Sequential cyclophosphamide and doxorubicin for induction of complete remission in children with disseminated neuroblastoma.

abstract：BACKGROUND:There are currently no systemic treatments for stage IV melanoma, which have been proven in randomized trials to benefit overall survival (OS). Lenalidomide has efficacy against melanoma in animal models and safety in phase 1 trials. The authors reported the results of a phase 2/3 study comparing the safety ...

journal_title：Cancer

authors： Glaspy J,Atkins MB,Richards JM,Agarwala SS,O'Day S,Knight RD,Jungnelius JU,Bedikian AY

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity of Akt and mTOR signaling...

journal_title：Cancer

authors： Akcakanat A,Sahin A,Shaye AN,Velasco MA,Meric-Bernstam F

更新日期：2008-06-01 00:00:00

abstract：:Increased in vitro tetraploidy occurred in skin cultures derived from all affected patients and some family members at risk studied in families with heritable colon cancer syndromes (15 of 16 Gardner syndrome families, three Oldfield syndrome families, and four families with heritable colon cancer syndrome without pol...

journal_title：Cancer

authors： Danes BS

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:The relation between undergoing a single computed tomography (CT) screening for lung carcinoma and the potential long-term impact on smoking status has been equivocal. Perhaps, recommendations from multiple cancer screenings may promote smoking abstinence among individuals at high risk for lung carcinoma. M...

journal_title：Cancer

authors： Townsend CO,Clark MM,Jett JR,Patten CA,Schroeder DR,Nirelli LM,Swensen SJ,Hurt RD

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostically challenging. Many cytologic features of Hurthle cell lesions t...

journal_title：Cancer

authors： Elliott DD,Pitman MB,Bloom L,Faquin WC

更新日期：2006-04-25 00:00:00

abstract：:A large lipoma and a large angiomyolipoma of the liver, one case each, are described. In the first case, a 24 X 14-cm homogeneous mass demonstrated a fatty density (-96H) on computed tomography (CT), echogenicity on sonography, and fine neovascular vessels on angiography in the right lobe of the liver. Histopathologic...

journal_title：Cancer

authors： Takayasu K,Shima Y,Muramatsu Y,Moriyama N,Yamada T,Makuuchi M,Hirohashi S

更新日期：1987-03-01 00:00:00

abstract：:In this review, I describe the polymerase chain reaction (PCR) and its application to cancer diagnostics. I present recent improvements to PCR methodology, and describe some state-of-the-art detection methods and approaches used to diagnose various cancer markers, including ras genes, BCR/abl translocations, and G-pro...

journal_title：Cancer

authors： Lyons J

更新日期：1992-03-15 00:00:00

abstract：:Laparoscopy is highly effective in diagnosing malignant liver disease, with overall accuracy in the 90% range. Up to 80% of the liver surface can be inspected, and biopsies can be directed with precision. A major advantage over scan guided percutaneous techniques is the ability to detect and biopsy lesions only a few ...

journal_title：Cancer

authors： Lightdale CJ

更新日期：1982-12-01 00:00:00

abstract：:The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...

journal_title：Cancer

authors： Sawabu N,Nakagen M,Ozaki K,Wakabayashi T,Toya D,Hattori N,Ishii M

更新日期：1983-01-15 00:00:00

abstract：BACKGROUND:The authors are interested in identifying molecular markers that can aid in the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their po...

journal_title：Cancer

authors： Patterson EE,Holloway AK,Weng J,Fojo T,Kebebew E

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:Hypothyroidism is a potential complication after radiation therapy (RT) when treatment fields include the thyroid. The authors assessed risk of hypothyroidism in breast cancer patients who were receiving RT to a supraclavicular field, which typically includes a portion of thyroid. METHODS:The authors identi...

journal_title：Cancer

authors： Smith GL,Smith BD,Giordano SH,Shih YC,Woodward WA,Strom EA,Perkins GH,Tereffe W,Yu TK,Buchholz TA

更新日期：2008-03-15 00:00:00

abstract：:Carcinoembryonic antigen (CEA) determinations performed in the milk of a nursing mother with an inoperable breast cancer revealed a 10-15-fold higher level compared with CEA levels in the milk of healthy nursing women. CEA was highly elevated in the milk of the tumor-bearing breast (1100 +/- 100 ng/ml) and moderately ...

journal_title：Cancer

authors： Bartal AH,Kahana L,Yarom J

更新日期：1980-11-01 00:00:00

abstract：:We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This repres...

journal_title：Cancer

authors： Valdez VA,Planas AT,Lopez VF,Goldberg M,Herrera NE

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Fas (CD95/APO-1) and Fas ligand (FasL) play key roles in immunologic homeostasis and immune privilege and may regulate normal cell turnover. Earlier studies had suggested that FasL-positive pancreatic carcinoma cell lines can induce apoptosis in T cells, thereby evading host immune surveillance. In the curre...

journal_title：Cancer

authors： Bernstorff WV,Glickman JN,Odze RD,Farraye FA,Joo HG,Goedegebuure PS,Eberlein TJ

更新日期：2002-05-15 00:00:00

abstract：:Malignant fibrous histiocytoma (MFH) was produced by injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) into the rat knee joint. The tumor was observed in or around the knee in nearly all the animals 13 to 36 weeks after the initial DMBA administration. Histologically, these lesions were of the storiform-pleomorphic...

journal_title：Cancer

authors： Sakamoto K

更新日期：1986-06-15 00:00:00

abstract：BACKGROUND:The authors hypothesized that comprehensive genomic profiling of advanced-stage cutaneous squamous cell carcinoma (cSCC) could identify genomic-derived drug targets of therapy for patients with conventional therapy-resistant disease. METHODS:Comprehensive genomic profiling of 315 cancer genes was applied to...

journal_title：Cancer

authors： Al-Rohil RN,Tarasen AJ,Carlson JA,Wang K,Johnson A,Yelensky R,Lipson D,Elvin JA,Vergilio JA,Ali SM,Suh J,Miller VA,Stephens PJ,Ganesan P,Janku F,Karp DD,Subbiah V,Mihm MC,Ross JS

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...

journal_title：Cancer

authors： Granter SR,Renshaw AA

更新日期：1997-04-25 00:00:00

abstract：:The endocrine action of medroxyprogesterone acetate (MPA) has been claimed to be of a glucocorticoid-like nature. Upon clinical observation, MPA has been shown to improve life quality and overall well-being in patients with advanced breast cancer, renal carcinoma, prostatic carcinoma, and uterine adenocarcinoma. The a...

journal_title：Cancer

authors： Lang I,Zielinski CC,Templ H,Spona J,Geyer G

更新日期：1990-11-01 00:00:00

abstract：:The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...

journal_title：Cancer

authors： Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

更新日期：1993-06-15 00:00:00

abstract：BACKGROUND:Race is associated with patterns of presentation and survival outcomes of gastric cancer in the United States. However, the impact of race on the receipt of guideline-recommended care is not well characterized. By using current recommendations, the authors examined the association between race and guideline-...

journal_title：Cancer

authors： Al-Refaie WB,Gay G,Virnig BA,Tseng JF,Stewart A,Vickers SM,Tuttle TM,Feig BW

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:In late reproductive-aged breast cancer survivors, there is a need for real-time biomarkers of postchemotherapy ovarian function. The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer t...

journal_title：Cancer

authors： Su HI,Sammel MD,Green J,Velders L,Stankiewicz C,Matro J,Freeman EW,Gracia CR,DeMichele A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Chemotherapy improves survival for patients with stage III colon cancer, but some older patients with lymph node-positive colon cancer do not see a medical oncologist and, thus, do not receive adjuvant chemotherapy. METHODS:To evaluate the role of the surgeon in determining referrals to medical oncology amo...

journal_title：Cancer

authors： Luo R,Giordano SH,Zhang DD,Freeman J,Goodwin JS

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the esophagus is endemic in parts of South Africa. Previous case-control studies have shown many associations but no clear etiologic pathway has been established. METHODS:A case-control study of dietary and social factors was performed for 130 patient/control pairs matched for age...

journal_title：Cancer

authors： Sammon AM

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:DNA ploidy and S-phase fraction measured by DNA flow cytometry were shown to correlate with several clinicopathologic characteristics in several types of tumors. METHODS:DNA flow cytometry was performed on 329 samples (164 normal mucosa, 165 tumors) obtained from 165 patients (112 men) with stomach cancer, ...

journal_title：Cancer

authors： Lee KH,Lee JS,Suh C,Ahn MJ,Kim SW,Doh BS,Min YI,Kim BS,Park KC,Lee IC

更新日期：1993-09-15 00:00:00

abstract：BACKGROUND:Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 ha...

journal_title：Cancer

authors： Campanella C,Rappa F,Sciumè C,Marino Gammazza A,Barone R,Bucchieri F,David S,Curcurù G,Caruso Bavisotto C,Pitruzzella A,Geraci G,Modica G,Farina F,Zummo G,Fais S,Conway de Macario E,Macario AJ,Cappello F

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...

journal_title：Cancer

authors： Liberman L,Freeman HP,Chandra S,Stein AL,McCord C,Godfrey D,Dershaw DD

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation (pCXCR4) and is essential for the migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts a poor prognosis in patients with acute myeloid leukemia. Data regarding the prognostic impact of CXCR4 in patients with B-acu...

journal_title：Cancer

authors： Konoplev S,Jorgensen JL,Thomas DA,Lin E,Burger J,Kantarjian HM,Andreeff M,Medeiros LJ,Konopleva M

更新日期：2011-10-15 00:00:00

abstract：:Oat-cell carcinoma of the thymus gland is exceedingly rare as a primary lesion, and only a few cases have been reported. We report a case in which a neoplasm interpreted as an oat-cell carcinoma was intimately associated with and arose in transition from a carcinoid tumor of the thymus. Ultrastructural features of thi...

journal_title：Cancer

authors： Wick MR,Scheithauer BW

更新日期：1982-04-15 00:00:00

abstract：BACKGROUND:Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences in factors that influence the course of disease. Furthermore, those studies were conducted when the currently accepted standards in diagnostics and therapy had not been fully established. The o...

journal_title：Cancer

authors： Güth U,Huang DJ,Bauer G,Stieger M,Wight E,Singer G

更新日期：2007-09-15 00:00:00

abstract：:Variation in response rates to chemotherapy and survival in patients with hepatic metastases from colorectal carcinoma may be due to patient selection factors. The prognostic importance of 13 factors were analyzed in 112 patients with only hepatic metastases, who were eligible for hepatic artery infusional chemotherap...

journal_title：Cancer

authors： Kemeny N,Niedzwiecki D,Shurgot B,Oderman P

更新日期：1989-02-15 00:00:00