Increased risk of cancer in patients with Gaucher disease.

Abstract:

BACKGROUND:An increased incidence of cancer, especially hematopoietic in origin, has long been suspected but never established in patients with Gaucher disease. METHODS:To determine whether patients with Gaucher disease have an increased risk of cancer, the authors conducted a retrospective cohort study, comparing the incidence and type of cancer in 48 patients with Gaucher disease with those of 511 control subjects without the disease. RESULTS:Among patients with Gaucher disease, 10 of 48 (20.8%) had cancer, as compared with 35 of 511 (6.8%) of the control group (P = 0.0027; relative risk, 3.6; 95% confidence interval, 1.7-7.5). As compared with the control group, patients with Gaucher disease had a 14.7-fold risk of having cancer of hematopoietic origin (10.4% [5 of 48] versus 0.78% [4 of 511], respectively; P = 0.00037; 95% confidence interval, 5.2-41.7). The mean age at cancer diagnosis in the group with Gaucher disease was 57 +/- 18 years. CONCLUSIONS:The authors conclude that patients with Gaucher disease have a significantly increased risk of cancer, occurring in late adulthood. Of all the cancers, hematologic cancers are significantly more prevalent.

journal_name

Cancer

journal_title

Cancer

authors

Shiran A,Brenner B,Laor A,Tatarsky I

doi

10.1002/1097-0142(19930701)72:1<219::aid-cncr28207

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

219-24

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

72

pub_type

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