Long survival in patients with acquired immune deficiency syndrome-related primary central nervous system lymphoma.

Abstract:

BACKGROUND:Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS:Four (of approximately 40) patients with AIDS and PCNSL seen by the University of California, San Diego (UCSD) Neuro-Oncology service were treated with multimodal therapy, including WBI with hydroxyurea, followed by 3 cycles of procarbazine/lomustine/vincristine (PCV) chemotherapy. RESULTS:Survival after tumor diagnosis ranged from 11 to 16 months, with a median of 13.5 months. CONCLUSION:Selected patients with AIDS and PCNSL may have long survival when treated with multimodal therapy.

journal_name

Cancer

journal_title

Cancer

authors

Chamberlain MC

doi

10.1002/1097-0142(19940315)73:6<1728::aid-cncr2820

subject

Has Abstract

pub_date

1994-03-15 00:00:00

pages

1728-30

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

73

pub_type

杂志文章

相关文献

CANCER文献大全
  • Mutations of the p53 gene in male breast cancer.

    abstract:BACKGROUND:Cancer of the male breast (MBC) is rare, accounting for less than 1% of cancer in males and representing less than 1% of all breast cancers. Reports of abnormalities in the expression of the tumor suppressor gene p53 in MBC have been few. METHODS:To assess the expression and mutations of the p53 gene, 35 pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950501)75:9<2233::aid-cncr2820

    authors: Anelli A,Anelli TF,Youngson B,Rosen PP,Borgen PI

    更新日期:1995-05-01 00:00:00

  • Atypical glandular cells of undetermined significance: clinically significant lesions and means of patient follow-up.

    abstract:BACKGROUND:The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients. METHODS:Computerized records from the authors' institu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Soofer SB,Sidawy MK

    更新日期:2000-08-25 00:00:00

  • The impact of conventional plus high dose chemotherapy with autologous bone marrow transplantation on hematologic toxicity during subsequent local-regional radiotherapy for breast cancer.

    abstract:BACKGROUND:Forty patients with Stage II-III breast cancer with 10 or more positive axillary nodes were treated with mastectomy followed by four cycles of standard dose CAF (cytoxan, Adriamycin, 5-FU), followed by high dose cytoxan, cisplatin, carmustine (HDCT) with autologous bone marrow transplant support (ABMT), and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941201)74:11<2964::aid-cncr282

    authors: Marks LB,Rosner GL,Prosnitz LR,Ross M,Vredenburgh JJ,Peters WP

    更新日期:1994-12-01 00:00:00

  • Gangliosides of human melanoma.

    abstract::Human melanoma synthesizes a large quantity of gangliosides, glycosphingolipids containing sialic acid. The authors previously have demonstrated that the ganglioside profile differs among individual melanomas and is widely heterogeneous. In the current study, a retrospective study was performed to compare the relation...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890315)63:6<1166::aid-cncr2820

    authors: Tsuchida T,Saxton RE,Morton DL,Irie RF

    更新日期:1989-03-15 00:00:00

  • Cardiac synovial sarcoma with translocation (X;18) associated with asbestos exposure.

    abstract::A primary cardiac spindle cell tumor with immunoreactivity for keratin proteins is reported. Cytogenetic analysis of the tumor demonstrated a translocation (X;18), an aberration almost exclusively reported in synovial sarcomas. Postmortem examination revealed amphibole asbestos within the lungs and diaphragmatic pleur...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940101)73:1<74::aid-cncr282073

    authors: Karn CM,Socinski MA,Fletcher JA,Corson JM,Craighead JE

    更新日期:1994-01-01 00:00:00

  • Effects of hepatic arterial yttrium 90 glass microspheres in dogs.

    abstract::A 22-micron glass microsphere called TheraSphere (Theragenics Corp., Atlanta, GA) has been developed in which yttrium 89 oxide is incorporated into the glass matrix and is activated by neutron bombardment to form the beta-emitting isotope yttrium 90 (Y 90) before using the spheres as radiotherapeutic vehicles. The inj...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880401)61:7<1336::aid-cncr2820

    authors: Wollner I,Knutsen C,Smith P,Prieskorn D,Chrisp C,Andrews J,Juni J,Warber S,Klevering J,Crudup J

    更新日期:1988-04-01 00:00:00

  • Is axillary lymph node dissection necessary in elderly patients with breast carcinoma who have a clinically uninvolved axilla?

    abstract:BACKGROUND:Axillary dissection in elderly patients with early-stage breast carcinoma who do not have palpable axillary lymph nodes is controversial because of the associated morbidity of the surgery, reduced life expectancy of the patients, and efficacy of hormone therapy in preventing recurrences and axillary events. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11173

    authors: Martelli G,Miceli R,De Palo G,Coradini D,Salvadori B,Zucali R,Galante E,Marubini E

    更新日期:2003-03-01 00:00:00

  • The sequential changes in DNA synthesis, glucose utilization, protein synthesis, and peripheral benzodiazepine receptor density in C6 brain tumors after chemotherapy to predict the response of tumors to chemotherapy.

    abstract:BACKGROUND:Monitoring therapy in patients with brain tumors is very difficult and unreliable. It has been shown that there is no good correlation between tumor sensitivity measured in vitro and in situ tumor response to therapies. METHODS:Sequential changes in tumor size, number of DNA synthesizing cells (labelling in...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19960315)77:6<1167::aid-cn

    authors: Takeda N,Diksic M,Yamamoto YL

    更新日期:1996-03-15 00:00:00

  • Gross and histological types of early gastric carcinomas in relation to the acid-secreting area.

    abstract::The relation of gastric acid-secreting function to the gross and histological types and locations of carcinomas was examined in 53 patients with early gastric carcinomas. Studies were made by the endoscopic Congo red test developed in this clinic. Results indicated a close correlation between the gross and histologica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197901)43:1<317::aid-cncr2820430

    authors: Tatsuta M,Okuda S,Taniguchi H,Tamura H

    更新日期:1979-01-01 00:00:00

  • Cyclophosphamide-induced ovarian failure and its therapeutic significance in patients with breast cancer.

    abstract::The effect of cyclophosphamide (CY) on ovarian function was studied in patients with breast cancer receiving prolonged daily administration of this agent (100 mg/day) after radical surgery. Out of 18 premenopausal patients that received 8.4-39.9 g CY, 15 developed permanent amenorrhea. The average dose given before th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197704)39:4<1403::aid-cncr282039

    authors: Koyama H,Wada T,Nishizawa Y,Iwanaga T,Aoki Y

    更新日期:1977-04-01 00:00:00

  • Metastatic carcinoma. The lung as the site for the clinically undiagnosed primary.

    abstract::Of 387 patients who died with lung cancer, 28 cases were reviewed (7.2%) which were clinically undiagnosed. The male:female ratio was 3.6 and mean age was 64 years in the males, 47 years in the females. The most frequent presenting symptoms were neurologic. Prior to death, 21 patients had known or suspected metastatic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830115)51:2<362::aid-cncr28205

    authors: Clary CF,Michel RP,Wang NS,Hanson RE

    更新日期:1983-01-15 00:00:00

  • A VM 26-based regimen for patients with previously untreated non-Hodgkin lymphoma. Prolonged disease-free survival in patients younger than 60 years of age: a phase II trial of the eastern Cooperative Oncology Group.

    abstract:BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19930115)71:2<464::aid-cncr28207

    authors: Gordon LI,Andersen J,Gregory S,Mazza J,Chervenick P,Hahn RG,O'Connell MJ

    更新日期:1993-01-15 00:00:00

  • Prognostic factors in the diagnosis and treatment of primary central nervous system lymphoma.

    abstract::The authors describe the results of multimodality therapy in 27 patients with biopsy-proven primary central nervous system (CNS) lymphoma treated between 1976 and 1986. Treatment included surgical resection (15 patients), radiotherapy (27 patients), and chemotherapy (nine patients). Actuarial survival rates for the 27...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890301)63:5<939::aid-cncr28206

    authors: Pollack IF,Lunsford LD,Flickinger JC,Dameshek HL

    更新日期:1989-03-01 00:00:00

  • Prognostic factors in gliomas. A multivariate analysis of clinical, pathologic, flow cytometric, cytogenetic, and molecular markers.

    abstract:BACKGROUND:The ability to divide subsets of patients with glial neoplasms into prognostic groups currently is limited because only a few clinical and pathologic variables are available. The goal of this investigation was to identify biologic factors of potential prognostic value in patients with cerebral gliomas. METH...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<920::aid-cncr28207

    authors: Ganju V,Jenkins RB,O'Fallon JR,Scheithauer BW,Ransom DT,Katzmann JA,Kimmel DW

    更新日期:1994-08-01 00:00:00

  • Survival outcome of adjuvant chemotherapy in deficient mismatch repair stage III colon cancer.

    abstract:BACKGROUND:The prognostic impact of DNA mismatch repair (MMR) status remains controversial in patients with stage III colon cancer who are treated with adjuvant chemotherapy (AC). The aim of this study was to evaluate the survival outcome of AC in deficient mismatch repair (dMMR)/microsatellite instable (MSI) stage III...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33049

    authors: Shaib WL,Zakka KM,Jiang R,Yan M,Alese OB,Akce M,Wu C,Behera M,El-Rayes BF

    更新日期:2020-09-15 00:00:00

  • A nonfunctioning paraganglioma of vagus nerve: an ultrastructural study.

    abstract::The clinical, histological, and ultrastructural aspects of a cervical paraganglioma of the vagus nerve, in a 66-year-old white man, have been discussed in detail. Ultrastructurally, the tumor chief cells contained characteristic membrane-bound and dense-cored neurosecretory granules which ranged in size from 85 millim...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197905)43:5<1689::aid-cncr282043

    authors: Chaudhry AP,Haar JG,Koul A,Nickerson PA

    更新日期:1979-05-01 00:00:00

  • Real-time tumor-tracking radiation therapy for lung carcinoma by the aid of insertion of a gold marker using bronchofiberscopy.

    abstract:BACKGROUND:The authors developed fluoroscopic real-time tumor-tracking radiation therapy (RTRT) by insertion of a gold marker using bronchofiberscopy to reduce uncertainties in organ motion and set-up error in external radiotherapy for moving tumors. The purpose of the current study was to evaluate RTRT's feasibility i...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.10856

    authors: Harada T,Shirato H,Ogura S,Oizumi S,Yamazaki K,Shimizu S,Onimaru R,Miyasaka K,Nishimura M,Dosaka-Akita H

    更新日期:2002-10-15 00:00:00

  • Factors influencing survival of children with nonmetastatic neuroblastoma.

    abstract::A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphoc...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197608)38:2<661::aid-cncr2820380

    authors: Evans AE,Albo V,D'Angio GJ,Finklestein JZ,Leiken S,Santulli T,Weiner J,Hammond GD

    更新日期:1976-08-01 00:00:00

  • Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.

    abstract::This protocol study (SWOG-7431) combining adriamycin and methyl CCNU (MAD) for metastatic sarcomas was initially used on patients who were refractory to cytoxan, vincristine, and/or actinomycin-D. After the initial good results, the study was expanded to include any untreated patients with metastatic sarcoma. The init...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800801)46:3<446::aid-cncr28204

    authors: Rivkin SE,Gottlieb JA,Thigpen T,El Mawla NG,Saiki J,Dixon DO

    更新日期:1980-08-01 00:00:00

  • MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy.

    abstract:BACKGROUND:The authors are interested in identifying molecular markers that can aid in the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their po...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25724

    authors: Patterson EE,Holloway AK,Weng J,Fojo T,Kebebew E

    更新日期:2011-04-15 00:00:00

  • Ultrastructural observations on the histogenesis of alveolar rhabdomyosarcoma.

    abstract::Ultrastructural examination of an alveolar rhabdomyosarcoma revealed that the bulk of the tumor was composed of small polygonal cells containing polyribosomes, short strands of rough endoplasmic reticulum, and variable amounts of glycogen; the cells were joined by small desmosome-like structures. Similar cells, as wel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197804)41:4<1355::aid-cncr282041

    authors: Churg A,Ringus J

    更新日期:1978-04-01 00:00:00

  • Intent and subsequent initiation of human papillomavirus vaccine among young cancer survivors.

    abstract:BACKGROUND:Despite an increased risk of subsequent human papillomavirus (HPV)-related malignancies, HPV vaccine initiation rates among cancer survivors remain critically low. The purpose of this study was to determine the relationship between HPV vaccine intent and subsequent vaccine initiation among cancer survivors b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32379

    authors: Cherven B,Castellino SM,Chen Y,Wong FL,York JM,Wasilewski-Masker K,Hudson MM,Bhatia S,Klosky JL,Landier W

    更新日期:2019-11-01 00:00:00

  • Reduced-intensity conditioning with fludarabine and busulfan versus fludarabine and melphalan for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.

    abstract:BACKGROUND:Fludarabine plus busulfan (FB) and fludarabine plus melphalan (FM) are 2 widely used reduced-intensity conditioning (RIC) regimens for allogeneic hematopoietic stem cell transplantation (allo-SCT). METHODS:The current survey compared transplantation outcomes for a cohort of 394 acute myeloid leukemia (AML) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29163

    authors: Baron F,Labopin M,Peniket A,Jindra P,Afanasyev B,Sanz MA,Deconinck E,Nagler A,Mohty M

    更新日期:2015-04-01 00:00:00

  • Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista

    abstract:BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20571

    authors: Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

    更新日期:2004-10-15 00:00:00

  • Diffuse pagetoid squamous cell carcinoma in situ of the esophagus: a case report.

    abstract:BACKGROUND:In Western countries, esophageal squamous cell carcinoma is usually advanced at presentation and is rarely diagnosed in situ. The authors studied an in situ squamous cell carcinoma that occupied the entire mucosa of a 9 cm length of esophagus, causing dysphagia for solid food in a woman aged 68 years. METHO...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Chu P,Stagias J,West AB,Traube M

    更新日期:1997-05-15 00:00:00

  • Risk of hypothyroidism in older breast cancer patients treated with radiation.

    abstract:BACKGROUND:Hypothyroidism is a potential complication after radiation therapy (RT) when treatment fields include the thyroid. The authors assessed risk of hypothyroidism in breast cancer patients who were receiving RT to a supraclavicular field, which typically includes a portion of thyroid. METHODS:The authors identi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23307

    authors: Smith GL,Smith BD,Giordano SH,Shih YC,Woodward WA,Strom EA,Perkins GH,Tereffe W,Yu TK,Buchholz TA

    更新日期:2008-03-15 00:00:00

  • Multiple myeloma and family history of cancer. A case-control study.

    abstract::A hospital-based case-control study was done to examine the hypothesis that persons with a family history of multiple myeloma (MM) or other cancers are at increased risk of multiple myeloma. Study members were 439 cases of multiple myeloma and 1317 matched controls seen at the Duke University Medical Center. Only 3 ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851015)56:8<2133::aid-cncr2820

    authors: Bourguet CC,Grufferman S,Delzell E,DeLong ER,Cohen HJ

    更新日期:1985-10-15 00:00:00

  • Resection of brain metastases from colorectal carcinoma in 73 patients.

    abstract:BACKGROUND:At the time of diagnosis of colorectal carcinoma, 2-3% of patients are likely to be harboring brain metastases, and another 10% of patients will develop brain lesions during the course of their disease. The purpose of this study was to examine the clinical course of a group of patients with metastatic brain ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990415)85:8<1677::aid-cn

    authors: Wroński M,Arbit E

    更新日期:1999-04-15 00:00:00

  • The impact of age, treatment, and symptoms on the physical and mental health of cancer patients. A longitudinal perspective.

    abstract:BACKGROUND:To describe continuing care and rehabilitation needs of cancer patients, a longitudinal design (6 months) was performed among patients 50 years of age and older with solid tumors. The study examined how age, type of treatment, site of cancer, and symptom experience affect physical functioning and their menta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941001)74:7+<2128::aid-cncr282

    authors: Given CW,Given BA,Stommel M

    更新日期:1994-10-01 00:00:00

  • Solid tumor models for the assessment of different treatment modalities. XIII. Comparison of response and recovery of host and solid tumor to cyclophosphamide and radiation.

    abstract::A study of the effects of local tumor radiation alone (1500R) and cyclophosphamide alone (150 mg/kg) on the experimental solid tumor rat hepatoma 3924A has been completed. Cyclophosphamide was more effective in controlling tumor growth than either radiation or 5-fluorouracil (5-FU) (150 mg/kg) previously reported. Par...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800601)45:11<2793::aid-cncr282

    authors: Looney WB,Hopkins HA,Grover WH,Macleod MS,Ritenour ER,Hobson AS

    更新日期:1980-06-01 00:00:00