Effect of secretin and cholecystokinin-pancreozymin on plasma CEA concentration in patients with pancreatic carcinoma and pancreatitis.

Abstract:

:Plasma CEA concentration before and after administration of secretin and cholecystokinin-pancreozymin has been determined in 89 patients with neoplastic or inflammatory pancreatric disease and other neoplastic and nonneoplastic disorders. The purpose of the study was to expore the specificity and sensitivity of such a provocation tests. Some rise of the plasma CEA concentration after hormonal stimulation could be observed in several patients in the various groups. However, none of the 37 patients with nonpancreatic disease who had a basal CEA concentration of 6 micrograms/l or less had a maximal CEA concentration above 13 micrograms/l after the stimulation whereas 7 out of 31 patients with pancreatic disease (3 with pancreatic carcinoma and 4 with chronic pancreatitis) showed such an elevation of plasma CEA concentration. Thus, the provocation test showed a satisfactory specificity for pancreatic disease but a low sensitivity. It is suggested that the possibility of an effect of physiologically released gastrointestinal hormones should be considered when "unexplained" high CEA values are found in plasma samples from nonfasting patients.

journal_name

Cancer

journal_title

Cancer

authors

Lindstedt G,Lundberg PA,Rolny P

doi

10.1002/1097-0142(197906)43:6<2465::aid-cncr282043

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

2465-70

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

43

pub_type

杂志文章

相关文献

CANCER文献大全
  • Alpha-fetoprotein and human chorionic gonadotropin in embryonal carcinoma of the ovary. An 8-year survival case.

    abstract::An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831015)52:8<1470::aid-cncr2820

    authors: Nakakuma K,Tashiro S,Uemura K,Takayama K

    更新日期:1983-10-15 00:00:00

  • Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence.

    abstract:BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960415)77:8<1729::AID-CN

    authors: Kato M,Ito Y,Kobayashi S,Isono K

    更新日期:1996-04-15 00:00:00

  • Long survival in patients with acquired immune deficiency syndrome-related primary central nervous system lymphoma.

    abstract:BACKGROUND:Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS:Four (of approximately 40) patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940315)73:6<1728::aid-cncr2820

    authors: Chamberlain MC

    更新日期:1994-03-15 00:00:00

  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group.

    abstract:BACKGROUND:This year, the 7th edition of the AJCC staging manual has for the first time attributed a unique pTNM staging to intrahepatic cholangiocarcinoma (IHCC) that is intended to replace the 2 Western and ideally also the 2 Eastern systems currently in use. This proposal, which has not yet been validated, was teste...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25712

    authors: Farges O,Fuks D,Le Treut YP,Azoulay D,Laurent A,Bachellier P,Nuzzo G,Belghiti J,Pruvot FR,Regimbeau JM

    更新日期:2011-05-15 00:00:00

  • Sequential testicular biopsies in childhood acute lymphocytic leukemia.

    abstract::Between August 1978 and November 1981, 33 boys with acute lymphocytic leukemia (ALL) (26 non-T, 7 T-cell) younger than 16 years underwent bilateral wedge testicular biopsies at the time of initial diagnosis. Seven (4 non-T, 3 T-cell) demonstrated focal leukemic infiltrates. Rebiopsy after successful induction therapy ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860301)57:5<1038::aid-cncr2820

    authors: Kim TH,Hargreaves HK,Chan WC,Brynes RK,Alvarado C,Woodard J,Ragab AH

    更新日期:1986-03-01 00:00:00

  • Lymphoplasmacytic lymphoma. Report of a case with three monoclonal proteins derived from a single neoplastic clone.

    abstract::The unique case of a 60-year-old patient with a non-Hodgkin's B-cell lymphoma of the lymphoplasmacytic type and three associated monoclonal proteins, is described. The patient also exhibited various autoimmune phenomena that were consistent with the diagnoses of Sjögren's syndrome and autoimmune thyroiditis. The evolu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860501)57:9<1794::aid-cncr2820

    authors: Berg AR,Weisenburger DD,Linder J,Armitage JO

    更新日期:1986-05-01 00:00:00

  • Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients.

    abstract:BACKGROUND:The importance of the bone marrow microenvironment in multiple myeloma is receiving increasing attention. Recent studies have suggested the importance of cytokine production and cell-cell contact by bone marrow stromal cells in the survival of myeloma cells. METHODS:In the current study, the authors examine...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010401)91:7<1219::aid-cncr1122

    authors: Wallace SR,Oken MM,Lunetta KL,Panoskaltsis-Mortari A,Masellis AM

    更新日期:2001-04-01 00:00:00

  • Diagnosis of brain metastases from a primary hemangiosarcoma of the spleen with magnetic resonance imaging.

    abstract:BACKGROUND:Primary malignant splenic neoplasms are rare tumors. Apart from involvement of the spleen by malignant lymphoma, hemangiosarcoma is the most common form of primary malignant neoplasm in the spleen. The diagnosis often is made at autopsy or after spontaneous splenic rupture. The prognosis is usually poor, and...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930101)71:1<138::aid-cncr28207

    authors: Søndenaa K,Heikkilä R,Nysted A,Søreide JA,Odegaard H,Pollard ML,Holter J

    更新日期:1993-01-01 00:00:00

  • Antibody response to Epstein-Barr virus Rta protein in patients with nasopharyngeal carcinoma: a new serologic parameter for diagnosis.

    abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is associated closely with Epstein-Barr virus (EBV). The authors previously reported that an EBV immediate-early gene, BRLF1, was expressed frequently in NPC tumors, and a significant elevation in immunoglobulin G (IgG) antibodies directed against BRLF1 gene product Rta was det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011001)92:7<1872::aid-cncr1704

    authors: Feng P,Chan SH,Soo MY,Liu D,Guan M,Ren EC,Hu H

    更新日期:2001-10-01 00:00:00

  • EphA2 overexpression is associated with angiogenesis in ovarian cancer.

    abstract:BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22415

    authors: Lin YG,Han LY,Kamat AA,Merritt WM,Landen CN,Deavers MT,Fletcher MS,Urbauer DL,Kinch MS,Sood AK

    更新日期:2007-01-15 00:00:00

  • Peripheral neuroepithelioma: a light and electron microscopic study.

    abstract::A primitive neuroectodermal tumor of peripheral nerve origin was examined by light and electron microscopy. The lesion arose in association with the S1 nerve root of the lumbosacral plexus in a 22-year-old female. Following a surgical biopsy, the patient received systemic chemotherapy; however, approximately one-and-a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801201)46:11<2456::aid-cncr282

    authors: Bolen JW,Thorning D

    更新日期:1980-12-01 00:00:00

  • Limb salvage for skeletal and soft tissue sarcomas. Multidisciplinary preoperative therapy.

    abstract::One hundred eighty-three patients with malignant skeletal (83) or soft tissue sarcoma (100) were entered into the multimodality preoperative limb salvage protocol. Local recurrences were observed in 5 of 183 (2.7%). Six patients required amputation because of complications, and 13 patients died within 1 year from meta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840615)53:12<2579::aid-cncr282

    authors: Eilber FR,Morton DL,Eckardt J,Grant T,Weisenburger T

    更新日期:1984-06-15 00:00:00

  • Osteosarcoma of the soft tissue of the larynx: report of a case with light and electron microscopic studies.

    abstract::A case of osteosarcoma arising in the soft tissue of the larynx in an elderly man is presented with light and electron microscopic documentation. The patient developed chronic hoarseness and a recurring polypoid laryngeal tumor, causing acute airway obstruction. He was treated by total laryngectomy, but he died with m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197811)42:5<2343::aid-cncr282042

    authors: Dahm LJ,Schaefer SD,Carder HM,Vellios F

    更新日期:1978-11-01 00:00:00

  • Early lung cancer action project: overall design and findings from baseline screening.

    abstract:BACKGROUND:The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low radiation dose computed tomography (low-dose CT) in persons at high-risk for lung cancer. The authors report on the baseline screening experience. For full evaluation of screening, they await the ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20001201)89:11+<2474::aid-cncr26

    authors: Henschke CI

    更新日期:2000-12-01 00:00:00

  • Use of Medicare claims data to measure county-level variations in the incidence of colorectal carcinoma.

    abstract:BACKGROUND:Population-based cancer registries that can be used to compare cancer incidence and mortality across regions of the U.S. are currently lacking. The authors conducted this study to validate Medicare claims as a measure of county-level colorectal carcinoma incidence among older Americans. Variations found amon...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980815)83:4<673::aid-cnc

    authors: Cooper GS,Yuan Z,Stange KC,Rimm AA

    更新日期:1998-08-15 00:00:00

  • The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases.

    abstract::This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841115)54:10<2137::aid-cncr282

    authors: Bonnin JM,Rubinstein LJ,Palmer NF,Beckwith JB

    更新日期:1984-11-15 00:00:00

  • Hypercalcemia may indicate Richter's syndrome: report of four cases and review.

    abstract:BACKGROUND:Hypercalcemia has rarely been reported in patients with Richter's syndrome (RS). In this article, the authors report four cases with complementary pathophysiologic examinations. METHODS:Four patients with hypercalcemia that indicated RS were admitted to the study unit between 1980 and 1994 with the followin...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Beaudreuil J,Lortholary O,Martin A,Feuillard J,Guillevin L,Lortholary P,Raphael M,Casassus P

    更新日期:1997-03-15 00:00:00

  • A case of AMMoL with 8/21 translocation and loss of the Y as probably secondary events.

    abstract::The clinical, hematological, and cytogenetic characteristics of a male patient with AMMoL are described. Before treatment a clone with the complex karyotype 45,X,del(7)(q32), t(8;21)(q22;q22) was present in the bone marrow. During partial remission induced by cytostatics, the percentage of normal cells increased, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800115)45:2<285::aid-cncr28204

    authors: Hustinx TW,Burghouts JT,Scheres JM,Smits AP

    更新日期:1980-01-15 00:00:00

  • Hormone receptor status of breast tumors in black, Hispanic, and non-Hispanic white women. An analysis of 13,239 cases.

    abstract:BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960415)77:8<1465::AID-CN

    authors: Gapstur SM,Dupuis J,Gann P,Collila S,Winchester DP

    更新日期:1996-04-15 00:00:00

  • Underestimation of malignancy of breast core-needle biopsy: concepts and precise overall and category-specific estimates.

    abstract:BACKGROUND:A review of the literature indicated variable underestimation rates for breast core-needle biopsy (CNB) based on generally small series. In this article, the authors present precise estimates for overall underestimation and for categories of histologic underestimates (including categories that reflect contem...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.22435

    authors: Houssami N,Ciatto S,Ellis I,Ambrogetti D

    更新日期:2007-02-01 00:00:00

  • Idiopathic thrombocytopenic purpura in Hodgkin's disease: a rare occurrence of no prognostic significance.

    abstract::Six patients with Hodgkin's disease who developed idiopathic thrombocytopenic purpura (ITP) are presented. In contrast to prior cases reported in the literature, none of these patients developed recurrent Hodgkin's disease at the time of or subsequent to their thrombocytopenia, with follow-up data available up to 10 y...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197802)41:2<743::aid-cncr2820410

    authors: Cohen JR

    更新日期:1978-02-01 00:00:00

  • Some observations concerning the demographic and geographic incidence of carcinoma of the lip and buccal cavity.

    abstract::The geographic and demographic data obtained during the Third National Cancer Survey have provided a perspective on etiologic factors and incidence trends for cancers of low frequency. The incidence of cancer of the lip, oral cavity and skin from this survey was compared to similar studies in 1947 and intra-regional p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197707)40:1<343::aid-cncr2820400

    authors: Szpak CA,Stone MJ,Frenkel EP

    更新日期:1977-07-01 00:00:00

  • Analysis of the levels of CA125, carcinoembryonic antigen, and CA19-9 in the cervical mucus for a detection of cervical adenocarcinoma.

    abstract::To verify whether analysis of the levels of CA125, carcinoembryonic antigen (CEA), and CA19-9 in the cervical mucus is effective for a detection of cervical adenocarcinomas or not, simultaneous measurement of these three tumor markers in the cervical mucus samples from women without gynecologic disorders, with leiomyo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880801)62:3<541::aid-cncr28206

    authors: Fujii S,Konishi I,Nanbu Y,Nonogaki H,Kobayashi F,Sagawa N,Mori T,Endo K

    更新日期:1988-08-01 00:00:00

  • Flow cytometric analysis of nuclear DNA from adrenocortical neoplasms. A retrospective study using paraffin-embedded tissue.

    abstract::Nuclear DNA content of paraffin-embedded tissue from 48 adrenocortical neoplasms, 18 histologically normal control adrenal glands, and five hyperplastic adrenal glands was analyzed retrospectively using flow cytometry. Aneuploidy was compared with morphologic criteria as a predictor of recurrence. All 18 controls, fiv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2091::aid-cncr282

    authors: Amberson JB,Vaughan ED Jr,Gray GF,Naus GJ

    更新日期:1987-06-15 00:00:00

  • Remission maintenance for acute nonlymphocytic leukemia: cytosine arabinoside plus 6-thioguanine versus a sequence of drug regimens.

    abstract::In order to determine whether the use of a sequence of chemotherapeutic regimens plus BCG could produce longer durations of remission in adult acute nonlymphocytic leukemia than maintenance therapy with cytosine arabinoside, 6-thioguanine, plus BCG, a randomized study was performed at Washington University. Upon achie...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19800701)46:1<22::aid-cncr282046

    authors: Presant CA,Berger NA,Klahr C,Phillips GL

    更新日期:1980-07-01 00:00:00

  • Hidden barriers between knowledge and behavior: the North Carolina prostate cancer screening and treatment experience.

    abstract:BACKGROUND:Prostate cancer (PC) mortality is much greater for African American than for Caucasian men. To identify patient factors that might account for some of this disparity, men within 6 months of diagnosis were surveyed about health attitudes and behavior. METHODS:Using Rapid Identification in the North Carolina ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22583

    authors: Talcott JA,Spain P,Clark JA,Carpenter WR,Do YK,Hamilton RJ,Galanko JA,Jackman A,Godley PA

    更新日期:2007-04-15 00:00:00

  • Adenocarcinoma of the proximal colon. Sites of initial dissemination and patterns of recurrence following surgery alone.

    abstract::Seven hundred ninety-five patients were adenocarcinomas of the proximal colon were reviewed. Two hundred forty-five patients presented with disseminated disease at the time of diagnosis, and were analyzed to identify mechanisms and sites of disease spread. Five hundred fifty patients underwent radical resection, and w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840115)53:2<360::aid-cncr28205

    authors: Russell AH,Tong D,Dawson LE,Wisbeck W

    更新日期:1984-01-15 00:00:00

  • Vincristine, dactinomycin, and cyclophosphamide in the treatment of malignant germ cell tumors of the ovary. A Gynecologic Oncology Group Study (a final report).

    abstract::Seventy-six patients with malignant germ cell tumors of the ovary received vincristine, dactinomycin, and cyclophosphamide (VAC) postoperatively. Fifty-four were treated after removal of all gross disease. The majority of these remain disease-free. Indeed, only 15 (28%) have failed, including 11 of 24 with pure endode...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850715)56:2<243::aid-cncr28205

    authors: Slayton RE,Park RC,Silverberg SG,Shingleton H,Creasman WT,Blessing JA

    更新日期:1985-07-15 00:00:00

  • A randomized clinical trial of energy conservation for patients with cancer-related fatigue.

    abstract:BACKGROUND:The efficacy of energy conservation and activity management (ECAM) for fatigue reduction and maintenance of functional performance has never been evaluated in adults with cancer who are undergoing treatment. METHODS:A randomized clinical trial compared an ECAM intervention with a control intervention focuse...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.20111

    authors: Barsevick AM,Dudley W,Beck S,Sweeney C,Whitmer K,Nail L

    更新日期:2004-03-15 00:00:00

  • Analysis of the presenting features of adult acute leukemia: the French-American-British classification.

    abstract::The authors have performed a clinical and statistical analysis of the presenting features of adult acute leukemia classified according to the French-American-British (FAB) hematopathologic criteria. Observations were made on 70 variables of history, physical examination, and laboratory examination recorded for 195 pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810515)47:10<2460::aid-cncr282

    authors: Burns CP,Armitage JO,Frey AL,Dick FR,Jordan JE,Woolson RF

    更新日期:1981-05-15 00:00:00