Pathology correlates of a Papanicolaou diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion.


BACKGROUND:The objective of this study was to compare findings after a cytologic report of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) with findings after a report of low-grade squamous intraepithelial lesion (LSIL). METHODS:A review of patient records revealed that 312 women had cytologic findings of LSIL-H, and 324 consecutive women in a comparison group had cytologic findings of LSIL during 2005. Findings over 6 months after diagnosis were retrieved and analyzed using chi-square tests, Fisher exact tests, and independent group t tests. RESULT:Histology was available for 194 of 312 women (64%) with LSIL-H and for 184 of 324 women (57%) with LSIL. Of these, 47 of 194 women (24%) with LSIL-H had grade 2 cervical intraepithelial neoplasia or greater (CIN2+) versus 13 of 184 women (7%) with LSIL (P < .0001). No cancers were identified. High-grade SIL cytology was reported in 2 of 105 women who had LSIL (2%) and in 4 of 93 women who had LSIL-H (4%). Women with LSIL-H who were positive for CIN2+ were younger than those without CIN2+ (25 years vs 30 years; P = .0067) CONCLUSIONS:Clinicians whose laboratories report LSIL-H should manage women who have LSIL-H with colposcopy, whereas only serial cytologic surveillance is required after a report of LSIL.






Al-Nourhji O,Beckmann MJ,Markwell SJ,Massad LS




Has Abstract


2008-12-25 00:00:00














  • Characterization of tumor-specific DNA sequences: molecular grading of the astrocytomas.

    abstract::Tumor-specific DNA sequences or unique sequences have been found in a number of human cancer cells including gliomas but not in equivalent normal cells. In a continuing effort to further elucidate the nature of these sequences, thermal analysis using the hydroxyapatite technique was carried out on the various grades o...


    pub_type: 杂志文章


    authors: Cuatico W

    更新日期:1980-07-15 00:00:00

  • Quantitative analysis of vascular endothelial growth factor in primary breast cancer.

    abstract:BACKGROUND:Recent clinical studies have demonstrated that tumor angiogenesis is a potent prognostic indicator for breast cancer patients. The quantitation of endothelial growth factors is thought to be useful to assess angiogenic phenotype in the tumor. Among the many new endothelial growth factors, vascular endothelia...


    pub_type: 杂志文章


    authors: Toi M,Kondo S,Suzuki H,Yamamoto Y,Inada K,Imazawa T,Taniguchi T,Tominaga T

    更新日期:1996-03-15 00:00:00

  • Extranodal small lymphocytic proliferation: a clinicopathologic and immunocytochemical study.

    abstract::Twelve patients who presented with extranodal small lymphocytic proliferations were studied. The patients ranged in age from 33 to 67 years; six were male and six female. Locations of the initial lesion included the conjunctiva and orbit, lung, stomach, small bowel, skin, and subcutis. The histopathologic picture in a...


    pub_type: 杂志文章


    authors: Evans HL

    更新日期:1982-01-01 00:00:00

  • The treatment of tumors by the induction of anemia and irradiation in hyperbaric oxygen.

    abstract::Because increased effects have been achieved when murine tumors are irradiated after a period of hypoxia and because of anecdotal clinical experiences of an improved result after irradiation of previously anemic patients in hyperbaric oxygen, the relationship between irradiation and increased survival was investigated...


    pub_type: 杂志文章


    authors: Sealy R,Jacobs P,Wood L,Levin W,Barry L,Boniaszczuk J,Blekkenhorst G

    更新日期:1989-08-01 00:00:00

  • Active immunotherapy of human solid tumor with autologous cells treated with cholesteryl hemisuccinate. A Phase I study.

    abstract::A marked increase in specific immunogenicity of tumor cells is induced upon incorporation of cholesteryl hemisuccinate (CHS) into the cell membrane, which presumably promotes the expression of latent tumor-associated antigens. Immunotherapy with CHS-treated and irradiated tumor cells as vaccine was found to be very ef...


    pub_type: 临床试验,杂志文章


    authors: Skornick YG,Rong GH,Sindelar WF,Richert L,Klausner JM,Rozin RR,Shinitzky M

    更新日期:1986-08-01 00:00:00

  • A Phase II trial of pegylated liposomal doxorubicin, vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma patients.

    abstract:BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...


    pub_type: 临床试验,杂志文章


    authors: Hussein MA,Wood L,Hsi E,Srkalovic G,Karam M,Elson P,Bukowski RM

    更新日期:2002-11-15 00:00:00

  • The size of breast masses at presentation. The impact of prior medical training.

    abstract::Five hundred and sixty-nine patients with breast cancer presenting for treatment at a community hospital were studied. The results showed no significant change in tumor size at presentation or reported patient delay over a 12-year span. This was in spite of considerable national discussion and increasing public concer...


    pub_type: 杂志文章


    authors: Buttlar CA,Templeton AC

    更新日期:1983-05-01 00:00:00

  • Primary hepatic or hepatosplenic non-Hodgkin's lymphoma in children.

    abstract::Non-Hodgkin's lymphoma confined to the liver is unusual in adults and has not been reported in children. Two children with primary hepatic and one with hepatosplenic NHL are described. All three patients are males, and both tumors examined for cell surface markers were of B-cell origin. Two patients, treated with chem...


    pub_type: 杂志文章


    authors: Miller ST,Wollner N,Meyers PA,Exelby P,Jereb B,Miller DR

    更新日期:1983-12-15 00:00:00

  • Enrollment on clinical trials does not improve survival for children with acute myeloid leukemia: A population-based study.

    abstract:BACKGROUND:It is questionable whether enrollment on clinical trials offers any survival advantage at the population level over standard-of-care treatment. The objectives of this study were to describe the impact of trial enrollment on event-free survival and overall survival in pediatric acute myeloid leukemia (AML) us...


    pub_type: 杂志文章


    authors: Truong TH,Pole JD,Barber R,Dix D,Kulkarni KP,Martineau E,Randall A,Stammers D,Strahlendorf C,Strother D,Sung L

    更新日期:2018-10-15 00:00:00

  • K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.

    abstract:BACKGROUND:The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in situ carcinoma provides an op...


    pub_type: 杂志文章


    authors: Zauber NP,Sabbath-Solitare M,Marotta SP,Bishop DT

    更新日期:1999-07-01 00:00:00

  • Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency?

    abstract::Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and cl...


    pub_type: 杂志文章


    authors: Gamelin E,Beldent V,Rousselet MC,Rieux D,Rohmer V,Ifrah N,Boasson M,Bigorgne JC

    更新日期:1992-05-01 00:00:00

  • Breast cancer in women of Japanese and Caucasian ancestry in Hawaii.

    abstract::A pathology review of breast cancers in Japanese and Caucasian women indicates more numerous in situ carcinomas in the Japanese. Carcinomas with uniform nuclei were also more numerous among Japanese. Japanese women showed more extensive lymphocytic infiltrates adjacent to their tumors than did Caucasian women, and als...


    pub_type: 杂志文章


    authors: Stemmermann GN,Catts A,Fukunaga FH,Horie A,Nomura AM

    更新日期:1985-07-01 00:00:00

  • Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas.

    abstract:BACKGROUND:The purpose of this study was to identify biologic differences between ovarian clear cell carcinoma and other ovarian adenocarcinomas by comparing the expression of cell cycle regulatory molecules and by analyzing the survival of the patients. METHODS:In 51 cases of epithelial ovarian carcinoma, the express...


    pub_type: 杂志文章


    authors: Shimizu M,Nikaido T,Toki T,Shiozawa T,Fujii S

    更新日期:1999-02-01 00:00:00

  • Radiation-related myocardial injury. Management of two cases.

    abstract::Pericardial effusion and trifascicular block developed 5 years following mediastinal irradiation for Hodgkin's disease in a 19-year-old patient. Another 24-year-old patients had an acute myocardial infarction followed by severe angina pectoris 5 years following mediastinal irradiation for the same disease. A pericardi...


    pub_type: 杂志文章


    authors: Ali MK,Kahlil KG,Fuller LM,Leachman RD,Sullivan MP,Loh KK,Gamble JF,Shullenberger CC

    更新日期:1976-11-01 00:00:00

  • Analysis of soluble melanoma cell membrane antigens in metastatic cells of various organs and further studies of antigens present in primary melanoma.

    abstract::In malignant melanoma, using Sephadex G-200 chromatography and polyacrylamide gel electrophoresis (PAGE), it has been possible to separate two types of skin reactive antigens. The first, found in Sephadex fraction II and PAGE region a appears specific for melanoma. Allogeneic extracts have produced positive reactions ...


    pub_type: 杂志文章


    authors: Hollinshead AC

    更新日期:1975-10-01 00:00:00

  • Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compression.

    abstract:BACKGROUND:Disruption of the lymphatic circulation through breast carcinoma-associated axillary lymph node dissection, with or without radiation therapy, reportedly is the most common cause of lymphedema in developed countries. There is no cure for breast carcinoma-associated lymphedema. Although intermittent pneumatic...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Szuba A,Achalu R,Rockson SG

    更新日期:2002-12-01 00:00:00

  • Probably benign lesions at breast magnetic resonance imaging: preliminary experience in high-risk women.

    abstract:BACKGROUND:The purpose of the current study was to determine the frequency of 'probably benign' interpretations at breast magnetic resonance (MR) imaging screening of high-risk women and the frequency of subsequent malignancy in these women. METHODS:The authors performed a retrospective review of the records of 367 as...


    pub_type: 杂志文章


    authors: Liberman L,Morris EA,Benton CL,Abramson AF,Dershaw DD

    更新日期:2003-07-15 00:00:00

  • A comparison of treatment outcomes for black patients and white patients with metastatic breast cancer. The Piedmont Oncology Association experience.

    abstract::Prior studies have shown that black patients with breast cancer have poorer survival times compared with white patients even when adjusted for stage. Seventy-four black patients treated on six Piedmont Oncology Association (POA) protocols were compared with 74 randomly selected white patients treated with the same pro...


    pub_type: 杂志文章


    authors: Kimmick G,Muss HB,Case LD,Stanley V

    更新日期:1991-06-01 00:00:00

  • Chemotherapy of disseminated testicular cancer. A random prospective study.

    abstract::Seventy-eight patients with disseminated testicular cancer were entered on a random prospective study evaluating three separate remission induction arms. Therapy with cis-diamminedichloroplatinum (20 mg/M2 for five consecutive days every three weeks for 3-4 courses) and bleomycin (30 units intravenous push weekly for ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Einhorn LH,Williams SD

    更新日期:1980-09-15 00:00:00

  • Human papillomavirus in cervical cancer and oropharyngeal cancer: One cause, two diseases.

    abstract::Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the sec...


    pub_type: 杂志文章,评审


    authors: Berman TA,Schiller JT

    更新日期:2017-06-15 00:00:00

  • Interleukin-6 and its receptor in cancer: implications for translational therapeutics.

    abstract::Interleukin-6 (IL-6) plays a major role in the response to injury or infection and is involved in the immune response, inflammation, and hematopoiesis. Its deregulation impacts numerous disease states, including many types of cancer. Consequently, modulating IL-6 may be an innovative therapeutic strategy in several di...


    pub_type: 杂志文章,评审


    authors: Hong DS,Angelo LS,Kurzrock R

    更新日期:2007-11-01 00:00:00

  • The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital Experience.

    abstract:BACKGROUND:It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS:The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblas...


    pub_type: 杂志文章


    authors: McGregor LM,Rao BN,Davidoff AM,Billups CA,Hongeng S,Santana VM,Hill DA,Fuller C,Furman WL

    更新日期:2005-12-15 00:00:00

  • A framework for cancer health economics research.

    abstract:LAY SUMMARY:Cancer has substantial economic impacts for patients, their families and/or caregivers, employers, and the health care system. However, there is only limited understanding of how economic issues can affect access to cancer care services and the receipt of high-quality cancer care. Health economics research ...


    pub_type: 杂志文章


    authors: Halpern MT,Shih YT,Yabroff KR,Ekwueme DU,Bradley CJ,Davidoff AJ,Sabik LM,Lipscomb J

    更新日期:2020-11-25 00:00:00

  • Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy.

    abstract:BACKGROUND:To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy. METHODS:Pretreatment tumor tissue samples were available from 82 patients who had ...


    pub_type: 杂志文章


    authors: Buchholz TA,Tu X,Ang KK,Esteva FJ,Kuerer HM,Pusztai L,Cristofanilli M,Singletary SE,Hortobagyi GN,Sahin AA

    更新日期:2005-08-15 00:00:00

  • Human immunodeficiency virus-associated Hodgkin's disease. Clinicopathologic studies of 24 cases and preponderance of mixed cellularity type characterized by the occurrence of fibrohistiocytoid stromal cells.

    abstract::Hodgkin's disease (HD) was diagnosed in 24 patients who were either seropositive for human immunodeficiency virus (HIV) (21) or members of a high-risk group (three), but had not developed acquired immune deficiency syndrome (AIDS). Clinical presentation of the disease was characterized by constitutional symptoms in al...


    pub_type: 杂志文章


    authors: Ree HJ,Strauchen JA,Khan AA,Gold JE,Crowley JP,Kahn H,Zalusky R

    更新日期:1991-03-15 00:00:00

  • Immunoelectron microscopic localization of prostatic-specific antigen in human prostate by the protein A-gold complex.

    abstract::Human prostate specimens from 25 patients provided 15 normal, four benign prostatic hypertrophy (BPH), and seven adenocarcinoma samples which were studied using a polyclonal antibody against prostatic specific antigen (PSA) and protein A-gold complex. Our study showed the presence of gold particles in cytoplasmic vesi...


    pub_type: 杂志文章


    authors: Sinha AA,Wilson MJ,Gleason DF

    更新日期:1987-09-15 00:00:00

  • Central neurocytomas express photoreceptor differentiation.

    abstract:BACKGROUND:Central neurocytomas are composed of mature neuronal elements, frequently arranged in rosettes similar to those present in pineocytomas. This suggests the possibility of similar patterns of differentiation, including photoreceptor differentiation. The authors analyzed the immunoreactivity of central neurocyt...


    pub_type: 杂志文章


    authors: Mena H,Morrison AL,Jones RV,Gyure KA

    更新日期:2001-01-01 00:00:00

  • Low-dose Adriamycin remission maintenance therapy for pediatric solid tumors.

    abstract::A low-dose maintenance schedule of Adriamycin was evaluated in six children whose metastatic solid tumors regressed following toxic induction therapy with Adriamycin. Three of these children are now disease-free more than one year following discontinuation of therapy. Adriamycin can be given on a low-dose maintenance ...


    pub_type: 杂志文章


    authors: Hvizdala EV,Komp DM,Arnold JB

    更新日期:1977-06-01 00:00:00

  • Irradiation in relapsing carcinoma of the prostate.

    abstract:BACKGROUND:Radiation therapy plays a major role in the management of patients with either locally recurrent or metastatic carcinoma of the prostate. RESULTS:In 23 patients with isolated postprostatectomy local recurrences treated with doses of 60-65 Gy, 17 (74%) had tumor control, and 45% survived relapse-free for 5 y...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Perez CA,Cosmatos D,Garcia DM,Eisbruch A,Poulter CA

    更新日期:1993-02-01 00:00:00

  • Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states.

    abstract::Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...


    pub_type: 杂志文章,评审


    authors: Loewenstein MS,Zamcheck N

    更新日期:1978-09-01 00:00:00