Abstract:
:This report describes 11 adults with non-Hodgkin's lymphoma who presented with symptoms caused by large mediastinal masses. Patients with lymphoblastic lymphoma were excluded from this analysis. Most of the patients were young women with localized disease at presentation. Ten tumors were diffuse large cell ("histiocytic") lymphomas and one was a diffuse, undifferentiated lymphoma, non-Burkitt's type. According to the Lukes' and Collins' classification scheme, seven were large cleaved cell type, three were large noncleaved and one was small noncleaved cell type. Sclerosis was present in four cases. Despite aggressive therapy nine patients died within 26 months of diagnosis and only two remain disease-free. Median survival of these patients was 16 months. Patients with symptomatic mediastinal masses and non-Hodgkin's lymphomas composed predominantly of large cell appear to share certain clinico-pathologic features and to present a poor prognosis subset of patients with non-Hodgkin's lymphoma.
journal_name
Cancerjournal_title
Cancerauthors
Trump DL,Mann RBdoi
10.1002/1097-0142(19820715)50:2<277::aid-cncr28205subject
Has Abstractpub_date
1982-07-15 00:00:00pages
277-82issue
2eissn
0008-543Xissn
1097-0142journal_volume
50pub_type
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