Subcutaneous heparin treatment increases survival in small cell lung cancer. "Petites Cellules" Group.


BACKGROUND:A positive influence of anticoagulant treatment in small cell lung cancer (SCLC) has been suggested by experimental and clinical data. METHODS:In a multicenter clinical trial, 277 patients with SCLC were randomized either to receive or not to receive subcutaneous heparin injections for 5 weeks at effective doses, which were monitored by blood coagulation tests. All patients received one of the two chemotherapy regimens studied in this trial, for eight courses in the case of patients with complete or partial response, and subsequently were randomized to receive delayed thoracic radiotherapy after these eight courses. RESULTS:In comparison to the 139 patients who did not receive heparin, the 138 patients who received anticoagulant treatment obtained better complete response rates (37% vs. 23%, P = 0.004), better median survival (317 days vs. 261 days, P = 0.01), and better survival rates at 1, 2, and 3 years (40% vs. 30%, 11% vs. 9% and 9% vs. 6%, respectively). At subgroups analysis, the results on survival were obtained for limited forms (P = 0.03) but not for extensive diseases (P = 0.31). No important bleeding or thrombocytopenia was related to heparin treatment. CONCLUSIONS:These results confirm the value of anticoagulant treatment in SCLC, already suspected for warfarin and now proven for heparin, but the modes of administration and the biologic explanations for this activity still warrant further investigation.






Lebeau B,Chastang C,Brechot JM,Capron F,Dautzenberg B,Delaisements C,Mornet M,Brun J,Hurdebourcq JP,Lemarie E




Has Abstract


1994-07-01 00:00:00














  • The National Cancer Data Base report on cancer in Hispanics. Relationships between ethnicity, poverty, and the diagnosis of some cancers.

    abstract:BACKGROUND:Previous Commission on Cancer studies have examined time trends in stage of disease, treatment patterns, and survival for special populations. Reported herein are the most current National Cancer Data Base data for Hispanics. METHODS:Two Calls for Data have yielded a total of 23,650 cancer reports for Hispa...


    pub_type: 杂志文章


    authors: Villar HV,Menck HR

    更新日期:1994-10-15 00:00:00

  • Thymic carcinoid. A histologic, immunohistochemical, and ultrastructural study of 12 cases.

    abstract::Twelve cases of thymic carcinoid were studied by electron microscopy and immunohistochemistry. Clinically, all of them presented either as asymptomatic, radiographically detected mediastinal masses or as neoplasms producing symptoms of thoracic structural displacement or Cushing's syndrome. By light microscopic examin...


    pub_type: 杂志文章


    authors: Wick MR,Scheithauer BW

    更新日期:1984-02-01 00:00:00

  • Histologic findings in the tracheobronchial tree of uranium miners and non-miners with lung cancer.

    abstract::The remaining tissue of the tracheobronchial tree from 210 men who died from lung cancer was studied to compare the histologic alterations leading to further sites of primary cancer. These men were uranium miners matched with nonminers for age and smoking habits. In the examination of a total of 28,928 cross-sections ...


    pub_type: 杂志文章


    authors: Auerbach O,Saccomanno G,Kuschner M,Brown RD,Garfinkel L

    更新日期:1978-08-01 00:00:00

  • Prognostic factors in pediatric spinal cord astrocytoma.

    abstract:BACKGROUND:Factors that could optimize the management of pediatric spinal cord astrocytoma remain unclear and controversial. METHODS:To determine the factors that influence the prognosis of pediatric patients with spinal cord astrocytomas, a series of 73 consecutive patients at 13 French treatment centers with histolo...


    pub_type: 杂志文章


    authors: Bouffet E,Pierre-Kahn A,Marchal JC,Jouvet A,Kalifa C,Choux M,Dhellemmes P,Guérin J,Tremoulet M,Mottolese C

    更新日期:1998-12-01 00:00:00

  • Prognostic value of CD44 isoform expression in thymic epithelial neoplasms.

    abstract:BACKGROUND:Many histologic classifications of thymic epithelial tumors have been reported to date, but to the authors' knowledge, none of them closely reflect the clinical behavior or prognosis of the tumor. Therefore, it is necessary to establish a biologic marker for thymic epithelial tumors. Variants of CD44 may be ...


    pub_type: 杂志文章


    authors: Sonobe S,Miyamoto H,Nobukawa B,Izumi H,Futagawa T,Ishikawa N,Yamazaki A,Uekusa T,Abe H,Suda K

    更新日期:2005-05-15 00:00:00

  • Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.

    abstract::The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutation-positive cases reve...


    pub_type: 杂志文章


    authors: Kobayashi T,Tsuda H,Noguchi M,Hirohashi S,Shimosato Y,Goya T,Hayata Y

    更新日期:1990-07-15 00:00:00

  • Superior vena cava syndrome caused by an intrathoracic plasmacytoma.

    abstract::A case of an extramedullary intrathoracic plasmacytoma causing superior vena cava syndrome is described. Review of the literature on intrathoracic plasmacytomas and superior vena cava syndrome revealed that no similar cases have been described to date. The initial presentation, management, and response to treatment ar...


    pub_type: 杂志文章,评审


    authors: Davis SR,King HS,Le Roux I,Bolding E

    更新日期:1991-09-15 00:00:00

  • Combination chemotherapy plus levamisole in the treatment of disseminated malignant melanoma. A Southwest Oncology Group study.

    abstract::Two hundred-eighty patients were randomized to receive either BCNU, hydroxyurea and imidazole carboxamide (BHD), BHD plus levamisole, or high-dose DTIC plus actinomycin D. There was no difference in response rate in the three groups (24%, 25% and 22%). Females responded better than males and, as expected, those with a...


    pub_type: 临床试验,杂志文章


    authors: Costanzi JJ,Fletcher WS,Balcerzak SP,Taylor S,Eyre HJ,O'Bryan RM,Al-Sarraf M,Frank J

    更新日期:1984-02-15 00:00:00

  • Automated tobacco assessment and cessation support for cancer patients.

    abstract:BACKGROUND:Tobacco assessment and cessation support are not routinely included in cancer care. An automated tobacco assessment and cessation program was developed to increase the delivery of tobacco cessation support for cancer patients. METHODS:A structured tobacco assessment was incorporated into the electronic heal...


    pub_type: 杂志文章


    authors: Warren GW,Marshall JR,Cummings KM,Zevon MA,Reed R,Hysert P,Mahoney MC,Hyland AJ,Nwogu C,Demmy T,Dexter E,Kelly M,O'Connor RJ,Houstin T,Jenkins D,Germain P,Singh AK,Epstein J,Dobson Amato KA,Reid ME

    更新日期:2014-02-15 00:00:00

  • Interferon activity and its characterization in the sera of patients with head and neck cancer.

    abstract::The interferon (IFN) assay of the sera from the 40 patients with head and neck cancer was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. The patients mainly had Stage III or IV lesion without distant metastasis, and previously had not received ...


    pub_type: 杂志文章


    authors: Sato M,Yoshida H,Yanagawa T,Yura Y,Urata M,Atsumi M,Furumoto N,Hayashi Y,Takegawa Y

    更新日期:1984-10-01 00:00:00

  • Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000.

    abstract:BACKGROUND:Although cervical carcinoma incidence and mortality rates have declined in the U.S. greatly since the introduction of the Papanicolaou smear, this decline has not been uniform for all histologic subtypes. Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and ad...


    pub_type: 杂志文章


    authors: Wang SS,Sherman ME,Hildesheim A,Lacey JV Jr,Devesa S

    更新日期:2004-03-01 00:00:00

  • Histogenesis of spontaneous regression of cervical intraepithelial neoplasias.

    abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...


    pub_type: 杂志文章


    authors: Bajardi F

    更新日期:1984-08-15 00:00:00

  • Religion, spirituality, and health outcomes in cancer: A case for a meta-analytic investigation.

    abstract::A growing body of research shows that a majority of patients with cancer report having religious and spiritual (R/S) beliefs, engaging in R/S behaviors, or deriving comfort from R/S experiences. These studies have been reviewed but not subjected to rigorous critical analysis. A meta-analytic approach is needed to prov...


    pub_type: 杂志文章,meta分析


    authors: Salsman JM,Fitchett G,Merluzzi TV,Sherman AC,Park CL

    更新日期:2015-11-01 00:00:00

  • Medroxyprogesterone acetate lowers plasma corticotropin and cortisol but does not suppress anterior pituitary responsiveness to human corticotropin releasing factor.

    abstract::The endocrine action of medroxyprogesterone acetate (MPA) has been claimed to be of a glucocorticoid-like nature. Upon clinical observation, MPA has been shown to improve life quality and overall well-being in patients with advanced breast cancer, renal carcinoma, prostatic carcinoma, and uterine adenocarcinoma. The a...


    pub_type: 杂志文章


    authors: Lang I,Zielinski CC,Templ H,Spona J,Geyer G

    更新日期:1990-11-01 00:00:00

  • Isolated vaginal recurrences of endometrial adenocarcinoma and their management.

    abstract::Eighteen patients with isolated vaginal recurrence of their previously treated endometrial carcinoma were treated with radiation therapy at North Carolina Baptist Hospital, Winston-Salem between 1971 and 1982. Most patients received external beam irradiation which were followed by boost treatments that were delivered ...


    pub_type: 杂志文章


    authors: Greven K,Olds W

    更新日期:1987-08-01 00:00:00

  • Loss of heterozygosity and genomic instability in synchronous endometrioid tumors of the ovary and endometrium.

    abstract:BACKGROUND:The unknown etiology of endometrioid carcinomas of the ovary and the relatively high frequency of a concomitant carcinoma of the endometrium in these patients warrants study of such tumors. The aim of this study was to identify the genetic alterations involved in endometrioid ovarian cancer development, and ...


    pub_type: 杂志文章


    authors: Shenson DL,Gallion HH,Powell DE,Pieretti M

    更新日期:1995-08-15 00:00:00

  • Present and future projects of the International Breast Cancer Study Group.

    abstract::The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of tim...


    pub_type: 杂志文章


    authors: Goldhirsch A,Gelber RD,Castiglione M,Price KN,Rudenstam CM,Lindtner J,Collins J,Senn HJ,Brunner KW,Galligioni E

    更新日期:1994-08-01 00:00:00

  • Immunostimulation with intrapleural BCG as adjuvant therapy in resected non-small cell lung cancer. The Ludwig Lung Cancer Study Group (LLCSG).

    abstract::A prospective randomized trial was performed to evaluate the role of adjuvant local immunostimulation with bacillus Calmette-Guérin (BCG) in resected Stage I and Stage II non-small cell bronchogenic carcinoma. The patients were stratified according to extent of resection and surgical stage, and randomized to treatment...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1986-12-01 00:00:00

  • Thyroid medullary carcinoma with thyroglobulin immunoreactivity in sporadic multiple endocrine neoplasia type 2-B.

    abstract:BACKGROUND:Thyroid carcinomas historically have been divided into two groups according to their presumedly separate embryonic origins: those of neuroectodermal derivation (parafollicular or medullary carcinoma [MCT]) and those of foregut endodermal origin (follicular and papillary carcinomas). The validity of this conc...


    pub_type: 杂志文章


    authors: Kovacs CS,Masé RM,Kovacs K,Nguyen GK,Chik CL

    更新日期:1994-08-01 00:00:00

  • Malignant inflammatory histiocytoma (inflammatory fibrous histiocytoma): report of a patient with four lesions.

    abstract::A patient with four subcutaneous inflammatory fibrous histiocytomas is presented. Three of these tumors developed synchronously. The neoplasms were examined by light and electron microscopy and were composed of well differentiated histiocytes, multinucleated histiocytes, and less differentiated cells. The ultrastructu...


    pub_type: 杂志文章


    authors: Miller R,Kreutner A Jr,Kurtz SM

    更新日期:1980-01-01 00:00:00

  • Whole-body protein metabolism in cancer-bearing patients. Effect of total parenteral nutrition and associated serum insulin response.

    abstract::Aggressive nutritional support of the cancer patient undergoing treatment has become widespread standard practice. In order to evaluate the effect of total parenteral nutrition (TPN) on protein metabolism, 11 patients with localized squamous cell carcinoma of the distal esophagus were studied in the postabsorptive sta...


    pub_type: 杂志文章


    authors: Burt ME,Stein TP,Schwade JG,Brennan MF

    更新日期:1984-03-15 00:00:00

  • Primary non-Hodgkin's lymphoma of the mediastinum.

    abstract::Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6+) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extr...


    pub_type: 杂志文章


    authors: Levitt LJ,Aisenberg AC,Harris NL,Linggood RM,Poppema S

    更新日期:1982-12-01 00:00:00

  • Colorectal cancer stage at diagnosis by socioeconomic and urban/rural status in California, 1988-2000.

    abstract:BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...


    pub_type: 杂志文章


    authors: Parikh-Patel A,Bates JH,Campleman S

    更新日期:2006-09-01 00:00:00

  • Immunohistochemical and cytogenetic studies indicate that malignant angioendotheliomatosis is a primary intravascular (angiotropic) lymphoma.

    abstract::The authors performed immunohistochemical and cytogenetic studies in a 73-year old man with malignant angioendotheliomatosis. The patient was referred for evaluation of fever of unknown origin, hepatic failure, and neurologic deterioration. Examination of a muscle biopsy revealed numerous, noncohesive atypical mononuc...


    pub_type: 杂志文章


    authors: Molina A,Lombard C,Donlon T,Bangs CD,Dorfman RF

    更新日期:1990-08-01 00:00:00

  • Highlights of the evidence of benefit for women aged 40-49 years from the 14-year follow-up of the Breast Cancer Detection Demonstration Project.

    abstract::Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size,...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Smart CR

    更新日期:1994-07-01 00:00:00

  • Ultrastructure of unusual cytoplasmic inclusions in a case of myeloproliferative disorder.

    abstract::An unusual case of myeloproliferative disorder in which mature and immature myeloid cells were found to contain unusual cytoplasmic inclusions is reported. By light microscopy, these inclusions could be observed with Wright's stain. By electron microscopy they appeared to consist of a pale, finely granular material wi...


    pub_type: 杂志文章


    authors: Coppola A,O'Connor J

    更新日期:1977-11-01 00:00:00

  • Evaluation of the quality of radiotherapy randomized trials for painful bone metastases.

    abstract:BACKGROUND:The quality of randomized radiotherapy studies investigating the palliation of painful bone metastases has been questioned, with some authors recognizing the potential impact of bias on result interpretation. However, there has been no published comprehensive evaluation of quality assessment. The goals of th...


    pub_type: 杂志文章,meta分析


    authors: Shakespeare TP,Thiagarajan A,Gebski V

    更新日期:2005-05-01 00:00:00

  • Prostate cancer outcomes for men aged younger than 65 years with Medicaid versus private insurance.

    abstract:BACKGROUND:In the current national debate regarding private insurance versus Medicaid expansion, understanding how insurance is associated with racial disparities in prostate cancer (CaP) outcomes has broad policy implications. In the current study, the authors examined the association between insurance status, race, a...


    pub_type: 杂志文章


    authors: Mahal AR,Mahal BA,Nguyen PL,Yu JB

    更新日期:2018-02-15 00:00:00

  • Carcinoid tumors of the thymus. An immunohistochemical study.

    abstract::Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...


    pub_type: 杂志文章


    authors: Herbst WM,Kummer W,Hofmann W,Otto H,Heym C

    更新日期:1987-11-15 00:00:00

  • Clinical relevance of Ki-67 expression in bone tumors.

    abstract:BACKGROUND:The availability of Ki-67 monoclonal antibody has opened new possibilities for an extensive analysis of cell kinetics in human neoplasms. Ki-67 antibody reveals a nuclear antigen that is expressed in proliferating but not in quiescent cells. Although the reliability of Ki-67 immunostaining has been evaluated...


    pub_type: 杂志文章


    authors: Scotlandi K,Serra M,Manara MC,Maurici D,Benini S,Nini G,Campanacci M,Baldini N

    更新日期:1995-02-01 00:00:00