Abstract:
BACKGROUND:The treatment of patients with hepatocellular carcinoma (HCC) presents a major challenge, because associated cirrhosis limits the choice of chemotherapeutic agents. However, the abundant vascularity of HCC presents an attractive target for antiangiogenic therapy that potentially may be tolerated by cirrhotic patients. The current study was conducted to assess the antitumor activity, treatment tolerance, treatment-related toxicity, and patient survival after the administration of thalidomide in a Phase II trial.
METHODS:Thirty-seven HCC patients were accrued between March, 1999, and March, 2000. Initially, the dose of oral thalidomide was escalated from 400 mg per day during the first week to 1000 mg per day by the fifth week, delivering one-third of the dose in the morning and the remaining two-thirds of the dose in the evening prior to bedtime. Changes in the daily drug administration schedule were allowed based on tolerance. Response was assessed at 8-week intervals.
RESULTS:Thirty-two of 37 registered patients were evaluable for response. One patient had a partial response (PR), 1 patient had a minor response (MR), 10 patients had stable disease (SD) (31%; 95% confidence interval [95%CI], 16-51%), and 20 patients) (61%; 95%CI, 42-78%) had disease progression. The most commonly encountered toxicity was somnolence, with Grade 3-4 somnolence (>or= 4 hours of sleep during normal waking hours) in 9 patients (35%) and Grade 2 somnolence (
journal_name
Cancerjournal_title
Cancerauthors
Patt YZ,Hassan MM,Lozano RD,Nooka AK,Schnirer II,Zeldis JB,Abbruzzese JL,Brown TDdoi
10.1002/cncr.20821subject
Has Abstractpub_date
2005-02-15 00:00:00pages
749-55issue
4eissn
0008-543Xissn
1097-0142journal_volume
103pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The reason for the thermal abnormality associated with some breast cancers is unclear. We previously reported that a thermographic abnormality is associated with tumor size and lymph node involvement. Despite this association, we were unable to demonstrate an independent association between an abnormal therm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960401)77:7<1324::AID-CN
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. METHODS:Using consecutive tissu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26406
更新日期:2012-02-15 00:00:00
abstract::The records of 1,497 patients with histologically proven adenocarcinoma of the stomach were reviewed from Charity Hospital over the 25-year period, 1948 to 1973. The operability rate was 82% and the resectability rate was 48%. In this series gastric carcinoma predominated in males and Negroes. Necropsy studies indicat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197803)41:3<941::aid-cncr2820410
更新日期:1978-03-01 00:00:00
abstract::Patients with ER positive primary tumors usually have initial metastases at the more favorable sites. Twelve out of 14 patients with ER positive had first site of metastases in either bone or soft tissue. In contrast, 13 of 17 patients with negative ER developed first metastases in viscera. ER positive patients respon...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12+<2932::aid-cncr28
更新日期:1980-12-15 00:00:00
abstract::The frequency and significance of hyperprolactinemia was studied in 21 consecutive, untreated male patients with bronchogenic carcinoma. Seven patients (33%) were found to have elevated serum prolactin (hPRL) levels. No correlation was demonstrated between increased hPRL levels, tissue histology, or tumor burden. L-do...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197908)44:2<676::aid-cncr2820440
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:During the last two decades, a rising incidence of adenocarcinoma of the esophagus has been observed in the Western world. The prognostic relevance of tumor-biological factors, such as DNA ploidy or c-erbB-2 overexpression, for overall survival following complete resection is still unknown. METHODS:In a ret...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940401)73:7<1785::aid-cncr2820
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Recent evidence has identified pre-existing type 2 diabetes mellitus (T2DM) as a risk factor for the development of PAC, but relatively little is known about its effects on survival. Our aim was to determine the effect of varying durations of pre-existing T2DM on survival in patients with PAC. METHODS:We co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27731
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) has been used with variable success as a diagnostic test for benign and malignant breast lesions. The goal of this study was to examine the effects of training physicians in the fine-needle aspiration sampling-technique on the diagnostic accuracy of FNAB of palpable breas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.9040
更新日期:2001-08-25 00:00:00
abstract:BACKGROUND:Forty patients with Stage II-III breast cancer with 10 or more positive axillary nodes were treated with mastectomy followed by four cycles of standard dose CAF (cytoxan, Adriamycin, 5-FU), followed by high dose cytoxan, cisplatin, carmustine (HDCT) with autologous bone marrow transplant support (ABMT), and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941201)74:11<2964::aid-cncr282
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in the cellular subtype. The authors evaluated the outcome of patients with MN who were enrolled in either the International Socie...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21836
更新日期:2006-05-15 00:00:00
abstract:BACKGROUND:Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:AEs observed during 1 of 3 randomized chemotherapy regimens (vincristine, dactinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26358
更新日期:2012-02-15 00:00:00
abstract::Fourteen patients with advanced salivary gland malignancies were treated with combination chemotherapy. Five of 13 patients responded to cyclophosphamide and adriamycin and two patients in the responding groups underwent further potentially curable treatment, rendering them disease-free. Three patients with mucoepider...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19821201)50:11<2261::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Response rates to second-line chemotherapy in recurrent high-grade glial tumors are low and new effective treatments are needed. The objective of this study was to evaluate response rates and tolerability of chemotherapy with bevacizumab and irinotecan in recurrent high-grade gliomas. METHODS:Twenty patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23401
更新日期:2008-05-15 00:00:00
abstract::Measurement of the alpha 1 (fast liver) fraction of alkaline phosphatases in the serum for 217 cancer patients, 92 patients with nonmalignant hepatic affections and 131 controls, revealed that the alpha 1 fraction offers better global value (94%), sensitivity (96%), and specificity (93%) than gamma GT or total alkalin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830701)52:1<140::aid-cncr28205
更新日期:1983-07-01 00:00:00
abstract::Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197912)44:6<2173::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract::In the evaluation of cervical cancer, computed tomography (CT) is used primarily to stage advanced tumors and evaluate for recurrence. Because of reports that CT imaging lacks sensitivity and specificity in the detection of primary tumors and metastatic lesions, its use in these applications has been limited, but rece...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11684
更新日期:2003-11-01 00:00:00
abstract::Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197502)35:2<450::aid-cncr2820350
更新日期:1975-02-01 00:00:00
abstract::The clinicopathologic significance of mucus production by adenocarcinoma of the colon and rectum was analyzed in retrospective study with stage matched non-mucus producing control carcinomas. Mucinous carcinoma of the colon and rectum comprised 132 (15%) of 893 cases of colorectal carcinoma. The rectum was the most co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197604)37:4<1891::aid-cncr282037
更新日期:1976-04-01 00:00:00
abstract::In order to investigate the relationship between histologic findings and clinical behavior in angioimmunoblastic lymphadenopathy (AILD), 44 patients with AILD were reviewed. These patients comprised 24 men and 20 women with age range from 25 to 84 years of age (median, 64 years). Lymphadenopathy was observed in all pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890415)63:8<1625::aid-cncr2820
更新日期:1989-04-15 00:00:00
abstract::The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28864
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:Multifocal tumor areas occurred in 12-22% of patients with renal cell carcinoma. It is unknown whether these tumors have malignant potential and characterize a higher risk for metastases. The performance of nephron-sparing surgery in patients with low grade or low stage tumors is controversial. METHODS:Prim...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::Nickel-related cancers of the respiratory tract have been recognized for nearly 50 years and represent a unique opportunity for prevention among refinery workers. Studies of exposed employees have been conducted in which evaluations were made of the histopathologic changes in the respiratory mucosa and the body burden...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800615)45:12<3061::aid-cncr282
更新日期:1980-06-15 00:00:00
abstract::One hundred four endocrine tumors found in the body and tail of the pancreas of a patient with the Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia (MEN-I) were investigated by immunohistochemistry for insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and gastrin. The results for each tumo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1815::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract::Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered intraperitoneally in combination with multidrug chemotherapy using methotrexate (M), vinblastine (V), doxorubicin (A), and cisplatin (C, or for the combination, MVAC) to C3H/He mice (5-week-old females) after experimental carcinoma, MBT...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920215)69:4<997::aid-cncr28206
更新日期:1992-02-15 00:00:00
abstract:BACKGROUND:The results of an international, multicenter, randomized, double-blind, controlled study assessing the efficacy and safety of lenalidomide treatment in patients with refractory stage IV metastatic malignant melanoma are reported. METHODS:The study compared treatment with lenalidomide (25 mg/d on Days 1-21 o...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.24686
更新日期:2010-01-01 00:00:00
abstract::The potential of using a blood test enumerating oncofetal ferritin-bearing lymphocytes (FBL) as a biomarker for early breast cancer was further explored. Nine hundred women attending a high-risk breast cancer clinic and 2500 normal-risk women were physically examined and their blood drawn for FBL determination using a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890801)64:3<691::aid-cncr28206
更新日期:1989-08-01 00:00:00
abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<616::aid-cncr282054040
更新日期:1984-08-15 00:00:00
abstract:BACKGROUND:Filanesib (ARRY-520) is a highly selective inhibitor of kinesin spindle protein, which has demonstrated preclinical antimyeloma activity. METHODS:This open-label Phase 1/2 study determined the maximum tolerated dose of Filanesib administered on Days 1 and 2 of 14-Day Cycles in patients with multiple myeloma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30892
更新日期:2017-12-01 00:00:00
abstract::Hereditary cancer represents approximately 5-10% of the total cancer burden and may account for 60,000 to 120,000 new cancer occurrences this year in the United States. New developments in molecular genetics and the cloning of cancer-prone genes have intensely fueled interest in dealing with hereditary forms of cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991201)86:11+<2449::aid-
更新日期:1999-12-01 00:00:00
abstract::A retrospective analysis of a series of 162 patients treated for isolated chest wall recurrence of breast cancer after mastectomy was undertaken. Cumulative survival, distant relapse-free survival, and freedom from local progression after 5 years from the diagnosis of recurrence were 34%, 28%, and 45% respectively. Fi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870715)60:2<240::aid-cncr28206
更新日期:1987-07-15 00:00:00