Abstract:
BACKGROUND:Idarubicin (IDR), an anthracycline that is a derivative of daunorubicin, was synthesized in an attempt to find new analogs of daunorubicin with an improved spectrum of activity and diminished acute or chronic toxicity. Because of the favorable pharmacokinetic profile of IDR (with the persistence of its active metabolite [idarubicinol], the penetration of idarubicinol into the cerebrospinal fluid, and the lipophilicity of IDR/idarubicinol compared with other anthracyclines), its more favorable therapeutic index regarding cardiotoxicity in animals, and its potential for oral administration, a Phase II trial of IDR in children with relapsed brain tumors was undertaken. METHODS:Patients received IDR at a dose of 5 mg/m2/day x 3 days by intravenous bolus, followed by granulocyte-colony stimulating factor (G-CSF) at a dose of 5 microg/kg/day, starting on Day 7 of each cycle and continuing for at least 7 days, until the absolute neutrophil count was > or =10,000/mm3. RESULTS:Three of 19 patients with high grade astrocytoma achieved a partial response, 1 of 20 patients with medulloblastoma had a complete response, and 0 of 13 patients with ependymoma and 0 of 13 patients with brainstem tumors had responses. In nine other brain tumor patients there were no responses. The most significant toxicity was myelosuppression. CONCLUSIONS:IDR, given at a dose of 5 mg/m2/day x 3 days, is not sufficiently active against relapsed medulloblastoma, ependymoma, or brain stem tumors to warrant further study of this agent in a Phase III setting. The response rate for patients with relapsed high grade astrocytoma was 15% (95% confidence interval, 3.3-40%).
journal_name
Cancerjournal_title
Cancerauthors
Arndt CA,Krailo MD,Steinherz L,Scheithauer B,Liu-Mares W,Reaman GHdoi
10.1002/(sici)1097-0142(19980815)83:4<813::aid-cncsubject
Has Abstractpub_date
1998-08-15 00:00:00pages
813-6issue
4eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19980815)83:4<813::AID-CNCjournal_volume
83pub_type
临床试验,杂志文章,多中心研究相关文献
CANCER文献大全abstract:BACKGROUND:Melanoma vaccine treatment appears to slow the progression of melanoma in some patients, particularly in patients in whom it stimulates cellular antimelanoma immune responses. The relationship of vaccine-induced antibody responses to clinical outcome is less clear. The purpose of this study was to investigat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950115)75:2<495::aid-cncr28207
更新日期:1995-01-15 00:00:00
abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc
更新日期:1997-04-25 00:00:00
abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:This study was performed to clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients surviving >10 years after hepatic resection. METHODS:Between January 1971 and April 1987, 142 patients underwent hepatic resection. Thirty-nine patients who died of surgical morbidity (surgical mort...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:In spite of many reports, it remains unclear whether the presence of tumor cells in circulating blood flow predicts a poor prognosis. METHODS:Competitive seminested reverse transcriptase-polymerase chain reaction (RT-PCR), a technique for the quantitative detection of tumor cells, was applied to detect the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1251::aid-cncr1445
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Although there have been several reports of cytologic features for salivary duct carcinoma (SDC), it still can be difficult to diagnose patients with these tumor accurately at the time of fine-needle aspiration (FNA). Review of the literature indicates that, immunohistochemically, SDC expresses androgen rece...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.9050
更新日期:2001-10-25 00:00:00
abstract:BACKGROUND:Assessment of the responses of osteosarcoma patients to preoperative chemotherapy is of clinical importance. The purpose of this study was to estimate the accuracy of angiography and thallium-201 scintigraphy, compared with histology, in assessing the responses of patients with osteosarcoma to preoperative c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990915)86:6<949::aid-cnc
更新日期:1999-09-15 00:00:00
abstract:BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32148
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Micropapillary serous carcinoma (MPSC), a recently described entity, is an ovarian tumor with a distinctive histologic architecture that lacks a destructive infiltrative growth pattern and behaves like a low-grade neoplasm. The purpose of this study was to determine if specific cytomorphologic features were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10619
更新日期:2002-06-25 00:00:00
abstract:BACKGROUND:As we approach the 21st century, clinically useful predictive models for prostate carcinoma are urgently needed to stratify patients reliably for future treatment strategies. Recently, many investigators have developed models that employ prostate specific antigen (PSA)-based constructs or groupings in an att...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970915)80:6<1093::aid-cn
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:Second primary tumors are a leading cause of death among patients with head and neck cancer; therefore, early detection of these tumors is necessary. In the current study, the authors aimed to evaluate the diagnostic capacity of (18)F-fluorodeoxyglucose dual-head positron emission tomography (FDG-PET) for de...
journal_title:Cancer
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11937
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase 2 (COX-2)-dependent signaling represents a potential mechanism of resistance to therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regul...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.29480
更新日期:2015-09-15 00:00:00
abstract::Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<131::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Pelvic irradiation to patients with prostate cancer is accompanied by urinary and intestinal reactions. In men older than 60 years, treatment-induced problems should be evaluated in relation to problems in an age-matched nonirradiated population. METHODS:In the present study, problems in the urinary tract a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941101)74:9<2520::aid-cncr2820
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Malignant cells exhibit increased glycolytic metabolism, and in many cases increased glucose transporter gene expression. The authors hypothesized that GLUT1 glucose transporter expression is increased in colorectal carcinoma, and that the degree of expression might have prognostic significance. METHODS:GLU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980701)83:1<34::aid-cncr
更新日期:1998-07-01 00:00:00
abstract::Various attempts have been made to improve the effectiveness of radiation in the treatment of cerebral malignant astrocytomas. A trend favoring multiple daily fractionated (MDF) radiation therapy over conventional single daily fractionated (CF) radiation therapy was identified in our previous study. In order to assess...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19850815)56:4<758::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:The objective of the current study was to correlate pretreatment computed tomography and magnetic resonance imaging studies with outcomes for patients with squamous or basal cell carcinoma of the skin and clinical perineural invasion. METHODS:Between 1986 and 2002, 45 patients were treated with radiotherapy...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20913
更新日期:2005-03-15 00:00:00
abstract::The efficacy of trioxifene mesylate, a new antiestrogen, in the management of advanced breast cancer was evaluated in 69 patients. Fifty-two patients were randomly allocated to dose schedules of 5 mg, 10 mg, and 20 mg orally twice daily. There were five complete responders (10%), 22 partial responders (42%), and 9 pat...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19860101)57:1<40::aid-cncr282057
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10640
更新日期:2002-07-01 00:00:00
abstract::The relation of gastric acid-secreting function to the gross and histological types and locations of carcinomas was examined in 53 patients with early gastric carcinomas. Studies were made by the endoscopic Congo red test developed in this clinic. Results indicated a close correlation between the gross and histologica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197901)43:1<317::aid-cncr2820430
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Case reports have associated neuroblastoma, a cancer derived from the embryonal neural crest, with aganglionosis coli and neurofibromatosis type I. The aim of the current study was to test the hypothesis that neuroblastoma is part of a global defect in neurodevelopment. METHODS:Neuropathologic findings from...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980415)82:8<1603::aid-cn
更新日期:1998-04-15 00:00:00
abstract::Detailed cytogenetic studies were performed in 41 patients with cutaneous T-cell lymphoma (CTCL): four patients had limited plaques, 13 patients had generalized plaques, eight patients had cutaneous tumors, 16 patients had generalized erythroderma, and four additional patients, who had relatively benign chronic dermat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821015)50:8<1539::aid-cncr2820
更新日期:1982-10-15 00:00:00
abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31873
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date. METHODS:The authors analyzed all patients who had localized and/...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26357
更新日期:2012-03-01 00:00:00
abstract::In order to quantify the lymphocyte to epithelial cell ratio (L/E ratio of the thymoma, actual counting was performed. The L/E ratio was investigated in 25 specimens of 22 cases (22 initial tumors and 3 recurrent tumors). L/E ratios ranged from 0.27 to 4.10, and the mean value was 1.93 +/- 0.21. The mean L/E ratio of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197709)40:3<1222::aid-cncr282040
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:The development of malignancies in recipients of a cardiothoracic transplant (CTT)--that is, heart, lung, or heart and lung recipients-is of concern. Cutaneous and lymphoproliferative malignancies comprise the two major groups of malignancies encountered. A small subgroup of patients will develop potentially...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-15 00:00:00
abstract::A case of endometrial adenoacanthoma is reported in which two histologically distinct populations of cells were identified in the primary tumor. The two cell types differed in that one had phagocytosed large numbers of polymorphonuclear leucocytes. A subsequent skin metastasis was composed entirely of cells capable of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800501)45:9<2348::aid-cncr2820
更新日期:1980-05-01 00:00:00
abstract:BACKGROUND:Studies postulate that certain religious beliefs related to medical care influence the end-of-life (EOL) medical decision making and care of patients with advanced cancer. Because to the best of the authors' knowledge no current measure explicitly assesses such beliefs, in the current study the authors intro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31946
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:A positive influence of anticoagulant treatment in small cell lung cancer (SCLC) has been suggested by experimental and clinical data. METHODS:In a multicenter clinical trial, 277 patients with SCLC were randomized either to receive or not to receive subcutaneous heparin injections for 5 weeks at effective ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/1097-0142(19940701)74:1<38::aid-cncr282074
更新日期:1994-07-01 00:00:00