Combination hyperthermia and radiation therapy for malignant melanoma.

Abstract:

:Since 1975, clinical studies have been carried out to determine whether radiation when combined with localized hyperthermia evokes improved tumor control compared to that achieved with radiation alone. Local tumor hyperthermia was achieved using radiofrequency inductive heating at 27.12 MHz. In bulky lesions (greater than 100 cm3), radiofrequency conductive heating at 13.56 MHz was also used. More than 100 lesions in 38 patients were treated with radiation alone and hyperthermia in combination with radiation. Most lesions were treated either twice a week or once a week, depending on radiation dose fractionation scheme used. The overall result of tumor control rate of the combined therapy is superior to radiation therapy alone (75% versus 46%; P less than 0.01). No enhanced normal tissue morbidity was seen following the combined therapy. The detailed analysis of the treatment results shows that the tumor control rate is dependent on dose per fraction, the total dose, and the initial tumor volume. The radiation alone, at high doses per fraction, was effective in controlling 80% of the lesions, if the tumor volume was less than 10 cm3, compared to 30% when the tumor volumes were larger. The combination therapy, on the other hand, effected 80% local tumor control regardless of the tumor volume. The importance of good thermal distribution within the tumor volume, selective heating of the tumor tissues and the sequence and time interval between the combined therapy is discussed.

journal_name

Cancer

journal_title

Cancer

authors

Kim JH,Hahn EW,Ahmed SA

doi

10.1002/1097-0142(19820801)50:3<478::aid-cncr28205

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

478-82

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

50

pub_type

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