Time for reappraisal of extracranial treatment options? Synchronous brain metastases from nonsmall cell lung cancer.

abstract：:Eighty-nine primary lung carcinomas and 23 metastatic lung tumors were immunohistochemically studied for the expression of pulmonary surfactant apoproteins, by using monoclonal (PE-10) and polyclonal antibodies. Surfactant apoprotein was demonstrated in the cytoplasm and/or nuclear inclusion bodies of only primary lun...

journal_title：Cancer

authors： Mizutani Y,Nakajima T,Morinaga S,Gotoh M,Shimosato Y,Akino T,Suzuki A

更新日期：1988-02-01 00:00:00

abstract：:A new method of arterially administering an oily anticancer agent was successfully established for the selective targeting of metastatic lymph nodes. A high molecular weight anticancer agent, a conjugate of copolymer (styrene maleic acid) to neocarzinostatin (SMANCS) was prepared in our laboratory and dissolved in a l...

journal_title：Cancer

authors： Ohtsuka N,Konno T,Miyauchi Y,Maeda H

更新日期：1987-05-01 00:00:00

abstract：:With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...

journal_title：Cancer

authors： Robison LL

更新日期：1993-05-15 00:00:00

abstract：:Detailed cytogenetic studies were performed in 41 patients with cutaneous T-cell lymphoma (CTCL): four patients had limited plaques, 13 patients had generalized plaques, eight patients had cutaneous tumors, 16 patients had generalized erythroderma, and four additional patients, who had relatively benign chronic dermat...

journal_title：Cancer

authors： Whang-Peng J,Bunn PA Jr,Knutsen T,Matthews MJ,Schechter G,Minna JD

更新日期：1982-10-15 00:00:00

abstract：:In 147 cases of mammary carcinoma, 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11. The tumor volume doubling times (TV); obtained by me...

journal_title：Cancer

authors： von Fournier D,Weber E,Hoeffken W,Bauer M,Kubli F,Barth V

更新日期：1980-04-15 00:00:00

abstract：:Results of remission induction therapy in refractory acute nonlymphocytic leukemia (ANLL) has been improved since the introduction of high-dose cytosine arabinoside. However, the toxicity of these regimens attributes to an early death rate of about 20% to 30%. The authors treated 37 poor-risk patients with ANLL with i...

journal_title：Cancer

authors： Dekker AW,Nieuwenhuis HK,Verdonck LF

更新日期：1990-05-01 00:00:00

abstract：:A total of 1026 patients with gastric cancer was followed up for five years after surgery and classified into different groups according to surgeons' assessment of nodal involvement, serosal invasion, peritoneal spread, and hepatic metastasis. The survival of each group was studied by parametric analysis, using the lo...

journal_title：Cancer

authors： Maetani S,Tobe T,Hirakawa A,Kashiwara S,Kuramoto S

更新日期：1980-12-15 00:00:00

abstract：BACKGROUND:Soft tissue sarcomas (STSs) are heterogeneous neoplasms that have variable clinical outcome. Several clinical parameters and few molecular markers, including Ki-67 proliferative index, have been shown to correlate with patient prognosis. To the authors' knowledge, no definitive report exists to identify one ...

journal_title：Cancer

authors： Hoos A,Stojadinovic A,Mastorides S,Urist MJ,Polsky D,Di Como CJ,Brennan MF,Cordon-Cardo C

更新日期：2001-08-15 00:00:00

abstract：:Although the existence of subclinical Pneumocystis carinii infection in pediatric patients with solid tumors or hematologic malignancies has been documented, similar data are lacking in adults. In addition, data are needed to define the epidemiology of this agent in adult malignancies to assess the validity of the met...

journal_title：Cancer

authors： Robert NJ,Pifer LL,Niell HB,Woods DR,Neely CL,Miller JH,Churchill H

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...

journal_title：Cancer

authors： Gohji K,Fujimoto N,Komiyama T,Fujii A,Ohkawa J,Kamidono S,Nakajima M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in ina...

journal_title：Cancer

authors： George S,Barysauskas C,Serrano C,Oduyebo T,Rauh-Hain JA,Del Carmen MG,Demetri GD,Muto MG

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:In vitro studies have shown an antiproliferative effect of tumor necrosis factor (TNF) against various nonsmall cell lung carcinoma (NSCLC) cell lines. However, clinical trials of combined interleukin-2 and TNF-alpha in patients with advanced NSCLC have demonstrated both conflicting and disappointing results...

journal_title：Cancer

authors： Tran TA,Kallakury BV,Ambros RA,Ross JS

更新日期：1998-07-15 00:00:00

abstract：:Mixed cellularity Hodgkin's disease and diffuse non-Hodgkin's lymphoma, mixed cell type, occurred consecutively in a husband and wife. Both patients demonstrated monoclonal IgM gammopathies. The unusual nature and possible significance of these findings are discussed. ...

journal_title：Cancer

authors： Offit K,Macris NT,Hellman G,Rotterdam HZ

更新日期：1986-01-15 00:00:00

abstract：BACKGROUND:Non-Hodgkin lymphoma (NHL), the most common cancer of the lymphatic system, is of unknown etiology. The identification of etiologic factors in the onset of NHL is a key event that could facilitate the prevention and cure of this malignancy. Simian virus 40 (SV40) has been considered an oncogenic agent in the...

journal_title：Cancer

authors： Tognon M,Luppi M,Corallini A,Taronna A,Barozzi P,Rotondo JC,Comar M,Casali MV,Bovenzi M,D'Agostino A,Vinante F,Rigo A,Ferrarini I,Barbanti-Brodano G,Martini F,Mazzoni E

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Histologic response to chemotherapy has been shown to be an independent prognostic factor in patients with osteosarcoma and Ewing sarcoma. However, in patients with soft tissue sarcoma (STS), the prognostic impact of histologic response to chemotherapy is less clear. In the current study, the authors sought ...

journal_title：Cancer

authors： Mullen JT,Hornicek FJ,Harmon DC,Raskin KA,Chen YL,Szymonifka J,Yeap BY,Choy E,DeLaney TF,Nielsen GP

更新日期：2014-12-01 00:00:00

abstract：:Pel-Epstein fever cycles, consisting of 1-2 weeks of high fever separated by afebrile periods of the same duration, are classically characteristic of Hodgkin's disease. Clinical observation has determined that the lymph nodes enlarge during periods of fever and reduce in size as the fever subsides. To our knowledge, t...

journal_title：Cancer

authors： Scanlon GT,Castellino RA,Rudders R

更新日期：1975-12-01 00:00:00

abstract：:Since primary lymphoma of bone (PLB) exhibits morphologic diversity and variability in individual survival, we analyzed the relationship between histopathologic features and biological behavior in 33 patients treated at the Massachusetts General Hospital. Three major histologic subgroups were identified, based on a va...

journal_title：Cancer

authors： Dosoretz DE,Raymond AK,Murphy GF,Doppke KP,Schiller AL,Wang CC,Suit HD

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS:This study reviewed the 10 published, well controlled, repeated-dose, comparative stud...

journal_title：Cancer

authors： Warfield CA

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:Differentiating primary glandular from high-grade squamous intraepithelial lesions (HSIL) that involve endocervical glands is not an uncommon diagnostic problem in liquid-based gynecological cytology. Squamous and atypical glandular cell lesions may show similar cytomorphologic features. The aim of this stud...

journal_title：Cancer

authors： Garcia MT,Acar BC,Jorda M,Gomez-Fernandez C,Ganjei-Azar P

更新日期：2007-02-25 00:00:00

abstract：BACKGROUND:Adenoid cystic carcinoma (ACC) of the head and neck (ACCHN) is a rare tumor of minor salivary, parotid, and submandibular glands. The biologic behavior of the disease is poorly understood, and nonsurgical treatment strategies have yet to be standardized. The long-term prognosis continues to be guarded, with ...

journal_title：Cancer

authors： Ellington CL,Goodman M,Kono SA,Grist W,Wadsworth T,Chen AY,Owonikoko T,Ramalingam S,Shin DM,Khuri FR,Beitler JJ,Saba NF

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-ti...

journal_title：Cancer

authors： Lynch HT,Kaurah P,Wirtzfeld D,Rubinstein WS,Weissman S,Lynch JF,Grady W,Wiyrick S,Senz J,Huntsman DG

更新日期：2008-06-15 00:00:00

abstract：BACKGROUND:Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role of MET in patients with recurrent=metastatic gastric cancer who received chemotherapy. MET...

journal_title：Cancer

authors： An X,Wang F,Shao Q,Wang FH,Wang ZQ,Wang ZQ,Chen C,Li C,Luo HY,Zhang DS,Xu RH,Li YH

更新日期：2014-03-01 00:00:00

abstract：:This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvem...

journal_title：Cancer

authors： Vandenbrouck C,Sancho-Garnier H,Chassagne D,Saravane D,Cachin Y,Micheau C

更新日期：1980-07-15 00:00:00

abstract：BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...

journal_title：Cancer

authors： Liberman L,Freeman HP,Chandra S,Stein AL,McCord C,Godfrey D,Dershaw DD

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND METHODS:A univariate and multivariate analysis for the correlation between histomorphologic factors and prognosis was made using data from 1116 patients with soft tissue sarcoma, including 1005 cases available with complete histologic and follow-up data. RESULTS:The overall 5-year survival rate was 43.6...

journal_title：Cancer

authors： Hashimoto H,Daimaru Y,Takeshita S,Tsuneyoshi M,Enjoji M

更新日期：1992-12-15 00:00:00

abstract：:Thirteen patients with regional or distant metastases from Merkel cell carcinoma were treated with combination chemotherapy. Three patients had a complete response to therapy. In two patients with nodal disease the duration of response was 10+ and 4+ years. In addition, three patients had a partial response, and six p...

journal_title：Cancer

authors： Feun LG,Savaraj N,Legha SS,Silva EG,Benjamin RS,Burgess MA

更新日期：1988-08-15 00:00:00

abstract：BACKGROUND:9-Aminocamptothecin (9AC) and its parent compound, camptothecin, have shown outstanding preclinical activity against colorectal carcinoma. Irinotecan (CPT-11), another camptothecin derivative, has demonstrated clinical activity in patients with 5-fluorouracil (5-FU)-refractory colorectal carcinoma. METHODS:...

journal_title：Cancer

authors： Saltz LB,Kemeny NE,Tong W,Harrison J,Berkery R,Kelsen DP

更新日期：1997-11-01 00:00:00

abstract：:Two patients diagnosed as having acute promyelocytic leukemia (APL) and disseminated intravascular coagulation (DIC) were closely followed from the day of admission until completion of the first course of chemotherapy with serial coagulation studies including plasma levels of functional antithrombin III activity (AT I...

journal_title：Cancer

authors： Sandler RM,Liebman HA,Patch MJ,Teitelbaum A,Levine AM,Feinstein DI

更新日期：1983-02-15 00:00:00

abstract：BACKGROUND:To evaluate the prevalence and significance of abnormal ovarian findings in asymptomatic postmenopausal women, screening for ovarian cancer with color Doppler ultrasound was performed. METHODS:One thousand three hundred sixty-four asymptomatic women aged 56-61 years (mean, 59 years) were examined by color D...

journal_title：Cancer

authors： Vuento MH,Pirhonen JP,Mäkinen JI,Laippala PJ,Grönroos M,Salmi TA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Since contact with Westerners in 1778, the native people of the Hawaiian Islands have experienced multiple health and social problems. Among these are the debilitating effects of high rates of cancer incidence and mortality. METHODS:The method used in this article was a review and integration of the literat...

journal_title：Cancer

authors： Hughes CK,Tsark JA,Mokuau NK

更新日期：1996-10-01 00:00:00