The role of radiation therapy in the multidisciplinary management of recurrent and metastatic breast cancer.


:Carcinoma of the breast is a disease that is associated with 10-year recurrence rates of 25% in operable patients with no spread to the axillary nodes and 75% in patients in whom the tumor has extended to the axillary nodes. Locoregional recurrence rates of close to 50% have been reported in patients with Stage III disease. Adjuvant prophylactic postoperative irradiation can reduce locoregional recurrences to less than 10%. When locoregional recurrence occurs after mastectomy, therapeutic irradiation is required. It can achieve tumor control in at least 50% of cases. The best conditions exist when a surgical procedure can achieve gross removal of the recurrent tumor before irradiation and when the fields of irradiation encompass the chest wall and pertinent lymph node areas. The required dose of radiation is lower after excision of the tumor, and the chances of local tumor control are higher. The dose of radiation must be 4500-5000 cGy (fractions of 180-200 cGy) to the subclinical disease and a boost of 1000-1500 cGy added to the known tumor areas. Distant metastatic manifestations must be dealt with for palliative purposes, except in the case of isolated supraclavicular metastasis, where radical irradiation can achieve cure. The need exists for a definition of the role of systemic therapy for locoregional recurrence, and for the development of the optimal integration of systemic chemotherapy and local radiotherapy in patients with locoregional or distant breast cancer recurrences.






Marcial VA




Has Abstract


1994-07-01 00:00:00




1 Suppl










  • No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment.

    abstract:BACKGROUND:Glucocorticoids can lead to weight gain during cancer treatment, but to the authors' knowledge, little is known regarding their long-term effects in childhood cancer survivors (CCS). METHODS:As part of the Swiss Childhood Cancer Survivor Study, the authors sent a questionnaire to CCS aged <21 years at diagn...


    pub_type: 杂志文章


    authors: Belle FN,Kasteler R,Schindera C,Bochud M,Ammann RA,von der Weid NX,Kuehni CE,Swiss Pediatric Oncology Group (SPOG).

    更新日期:2018-09-01 00:00:00

  • Long-term adjustment of survivors of early-stage breast carcinoma, 20 years after adjuvant chemotherapy.

    abstract:BACKGROUND:The long-term impact of breast carcinoma and its treatment was assessed in 153 breast carcinoma survivors previously treated on a Phase III randomized trial (Cancer and Leukemia Group B [CALGB 7581]) a median of 20 years after entry to CALGB 7581. METHODS:Survivors were interviewed by telephone using the fo...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kornblith AB,Herndon JE 2nd,Weiss RB,Zhang C,Zuckerman EL,Rosenberg S,Mertz M,Payne D,Jane Massie M,Holland JF,Wingate P,Norton L,Holland JC

    更新日期:2003-08-15 00:00:00

  • Loss of heterozygosity and genomic instability in synchronous endometrioid tumors of the ovary and endometrium.

    abstract:BACKGROUND:The unknown etiology of endometrioid carcinomas of the ovary and the relatively high frequency of a concomitant carcinoma of the endometrium in these patients warrants study of such tumors. The aim of this study was to identify the genetic alterations involved in endometrioid ovarian cancer development, and ...


    pub_type: 杂志文章


    authors: Shenson DL,Gallion HH,Powell DE,Pieretti M

    更新日期:1995-08-15 00:00:00

  • Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma.

    abstract::A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci...


    pub_type: 杂志文章


    authors: Dayal Y,Tashjian AH Jr,Wolfe HJ

    更新日期:1979-04-01 00:00:00

  • Targeted radiotherapy with [(90)Y]-SMT 487 in mice bearing human nonsmall cell lung tumor xenografts induced to express human somatostatin receptor subtype 2 with an adenoviral vector.

    abstract:BACKGROUND:Novel approaches to increasing the therapeutic efficacy of targeted radiotherapy of cancer are required. One strategy to achieve this goal is to induce high-level expression of a receptor on the surface of tumor cells that can be targeted with a radiolabeled peptide. The objectives of this study were to 1) i...


    pub_type: 杂志文章


    authors: Rogers BE,Zinn KR,Lin CY,Chaudhuri TR,Buchsbaum DJ

    更新日期:2002-02-15 00:00:00

  • Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer.

    abstract::The infiltration of dendritic cells determined in 210 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. Dendritic cell infiltration was graded as "slight" and "marked." The 39% frequency in the marked infiltration group at the mucosal stage di...


    pub_type: 杂志文章


    authors: Tsujitani S,Kakeji Y,Watanabe A,Kohnoe S,Maehara Y,Sugimachi K

    更新日期:1990-11-01 00:00:00

  • Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of Ch

    abstract:BACKGROUND:The objective of this study was to evaluate the long-term survival and late toxicities of concurrent-adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China. METHODS:Patients with stage III to IVB NPC were assigned randomly to receive radioth...


    pub_type: 杂志文章,随机对照试验


    authors: Chen Y,Sun Y,Liang SB,Zong JF,Li WF,Chen M,Chen L,Mao YP,Tang LL,Guo Y,Lin AH,Liu MZ,Ma J

    更新日期:2013-06-15 00:00:00

  • A different pattern of cytotoxic T lymphocyte recognition against primary and metastatic tumor cells in a patient with nonsmall cell lung carcinoma.

    abstract:BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from pr...


    pub_type: 杂志文章


    authors: So T,Takenoyama M,Ichiki Y,Mizukami M,So T,Hanagiri T,Sugio K,Yasumoto K

    更新日期:2005-01-01 00:00:00

  • Plasma sex hormone binding globulin in patients with prostatic carcinoma.

    abstract::The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14...


    pub_type: 杂志文章


    authors: Grasso M,Buonaguidi A,Mondina R,Borsellino G,Lania C,Banfi G,Rigatti P

    更新日期:1990-07-15 00:00:00

  • Characterization of cancer cell dissociation factor in a highly invasive pancreatic cancer cell line.

    abstract:BACKGROUND:Two pancreatic cancer cell lines, the highly invasive and metastatic cell line PC-1.0 and the weakly invasive and rarely metastatic cell line PC-1, were established from a pancreatic ductal carcinoma induced by N-nitrosobis (2-oxopropyl) amine in a Syrian golden hamster. METHODS:The cancer cell dissociation...


    pub_type: 杂志文章


    authors: Kurizaki T,Egami H,Hirota M,Akagi J,Ohmachi H,Yamamoto S,Ogawa M

    更新日期:1995-03-15 00:00:00

  • Multifocal occurrence of gastric carcinoma in patients with a family history of gastric carcinoma.

    abstract:BACKGROUND:Smoking and alcoholic beverage drinking habits as well as a family history of cancer are well known risk factors for the multifocal occurrence of squamous cell carcinoma of the esophagus and the head and neck region. However, the role of these risk factors in multiple gastric carcinoma remains to be clarifie...


    pub_type: 杂志文章


    authors: Morita M,Kuwano H,Baba H,Taketomi A,Kohnoe S,Tomoda H,Araki K,Saeki H,Kitamura K,Sugimachi K

    更新日期:1998-10-01 00:00:00

  • Primary malignant fibrous histiocytoma of the aorta.

    abstract::A rare case of malignant fibrous histiocytoma of the aorta is reported. Review of the literature revealed that primary tumors of the aorta are exclusively mesenchymal tumors that almost invariably pursue a fatal course. ...


    pub_type: 杂志文章


    authors: Chen KT

    更新日期:1981-08-01 00:00:00

  • Telomere length and genetic analyses in population-based studies of endometrial cancer risk.

    abstract:BACKGROUND:Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic. METHODS:The authors used ...


    pub_type: 杂志文章


    authors: Prescott J,McGrath M,Lee IM,Buring JE,De Vivo I

    更新日期:2010-09-15 00:00:00

  • Cytotoxic and cytostatic effects of the streptococcal preparation OK-432 and its subcellular fractions on human ovarian tumor cells.

    abstract::Previous studies have indicated that OK-432 is a potent biologic response modifier (BRM) and that it augments immune responses to tumor cells. We studied the direct effect of OK-432 on tumor cells. Established and freshly derived human ovarian carcinoma lines were examined for their susceptibility to OK-432 or its sub...


    pub_type: 杂志文章


    authors: Nio Y,Zighelboim J,Berek J,Bonavida B

    更新日期:1989-07-15 00:00:00

  • Comparability of prostate trials.

    abstract::The present overview of advanced prostate cancer required the identification of randomized clinical trials studying the question of maximal androgen blockade versus the classic castration therapy. The heterogeneity of the trials concerned the type of castration (surgical or chemical) and the type of antiandrogen (flut...


    pub_type: 杂志文章,评审


    authors: Suciu S,Sylvester R,Iversen P,Christensen I,Denis L

    更新日期:1993-12-15 00:00:00

  • Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis.

    abstract::The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...


    pub_type: 杂志文章


    authors: Stock RJ,Fu YS,Carter JR

    更新日期:1979-09-01 00:00:00

  • Mucinous carcinoma of the colon and rectum.

    abstract::The clinicopathologic significance of mucus production by adenocarcinoma of the colon and rectum was analyzed in retrospective study with stage matched non-mucus producing control carcinomas. Mucinous carcinoma of the colon and rectum comprised 132 (15%) of 893 cases of colorectal carcinoma. The rectum was the most co...


    pub_type: 杂志文章


    authors: Symonds DA,Vickery AL

    更新日期:1976-04-01 00:00:00

  • Cytologic diagnosis of atypical squamous cells of undetermined significance in perimenopausal and postmenopausal women: lessons learned from human Papillomavirus DNA testing.

    abstract:BACKGROUND:The authors have noted that in cervical cytology specimens from perimenopausal and postmenopausal women, the diagnosis of atypical squamous cells of undetermined significance (ASC-US), as defined in the Bethesda system, is often not associated with a clinically evident lesion on follow-up. Reflex human papil...


    pub_type: 杂志文章


    authors: Johnston EI,Logani S

    更新日期:2007-06-25 00:00:00

  • Combined treatment with buserelin and cyproterone acetate in metastatic male breast cancer.

    abstract:BACKGROUND:Male breast cancer (MBC) is considered an androgen-dependent tumor, and as in prostatic cancer, responses have been reported with use of antiandrogens or gonadotropin-releasing hormone analogs. Thus, it is reasonable to postulate that better results could be achieved by combining these two agents. METHODS:E...


    pub_type: 杂志文章


    authors: Lopez M,Natali M,Di Lauro L,Vici P,Pignatti F,Carpano S

    更新日期:1993-07-15 00:00:00

  • Contrast-enhancing tumor growth dynamics of preoperative, treatment-naive human glioblastoma.

    abstract:BACKGROUND:Little is known about the natural growth characteristics of untreated glioblastoma before surgical or therapeutic intervention, because patients are rapidly treated after preliminary radiographic diagnosis. Understanding the growth characteristics of uninhibited human glioblastoma may be useful for character...


    pub_type: 杂志文章


    authors: Ellingson BM,Nguyen HN,Lai A,Nechifor RE,Zaw O,Pope WB,Yong WH,Nghiemphu PL,Liau LM,Cloughesy TF

    更新日期:2016-06-01 00:00:00

  • Importance of quality-of-life priorities and preferences surrounding treatment decision making in patients with cancer and oncology clinicians.

    abstract:BACKGROUND:Shared decision-making (SDM) occurs when a patient partners with their oncologist to integrate personal preferences and values into treatment decisions. A key component of SDM is the elicitation of patient preferences and values, yet little is known about how and when these are elicited, communicated, priori...


    pub_type: 杂志文章


    authors: Williams CP,Miller-Sonet E,Nipp RD,Kamal AH,Love S,Rocque GB

    更新日期:2020-08-01 00:00:00

  • Nasopharyngeal carcinoma in childhood and adolescence: a single-institution experience with combined therapy.

    abstract:BACKGROUND:A high cure rate may be attained for locally advanced, undifferentiated nasopharyngeal carcinoma (NPC) in children, provided that a combined modality of treatment is employed. Both local and systemic therapies are necessary. Results at a single pediatric institution were analyzed. METHODS:From November 1988...


    pub_type: 杂志文章


    authors: Zubizarreta PA,D'Antonio G,Raslawski E,Gallo G,Preciado MV,Casak SJ,Scopinaro M,Morales G,Sackmann-Muriel F

    更新日期:2000-08-01 00:00:00

  • In vivo metabolism of childhood posterior fossa tumors and primitive neuroectodermal tumors before and after treatment.

    abstract:BACKGROUND:Despite an increasing interest in the clinical application of positron emission tomography (PET) in tumors of the adult patient as a diagnostic and prognostic tool, only a few studies have been concerned with the usefulness of PET with [18F]2-deoxy-2-fluoro-D-glucose (FDG) in childhood tumors. METHODS:Fifte...


    pub_type: 杂志文章


    authors: Holthoff VA,Herholz K,Berthold F,Widemann B,Schröder R,Neubauer I,Heiss WD

    更新日期:1993-08-15 00:00:00

  • A human liposarcoma cell line producing hyaluronic acid.

    abstract::A human liposarcoma cell line COLO 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. COLO 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. A chromosome mode of 53 predominates and uniqu...


    pub_type: 杂志文章


    authors: Morgan RT,Quinn LA,Moore GE,Semple TU,Woods LK

    更新日期:1980-03-15 00:00:00

  • Brain metastases from esophageal carcinoma: natural history, prognostic factors, and outcome.

    abstract:BACKGROUND:Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, and possible prognostic factors in these patients is limited. METHODS:The records of 36 patients with brain metastases from esophageal carcinoma who were treated between 1986 a...


    pub_type: 杂志文章


    authors: Ogawa K,Toita T,Sueyama H,Fuwa N,Kakinohana Y,Kamata M,Adachi G,Saito A,Yoshii Y,Murayama S

    更新日期:2002-02-01 00:00:00

  • Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors.

    abstract:BACKGROUND:Arthralgia is common in postmenopausal breast cancer survivors (BCS) who are receiving aromatase inhibitors (AIs). The objective of this study was to evaluate the perceived onset, characteristics, and risk factors for AI-related arthralgia (AIA). METHODS:In a cross-sectional survey of postmenopausal BCS who...


    pub_type: 杂志文章


    authors: Mao JJ,Stricker C,Bruner D,Xie S,Bowman MA,Farrar JT,Greene BT,DeMichele A

    更新日期:2009-08-15 00:00:00

  • Impact of state-specific Medicaid reimbursement and eligibility policies on receipt of cancer screening.

    abstract:BACKGROUND:Although state Medicaid programs cover cancer screening, Medicaid beneficiaries are less likely to be screened for cancer and are more likely to present with tumors of an advanced stage than are those with other insurance. The current study was performed to determine whether state Medicaid eligibility and re...


    pub_type: 杂志文章


    authors: Halpern MT,Romaire MA,Haber SG,Tangka FK,Sabatino SA,Howard DH

    更新日期:2014-10-01 00:00:00

  • Prognosis for primary retroperitoneal sarcoma survivors: a conditional survival analysis.

    abstract:BACKGROUND:The AJCC staging system and post-operative nomograms use patient and tumor characteristics to provide prognostic estimates after resection of retroperitoneal sarcoma (RPS). While these variables help to predict survival at the time of diagnosis and resection, the applicability of these prognostic factors to ...


    pub_type: 杂志文章


    authors: Abbott AM,Habermann EB,Parsons HM,Tuttle T,Al-Refaie W

    更新日期:2012-07-01 00:00:00

  • Changes in guinea pig plasma cyclic nucleotide levels during the development of a transplantable leukemia.

    abstract::Plasma levels of cyclic AMP and cyclic GMP were determined in 35 guinea pigs for up to 9 days following subcutaneous passage of L2C leukemia cells. Twenty guinea pigs into which normal syngeneic guinea pig thymocytes were passaged served as controls. Cyclic AMP levels in plasma showed little change and were only eleva...


    pub_type: 杂志文章


    authors: Wood PJ,Pao G,Cooper A

    更新日期:1984-01-01 00:00:00

  • Randomized study of 5-FU and CCNU in pancreatic cancer: report of the Veterans Administration Surgical Adjuvant Cancer Chemotherapy Study Group.

    abstract::Between the years 1973-1977, 152 male patients from 28 participating Veterans Hospitals with histologically proven nonresectable cancer of the pancreas were randomized in a two-arm study. The treated group was to receive combination chemotherapy with 5-FU and CCNU, and the controls were to receive no chemotherapy. Bot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frey C,Twomey P,Keehn R,Elliott D,Higgins G

    更新日期:1981-01-01 00:00:00