Characterization of tumor-specific DNA sequences: molecular grading of the astrocytomas.

abstract：BACKGROUND:There is limited published evidence regarding the efficacy of total skin electron beam radiation for patients with the diffuse erythrodermic form of mycosis fungoides. METHODS:Forty-five patients with erythrodermic mycosis fungoides were managed at McMaster University in Hamilton, Ontario, Canada (n=34), an...

journal_title：Cancer

authors： Jones GW,Rosenthal D,Wilson LD

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Circulating prostate cells can be detected in the venous blood of patients with clinically localized prostate carcinoma by applying reverse transcriptase-polymerase chain reaction (RT-PCR) techniques using primers specific for the prostate specific antigen (PSA) gene. This study evaluates whether the detecti...

journal_title：Cancer

authors： Ennis RD,Katz AE,de Vries GM,Heitjan DF,O'Toole KM,Rubin M,Buttyan R,Benson MC,Schiff PB

更新日期：1997-06-15 00:00:00

abstract：:Thirty-one patients with advanced, biopsy-proven squamous cell carcinoma (SCC) of the head and neck were treated with intraarterial chemotherapy (IAC) and subsequent radical surgery. Cisplatin at 25 mg/d (4 hours of infusion) and bleomycin at 15 mg/d (20 hours of infusion) were administered for 10 consecutive days. Ra...

journal_title：Cancer

authors： Sulfaro S,Frustaci S,Volpe R,Barzan L,Comoretto R,Monfardini S,Carbone A

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant...

journal_title：Cancer

authors： Gatalica Z,Lele SM,Rampy BA,Norris BA

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:In the current national debate regarding private insurance versus Medicaid expansion, understanding how insurance is associated with racial disparities in prostate cancer (CaP) outcomes has broad policy implications. In the current study, the authors examined the association between insurance status, race, a...

journal_title：Cancer

authors： Mahal AR,Mahal BA,Nguyen PL,Yu JB

更新日期：2018-02-15 00:00:00

abstract：:Twenty of 391 newly diagnosed cases of prostatic cancer (5%) had a prior prostatectomy for benign disease. Digital rectal examination in 16 of 19 patients (84%) revealed a significant prostatic abnormality. Continued serial digital rectal examination should be performed routinely after prostatectomy for benign disease...

journal_title：Cancer

authors： Schwartz I,Wein AJ,Malloy TR,Glick JH

更新日期：1986-08-15 00:00:00

abstract：:Forty-two cases of sarcomatoid renal cell carcinoma were reviewed clinicopathologically. Twenty-four patients were men, and 18 women; average age was 56.2 years (range, 30-81 years). Eight, 9, 13, and 12 cases were Stages I, II, III, and IV, respectively. Three morphologic patterns of sarcomatoid components were ident...

journal_title：Cancer

authors： Ro JY,Ayala AG,Sella A,Samuels ML,Swanson DA

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Chemoradiation with 5-fluorouracil and mitomycin remains the standard of care for squamous cell carcinoma (SCC) of the anal canal. A prolonged treatment time is associated with inferior disease-specific outcomes. Radiation Therapy Oncology Group trial 0529 demonstrated decreased toxicity and fewer treatment ...

journal_title：Cancer

authors： Elson JK,Kachnic LA,Kharofa JR

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:The natural history of desmoid tumors remains an enigma. Previous reports attempting to identify their biology have included recurrent and primary tumors as well as tumors from both intra- and extra-abdominal sites. The purpose of this study was to analyze patients with primary extremity and trunk desmoid tu...

journal_title：Cancer

authors： Merchant NB,Lewis JJ,Woodruff JM,Leung DH,Brennan MF

更新日期：1999-11-15 00:00:00

abstract：BACKGROUND:An epidermal growth factor receptor (EGFR) immunohistochemical detection system currently is being developed. The current study attempts to address background EGFR reactivity issues before determining the optimum EGFR scoring system. METHODS:Tissue sections from 102 patients with T3N1-2M1 colon adenocarcino...

journal_title：Cancer

authors： Goldstein NS,Armin M

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Many studies have tried to identify prognostic factors to guide the selection of patients at high risk for metastases in penile carcinoma. The authors evaluated human papillomavirus (HPV) status with respect to clinical features, incidence of metastases, and prognosis of penile carcinoma. METHODS:Human papi...

journal_title：Cancer

authors： Bezerra AL,Lopes A,Santiago GH,Ribeiro KC,Latorre MR,Villa LL

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:Positron emission tomography (PET) with labeled fluorodeoxyglucose (FDG) demonstrates increased tracer uptake in many neoplasms. This study was undertaken to define the patterns of FDG uptake in head and neck neoplasms before and after high dose irradiation. METHODS:Twenty-five patients were evaluated prosp...

journal_title：Cancer

authors： Greven KM,Williams DW 3rd,Keyes JW Jr,McGuirt WF,Watson NE Jr,Randall ME,Raben M,Geisinger KR,Cappellari JO

更新日期：1994-08-15 00:00:00

abstract：BACKGROUND:RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical activity in patients wi...

journal_title：Cancer

authors： Borthakur G,Popplewell L,Boyiadzis M,Foran J,Platzbecker U,Vey N,Walter RB,Olin R,Raza A,Giagounidis A,Al-Kali A,Jabbour E,Kadia T,Garcia-Manero G,Bauman JW,Wu Y,Liu Y,Schramek D,Cox DS,Wissel P,Kantarjian H

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Studies postulate that certain religious beliefs related to medical care influence the end-of-life (EOL) medical decision making and care of patients with advanced cancer. Because to the best of the authors' knowledge no current measure explicitly assesses such beliefs, in the current study the authors intro...

journal_title：Cancer

authors： Balboni TA,Prigerson HG,Balboni MJ,Enzinger AC,VanderWeele TJ,Maciejewski PK

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND METHODS:Specimens obtained from 192 patients with Stage III squamous cell carcinoma of the cervix treated by radiation therapy alone were investigated with an immunohistochemical method for the expression of p53CM1, a monoclonal antibody that recognizes wild and mutant type p53 gene products in histologi...

journal_title：Cancer

authors： Oka K,Nakano T,Arai T

更新日期：1993-07-01 00:00:00

abstract：:Ultrasonographic examinations and measurements of CA 19-9 and elastase 1 were done simultaneously in 14 patients with resectable pancreatic cancer of less than 3.0 cm in longest diameter and 48 patients with pancreatitis. Although a pancreatic mass was detected ultrasonically in only six (42.9%) of the patients with t...

journal_title：Cancer

authors： Iishi H,Yamamura H,Tatsuta M,Okuda S,Kitamura T

更新日期：1986-05-15 00:00:00

abstract：BACKGROUND:Multimodality treatment has dramatically improved the outcome of patients with Ewing sarcoma. However, there appears to be little information concerning treatment-related complications in patients who are long-term survivors. METHODS:Forty-one patients with Ewing sarcoma who were treated between 1960-1980 a...

journal_title：Cancer

authors： Fuchs B,Valenzuela RG,Inwards C,Sim FH,Rock MG

更新日期：2003-12-15 00:00:00

abstract：BACKGROUND:Full-scale implementation of lung cancer screening in the United States will increase detection of early stages. This study was aimed at assessing the capacity required for treating those cancers. METHODS:A well-established microsimulation model was extended with treatment data from the National Cancer Data...

journal_title：Cancer

authors： Blom EF,Ten Haaf K,Arenberg DA,de Koning HJ

更新日期：2019-06-15 00:00:00

abstract：:Cystic medullary carcinoma of the breast is unusual. This report describes five patients with medullary carcinoma who presented clinically with a breast cyst. Fine-needle aspiration biopsy (NAB) was performed as part of the initial physical examination and the retrieved cyst fluid was examined cytologically. Four of t...

journal_title：Cancer

authors： Howell LP,Kline TS

更新日期：1990-01-15 00:00:00

abstract：BACKGROUND:Previous studies have suggested that the prognosis in patients with extremity soft-tissue sarcomas (ESTS) with isolated lymph node (LN) metastases (stage IV) is comparable to that of patients with high-risk ESTS without metastases (stage III). This study was performed to determine the outcomes of patients wh...

journal_title：Cancer

authors： Al-Refaie WB,Andtbacka RH,Ensor J,Pisters PW,Ellis TL,Shrout A,Hunt KK,Cormier JN,Pollock RE,Feig BW

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...

journal_title：Cancer

authors： Tsukamoto N,Kojima M,Hasegawa M,Oriuchi N,Matsushima T,Yokohama A,Saitoh T,Handa H,Endo K,Murakami H

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...

journal_title：Cancer

authors： Vicini FA,Antonucci JV,Goldstein N,Wallace M,Kestin L,Krauss D,Kunzmann J,Gilbert S,Schell S

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Patients with renal masses are at risk for having or developing chronic kidney disease (CKD) stage 3 (glomerular filtration rate [GFR] <60 mL per minute/1.73 m2). In this study, the authors investigated whether the Screening for Occult Renal Disease (SCORED) model could identify patients with renal masses wh...

journal_title：Cancer

authors： Lucas SM,Nuss G,Stern J,Lotan Y,Sagalowsky AI,Cadeddu JA,Raj GV

更新日期：2008-11-15 00:00:00

abstract：BACKGROUND:To identify potential genetic markers for severe oxaliplatin-induced chronic peripheral neuropathy (OXCPN), the authors performed a genome-wide association analysis of patients with colon cancer who received oxaliplatin-based chemotherapy. METHODS:This was a prospective study in which DNA was purified in pe...

journal_title：Cancer

authors： Won HH,Lee J,Park JO,Park YS,Lim HY,Kang WK,Kim JW,Lee SY,Park SH

更新日期：2012-06-01 00:00:00

abstract：:A case of multiple myeloma is described that contained two morphologically identical but immunologically diverse subpopulations. One of the subclones produced only kappa chains, whereas the other contained only gamma chains. Additional immunohistologic investigations revealed production by one of the subpopulations of...

journal_title：Cancer

authors： Metz K,Leder LD

更新日期：1985-09-15 00:00:00

abstract：BACKGROUND:Biomarker-guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not available are not eligible. Technological advancements in sequencing have made cell-free circulating DNA (cfDNA) next-generation sequencing (NGS) readily a...

journal_title：Cancer

authors： Agarwal N,Pal SK,Hahn AW,Nussenzveig RH,Pond GR,Gupta SV,Wang J,Bilen MA,Naik G,Ghatalia P,Hoimes CJ,Gopalakrishnan D,Barata PC,Drakaki A,Faltas BM,Kiedrowski LA,Lanman RB,Nagy RJ,Vogelzang NJ,Boucher KM,Vaishampa

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Based on the 1998 Patient Care Evaluation (PCE) from the American College of Surgeons National Cancer Data Base (NCDB), the authors described contemporary nationwide patterns of prostate carcinoma presentation, diagnosis, and staging. METHODS:The authors reviewed 54,212 cases from the 1998 PCE. Demographics...

journal_title：Cancer

authors： Miller DC,Hafez KS,Stewart A,Montie JE,Wei JT

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess prostate carcinoma detection and discrimination of benign from malignant prostate tissue with contrast-enhanced ultrasonography. METHODS:In all, 301 subjects referred for prostate biopsy were evaluated with contrast-enhanced sonography using continuous harmonic imagin...

journal_title：Cancer

authors： Halpern EJ,Ramey JR,Strup SE,Frauscher F,McCue P,Gomella LG

更新日期：2005-12-01 00:00:00

abstract：:Nine years after biopsy and radiation therapy for an extramedullary plasmacytoma of the nasal cavity, a 64-year-old man developed locally recurrent tumor. Repeat biopsy revealed tumor identical in hematoxylin and eosin stain (H & E) appearance to that found originally, leading to the diagnosis of recurrent extramedull...

journal_title：Cancer

authors： Abrams RA,Wilson JF,Komorowski RA,Collins D,Toohill RJ

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate whether polymorphisms in DNA repair genes affect clinical outcome of never-smokers with lung adenocarcinoma (NSLA). METHOD:Common polymorphisms in the DNA repair genes ribonucleotide reductase M1 (RRM1), excision repair cross-complementation group 1 (ERCC1), an...

journal_title：Cancer

authors： Han JY,Yoon KA,Park JH,Lee YJ,Lee GK,Han JH,Yoon SJ,Yun T,Kim HT,Lee JS

更新日期：2011-07-15 00:00:00