当前位置： SCI文献检索 > CANCER期刊下所有文献 > High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas.

High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas.

Abstract：

BACKGROUND:Soft tissue sarcomas (STSs) are heterogeneous neoplasms that have variable clinical outcome. Several clinical parameters and few molecular markers, including Ki-67 proliferative index, have been shown to correlate with patient prognosis. To the authors' knowledge, no definitive report exists to identify one molecular marker that can be analyzed easily in a clinical setting and that predicts survival in a cohort of patients with high-risk STS of identical clinical characteristics but variable outcome. METHODS:The influence of clinical prognostic factors was eliminated by selecting two patient groups with identical high-risk characteristics: large (> 10 cm), high-grade, deep, completely resected primary extremity STS (n = 47). Patients in the first group remained disease free (no evidence of disease [NED]) after primary tumor treatment (n = 19), whereas patients in the second group subsequently died of disease (DOD; n = 28). Triplicate 0.6-mm core biopsies from defined morphologic areas of paraffin embedded primary tumors were assembled on a tissue microarray and analyzed by immunohistochemistry with the MIB-1 antibody, and Ki-67 proliferative indices were correlated with patient outcome. RESULTS:High Ki-67 proliferative index, defined as greater than 30% tumor cells showing nuclear immunoreactivity, was significantly more frequent in the DOD group than in the NED group and was associated with tumor-related mortality (P = 0.02). This marker identifies an especially aggressive malignant phenotype within a cohort of high-risk tumors that is based on well established clinical and pathologic parameters alone and is easy to use in a clinical setting. CONCLUSIONS:On the basis of these data and previous reports, high Ki-67 proliferative index is suggested as a significant factor for predicting the prognosis of patients with high-risk STS and should be evaluated prospectively based on clinical trials.

journal_name

Cancer

journal_title

Cancer

authors

Hoos A,Stojadinovic A,Mastorides S,Urist MJ,Polsky D,Di Como CJ,Brennan MF,Cordon-Cardo C

doi

10.1002/1097-0142(20010815)92:4<869::aid-cncr1395>

subject

Has Abstract

pub_date

2001-08-15 00:00:00

pages

869-74

issue

4

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20010815)92:4<869::AID-CNCR1395>

journal_volume

92

pub_type

杂志文章

相关文献

CANCER文献大全
  • Antigenic markers of hepatocellular carcinoma.

    abstract：:One hundred thirty-five hepatocellular carcinomas were examined for the presence of antigenic tumor markers by the avidin-biotin-peroxidase complex method. Ninety-seven were from the US and 38 came from Argentina. The following markers were tested: alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), hepatitis B surfac...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19900101)65:1<84::aid-cncr282065

    authors： Chedid A,Chejfec G,Eichorst M,Villamil F,Terg R,Telenta M,Hojman R

    更新日期：1990-01-01 00:00:00

  • I. Carcinoma of the rectum and rectosigmoid: cancer specific long-term survival. A series of 1061 cases treated by one surgeon.

    abstract：:The long-term cancer specific survival based on individual follow-up and analysis of prospectively collected data from 1061 patients undergoing resection for carcinoma of the rectum is presented. All patients were operated on and managed by one surgeon. Survival data for 978 cases were analyzed according to the method...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19800601)45:11<2902::aid-cncr282

    authors： Pihl E,Hughes ES,McDermott FT,Milne BJ,Korner JM,Price AB

    更新日期：1980-06-01 00:00:00

  • Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy.

    abstract：BACKGROUND:Histologic response to chemotherapy has been shown to be an independent prognostic factor in patients with osteosarcoma and Ewing sarcoma. However, in patients with soft tissue sarcoma (STS), the prognostic impact of histologic response to chemotherapy is less clear. In the current study, the authors sought ...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/cncr.28945

    authors： Mullen JT,Hornicek FJ,Harmon DC,Raskin KA,Chen YL,Szymonifka J,Yeap BY,Choy E,DeLaney TF,Nielsen GP

    更新日期：2014-12-01 00:00:00

  • Chemoprevention of bladder cancer.

    abstract：:There is a growing body of basic science and epidemiologic evidence to support a research thrust to determine whether several natural or synthetic agents, given alone or together, can lower cancer incidence. Candidate agents include analogs of vitamin A and the vitamin A precursor, beta-carotene, vitamins C and E, and...

    journal_title：Cancer

    pub_type： 临床试验,杂志文章

    doi：10.1002/1097-0142(19870801)60:3+<650::aid-cncr2820

    authors： Malone WF,Kelloff GJ,Pierson H,Greenwald P

    更新日期：1987-08-01 00:00:00

  • Beta-glucuronidase activity in prostatic carcinoma and benign prostatic hyperplasia.

    abstract：:Beta-glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6-fold higher (P less than 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta-glucuronidase by disc-gel electrophoresis in nondenaturing polyacrylamide gels demo...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19890815)64:4<911::aid-cncr28206

    authors： Pearson JP,Pretlow TP,Bradley EL Jr,McGinnis MC,Pretlow TG

    更新日期：1989-08-15 00:00:00

  • Efficacy of ondansetron against nausea and vomiting caused by dacarbazine-containing chemotherapy.

    abstract：BACKGROUND AND METHODS:The antiemetic activity of ondansetron (Zofran, Glaxo Pharmaceuticals, Research Triangle Park, NC) was evaluated in 25 patients with recurrent melanoma who were treated sequentially with dacarbazine (DTIC), vinblastine, and cisplatin. The antiemetic regimen included ondansetron alone in 11 patien...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19921001)70:7<2018::aid-cncr2820

    authors： Legha SS,Hodges C,Ring S

    更新日期：1992-10-01 00:00:00

  • NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway.

    abstract：BACKGROUND:Resistance to apoptosis is 1 of the key events that confer chemoresistance and is mediated by the overexpression of antiapoptotic proteins, which inhibit caspase activation. The objective of this study was to evaluate whether the activation of an alternative, caspase-independent cell death pathway could prom...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/cncr.24397

    authors： Alvero AB,Montagna MK,Chen R,Kim KH,Kyungjin K,Visintin I,Fu HH,Brown D,Mor G

    更新日期：2009-07-15 00:00:00

  • The past 60 years in liver surgery.

    abstract：:The anniversary of the first publication of Cancer provides an opportunity to review the progress in liver cancer surgery in the past 60 years. Indeed, the past half century has been witness to remarkable advances in liver surgery that have provided benefit to so many patients afflicted with primary or secondary liver...

    journal_title：Cancer

    pub_type： 杂志文章,评审

    doi：10.1002/cncr.23652

    authors： Tanabe KK

    更新日期：2008-10-01 00:00:00

  • Familial prostate cancer in Sweden. A nationwide register cohort study.

    abstract：BACKGROUND:Although prostate carcinoma is not widely recognized as a familial cancer, familial aggregation of this disease has been shown in some retrospective case-control studies. To study familial prostate cancer in Sweden, a population-based cohort study was performed, that attempted to avoid possible bias connecte...

    journal_title：Cancer

    pub_type： 杂志文章,评审

    doi：10.1002/(SICI)1097-0142(19960101)77:1<138::AID-CNC

    authors： Grönberg H,Damber L,Damber JE

    更新日期：1996-01-01 00:00:00

  • Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compression.

    abstract：BACKGROUND:Disruption of the lymphatic circulation through breast carcinoma-associated axillary lymph node dissection, with or without radiation therapy, reportedly is the most common cause of lymphedema in developed countries. There is no cure for breast carcinoma-associated lymphedema. Although intermittent pneumatic...

    journal_title：Cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1002/cncr.10976

    authors： Szuba A,Achalu R,Rockson SG

    更新日期：2002-12-01 00:00:00

  • Synovial sarcoma of the abdominal wall.

    abstract：BACKGROUND:Synovial sarcoma usually arises in the extremities and in close proximity to large joints. Reported examples arising in the anterior abdominal wall are rare. Because most accounts from this location consist of case reports, neither clinical nor prognostic features have been well delineated. METHODS:Twenty-s...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19930715)72:2<469::aid-cncr28207

    authors： Fetsch JF,Meis JM

    更新日期：1993-07-15 00:00:00

  • Ultrastructural studies of xenografted human germ cell tumors.

    abstract：:Xenografts have been established in immune-suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a 'seminoma-like' tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patien...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19820215)49:4<683::aid-cncr28204

    authors： Monaghan P,Raghavan D,Neville AM

    更新日期：1982-02-15 00:00:00

  • Do histocompatibility antigens influence the risk of head and neck carcinoma?

    abstract：:Associations were sought between specific histocompatibility antigens (HLA) of the human major histocompatibility complex and the incidence of head and neck squamous cell carcinoma (SqCC). Seventy sequential patients with SqCC and 217 control subjects from the same geographic region were typed for HLA-A, HLA-B, and HL...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19920501)69:9<2327::aid-cncr2820

    authors： Houck JR,Romano PJ,Bartholomew M,Smith PJ,Kloszewski F,Vesell ES

    更新日期：1992-05-01 00:00:00

  • Genetic testing for colorectal carcinoma susceptibility: focus group responses of individuals with colorectal carcinoma and first-degree relatives.

    abstract：BACKGROUND:Colorectal carcinoma (CRC) may be the most frequent form of hereditary cancer. Genetic counseling and testing for heritable CRC is a promising approach for reducing the high incidence and mortality rates associated with the disease. Patients with CRC or those with at least one family member with the disease ...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(20010101)91:1<57::aid-cncr8>3.0.

    authors： Kinney AY,DeVellis BM,Skrzynia C,Millikan R

    更新日期：2001-01-01 00:00:00

  • Combination versus successive single agent chemotherapy in lymphocytic lymphoma.

    abstract：:Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...

    journal_title：Cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1002/1097-0142(197801)41:1<23::aid-cncr28204101

    authors： Kennedy BJ,Bloomfield CD,Kiang DT,Vosika G,Peterson BA,Theologides A

    更新日期：1978-01-01 00:00:00

  • Glomangioma of the trachea.

    abstract：:A case of a glomus tumor arising in an unusual site, the trachea, is described. The tumor was composed of a mixture of glomus cells and mast cells. At the ultrastructural level, the glomus cells exhibited features of modified smooth-muscle cells. ...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19800501)45:9<2337::aid-cncr2820

    authors： Fabich DR,Hafez GR

    更新日期：1980-05-01 00:00:00

  • Bleomycin-sensitivity test: application for human squamous cell carcinoma.

    abstract：:Bleomycin (BLM)-inactivating enzyme activity, which is probably a parameter for the efficacy of this antibiotic in cancer therapy, was determined in biopsies from human carcinomas in the head and neck region. Twenty-three cases were studied. It was found that highly differentiated as well as moderately differentiated ...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(197712)40:6<2787::aid-cncr282040

    authors： Müller WE,Schmidseder R,Rohde HJ,Zahn RK,Scheunemann H

    更新日期：1977-12-01 00:00:00

  • Primary malignant fibrous histiocytoma of bone.

    abstract：:A review of over 400 primary bone tumors yielded 11 lesions with features allowing classification as malignant fibrous histiocytoma on a purely histological basis. Correlation with roentgenograms and clinical data indicated that these tumors occurred as osteolytic lesions associated with a high incidence of pathologic...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/cncr.2820360925

    authors： Spanier SS,Enneking WF,Enriquez P

    更新日期：1975-12-01 00:00:00

  • Breast carcinoma etiology: current knowledge and new insights into the effects of reproductive and hormonal risk factors in black and white populations.

    abstract：BACKGROUND:A crossover in breast carcinoma incidence at ages 45-49 years has been observed between black and white women, with blacks experiencing higher incidence at younger ages and lower incidence after age 50 years. Can this phenomenon be partially explained by the differences in the distributions of reproductive r...

    journal_title：Cancer

    pub_type： 杂志文章,评审

    doi：10.1002/(sici)1097-0142(20000301)88:5+<1230::aid-c

    authors： Pathak DR,Osuch JR,He J

    更新日期：2000-03-01 00:00:00

  • Immunoblastic lymphadenopathy associated with methyldopa therapy: a case report.

    abstract：:The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter,...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(197811)42:5<2322::aid-cncr282042

    authors： Weisenburger DD

    更新日期：1978-11-01 00:00:00

  • Nerve sheath myxoma of digital nerve.

    abstract：:A case of a dermal nerve sheath myxoma arising in a digital nerve is reported. Similar tumors and its variants have been termed neurothekeoma, pacinian neurofibroma, bizarre cutaneous neurofibroma, and plexiform neurofibroma. The perineural sheath or the Schwann cell have been presumed to be the cell of origin by seve...

    journal_title：Cancer

    pub_type： 杂志文章,评审

    doi：10.1002/1097-0142(19890315)63:6<1215::aid-cncr2820

    authors： Blumberg AK,Kay S,Adelaar RS

    更新日期：1989-03-15 00:00:00

  • Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases.

    abstract：:A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor saliva...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(197702)39:2<388::aid-cncr2820390

    authors： Spiro RH,Huvos AG,Strong EW

    更新日期：1977-02-01 00:00:00

  • Epidermal Langerhans' cell densities influence survival in mycosis fungoides and Sézary syndrome.

    abstract：:Because Langerhans' cells (LC) (CD1a-positive epidermal cells) have been discussed to be involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the authors examined the influence of densities of Langerhans' cells and, concurrently, of other phenotypes retrospectively on survival of 35 patients. Cell de...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19900501)65:9<2069::aid-cncr2820

    authors： Meissner K,Michaelis K,Rehpenning W,Löning T

    更新日期：1990-05-01 00:00:00

  • Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies.

    abstract：BACKGROUND:The authors suggested that the loss of collagen IV and laminin-containing basement membrane and the loss of Disabled-2 (Dab2) expression were two critical events associated with morphologic dysplastic changes of the ovarian surface epithelium as a step in tumorigenicity. Both the basement membrane and Dab2, ...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/cncr.11847

    authors： Roland IH,Yang WL,Yang DH,Daly MB,Ozols RF,Hamilton TC,Lynch HT,Godwin AK,Xu XX

    更新日期：2003-12-15 00:00:00

  • Alterations in plasma sialyltransferase levels in patients with neoplastic disease.

    abstract：:Levels of glycoprotein:sialyltransferase activity (EC 2.4.99.1; CMP-acetyl-neuraminate:D-galactosyl-glycoprotein N-acetylneuraminyl-transferase) were measured in plasma of patients with neoplastic disease, and were found elevated above normal control values in 85% of patients examined. There was a correlation between ...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(197703)39:3<1129::aid-cncr282039

    authors： Henderson M,Kessel D

    更新日期：1977-03-01 00:00:00

  • Prognostic index for patients with parotid carcinoma: external validation using the nationwide 1985-1994 Dutch Head and Neck Oncology Cooperative Group database.

    abstract：BACKGROUND:Validation of the prognostic indices for the recurrence-free interval of patients with parotid carcinoma, the development of which was described in a previous report, is needed to be confident of their generalizability and justified prospective use. METHODS:The Dutch Cooperative Group on Head and Neck Cance...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/cncr.11254

    authors： Vander Poorten VL,Hart AA,van der Laan BF,Baatenburg de Jong RJ,Manni JJ,Marres HA,Meeuwis CA,Lubsen H,Terhaard CH,Balm AJ

    更新日期：2003-03-15 00:00:00

  • Bone sarcomas associated with Ollier's disease.

    abstract：:Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0142(19870401)59:7<1376::aid-cncr2820

    authors： Liu J,Hudkins PG,Swee RG,Unni KK

    更新日期：1987-04-01 00:00:00

  • DNA ploidy analysis of mucinous cystic tumors of the pancreas. Correlation of aneuploidy with malignancy and poor prognosis.

    abstract：BACKGROUND:Benign and malignant pancreatic mucinous tumors differ in proliferative activity, production of tumor markers, and expression of growth factors. DNA ploidy is a useful index of aggressiveness and poor survival in ductal adenocarcinoma, but has not been studied in pancreatic cystic tumors. METHODS:The DNA pl...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0142(19960101)77:1<58::AID-CNCR

    authors： Southern JF,Warshaw AL,Lewandrowski KB

    更新日期：1996-01-01 00:00:00

  • MIB-1 labeling index in nonpilocytic astrocytoma of childhood: a study of 101 cases.

    abstract：BACKGROUND:The prognosis of pediatric patients with nonpilocytic astrocytoma, and in particular those with anaplastic astrocytoma, is somewhat unpredictable. This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric as...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0142(19980615)82:12<2459::aid-c

    authors： Ho DM,Wong TT,Hsu CY,Ting LT,Chiang H

    更新日期：1998-06-15 00:00:00

  • The clinical significance of p21(WAF1/CIP-1) and p53 expression in pancreatic adenocarcinoma.

    abstract：BACKGROUND:Wild-type p53 protein activates the WAF1/CIP-1 (p21) gene, leading to G1 arrest after DNA damage. The authors investigated the relation of p21 and p53 expression in pancreatic adenocarcinomas to disease stage, overall patient survival, and survival when chemotherapy or radiation therapy was given. METHODS:P...

    journal_title：Cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0142(19970801)80:3<372::aid-cnc

    authors： Dergham ST,Dugan MC,Joshi US,Chen YC,Du W,Smith DW,Arlauskas P,Crissman JD,Vaitkevicius VK,Sarkar FH

    更新日期：1997-08-01 00:00:00