Abstract:
BACKGROUND:Helicobacter pylori recently was identified as a risk factor for gastric cancer. Its association with preneoplastic conditions of the stomach, however, is undocumented. METHODS:Gastric biopsy specimens from 245 symptomatic patients were examined for neoplastic and preneoplastic lesions and for gastric H. pylori infection. The sera of 183 subjects were tested by enzyme-linked immunosorbent assay (ELISA) for anti-H. pylori immunoglobulin G. RESULTS:Histologic H. pylori infection, usually accompanied by acute and chronic gastritis, was found in 85.7% of patients. There was a strong association between H. pylori in the tissue and atrophy (relative risk, 15.0; 95% confidence interval, 4.2-56.6), intestinal metaplasia (relative risk, 5.7; 95% confidence interval, 1.9-16.8), and dysplasia or cancer (relative risk, 4.0; 95% confidence interval, 1.1-14.8). The ELISA was 93.2% sensitive and 57.1% specific for histologic infection with a positive predictive value of 96.1%. The overall seroprevalence rate was 86.1%, with no significant difference in rates between patients with cancer precursors and those with normal stomachs. CONCLUSIONS:In this high-risk population, precursor lesions for adenocarcinoma were associated universally with H. pylori infection.
journal_name
Cancerjournal_title
Cancerauthors
Guarner J,Mohar A,Parsonnet J,Halperin Ddoi
10.1002/1097-0142(19930115)71:2<297::aid-cncr28207subject
Has Abstractpub_date
1993-01-15 00:00:00pages
297-301issue
2eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
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