Impact of radiographic findings on prognosis for skin carcinoma with clinical perineural invasion.

Abstract:

BACKGROUND:The objective of the current study was to correlate pretreatment computed tomography and magnetic resonance imaging studies with outcomes for patients with squamous or basal cell carcinoma of the skin and clinical perineural invasion. METHODS:Between 1986 and 2002, 45 patients were treated with radiotherapy alone (21 patients) or combined with surgery (24 patients), and 4 patients received concomitant chemotherapy. Follow-up ranged from 0.85 years to 17.4 years (median, 3.8 years). Patients were stratified as follows: imaging negative, 10 patients; minimal or moderate peripheral disease, 14 patients; and central and/or macroscopic disease, 21 patients. RESULTS:The 5-year local control rates were as follows: imaging negative, 76%; minimal or moderate peripheral disease, 57%; and central and/or macroscopic disease, 25%. The 5-year absolute and cause-specific survival rates were as follows: imaging negative, 90% and 100%, respectively; minimal or moderate peripheral disease, 50% and 56%, respectively; and central and/or macroscopic disease, 58% and 61%, respectively. CONCLUSIONS:Patients who had symptomatic but imaging-negative perineural invasion had a relatively good prognosis after receiving definitive radiotherapy alone or combined with surgery. Patients who had imaging-positive minimal or moderate peripheral disease had a better local control rate but a similar survival rate compared with patients who had central and/or macroscopic disease.

journal_name

Cancer

journal_title

Cancer

authors

Galloway TJ,Morris CG,Mancuso AA,Amdur RJ,Mendenhall WM

doi

10.1002/cncr.20913

subject

Has Abstract

pub_date

2005-03-15 00:00:00

pages

1254-7

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

103

pub_type

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