Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement.

Abstract:

:This report describes 11 adults with non-Hodgkin's lymphoma who presented with symptoms caused by large mediastinal masses. Patients with lymphoblastic lymphoma were excluded from this analysis. Most of the patients were young women with localized disease at presentation. Ten tumors were diffuse large cell ("histiocytic") lymphomas and one was a diffuse, undifferentiated lymphoma, non-Burkitt's type. According to the Lukes' and Collins' classification scheme, seven were large cleaved cell type, three were large noncleaved and one was small noncleaved cell type. Sclerosis was present in four cases. Despite aggressive therapy nine patients died within 26 months of diagnosis and only two remain disease-free. Median survival of these patients was 16 months. Patients with symptomatic mediastinal masses and non-Hodgkin's lymphomas composed predominantly of large cell appear to share certain clinico-pathologic features and to present a poor prognosis subset of patients with non-Hodgkin's lymphoma.

journal_name

Cancer

journal_title

Cancer

authors

Trump DL,Mann RB

doi

10.1002/1097-0142(19820715)50:2<277::aid-cncr28205

subject

Has Abstract

pub_date

1982-07-15 00:00:00

pages

277-82

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

50

pub_type

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