Prolymphocytic leukemia: treatment with combination chemotherapy to include doxorubicin.

abstract：BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...

journal_title：Cancer

authors： van der Lelie H,Baars JW,Rodenhuis S,van Dijk MA,de Glas-Vos CW,Thomas BL,van Oers RH,von dem Borne AE

更新日期：1995-12-01 00:00:00

abstract：:During the period 1955 to 1975, 63 consecutive cases of apical lung carcinoma were treated in the Radiation Therapy Division of the University of Michigan Medical Center (UMMC). Supervoltage external radiation alone or combination of radiation and surgery were the main modalities of treatment used in these patients. O...

journal_title：Cancer

authors： Ahmad K,Fayos JV,Kirsh MM

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...

journal_title：Cancer

authors： Truica CI,Hansen CH,Garvin DF,Meehan KR

更新日期：1998-09-15 00:00:00

abstract：:There were no significant differences between the mean blood plasma (leukocyte-free) RNAase activity among 128 healthy women volunteers age 13-70 and 49 women with benign gynecological tumors. Exceptions to this finding were three apparently healthy women volunteers who had plasma enzyme activity which was higher than...

journal_title：Cancer

authors： Sheid B,Lu T,Pedrinan L,Nelson JH Jr

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Resistance to apoptosis is 1 of the key events that confer chemoresistance and is mediated by the overexpression of antiapoptotic proteins, which inhibit caspase activation. The objective of this study was to evaluate whether the activation of an alternative, caspase-independent cell death pathway could prom...

journal_title：Cancer

authors： Alvero AB,Montagna MK,Chen R,Kim KH,Kyungjin K,Visintin I,Fu HH,Brown D,Mor G

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:The induction of estrogen and progesterone receptors (ER and PGR) has been reported in breast and endometrial cancer cells exposed to human fibroblast interferon-beta (hIFN-beta). Clinical verification of this finding might provide the rationale for new therapeutic approaches. This study was designed to eval...

journal_title：Cancer

authors： Codegoni AM,Landoni F,Lomonico S,Losa G,Mangioni C,Taverna M,Lucchini V,D'Incalci M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The authors previously demonstrated that never-smokers with stage IIIB/IV nonsmall cell lung cancer (NSCLC) lived 50% longer than former/current smokers. This observation persisted after adjusting for age, performance status, and sex. In this study, the authors hypothesized that smoking-dependent differences...

journal_title：Cancer

authors： Paik PK,Johnson ML,D'Angelo SP,Sima CS,Ang D,Dogan S,Miller VA,Ladanyi M,Kris MG,Riely GJ

更新日期：2012-12-01 00:00:00

abstract：:Xenografts have been established in immune-suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a 'seminoma-like' tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patien...

journal_title：Cancer

authors： Monaghan P,Raghavan D,Neville AM

更新日期：1982-02-15 00:00:00

abstract：BACKGROUND:The influence of various clinicopathologic features on survival of patients with papillary thyroid carcinoma has been examined. In particular, histologic grade, which was obtained by a combined assessment of nuclear atypia, tumor necrosis, and vascular invasion (VAN score) was studied. According to this, his...

journal_title：Cancer

authors： Akslen LA

更新日期：1993-11-01 00:00:00

abstract：:Although androgen-deprivation therapy (ADT) remains the mainstay of castration-sensitive prostate cancer (CSPC) therapy, the disease's heterogeneity and the limited duration of the response have chaperoned the introduction of chemotherapy and the investigation of novel hormonal targeted agents in this setting. Combina...

journal_title：Cancer

authors： Francini E,Taplin ME

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Sunitinib and sorafenib are small-molecule tyrosine kinase inhibitors (TKI) with antitumor activity in advanced renal cell carcinoma. A retrospective study was conducted to assess the response of renal cell carcinoma to sequential treatment with these two agents. METHODS:Tumor response was evaluated by usin...

journal_title：Cancer

authors： Dudek AZ,Zolnierek J,Dham A,Lindgren BR,Szczylik C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Transitional cell carcinoma (TCC) is rare in the female genital tract. Although it is most common in the ovary, small series of cases in the cervix have been reported, with isolated cases described in the fallopian tube, adnexa uteri, and endometrium. METHODS:Eight cases of primary TCC involving the endomet...

journal_title：Cancer

authors： Lininger RA,Ashfaq R,Albores-Saavedra J,Tavassoli FA

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:Although randomized controlled trials (RCTs) require a great deal of time, money, and effort, the majority of them have resulted in failure to verify a priori hypotheses. Therefore, the intention in the current study was to clarify the differential elements of studies with 'positive' and 'negative' outcomes....

journal_title：Cancer

authors： Yanada M,Narimatsu H,Suzuki T,Matsuo K,Naoe T

更新日期：2007-07-15 00:00:00

abstract：BACKGROUND:In the United States, only approximately 0.4% of all melanomas are diagnosed in patients aged <20 years. To the authors' knowledge, melanoma in pediatric members of melanoma-prone families has not been fully investigated to date. The objective of the current study was to evaluate pediatric patients with mela...

journal_title：Cancer

authors： Goldstein AM,Stidd KC,Yang XR,Fraser MC,Tucker MA

更新日期：2018-09-15 00:00:00

abstract：:A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes a...

journal_title：Cancer

authors： Haas RJ,Helmig MS,Prechtel K

更新日期：1978-07-01 00:00:00

abstract：:Two hundred ninety-three patients with Stage IB carcinoma of the uterine cervix were treated by intracavitary irradiation followed by radical hysterectomy and pelvic lymph node dissection in the 3-year period 1970 to 1972, inclusive. Preoperative lymphography was performed and intraoperative films were taken to obtain...

journal_title：Cancer

authors： Kjorstad KE,Kolbenstvedt A,Strickert T

更新日期：1984-11-15 00:00:00

abstract：:Tumor-bearing patients with breast cancer were assayed for their natural killer (NK) cell activity and for the function of activated cytotoxic T-cells, as assessed by lectin-dependent cellular cytotoxicity (LDCC). Tumor-bearing patients with breast cancer had a significant increase in NK activity and in LDCC, as compa...

journal_title：Cancer

authors： Zielinski CC,Tichatschek E,Müller C,Kalinowski W,Sevelda P,Czerwenka K,Kubista E,Spona J

更新日期：1989-05-15 00:00:00

abstract：BACKGROUND:In this report, the authors present the results from a study of patients with unresectable oropharyngeal squamous cell carcinomas who were treated on a protocol of hyperfractionated radiation and high-dose intraarterial cisplatin (HYPERRADPLAT) at the University of Kentucky. METHODS:The study was designed a...

journal_title：Cancer

authors： Spring PM,Valentino J,Arnold SM,Sloan D,Kenady D,Kudrimoti M,Haydon RC 3rd,Lee C,Given C,Mohiuddin M,Regine WF

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:The increasing incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) highlights the need for simple and effective tools to evaluate head and neck lesions and their HPV status. The main objective of the current study was to investigate the association between abnormal c...

journal_title：Cancer

authors： Donà MG,Giuliani M,Vocaturo A,Spriano G,Pichi B,Rollo F,Ronchetti L,Covello R,Pescarmona E,Benevolo M

更新日期：2014-11-15 00:00:00

abstract：BACKGROUND:Telomerase is commonly recognized as an effective anticancer target. The human telomerase reverse transcriptase (hTERT), the rate-limiting component of telomerase, is expressed in most malignant tumors, but it is not found in most normal somatic cells. Here, we report a real-time and noninvasive method to mo...

journal_title：Cancer

authors： Yu ST,Li C,Lü MH,Liang GP,Li N,Tang XD,Wu YY,Shi CM,Chen L,Li CZ,Cao YL,Fang DC,Yang SM

更新日期：2012-04-01 00:00:00

abstract：:Conjugal tumors are rarely reported; but nevertheless, raise important questions of possible etiologic factors. In this report, the presentation of grade 2 gemistocytic astrocytomas in an unrelated married couple in their early thirties within 18 months of each other is described. In both cases the left frontal region...

journal_title：Cancer

authors： Tupchong L,Levison DA,Jones AE

更新日期：1985-02-15 00:00:00

abstract：BACKGROUND:Multiple lymphomatous polyposis (MLP) results from gastrointestinal involvement by a B-cell lymphoma that originates from the mantle zone of lymphoid follicles. This well described clinicopathologic entity has a poor prognosis: the rate of complete response after conventional chemotherapy is very low. High d...

journal_title：Cancer

authors： Mahé B,Moreau A,Moreau P,Le Tortorec S,Harousseau JL,Milpied N

更新日期：1995-06-01 00:00:00

abstract：:The diagnosis of brain metastasis from prostate carcinoma is rarely made antemortem, and has previously been reported only in patients with known extensive metastatic disease of long duration. A case of adenocarcinoma of the prostate presenting as a brain metastasis is described. Current concepts of metastatic spread ...

journal_title：Cancer

authors： Baumann MA,Holoye PY,Choi H

更新日期：1984-10-15 00:00:00

abstract：BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...

journal_title：Cancer

authors： Liberman L,Freeman HP,Chandra S,Stein AL,McCord C,Godfrey D,Dershaw DD

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The authors have noted that in cervical cytology specimens from perimenopausal and postmenopausal women, the diagnosis of atypical squamous cells of undetermined significance (ASC-US), as defined in the Bethesda system, is often not associated with a clinically evident lesion on follow-up. Reflex human papil...

journal_title：Cancer

authors： Johnston EI,Logani S

更新日期：2007-06-25 00:00:00

abstract：:For 52 patients with depressed adenomas of the stomach, histopathologic studies were done on 56 tumors and for 43 of them, histochemical and immunohistochemical features were examined. In addition, nondepressed adenomas (n = 57) and the depressed type of early gastric adenocarcinomas of the well-differentiated variety...

journal_title：Cancer

authors： Xuan ZX,Ambe K,Enjoji M

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the ...

journal_title：Cancer

authors： Ganti AK,Williams CD,Gajra A,Kelley MJ

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Little is known about genetic aberrations associated with development and progression of biliary tract carcinomas. METHODS:To study chromosomal aberrations associated with development and progression of biliary tract carcinomas, the authors used comparative genomic hybridization to examine 50 such carcinoma...

journal_title：Cancer

authors： Shiraishi K,Okita K,Harada T,Kusano N,Furui T,Kondoh S,Oga A,Kawauchi S,Fukumoto Y,Sasaki K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk METHODS:This was a retr...

journal_title：Cancer

authors： Choueiri TK,Chen MH,D'Amico AV,Sun L,Nguyen PL,Hayes JH,Robertson CN,Walther PJ,Polascik TJ,Albala DM,Moul JW

更新日期：2010-04-15 00:00:00

abstract：BACKGROUND:The first analysis of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial (median follow-up, 33 months) demonstrated that in adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer, anastrozole was superior to tamoxifen in terms of disease-free survival (DFS), time to r...

journal_title：Cancer

authors： Baum M,Buzdar A,Cuzick J,Forbes J,Houghton J,Howell A,Sahmoud T,ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists' Group.

更新日期：2003-11-01 00:00:00