Remission of rapidly growing desmoid tumors after tamoxifen therapy.

Abstract:

:A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbearing years, it was decided to treat these painful lesions with an anti-estrogen, tamoxifen (20 mg orally, four times daily). This therapy led to a complete relief of pain within 1 week and a progressive decrease in the size of the desmoid tumors to less than 50% of their initial volume by the end of the second week. Unfortunately, the patient's metastatic adenocarcinoma progressed and was complicated by sepsis leading to her death. This case suggests that the growth of desmoid tumors is under hormonal influence, a suggestion which deserves further investigation.

journal_name

Cancer

journal_title

Cancer

authors

Kinzbrunner B,Ritter S,Domingo J,Rosenthal CJ

doi

10.1002/1097-0142(19831215)52:12<2201::aid-cncr282

subject

Has Abstract

pub_date

1983-12-15 00:00:00

pages

2201-4

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

52

pub_type

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