Abstract:
:Alpha Heavy Chain Disease has generally been described in the Mediterranean area in young people with a diffuse gastrointestinal lymphoma and malabsorption. We describe a patient from the United States with polypoid lymphoma of the gastrointestinal tract and a prolonged clinical course, who had the characteristic alpha heavy chain disease protein. He did not have malabsorption, and the gastrointestinal tract, though containing multiple discrete lymphomatous polyps had little plasmacytic reaction. Lymphosarcoma cell leukemia developed late in the course and the malignant cells had the characteristics of B lymphocytes but did not contain alpha heavy chains. The data support the contention that the lymphoma in this form of alpha heavy chain disease may involve B lymphocytes but that the abnormal protein may be produced by other cells. Polypoid varieties of gastrointestinal lymphoma in North America must now be considered part of the spectrum of alpha heavy chain disease and the diagnostic protein searched for diligently.
journal_name
Cancerjournal_title
Cancerauthors
Cohen HJ,Gonzalvo A,Krook J,Thompson TT,Kremer WBdoi
10.1002/1097-0142(197803)41:3<1161::aid-cncr282041subject
Has Abstractpub_date
1978-03-01 00:00:00pages
1161-9issue
3eissn
0008-543Xissn
1097-0142journal_volume
41pub_type
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