Disseminated coagulopathy in chronic myelomonocytic leukemia.

Abstract:

:The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in this series. No single clinical or laboratory finding was diagnostic for the disease. Most importantly, seven of nine patients had abnormal coagulation values; in two cases the abnormalities were consistent with disseminated intravascular coagulation and correlated with a hemorrhagic diathesis. It is concluded that patients with chronic myelomonocytic leukemia who have thrombocytopenia or a bleeding tendency should be evaluated for evidence of disseminated intravascular coagulation.

journal_name

Cancer

journal_title

Cancer

authors

Gingrich RD,Burns CP

doi

10.1002/1097-0142(197912)44:6<2249::aid-cncr282044

subject

Has Abstract

pub_date

1979-12-01 00:00:00

pages

2249-53

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

44

pub_type

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