Abstract:
:A solitary hepatic tumor in a 50-year-old woman, which was observed as a hemangioma, ultimately was resected because it increased in size. The tumor volume doubling time was 28.8 months over the observed period of 30 months. The histologic diagnosis was carcinoid tumor. Immunohistochemical staining showed strong focal reactivity for gastrin and diffuse reactivity for pancreatic polypeptide, vasointestinal polypeptide, calcitonin, and parathormone. Preoperative gastric hyperacidity with diarrhea and a body weight loss of 7 kg, moderately controlled by cimetidine on admission, suggested high serum gastrin levels produced by the tumor. Her symptoms resolved after surgery, and she had a normal serum gastrin level with negative secretin stimulation test results. A review of six cases of hepatic gastrinoma suggests that surgical resection, if feasible, would be the treatment of choice.
journal_name
Cancerjournal_title
Cancerauthors
Moriura S,Ikeda S,Hirai M,Naiki K,Fujioka T,Yokochi K,Gotou Sdoi
10.1002/1097-0142(19930901)72:5<1547::aid-cncr2820subject
Has Abstractpub_date
1993-09-01 00:00:00pages
1547-50issue
5eissn
0008-543Xissn
1097-0142journal_volume
72pub_type
杂志文章,评审相关文献
CANCER文献大全abstract:BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.29983
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Little is known about cellular level genetic alterations in preinvasive breast lesions, particularly lobular carcinoma in situ. METHODS:We employed fluorescence in situ hybridization (FISH) using pericentromeric (alpha satellite) probes to assess numerical alterations of chromosomes 1, 7, 8, 16, 17, and X i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960115)77:2<315::AID-CNC
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:PD-L1 (programmed death ligand 1, B7-H1) is a cell surface glycoprotein that can impair T-cell function. PD-L1 is aberrantly expressed by multiple human malignancies and has been shown to carry a highly unfavorable prognosis in patients with kidney cancer. The role of PD-L1 was evaluated as a mechanism for l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22588
更新日期:2007-04-15 00:00:00
abstract::Two patients developed extremely bizarre (pseudomalignant) granulation-tissue reactions in the larynx and facial sinuses, following radiation therapy for carcinoma. Containing pleomorphic spindle cells and numerous (sometimes atypical) mitotic figures, both tumefactive lesions simulated high grade malignancies. While ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870415)59:8<1509::aid-cncr2820
更新日期:1987-04-15 00:00:00
abstract:BACKGROUND:Activating mutations in RAS are frequently present in patients with acute myeloid leukemia (AML), but their overall prognostic impact is not clear. METHODS:A retrospective analysis was performed to establish the clinical characteristics of patients with RAS-mutated (RAS(mut) ) AML, to analyze their outcome ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27596
更新日期:2012-11-15 00:00:00
abstract::Comparison of 50 proliferating trichilemmal cysts with 50 "ordinary" trichilemmal cysts indicated that both types almost invariably occurred on the scalps of women, were diagnosed clinically as cysts, followed a benign course, and featured trichilemmal keratinization. A spectrum was observed from trichilemmal cyst wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810901)48:5<1207::aid-cncr2820
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:Approximately 30% of breast carcinoma patients with negative lymph nodes die of their disease. Biologic markers such p53 protein and c-erb B-2 have been related to tumor progression, but their prognostic value remains controversial. METHODS:Two large series of a total of 613 lymph node negative breast carci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000215)88:4<804::aid-cnc
更新日期:2000-02-15 00:00:00
abstract::A 58-year-old man with mycosis fungoides developed headache, back pain, and dorsal column signs. A diagnosis of central nervous system (CNS) involvement by mycosis fungoides was made on examination of his spinal fluid. In this patient, cranial and local radiotherapy and aggressive treatment with intrathecal methotrexa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820915)50:6<1181::aid-cncr2820
更新日期:1982-09-15 00:00:00
abstract::The discovery of genes responsible for inherited forms of colorectal cancer have the potential to improve cancer risk assessment and counseling. Germline mutations (nonsense, frameshift) of APC are associated with familial adenomatous polyposis, an autosomal dominant syndrome, clinically characterized by young onset, ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19991201)86:11+<2540::aid-
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Stereotactic radiation therapy is highly effective in the treatment of small brain metastases, regardless of the histology. This suggests that small extracranial malignancies may be curable with similar radiation therapy. The authors developed a novel treatment unit for administering such therapy. METHODS:T...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980315)82:6<1062::aid-cn
更新日期:1998-03-15 00:00:00
abstract:BACKGROUND:Long-term survivors of testicular cancer (TC) who received cisplatin-based chemotherapy have an increased risk of cardiovascular disease. A cross-sectional study was performed to objectively assess cardiovascular risk, subclinical atherosclerosis, and endothelial function in long-term survivors of TC. METHO...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23389
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Approximately 5-10% of patients with rhabdomyosarcomas (RMS) are diagnosed during the first year of life, and their clinical characteristics have been well documented. However, because RMS rarely occurs during the neonatal period, little is known about neonatal RMS. METHODS:Four patients with neonatal RMS w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1613::aid-cncr1487
更新日期:2001-09-15 00:00:00
abstract::An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850215)55:4<745::aid-cncr28205
更新日期:1985-02-15 00:00:00
abstract::The authors report on five patients with secondary leukemia (SL) and one of the "specific" chromosomal rearrangements usually encountered in de novo acute nonlymphoblastic leukemia: inv(16), t(15;17), t(8;21), and t(9;11). They were characterized by solid tumor as the primary malignancy in four of five cases, absence ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2505::aid-cncr282
更新日期:1989-06-15 00:00:00
abstract:BACKGROUND:Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dose of everolimus with gefitinib in pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22816
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:This study aimed to determine the potential diagnostic value of migration-inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer. METHODS:A cohort of 97 patients with histologically confirmed gastric adenocarcinoma and 222 patients with d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24609
更新日期:2009-12-01 00:00:00
abstract::The kinetics of initial arrest in organs, distribution, survival, and fate of 125I-iododeoxyuridine-labeled B16 melanoma tumor cells injected intravenously into normal, tumor-sensitized and immune manipulated syngeneic and allogeneic mice were investigated. Groups of animals were killed at intervals ranging from two m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197707)40:1<46::aid-cncr28204001
更新日期:1977-07-01 00:00:00
abstract::A 48-year-old male presented with the nephrotic syndrome 3 years after resection and irradiation of a thymoma. Renal biopsy revealed membranous glomerulonephritis by electron microscopy. IgA, IgG, and C3 deposition were present in the glomerular basement membrane by immunofluorescence. There was no evidence of other a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<387::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract:BACKGROUND:We investigated p16(INK4A) expression in branchial cleft cysts and its utility in distinguishing branchial cleft cysts from metastatic head and neck squamous cell carcinomas (SCCs) in fine-needle aspiration biopsies (FNABs). METHODS:A study set comprising 41 resections (15 SCC and 26 branchial cleft cysts) ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20001
更新日期:2009-04-25 00:00:00
abstract:BACKGROUND:The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories. METHODS:Our analysis included 141 BCS a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32757
更新日期:2020-05-15 00:00:00
abstract::Vitamin B6 is involved in many biological processes of potential relevance to carcinogenesis and tumor growth, including DNA synthesis and maintenance of immunocompetence, yet very little information exists on B6 nutritional status in childhood leukemia. Using a radioenzymatic assay, the authors measured plasma pyrido...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19901201)66:11<2421::aid-cncr282
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:In this report, the authors present the results from a study of patients with unresectable oropharyngeal squamous cell carcinomas who were treated on a protocol of hyperfractionated radiation and high-dose intraarterial cisplatin (HYPERRADPLAT) at the University of Kentucky. METHODS:The study was designed a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21368
更新日期:2005-10-15 00:00:00
abstract::Tumor-specific DNA sequences or unique sequences have been found in a number of human cancer cells including gliomas but not in equivalent normal cells. In a continuing effort to further elucidate the nature of these sequences, thermal analysis using the hydroxyapatite technique was carried out on the various grades o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800715)46:2<303::aid-cncr28204
更新日期:1980-07-15 00:00:00
abstract:BACKGROUND:Telomerase is an enzyme that can reconstitute the ends (telomeres) of chromosomes after cell division and thus circumvent the cumulative damage that occurs in normal adult somatic cells during successive mitotic cycles. Recently, it has been proposed that this enzyme should, therefore, be detectable in immor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970115)79:2<362::aid-cnc
更新日期:1997-01-15 00:00:00
abstract:BACKGROUND:Patients with advanced soft tissue sarcomas (STS) have limited therapeutic options. Sorafenib (BAY 43-9006) is a multitargeted tyrosine kinase inhibitor of raf, vascular endothelial growth factor receptors 1 (VEGFR1) through 3, platelet-derived growth factor B, fms-like tyrosine kinase 3, and c-kit, and some...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.26334
更新日期:2012-02-01 00:00:00
abstract::The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no hist...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820215)49:4<819::aid-cncr28204
更新日期:1982-02-15 00:00:00
abstract:BACKGROUND:The unknown etiology of endometrioid carcinomas of the ovary and the relatively high frequency of a concomitant carcinoma of the endometrium in these patients warrants study of such tumors. The aim of this study was to identify the genetic alterations involved in endometrioid ovarian cancer development, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950815)76:4<650::aid-cncr28207
更新日期:1995-08-15 00:00:00
abstract:BACKGROUND:This multicenter, retrospective study explored the value of oncogene driver subtype, programmed death-1 ligand (PD-L1) status, and smoking status for predicting which patients with oncogene-driven non-small cell lung cancer (NSCLC) would benefit from treatment with programmed death-1 (PD-1)/PD-L1 inhibitors....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31871
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Fulvestrant (ICI 182,780) is a new type of estrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. The authors report the prospectively planned combined analysis of data from 2 Phase III trials comparing fulvestrant 250 mg monthly (n=428) and anastrozole 1 mg daily (n=4...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.11468
更新日期:2003-07-15 00:00:00
abstract:BACKGROUND:The growing number of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most worrisome complications after cancer therapy is the development of second malignant neoplasms (SMNs). METHODS:The authors describe the incidence of solid organ SMN in survi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23860
更新日期:2008-11-01 00:00:00