Abstract:
BACKGROUND:Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS:Four (of approximately 40) patients with AIDS and PCNSL seen by the University of California, San Diego (UCSD) Neuro-Oncology service were treated with multimodal therapy, including WBI with hydroxyurea, followed by 3 cycles of procarbazine/lomustine/vincristine (PCV) chemotherapy. RESULTS:Survival after tumor diagnosis ranged from 11 to 16 months, with a median of 13.5 months. CONCLUSION:Selected patients with AIDS and PCNSL may have long survival when treated with multimodal therapy.
journal_name
Cancerjournal_title
Cancerauthors
Chamberlain MCdoi
10.1002/1097-0142(19940315)73:6<1728::aid-cncr2820subject
Has Abstractpub_date
1994-03-15 00:00:00pages
1728-30issue
6eissn
0008-543Xissn
1097-0142journal_volume
73pub_type
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