A case of AMMoL with 8/21 translocation and loss of the Y as probably secondary events.

Abstract:

:The clinical, hematological, and cytogenetic characteristics of a male patient with AMMoL are described. Before treatment a clone with the complex karyotype 45,X,del(7)(q32), t(8;21)(q22;q22) was present in the bone marrow. During partial remission induced by cytostatics, the percentage of normal cells increased, and a cell line having a 46,XY,del(7)(q32) karyotype was found. After four therapy courses, when remission was complete, only chromosomally normal cells were seen. The cytogenetic data suggest that in this case the 8/21 translocation and loss of the Y chromosome were only secondary events.

journal_name

Cancer

journal_title

Cancer

authors

Hustinx TW,Burghouts JT,Scheres JM,Smits AP

doi

10.1002/1097-0142(19800115)45:2<285::aid-cncr28204

subject

Has Abstract

pub_date

1980-01-15 00:00:00

pages

285-8

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

45

pub_type

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