Abstract:
:Two patients developed extremely bizarre (pseudomalignant) granulation-tissue reactions in the larynx and facial sinuses, following radiation therapy for carcinoma. Containing pleomorphic spindle cells and numerous (sometimes atypical) mitotic figures, both tumefactive lesions simulated high grade malignancies. While the pleomorphic cells contained vimentin immunoreactivity, they were nonreactive for low or high molecular weight keratin. Flowcytometric study of paraffin-embedded tissues revealed DNA indexes of 0.75 and 1.0. Neither recurred locally nor spread distantly after therapy. Their granulation-tissue growth pattern, and the presence of stromal and endothelial cells showing similar degrees of cytologic atypia were central to their recognition as benign. These findings show that severely atypical, sometimes aneuploid, granulation-tissue reactions can occur following radiation exposure. Care should be taken not to misinterpret these lesions as malignant.
journal_name
Cancerjournal_title
Cancerauthors
Weidner N,Askin FB,Berthrong M,Hopkins MB,Kute TE,McGuirt FWdoi
10.1002/1097-0142(19870415)59:8<1509::aid-cncr2820subject
Has Abstractpub_date
1987-04-15 00:00:00pages
1509-14issue
8eissn
0008-543Xissn
1097-0142journal_volume
59pub_type
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