Abstract:
BACKGROUND:In this report, the authors present the results from a study of patients with unresectable oropharyngeal squamous cell carcinomas who were treated on a protocol of hyperfractionated radiation and high-dose intraarterial cisplatin (HYPERRADPLAT) at the University of Kentucky. METHODS:The study was designed as a prospective, single-armed case series that was conducted in the setting of a single, academic, tertiary referral center. The patient cohort consisted of 24 previously untreated patients who were diagnosed with unresectable oropharyngeal carcinoma and were treated on the HYPERRADPLAT regimen, which included hyperfractionated external beam radiotherapy (1.2 grays [Gy] twice daily) was given for 5 weeks (60 Gy) followed by high-dose intraarterial cisplatin (150 mg/m2) and sodium thiosulfate. Shrinking "large-field" portals were started on Week 6 and finished on Week 7 with a cumulative dose of 76.8-81.6 Gy. The main outcome measures of the study were the primary and neck response rates, the 2-year and 5-year overall survival and disease-specific survival rates, and acute and late treatment morbidity. RESULTS:The median follow-up was 77 months. Complete response rates at the primary and regional lymph nodes were both 88%. The 2-year overall survival and disease-specific survival rates were 57% and 68%, respectively; whereas the 5-year overall survival and disease-specific survival rates were 33% and 42%, respectively. Two patients had Grade 4 mucosal toxicity, and no patient experienced neurologic or significant hematologic toxicities. Within 1 year of treatment, 58% of patients had used a feeding tube. CONCLUSIONS:The HYPERRADPLAT regimen produced excellent response rates and overall survival rates comparable to those achieved by patients who had unresectable oropharyngeal carcinomas. Tolerance of the therapy was good, and further studies using HYPERRADPLAT with induction therapy may improve outcomes further in this subset of patients with unfavorable disease.
journal_name
Cancerjournal_title
Cancerauthors
Spring PM,Valentino J,Arnold SM,Sloan D,Kenady D,Kudrimoti M,Haydon RC 3rd,Lee C,Given C,Mohiuddin M,Regine WFdoi
10.1002/cncr.21368subject
Has Abstractpub_date
2005-10-15 00:00:00pages
1765-71issue
8eissn
0008-543Xissn
1097-0142journal_volume
104pub_type
杂志文章相关文献
CANCER文献大全abstract::The cellular DNA content in colorectal biopsies from 51 patients with chronic ulcerative colitis has been studied with flow-cytometric technique. The DNA pattern has been related to the duration of the disease, and to histopathology. Aneuploid cell lines were found in eight patients, two of which had histopathological...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840115)53:2<291::aid-cncr28205
更新日期:1984-01-15 00:00:00
abstract:BACKGROUND:The degree of response and the duration of survival of patients treated with mitogen-activated protein kinase (MAPK) inhibitors are highly variable. Whether baseline clinicopathologic factors can predict the clinical course with treatment is largely unknown. METHODS:For 142 consecutive immunotherapy- and MA...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29586
更新日期:2015-11-01 00:00:00
abstract::Radiation-induced small bowel injury is a limiting factor to postoperative tumoricidal pelvic doses exceeding 4500 to 5000 cGy. Data from a review of the literature showed the inadequacy of medical measures and the bad reproducibility of radiation therapeutic attempts to decrease small intestine damage. Recent studies...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19911215)68:12<2545::aid-cncr282
更新日期:1991-12-15 00:00:00
abstract:BACKGROUND:The authors analyzed the secretion of extracellular matrix-degrading proteinases, including urinary-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2, gelatinase A), and MMP-9 (gelatinase B), by short term primary cultures of epithelial ovarian carcinoma cells derived from primary ovarian ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971015)80:8<1457::aid-cn
更新日期:1997-10-15 00:00:00
abstract::A 69-year-old man with metastatic islet cell carcinoma was treated with streptozotocin and achieved excellent tumor regression. Sixty-seven grams of streptozotocin were given over 28 months. After completion of streptozotocin therapy, the patient had progressive leukopenia. Thirteen months after discontinuation of str...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810415)47:8<1963::aid-cncr2820
更新日期:1981-04-15 00:00:00
abstract::Over the last several decades, significant "new eyes" have been developed that improve the diagnosis, treatment, planning, and monitoring of human cancer: computer tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomogra...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910215)67:4+<1121::aid-cncr282
更新日期:1991-02-15 00:00:00
abstract::There is justifiable excitement about the recent introduction of prophylactic vaccines against human papillomavirus (HPV) types 16 (HPV-16) and HPV-18. Preventing these infections theoretically could avert approximately 70% of cervical cancer cases worldwide. In the U.S., numerous influential advocates are calling for...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22751
更新日期:2007-06-25 00:00:00
abstract:BACKGROUND:The delayed effects (12-16 hours) of transdermal fentanyl make dose titration difficult during acute exacerbations of cancer pain. Patients at the authors' institution routinely are switched from transdermal to intravenous (IV) fentanyl using a 1:1 (transdermal:IV) conversion during severe episodes of pain. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11457
更新日期:2003-06-15 00:00:00
abstract::Unnecessary, inappropriate, and futile care are given in all areas of health care including cancer care. Not only does such care increase costs and waste precious resources, but patients may have adverse outcomes when the wrong care is given. One of the ways to address this issue is to measure performance with the use...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980515)82:10+<2016::aid-
更新日期:1998-05-15 00:00:00
abstract:BACKGROUND:Black females have lower breast carcinoma survival rates compared with white females. One possible reason is that black females have more advanced-stage breast disease. Another factor may be racial differences in the utilization of cancer treatments. METHODS:The authors determined racial differences in 6-ye...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11411
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The authors purpose in this study was to clarify the difference in terms of clinicopathologic features between gastric cancer (GC) with high numbers of DNA methylated genes and CpG island methylator phenotype (CIMP)-positive GC as originally defined. METHODS:We analyzed DNA methylation of 12 tumor-related g...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21754
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Sperm cryopreservation before cancer chemotherapy is available for young patients with cancer. However, few patients bank their sperm. The authors evaluated by questionnaire the psychological impact of sperm cryopreservation. METHODS:The authors cryopreserved the sperm of 111 patients with cancer for free a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21185
更新日期:2005-08-01 00:00:00
abstract::Eleven patients with advanced soft tissue sarcoma were treated with whole body hyperthermia (41.8 degrees C-43.0 degrees C) for 2 hours, doxorubicin (45 mg/m2) at the beginning of peak temperature and cyclophosphamide (1000 mg/m2) 6 hours after doxorubicin. Warming was accomplished with a nylon and vinyl mesh water pe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840615)53:12<2585::aid-cncr282
更新日期:1984-06-15 00:00:00
abstract:BACKGROUND:The relation between undergoing a single computed tomography (CT) screening for lung carcinoma and the potential long-term impact on smoking status has been equivocal. Perhaps, recommendations from multiple cancer screenings may promote smoking abstinence among individuals at high risk for lung carcinoma. M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21045
更新日期:2005-05-15 00:00:00
abstract:BACKGROUND:Most relapses of Hodgkin's disease (HD) occur within the first 2 years after diagnosis, but they may develop after a longer observation period. The aim of this study was to define the incidence, clinical course, and prognostic factors for late relapse (LR) of Hodgkin's disease. For this purpose, the authors ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::A study of the effects of local tumor radiation alone (1500R) and cyclophosphamide alone (150 mg/kg) on the experimental solid tumor rat hepatoma 3924A has been completed. Cyclophosphamide was more effective in controlling tumor growth than either radiation or 5-fluorouracil (5-FU) (150 mg/kg) previously reported. Par...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800601)45:11<2793::aid-cncr282
更新日期:1980-06-01 00:00:00
abstract::From a total of 874 patients with small cell lung cancer (SCC), a series of 104 patients were reviewed to determine if bone marrow relapses are detectable by routine clinical investigations. Autopsy, including microscopical bone marrow examination, was performed in all the 104 patients and bone metastases were disclos...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861201)58:11<2538::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract::This study delineates the temporal relationship between immune complex formation and tumor growth, and provides one possible explanation for host immunosuppression during tumor growth. The authors have studied serial circulating immune complex (CIC) levels and interleukin (IL) elaboration by peripheral blood cells (IL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840315)53:6<1373::aid-cncr2820
更新日期:1984-03-15 00:00:00
abstract::Seventy-seven patients with relapsed or refractory acute leukemia and three with acute blastic chronic myeloid leukemia (CML) were treated in an open Phase II study using mitoxantrone 12 mg/m2 intravenously daily X 5 days. Complete remission (CR) was achieved in 32 of 80 (40%), including 23/45 (52%) with relapsed acut...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19900801)66:3<418::aid-cncr28206
更新日期:1990-08-01 00:00:00
abstract::Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2252::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract::Activities of glucosephosphate isomerase, lactate dehydrogenase, and NADP-isocitrate dehydrogenase were significantly elevated in breast cancer specimens from patients who responded favorably to combination cytotoxic chemotherapy regimens compared with those in carcinomas from patients failing to respond to the same c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<695::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:Although systemic therapy for metastatic breast cancer (MBC) continues to evolve, there are scant data to guide physicians and patients when symptoms develop. In this article, the authors report the frequency and durability of palliative procedures performed in the setting of MBC. METHODS:From July 2002 to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25034
更新日期:2010-07-15 00:00:00
abstract::The clinical features and laboratory results of 63 patients with or at risk for AIDS with lymphoid neoplasias seen from November 1980 through November 1986 are reviewed. Forty-three had systemic non-Hodgkin's lymphoma (NHL), nine had primary large cell lymphomas of the brain, 11 had Hodgkin's disease (HD), and one had...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880601)61:11<2325::aid-cncr282
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Idarubicin (IDR), an anthracycline that is a derivative of daunorubicin, was synthesized in an attempt to find new analogs of daunorubicin with an improved spectrum of activity and diminished acute or chronic toxicity. Because of the favorable pharmacokinetic profile of IDR (with the persistence of its activ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/(sici)1097-0142(19980815)83:4<813::aid-cnc
更新日期:1998-08-15 00:00:00
abstract:BACKGROUND:Ewing's sarcomas, osteosarcomas, and rhabdomyosarcomas are significantly more responsive to chemotherapy than other sarcomas. Adjuvant chemotherapy is used routinely based on data from randomized trials. Although a percentage of children with locally advanced or metastatic tumors remain curable, few data exi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Prognosis of patients with adenocarcinoma of the pancreatic body and tail is extremely poor. Anatomically, this part of the pancreas is thin, and cancerous invasion to the retropancreatic structures occurs easily. The majority of patients have residual tumor in the retroperitoneal tissues after conventional ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960601)77:11<2240::AID-C
更新日期:1996-06-01 00:00:00
abstract::The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13) covers 13 typical symptoms of lung cancer patients and was the first module developed in conjunction with the EORTC core quality-of-life (QL) questionnaire. This review investigates how the mo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.29682
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22807
更新日期:2007-08-01 00:00:00
abstract::Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811201)48:11<2371::aid-cncr282
更新日期:1981-12-01 00:00:00
abstract::Carcinoma of the breast is a disease that is associated with 10-year recurrence rates of 25% in operable patients with no spread to the axillary nodes and 75% in patients in whom the tumor has extended to the axillary nodes. Locoregional recurrence rates of close to 50% have been reported in patients with Stage III di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820741334
更新日期:1994-07-01 00:00:00