5eissn
0008-543Xissn
1097-0142journal_volume
39pub_type
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