当前位置： SCI文献检索 > CANCER期刊下所有文献 > Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN.

Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN.

Abstract：

BACKGROUND:The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories. METHODS:Our analysis included 141 BCS and 2086 controls from the Study of Women's Health Across the Nation (SWAN), a multiracial/ethnic cohort study of mid-life women assessed approximately annually from 1995 to 2015. Pink SWAN participants reported no cancer at SWAN enrollment and developed (cases) or did not develop (controls) incident breast cancer after enrollment. We assessed HRQL with SF-36 Mental Component Summary and Physical Component Summary scores. We modeled each as a function of case/control status, years since diagnosis, years since diagnosis squared, and the interaction terms between case/control status and the 2 time variables in linear models. We characterized heterogeneity in postdiagnosis HRQL of cases using group-based trajectories. RESULTS:BCS had significantly lower HRQL compared with controls at diagnosis and 1 year postdiagnosis. By 2 years, BCS and controls no longer differed significantly. Among BCS, 2 trajectory groups were identified for both scores. For the Mental Component Summary, 88.4% of BCS had consistently good and 11.6% had very low scores. For the Physical Component Summary, 73.9% had good scores, and 26.1% had consistently low scores. Prediagnosis perceived stress and current smoking were related to being in the low mental trajectory group, and a higher number of comorbidities was related to being in the low physical trajectory group. CONCLUSION:Although the majority of BCS have HRQL similar to non-cancer controls after 2 years, subgroups of BCS continue to have low HRQL. Prediagnosis stress, comorbidities, and smoking are vulnerability factors for long-term, low HRQL in BCS.

journal_name

Cancer

journal_title

Cancer

authors

Avis NE,Levine B,Goyal N,Crawford SL,Hess R,Colvin A,Bromberger JT,Greendale GA

doi

10.1002/cncr.32757

subject

Has Abstract

pub_date

2020-05-15 00:00:00

pages

2296-2304

issue

eissn

0008-543X

issn

1097-0142

journal_volume

126

pub_type

杂志文章

在线工具

Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN.