Abstract:
:A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbearing years, it was decided to treat these painful lesions with an anti-estrogen, tamoxifen (20 mg orally, four times daily). This therapy led to a complete relief of pain within 1 week and a progressive decrease in the size of the desmoid tumors to less than 50% of their initial volume by the end of the second week. Unfortunately, the patient's metastatic adenocarcinoma progressed and was complicated by sepsis leading to her death. This case suggests that the growth of desmoid tumors is under hormonal influence, a suggestion which deserves further investigation.
journal_name
Cancerjournal_title
Cancerauthors
Kinzbrunner B,Ritter S,Domingo J,Rosenthal CJdoi
10.1002/1097-0142(19831215)52:12<2201::aid-cncr282subject
Has Abstractpub_date
1983-12-15 00:00:00pages
2201-4issue
12eissn
0008-543Xissn
1097-0142journal_volume
52pub_type
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