New presentation of alpha heavy chain disease: North American polypoid gastrointestinal lymphoma. Clinical and cellular studies.

Abstract:

:Alpha Heavy Chain Disease has generally been described in the Mediterranean area in young people with a diffuse gastrointestinal lymphoma and malabsorption. We describe a patient from the United States with polypoid lymphoma of the gastrointestinal tract and a prolonged clinical course, who had the characteristic alpha heavy chain disease protein. He did not have malabsorption, and the gastrointestinal tract, though containing multiple discrete lymphomatous polyps had little plasmacytic reaction. Lymphosarcoma cell leukemia developed late in the course and the malignant cells had the characteristics of B lymphocytes but did not contain alpha heavy chains. The data support the contention that the lymphoma in this form of alpha heavy chain disease may involve B lymphocytes but that the abnormal protein may be produced by other cells. Polypoid varieties of gastrointestinal lymphoma in North America must now be considered part of the spectrum of alpha heavy chain disease and the diagnostic protein searched for diligently.

journal_name

Cancer

journal_title

Cancer

authors

Cohen HJ,Gonzalvo A,Krook J,Thompson TT,Kremer WB

doi

10.1002/1097-0142(197803)41:3<1161::aid-cncr282041

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

1161-9

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

41

pub_type

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