Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy.

Abstract:

:An analysis of patterns of relapse from complete remission in patients with non-Hodgkin's lymphoma treated with combination chemotherapy has demonstrated differences between histologic subgroups. Patients with diffuse histiocytic lymphoma who achieved a histologically proven complete remission after 6 months of treatment without maintenance have remained disease-free whereas those with nodular poorly differentiated lymphocytic and diffuse well-differentiated lymphocytic lymphomas have demonstrated a pattern of continuous late recurrence. The initial sites of relapse from complete remission in lymphocytic lymphoma were lymph nodes and bone marrow which were involved prior to treatment. Aggressive attempts at remission induction appear warranted in patients with diffuse histiocytic lymphoma because of the potential for extended disease-free survival. Patients with nodular poorly differentiated lymphocytic lymphoma may benefit from the use of maintenance chemotherapy, or radiotherapy to regions of previously known involvement after initiation of remission with chemotherapy.

journal_name

Cancer

journal_title

Cancer

authors

Schein PS,Chabner BA,Canellos GP,Young RC,DeVita VT Jr

doi

10.1002/1097-0142(197502)35:2<354::aid-cncr2820350

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

354-7

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

35

pub_type

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