Abstract:
:An analysis of patterns of relapse from complete remission in patients with non-Hodgkin's lymphoma treated with combination chemotherapy has demonstrated differences between histologic subgroups. Patients with diffuse histiocytic lymphoma who achieved a histologically proven complete remission after 6 months of treatment without maintenance have remained disease-free whereas those with nodular poorly differentiated lymphocytic and diffuse well-differentiated lymphocytic lymphomas have demonstrated a pattern of continuous late recurrence. The initial sites of relapse from complete remission in lymphocytic lymphoma were lymph nodes and bone marrow which were involved prior to treatment. Aggressive attempts at remission induction appear warranted in patients with diffuse histiocytic lymphoma because of the potential for extended disease-free survival. Patients with nodular poorly differentiated lymphocytic lymphoma may benefit from the use of maintenance chemotherapy, or radiotherapy to regions of previously known involvement after initiation of remission with chemotherapy.
journal_name
Cancerjournal_title
Cancerauthors
Schein PS,Chabner BA,Canellos GP,Young RC,DeVita VT Jrdoi
10.1002/1097-0142(197502)35:2<354::aid-cncr2820350subject
Has Abstractpub_date
1975-02-01 00:00:00pages
354-7issue
2eissn
0008-543Xissn
1097-0142journal_volume
35pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Among patients with core-needle biopsy (CNB)-diagnosed ductal carcinoma in situ (DCIS), the guidelines for the selection of patients to undergo sentinel lymph node (SLN) biopsy are not well defined, and many patients with no invasion undergo an unnecessary SLN biopsy. The objective of this study was to ident...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22216
更新日期:2006-10-15 00:00:00
abstract::A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800215)45:4<824::aid-cncr28204
更新日期:1980-02-15 00:00:00
abstract:BACKGROUND:Racial disparity in the incidence of multiple myeloma is well established; however, to the authors' knowledge, little is known regarding the impact of racial differences on disease characteristics, response to therapy, and clinical outcome. METHODS:The authors studied 453 patients (174 of whom were black an...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.29160
更新日期:2015-04-01 00:00:00
abstract::Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197808)42:2<570::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene resulting from the chromosome inversion inv(2)(p21;p23) recently was identified in nonsmall cell lung cancer (NSCLC). The authors of this study investigated the frequency, genetic and clinicopathologic prof...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24181
更新日期:2009-04-15 00:00:00
abstract::The geographic and demographic data obtained during the Third National Cancer Survey have provided a perspective on etiologic factors and incidence trends for cancers of low frequency. The incidence of cancer of the lip, oral cavity and skin from this survey was compared to similar studies in 1947 and intra-regional p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197707)40:1<343::aid-cncr2820400
更新日期:1977-07-01 00:00:00
abstract::The clinical course of a 33-year-old man with generalized lymphadenopathy bearing all physical, laboratory and histologic characteristics of "angio-immunoblastic lymphadenopathy with dysproteinemia" (AILD) is described. Therapy was without significant benefit and the patient died 22 months after initial diagnosis. At ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2183::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Some vasoactive drugs have been studied in the hope of altering the vascular permeability and/or blood of tumors to enhance monoclonal antibody (MoAb) uptake. The pretreatment of interleukin-2 (IL-2), one of the vasoactive reagents, produced a generalized vascular permeability, but its function was not tumor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971215)80:12+<2650::aid-
更新日期:1997-12-15 00:00:00
abstract::In this retrospective study, the degree of differentiation of atypical lymphoid cells was assessed in pretreatment cutaneous biopsy specimens from 248 patients with cutaneous T-cell lymphomas (mycosis fungoides and Sézary syndrome) and the findings were correlated with the subsequent therapeutic results. Overall, pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810101)47:1<119::aid-cncr28204
更新日期:1981-01-01 00:00:00
abstract::The efficacy of trioxifene mesylate, a new antiestrogen, in the management of advanced breast cancer was evaluated in 69 patients. Fifty-two patients were randomly allocated to dose schedules of 5 mg, 10 mg, and 20 mg orally twice daily. There were five complete responders (10%), 22 partial responders (42%), and 9 pat...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19860101)57:1<40::aid-cncr282057
更新日期:1986-01-01 00:00:00
abstract::A specimen from the small intestine with multiple (three) classic carcinoid tumors and one appendiceal carcinoid tumor displaying argentaffinity, argyrophilia (Grimelius stain), and serotonin and neuron specific enolase immunoreactivity was examined by light microscopy with regard to the tumor cell histopathogenesis. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870715)60:2<201::aid-cncr28206
更新日期:1987-07-15 00:00:00
abstract::The ability of infantile hypercalcemic tumors (three rhabdoid renal tumors, one cellular mesoblastic nephroma, and one hepatoblastoma) to produce parathyroid hormone (PTH) was tested using RNA-DNA hybridization. Results were compared with those obtained in one lung epidermoid carcinoma and one parathyroid adenoma from...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880715)62:2<303::aid-cncr28206
更新日期:1988-07-15 00:00:00
abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<616::aid-cncr282054040
更新日期:1984-08-15 00:00:00
abstract:BACKGROUND:Cancers of individual organs generally are composed of various histologic types, each with its own frequency and demographic patterns. For childhood cancers in particular, a classification of cancers by histologic type is important for understanding the etiology and progression of the disease. METHODS:Data ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950101)75:1+<395::aid-cncr2820
更新日期:1995-01-01 00:00:00
abstract::The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900715)66:2<354::aid-cncr28206
更新日期:1990-07-15 00:00:00
abstract::Studies of calcium metabolism in 38 patients with cancer indicated that: 1) intestinal absorption of calcium was reduced in patients with skeletal metastases and in those with hypercalcemia; 2) calcium-47 space (a measurement of bone turnover rate) was high in the patients with skeletal metastases; 3) hypercalcemic pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197611)38:5<2111::aid-cncr282038
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960915)78:6<1267::AID-CN
更新日期:1996-09-15 00:00:00
abstract::Twenty-one cases of clear cell adenocarcinoma of the cervix and vagina have been reviewed. Fifteen cases occurred in females under 25 years of age and four in women over 45 years. In seven cases, a positive history of maternal ingestion of diethylstilbestrol (DES) was obtained. One mother gave a history of medication ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<858::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::A Chinese patient with documented hepatocellular carcinoma (HCC) satisfied the criteria of Everson and Cole for spontaneous regression of malignant tumors. Subsequently he survived a tumor-free period of at least 13 years. During the period of regression, shrinkage of liver coincided with a rise of SGOT to a level com...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<332::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNA) has been successful in diagnosing epithelial lesions of the breast. Its role in the evaluation of spindle cell and mesenchymal lesions of the breast, which include a variety of benign and malignant conditions, is less clear. This article discusses the cytologic features an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991225)87:6<359::aid-cnc
更新日期:1999-12-25 00:00:00
abstract::The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the author...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<353::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::Flow cytometry examinations (FCM) were carried out on 110 bladder irrigation specimens from 84 urologic outpatients who had had prior conservative treatment for low stage bladder tumors. The specimens were easily obtained, and adequately cellular in all cases. Of 60 examinations on patients with no cytoscopic abnormal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<109::aid-cncr28204
更新日期:1982-01-01 00:00:00
abstract::Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870401)59:7<1376::aid-cncr2820
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:Since mid-1987, 29 patients with invasive transitional cell carcinoma of the urinary bladder (T1-3 N0-X M0) were treated with concurrent radiation therapy (RT) (target dose [TD], 62-66 Gy) 1.8-2.0 Gy/day for 5 days a week with a break in the middle of treatment of 2-3 weeks and vinblastine weekly 2 mg/5-12 h...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921215)70:12<2885::aid-cncr282
更新日期:1992-12-15 00:00:00
abstract:BACKGROUND:Although protein expressions of glucocorticoid receptor (GR), estrogen receptors (ERα and ERβ), progesterone receptor A (PgR-A), and androgen receptor (AR) were shown to play roles in the growth and differentiation of normal thymus and thymic tumors, to the authors' knowledge their association with patient c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26061
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:National Cancer Institute of Canada Clinical Trials Group PA.3 (NCIC CTG PA.3) was a phase 3 study (n = 569) that demonstrated benefits for overall survival and progression-free survival with the addition of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib to gemcitabine ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.25393
更新日期:2010-12-15 00:00:00
abstract::The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been foun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830601)51:11<2105::aid-cncr282
更新日期:1983-06-01 00:00:00
abstract::The design of many antineoplastic agents has been based on atom or group replacement in normal metabolites. New dimensions are being added to this approach by the synthesis of transition state, bisubstrate and "suicide" inhibitors. These provide greater potency and in some cases selectivity. Leads for differential sen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197707)40:1+<529::aid-cncr282040
更新日期:1977-07-01 00:00:00
abstract::This trial determines the feasibility for patients with resectable Stages III/IV head and neck cancer who achieved a complete response to induction chemotherapy of eliminating surgery from their treatment program. Thirty patients were treated with three cycles of cisplatin and 5-fluorouracil (5-FU), followed by reendo...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870915)60:6<1178::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract:BACKGROUND:Human breast cancers frequently show loss of heterozygosity (LOH) and/or amplification at specific chromosomal regions. METHODS:To investigate the roles of these genetic alterations during tumor development and/or progression, 457 cases of primary breast cancer were examined for LOH at chromosomal regions 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941015)74:8<2281::aid-cncr2820
更新日期:1994-10-15 00:00:00