Abstract:
:In this review, I describe the polymerase chain reaction (PCR) and its application to cancer diagnostics. I present recent improvements to PCR methodology, and describe some state-of-the-art detection methods and approaches used to diagnose various cancer markers, including ras genes, BCR/abl translocations, and G-proteins.
journal_name
Cancerjournal_title
Cancerauthors
Lyons Jdoi
10.1002/1097-0142(19920315)69:6+<1527::aid-cncr282subject
Has Abstractpub_date
1992-03-15 00:00:00pages
1527-31issue
6 Suppleissn
0008-543Xissn
1097-0142journal_volume
69pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::Three children with ALL having poor prognostic features developed clinical and laboratory evidence of disseminated intravascular coagulation (DIC). Two developed a bleeding diathesis associated temporally with a rapid drop in blast cell counts during induction therapy with L-asparaginase, prednisone, and vincristine. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197804)41:4<1642::aid-cncr282041
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Epithelioid sarcoma is a highly malignant soft tissue tumor that is largely resistant to conventional chemotherapy and radiotherapy. Because paclitaxel has been proven to be effective in other human malignancies refractory to conventional chemotherapy, the authors analyzed the in vitro growth inhibitory effe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000401)88:7<1614::aid-cn
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Little is understood about the factors that influence survival in patients who undergo gamma-knife stereotactic radiosurgery (SRS) for brain metastases. METHODS:Demographic, disease, treatment, and survival data on 334 patients with intracranial metastases who underwent initial SRS from 1998 to 2004 were ab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22367
更新日期:2007-01-01 00:00:00
abstract::Malignant schwannomas with rhabdomyoblastic differentiation have been termed malignant "Triton" tumors (MTT). To define the natural history of MTT, we have analyzed our experience (9 cases, the largest series reported) in combination with the 27 previously described in the literature (total 36 cases). This study was i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850601)55:11<2543::aid-cncr282
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:To describe continuing care and rehabilitation needs of cancer patients, a longitudinal design (6 months) was performed among patients 50 years of age and older with solid tumors. The study examined how age, type of treatment, site of cancer, and symptom experience affect physical functioning and their menta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941001)74:7+<2128::aid-cncr282
更新日期:1994-10-01 00:00:00
abstract::This paper reports the prognosis results of a retrospective study of over 2000 cases of uterine cervix carcinoma totally treated at Institut Gustave-Roussy from 1950 to 1963. From the study of their long-term survival, an overall cure rate was estimated at 49% seven years after the start of primary treatment. A study ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810101)47:1<203::aid-cncr28204
更新日期:1981-01-01 00:00:00
abstract::Of a total of 1561 patients registered in the Intergroup Rhabdomyosarcoma Study (IRS) as of May 1983, 78 patients (5%) were younger than 1 year of age. These infants did not differ from the older children (1-20 years of age) in male/female ratio, clinical grouping, or survival rates. Infants younger than 1 year of age...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861215)58:12<2606::aid-cncr282
更新日期:1986-12-15 00:00:00
abstract:BACKGROUND:Cirrhosis of viral etiology due to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for hepatocellular carcinoma (HCC). The current study evaluated the rate of incidence of HCC in patients with compensated cirrhosis of viral etiology. METHODS:Two hundred fifty-nine cirrhotic pat...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. METHODS:Eli...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.32057
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The AJCC staging system and post-operative nomograms use patient and tumor characteristics to provide prognostic estimates after resection of retroperitoneal sarcoma (RPS). While these variables help to predict survival at the time of diagnosis and resection, the applicability of these prognostic factors to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26665
更新日期:2012-07-01 00:00:00
abstract::Ninety-five patients with non-oat cell lung cancer underwent resection of all apparent disease and were followed for a minimum of 36 months. Incidence of recurrence was 34% in 47 patients with N0 disease, 65% in 32 patients with N1 disease, and 81.3% in 16 patients with N2 disease (P less than 0.02 and P less than 0.0...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860201)57:3<471::aid-cncr28205
更新日期:1986-02-01 00:00:00
abstract::A retrospective analysis of a series of 162 patients treated for isolated chest wall recurrence of breast cancer after mastectomy was undertaken. Cumulative survival, distant relapse-free survival, and freedom from local progression after 5 years from the diagnosis of recurrence were 34%, 28%, and 45% respectively. Fi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870715)60:2<240::aid-cncr28206
更新日期:1987-07-15 00:00:00
abstract:BACKGROUND:The effects of relaxin (RLX) on the human breast adenocarcinoma cell line MCF-7 have been evaluated. METHODS:The cells were maintained in culture with Dulbecco's modified Eagle's medium with 1% and 10% fetal calf serum. Highly purified porcine RLX was added at concentrations ranging between 10(-11) and 10(-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920801)70:3<639::aid-cncr28207
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS:A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cance...
journal_title:Cancer
pub_type: 共识发展会议,杂志文章,评审
doi:10.1002/cncr.30380
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Although cervical carcinoma incidence and mortality rates have declined in the U.S. greatly since the introduction of the Papanicolaou smear, this decline has not been uniform for all histologic subtypes. Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and ad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20064
更新日期:2004-03-01 00:00:00
abstract::With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930515)71:10+<3406::aid-cncr28
更新日期:1993-05-15 00:00:00
abstract::Thirty-one patients were treated with cisplatin combination chemotherapy for advanced seminoma (26 Stage III or bulky Stage II testicular, and five disseminated extragonadal). Seventeen (89%) of 19 patients not previously pretreated and four (80%) of five who had received only abdominal irradiation entered continuous ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1625::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract::The various radiologic methods used in the detection of hepatic lesions in the oncologic patient are discussed. The advantages and disadvantages of each imaging technique as well as a new diagnostic approach are also discussed. With the rapid technological advances made in cross-sectional imaging, the authors believe ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Serum alpha-L-fucosidase activity is considered a marker of hepatocellular carcinoma. To the authors' knowledge, its clinical usefulness in the early detection of hepatocellular carcinoma in the follow-up of cirrhotic patients has not been reported previously. METHODS:The authors prospectively studied serum...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21853
更新日期:2006-05-15 00:00:00
abstract:BACKGROUND:Although < 1% of men present with prostate-specific antigen (PSA)-negative prostate carcinoma, in that they have serum PSA levels much lower than the tumor burden would suggest, such patients represent a management dilemma. To the authors' knowledge, little information exists in the literature regarding patt...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11821
更新日期:2003-12-01 00:00:00
abstract::A case of fatal acute hepatic vein thrombosis occurred during treatment for Hodgkin's disease. At necropsy no evidence of Hodgkin's disease or obliterative venoocclusive disease of the liver was found. We speculate that Adriamycin, DTIC and/or vinblastine may have been responsible for this unusual disorder. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2324::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract::There is currently no adequate staging system for cerebral astrocytomas. A scheme for acquiring data that can be used to stage cerebral hemisphere tumors is suggested. This data base, in conjunction with treatment and survival information, may be useful in the management of childhood hemispheric tumors. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7+<1784::aid-cncr282
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc
更新日期:1997-04-25 00:00:00
abstract::Twenty-two patients received specific active immunotherapy (TAA vaccine once per month for 3 months), with the duration of follow-up, as of July 1984, ranging from 3 months to 36 months (median, 21 months). Of these, seven had Dukes B2, seven had Dukes C, and eight had Dukes D lesions. All received surgical resection,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<480::aid-cncr28205
更新日期:1985-08-01 00:00:00
abstract::The Nb rat prostatic adenocarcinoma is a well-characterized, hormonally induced family of tumors that are all readily transplantable into congenitally athymic (nude) mice. Because of this versatile heterotransplantation model, multiple replicate copies of individual tumors can be studied "in rodent." We have extended ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197908)44:2<424::aid-cncr2820440
更新日期:1979-08-01 00:00:00
abstract::Twelve patients with pulmonary neoplasms treated at the Fox Chase Cancer Center were found to have a syndrome of axillary-subclavian vein occlusion. Ten patients had non-small-cell lung carcinoma, one had small cell carcinoma, and one had mesothelioma. In eight patients, this vascular syndrome developed as a consequen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811015)48:8<1886::aid-cncr2820
更新日期:1981-10-15 00:00:00
abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27401
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Pancreatic-duodenal homeobox 1 (PDX-1) is a transcription factor that regulates embryologic pancreas development and insulin expression in the adult islet; however, it is overexpressed in many types of cancer, including pancreatic cancer. The purpose of this study was to investigate the role of PDX-1 in tumo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25629
更新日期:2011-02-15 00:00:00
abstract::The records of all 27 adult patients (age, greater than or equal to 16 years) diagnosed with cerebellar medulloblastoma between 1968 and 1986 were reviewed. Twenty-four patients (89%) were treated with postoperative megavoltage irradiation. Twenty of these patients underwent craniospinal irradiation. Sixteen patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920415)69:8<2143::aid-cncr2820
更新日期:1992-04-15 00:00:00